Douglas A. Lauffenburger

发表

Collecting and organizing systematic sets of protein data

John G. Albeck, Gavin MacBeath, Forest M. White, 2006, Nature Reviews Molecular Cell Biology.

Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity

Miles Miller, Marc Hafner, Ron Weiss, 2012, PLoS Comput. Biol..

Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling

Julio Saez-Rodriguez, Peter K. Sorger, Douglas A. Lauffenburger, 2007, PLoS Comput. Biol..

Modeling pro-death signaling pathways in cancer hepatocytes using multi-combinatorial treatments of inhibitors and stimuli

Peter K. Sorger, Douglas A. Lauffenburger, Leonidas G. Alexopoulos, 2008, 2008 8th IEEE International Conference on BioInformatics and BioEngineering.

CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms

Julio Saez-Rodriguez, Martijn P. van Iersel, Emanuel J. V. Gonçalves, 2012, BMC Systems Biology.

Modeling HER2 Effects on Cell Behavior from Mass Spectrometry Phosphotyrosine Data

Forest M. White, Douglas A. Lauffenburger, Alejandro Wolf-Yadlin, 2006, PLoS Comput. Biol..

Cellular defense processes regulated by pathogen-elicited receptor signaling

Douglas A. Lauffenburger, Rongcong Wu, Arthur Goldsipe, 2011, Defense + Commercial Sensing.

Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli

Julio Saez-Rodriguez, Peter K. Sorger, Douglas A. Lauffenburger, 2011, PLoS Comput. Biol..

Exploiting glycan topography for computational design of Env glycoprotein antigenicity

Douglas A. Lauffenburger, Michael Tiemeyer, Wen-Han Yu, 2018, PLoS Comput. Biol..

Non Linear Programming (NLP) Formulation for Quantitative Modeling of Protein Signal Transduction Pathways

Julio Saez-Rodriguez, Alexander Mitsos, Douglas A. Lauffenburger, 2012, PloS one.

Probability of Autocrine Ligand Capture by Cell-Surface Receptors: Implications for Ligand Secretion Measurements

Douglas A. Lauffenburger, Kimberly E. Forsten, D. Lauffenburger, 1994, J. Comput. Biol..

Cue-Signal-Response Analysis of TNF-Induced Apoptosis by Partial Least Squares Regression of Dynamic Multivariate Data

John G. Albeck, Peter K. Sorger, Douglas A. Lauffenburger, 2004, J. Comput. Biol..

A Course in Applied Mathematics in Chemical Engineering.

Douglas A. Lauffenburger, 1984 .

Receptor/ligand sorting along the endocytic pathway

Douglas A. Lauffenburger, Jennifer J. Linderman, 1989 .

Analysis of signaling pathways in human T-cells using Bayesian network modeling of single cell data

Tommi S. Jaakkola, David K. Gifford, Douglas A. Lauffenburger, 2004 .

MCAM: Multiple Clustering Analysis Methodology for Deriving Hypotheses and Insights from High-Throughput Proteomic Datasets

Roy E. Welsch, Kristen M. Naegle, Forest M. White, 2011, PLoS Comput. Biol..

Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility

Shan Wu, Alan Wells, Sampsa Hautaniemi, 2007, BMC Systems Biology.

Linking Proteomic and Transcriptional Data through the Interactome and Epigenome Reveals a Map of Oncogene-induced Signaling

Ernest Fraenkel, Douglas A. Lauffenburger, William Gordon, 2013, PLoS Comput. Biol..

A Dynamical Systems Model for Combinatorial Cancer Therapy Enhances Oncolytic Adenovirus Efficacy by MEK-Inhibition

Douglas A. Lauffenburger, Neda Bagheri, W. Michael Korn, 2011, PLoS Comput. Biol..

Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling

Steffen Klamt, Fabian J. Theis, Julio Saez-Rodriguez, 2009, BMC Systems Biology.

Bayesian analysis of signaling networks governing embryonic stem cell fate decisions

Peter J. Woolf, George Q. Daley, Douglas A. Lauffenburger, 2005, Bioinform..

Making connections count

Douglas A. Lauffenburger, D. Lauffenburger, 1996, Nature.

