Paul N. Devine

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Extending the application of biocatalysis to meet the challenges of drug development

Rajesh Kumar, Matthew P. Thompson, Paul N. Devine, 2018, Nature Reviews Chemistry.

Mass Activated Droplet Sorting (MADS) Enables High Throughput Screening of Enzymatic Reactions at Nanoliter Scale.

Paul N. Devine, Daniel A Holland-Moritz, C. Welch, 2019, Angewandte Chemie.

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

Paul N. Devine, Gjalt W. Huisman, E. Mundorff, 2010, Science.

A generic platform for the immobilisation of engineered biocatalysts

Nicholas J. Turner, Paul N. Devine, Matthew D. Truppo, 2019, Tetrahedron.

Advances in the Enzymatic Reduction of Ketones

Paul N. Devine, Jeffrey C. Moore, David Pollard, 2008 .

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

Shane T. Grosser, Deeptak Verma, Edward C. Sherer, 2019, Science.

Asymmetric bioreduction of α,β-unsaturated nitriles and ketones

Paul N. Devine, Jeffrey T. Kuethe, F. Fleitz, 2008 .

Convergent Kilogram-Scale Synthesis of Dual Orexin Receptor Antagonist

Paul N. Devine, Louis-Charles Campeau, Paul D. O’Shea, 2013 .

Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-membered [corrected] macrocycle.

Paul N. Devine, D. Tellers, D. Zewge, 2011, The Journal of organic chemistry.

An Efficient Chemoenzymatic Approach to (S)-γ-Fluoroleucine Ethyl Ester

Paul N. Devine, R. Volante, R. Reamer, 2005 .

Production of (S)-γ-fluoroleucine ethyl ester by enzyme mediated dynamic kinetic resolution: Comparison of batch and fed batch stirred tank processes to a packed bed column reactor

Paul N. Devine, Jeffrey C. Moore, M. Truppo, 2008 .

Synthesis of Chiral Non‐Racemic Diols from (S,S)‐1,2,3,4‐Diepoxybutane: (2S,3S)‐Dihydroxy‐1,4‐Diphenylbutane

Paul N. Devine, Taeboem Oh, M. Robbins, 2003 .

Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation

Paul N. Devine, D. Tellers, D. Zewge, 2014 .

Preparation and application of cross-linked aggregates of chloroperoxidase with enhanced hydrogen peroxide tolerance

Paul N. Devine, D. Pollard, Christopher Roberge, 2009 .

Synthesis of chiral nonracemic diols via nucleophilic opening of (S,S)-1,2,3,4-diepoxybutane

Paul N. Devine, Taeboem Oh, 1991 .

A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins

Katrina W. Lexa, Paul N. Devine, W. Schafer, 2022, Science.

Asymmetric synthesis of cis-2,5-disubstituted pyrrolidine, the core scaffold of β3-AR agonists.

Paul N. Devine, K. Maloney, M. Royzen, 2013, Organic letters.

Stereoselective synthesis of 2-aryloxy acids from lactamide derived esters of racemic α-halo carboxylic acids

Paul N. Devine, R. Heid, D. Tschaen, 1996 .

Asymmetric Biosynthesis of Key Aromatic Intermediates in the Synthesis of an Endothelin Receptor Antagonist

Paul N. Devine, M. Chartrain, R. Greasham, 2001 .

Synthesis of Grazoprevir, a Potent NS3/4a Protease Inhibitor for the Treatment of Hepatitis C Virus.

Paul N. Devine, Feng Xu, Jungchul Kim, 2018, Organic letters.

Asymmetric synthesis of cyanohydrin derived from pyridine aldehyde with cross-linked aggregates of hydroxynitrile lyases

Paul N. Devine, D. Pollard, F. Fleitz, 2007 .

Asymmetric Diels-Alder reactions of carboxylic ester dienophiles promoted by chiral Lewis acids

Paul N. Devine, Taeboem Oh, 1992 .

Facile synthesis of 2-bromo-3-fluorobenzonitrile: an application and study of the halodeboronation of aryl boronic acids.

Paul N. Devine, R. Volante, D. Gauthier, 2004, The Journal of organic chemistry.

Practical Asymmetric Synthesis of an Endothelin Receptor Antagonist

Paul N. Devine, R. Volante, P. Reider, 1999 .

Non-cryogenic CeCl3-promoted double additions of methyllithium and n-butyllithium to unsaturated nitriles

Paul N. Devine, J. Limanto, B. Dorner, 2006 .

Asymmetric synthesis of telcagepant, a CGRP receptor antagonist for the treatment of migraine.

Paul N. Devine, T. Itoh, Feng Xu, 2010, The Journal of organic chemistry.

Stereoselective synthesis of 2-aryloxy esters: An asymmetric approach to fluoxetine, tomoxetine and nisoxetine

Paul N. Devine, R. Heid, D. Tschaen, 1997 .

Enzyme-catalyzed enantioselective diaryl ketone reductions.

Paul N. Devine, M. Truppo, D. Pollard, 2007, Organic letters.