Identification of signaling pathways related to drug efficacy in hepatocellular carcinoma via integration of phosphoproteomic, genomic and clinical data

Douglas A. Lauffenburger, Leonidas G. Alexopoulos, Ioannis N. Melas, 2013, 13th IEEE International Conference on BioInformatics and BioEngineering.

Modeling cellular signal processing using interacting Markov chains

Alan V. Oppenheim, Douglas A. Lauffenburger, Maya R. Said, 2003, 2003 IEEE International Conference on Acoustics, Speech, and Signal Processing, 2003. Proceedings. (ICASSP '03)..

Learning Signaling Network Structures with Sparsely Distributed Data

Douglas A. Lauffenburger, Karen Sachs, Garry P. Nolan, 2009, J. Comput. Biol..

Modeling of signal-response cascades using decision tree analysis

Alan Wells, Sampsa Hautaniemi, Douglas A. Lauffenburger, 2005, Bioinform..

Flexible informatics for linking experimental data to mathematical models via DataRail

Julio Saez-Rodriguez, Peter K. Sorger, Douglas A. Lauffenburger, 2008, Bioinform..

Analysis of signaling pathways in human T-cells using Bayesian network modeling of single cell data

Tommi S. Jaakkola, David K. Gifford, Douglas A. Lauffenburger, 2004, Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004..

Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks

Julio Saez-Rodriguez, Peter K. Sorger, Douglas A. Lauffenburger, 2012, BMC Systems Biology.

Logic-Based Models for the Analysis of Cell Signaling Networks†

Peter K. Sorger, Douglas A. Lauffenburger, Melody K. Morris, 2010, Biochemistry.

A Course in Cellular Bioengineering.

Douglas A. Lauffenburger, 1989 .

Bioengineering and Systems Biology

Douglas A. Lauffenburger, Trey Ideker, L. Raimond Winslow, 2006, Annals of Biomedical Engineering.

Analysis of chemotactic bacterial distributions in population migration assays using a mathematical model applicable to steep or shallow attractant gradients

R. M. Ford, Douglas A. Lauffenburger, Roseanne M. Ford, 1991 .

An hypothesis for approaching swarms of myxobacteria

Douglas A. Lauffenburger, Kenneth H. Keller, D. Lauffenburger, 1984 .

networks Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling

Douglas A. Lauffenburger, Sampsa Hautaniemi, Sampsa Hautaniemi, 2007 .

Understanding Effects of Matrix Protease and Matrix Organization on Directional Persistence and Translational Speed in Three-Dimensional Cell Migration

Douglas A. Lauffenburger, Muhammad H. Zaman, Paul Matsudaira, 2006, Annals of Biomedical Engineering.

Measurement of individual cell migration parameters for human tissue cells

Douglas A. Lauffenburger, Paul A. DiMilla, D. Lauffenburger, 1992 .

Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging

Douglas A. Lauffenburger, Anna C. Belkina, Jennifer E. Snyder-Cappione, 2018, bioRxiv.

Quantitative and Systems Pharmacology in the Post-genomic Era : New Approaches to Discovering Drugs and Understanding Therapeutic

Ravi Iyengar, Darrell R. Abernethy, Paolo Vicini, 2011 .

In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF-α–Induced Apoptosis and Proliferation by MAPKs

Douglas A. Lauffenburger, Ken S. Lau, D. Lauffenburger, 2011, Science Signaling.

Transport models for chemotactic cell populations based on individual cell behavior

Douglas A. Lauffenburger, Helen M. Buettner, Robert T. Tranquillo, 1989 .

Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks

Gavin MacBeath, Douglas A. Lauffenburger, Alejandro Wolf-Yadlin, 2013, Science Signaling.

Prioritisation and Network Analysis of Crohn's Disease Susceptibility Genes

Douglas A. Lauffenburger, Daniele Muraro, Alison Simmons, 2014, PloS one.

NUMERICAL SOLUTION OF THE NONLINEAR POISSON-BOLTZMANN EQUATION FOR A MEMBRANE-ELECTROLYTE SYSTEM

Douglas A. Lauffenburger, Shankar Subramaniam, Kimberly E. Forsten, 1994 .