Chemo- and enantioselective routes to chiral fluorinated hydroxyketones using ketoreductases.

Paul N. Devine, B. Kosjek, L. Dimichele, 2007, Organic letters.

Thio-Claisen Rearrangements. An Asymmetric Synthesis of 4,4-Disubstituted Cyclohexenones with Vicinal Quaternary and Tertiary Stereocenters

Paul N. Devine, A. Meyers, 1994 .

Advances in the enzymatic reduction of ketones.

Paul N Devine, Paul N. Devine, Jeffrey C. Moore, 2007, Accounts of chemical research.

Efficient synthesis of NK(1) receptor antagonist aprepitant using a crystallization-induced diastereoselective transformation.

Jing Li, Paul N Devine, Paul N. Devine, 2003, Journal of the American Chemical Society.

Scalable, efficient process for the synthesis of (R)-3,5-bistrifluoromethylphenyl ethanol via catalytic asymmetric transfer hydrogenation and isolation as a DABCO inclusion complex

Paul N. Devine, D. Mathre, E. Grabowski, 2003 .

Palladium and nickel catalyzed thio-Claisen rearrangements of chiral bicyclic thiolactams (via N,S-ketene acetals)

Paul N. Devine, A. Meyers, Daniel J. Watson, 2000 .

An Asymmetric Route to Novel Chiral Cyclohexenones with Spiro-Connected Cyclopentenes. Further Utility of Chiral Bicyclic Thiolactams and the [3,3] Thio-Claisen Products.

Paul N. Devine, A. Meyers, R. Lemieux, 1999, The Journal of organic chemistry.

Diastereoselective Reductive Amination of Aryl Trifluoromethyl Ketones and α‐Amino Esters

Paul N. Devine, J. R. Naber, G. Hughes, 2007 .

Biocatalysis in drug discovery and development.

Anna Fryszkowska, Paul N Devine, Paul N. Devine, 2020, Current opinion in chemical biology.

An Asymmetric Synthesis of 3-Aryl-1,4-oxazin-2-ones: Synthesis of a Key Intermediate of an NK1 Receptor Antagonist

Paul N. Devine, P. Reider, E. Grabowski, 2002 .

Chiral bicyclic Lactams as homoenolate equivalents: An asymmetric route to 5-substituted cyclohexenones

Paul N. Devine, A. Meyers, J. Schwarz, 1997 .

Asymmetric synthesis of cis-aminochromanol

Paul N. Devine, P. Reider, E. Grabowski, 2001 .

Synthesis of a tertiary carbinamide via a novel Rh-catalyzed asymmetric hydrogenation.

Paul N. Devine, S. Krska, J. Limanto, 2008, The Journal of organic chemistry.

Copper-catalyzed synthesis of enantioenriched tetraarylethanes.

Paul N. Devine, M. Truppo, Mirlinda Biba, 2008, Organic Letters.

An asymmetric synthesis of novel aminocyclopropyl carboxylic acids (ACC)

Paul N. Devine, A. Meijere, A. Meyers, 1995 .

Copper‐Catalyzed Synthesis of Enantioenriched Tetraarylethanes.

Paul N. Devine, M. Truppo, Mirlinda Biba, 2008 .

A kinase-cGAS cascade to synthesize a therapeutic STING activator

Steven P. Miller, Paul N. Devine, Matthew L. Maddess, 2022, Nature.

Acyclic Diastereoselection via Claisen Rearrangement with Boron Enolates. Chelation Control of Enolate Geometry

Paul N. Devine, Taeboem Oh, Z. Wróbel, 1992 .

Mass Activated Droplet Sorting (MADS) Enables High‐Throughput Screening of Enzymatic Reactions at Nanoliter Scale

Paul N. Devine, R. Kennedy, B. Mann, 2020, Angewandte Chemie.

A regioselective approach to 5-substituted-3-amino-1,2,4-triazines.

Paul N. Devine, R. Volante, R. Reamer, 2003, Organic letters.

Synthesis of optically active cyanohydrins from aromatic ketones: evidence of an increased substrate range and inverted stereoselectivity for the hydroxynitrile lyase from Linum usitatissimum

Paul N. Devine, D. Pollard, F. Fleitz, 2007 .

Factors influencing the stereoselectivity in the cycloaddition of imino-dienophiles derived from amino ethers, amino alcohols, and amino acid esters

Paul N. Devine, Michael Reilly, Taeboem Oh, 1993 .

Factors Influencing the Stereoselectivity in the Cycloaddition of Imino-Dienophiles Derived from Amino Ethers, Amino Alcohols, and Amino Acid Esters.

Paul N. Devine, Michael Reilly, Taeboem Oh, 1994 .

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

Paul N. Devine, E. Mundorff, Sarena Tam, 2010, Science.

Hemoprotein‐Catalyzed Cyclopropanation En Route to the Chiral Cyclopropanol Fragment of Grazoprevir

Paul N. Devine, J. McIntosh, Taejin Kim, 2019, Chembiochem : a European journal of chemical biology.