Kinetic Model for Integrin-mediated Adhesion Release During Cell Migration

Sean P. Palecek, Douglas A. Lauffenburger, D. Lauffenburger, 1999, Annals of Biomedical Engineering.

Synergistic Communication between CD4+ T Cells and Monocytes Impacts the Cytokine Environment

Douglas A. Lauffenburger, Sarah B Schrier, D. Lauffenburger, 2016, Scientific Reports.

Cellular Regulatory Networks

Julio Saez-Rodriguez, Douglas A. Lauffenburger, R. Krishna Murthy Karuturi, 2010 .

Polyfunctional responses by human T cells result from sequential release of cytokines

Douglas A. Lauffenburger, Neda Bagheri, J. Christopher Love, 2011, Proceedings of the National Academy of Sciences.

Normalization and Statistical Analysis of Multiplexed Bead-based Immunoassay Data Using Mixed-effects Modeling*

Douglas A. Lauffenburger, David C. Clarke, D. C. Clarke, 2012, Molecular & Cellular Proteomics.

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

Sean P. Palecek, Douglas A. Lauffenburger, Joseph C. Loftus, 1997, Nature.

Common effector processing mediates cell-specific responses to stimuli

Douglas A. Lauffenburger, Kevin A. Janes, Kathryn Miller-Jensen, 2007, Nature.

Increased Endosomal Sorting of Ligand to Recycling Enhances Potency of an Interleukin-2 Analog*

Douglas A. Lauffenburger, D. Lauffenburger, T. Ciardelli, 2000, The Journal of Biological Chemistry.

Multivariate Computational Analysis of Gamma Delta T cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging

Douglas A. Lauffenburger, Anna C. Belkina, Jennifer E. Snyder-Cappione, 2018 .

Diffusion and Probability in Receptor Binding and Signaling

Douglas A. Lauffenburger, Jennifer J. Linderman, D. Lauffenburger, 1994 .

Traveling bands of chemotactic bacteria in the context of population growth

Douglas A. Lauffenburger, R. Aris, C. R. Kennedy, 1984 .

A multipathway phosphoproteomic signaling network model of idiosyncratic drug- and inflammatory cytokine-induced toxicity in human hepatocytes

Linda G. Griffith, Julio Saez-Rodriguez, Douglas A. Lauffenburger, 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Engineering epidermal growth factor for enhanced mitogenic potency

Alan Wells, H. Steven Wiley, Douglas A. Lauffenburger, 1996, Nature Biotechnology.

CHAPTER 17 – QUANTITATIVE ASPECTS OF TISSUE ENGINEERING: BASIC ISSUES IN KINETICS, TRANSPORT, AND MECHANICS

Roger D. Kamm, Douglas A. Lauffenburger, Alan J. Grodzinsky, 2000 .

2D protrusion but not motility predicts growth factor–induced cancer cell migration in 3D collagen

Alan Wells, Douglas A. Lauffenburger, Frank B. Gertler, 2012, The Journal of cell biology.

Effect of Epidermal Growth Factor Receptor Internalization on Regulation of the Phospholipase C-γ1 Signaling Pathway*

Alan Wells, H. Steven Wiley, Douglas A. Lauffenburger, 1999, The Journal of Biological Chemistry.

Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production

Thomas B. Kepler, Min Zhu, Douglas A. Lauffenburger, 2015, Obesity.

A Model for Mechanotransduction in Cardiac Muscle: Effects of Extracellular Matrix Deformation on Autocrine Signaling

Douglas A. Lauffenburger, Richard T. Lee, Ivan V. Maly, 2004, Annals of Biomedical Engineering.

A dynamical model for receptor-mediated cell adhesion to surfaces in viscous shear flow

Daniel A. Hammer, Douglas A. Lauffenburger, D. Lauffenburger, 1989, Cell Biophysics.

Mechanotransduction through growth-factor shedding into the extracellular space

Roger D. Kamm, Peter T. C. So, Douglas A. Lauffenburger, 2004, Nature.

MATHEMATICAL ANALYSIS OF CELL TRANSPORT PHENOMENA: BACTERIAL CHEMOTAXIS IN THE CAPILLARY ASSAY

Douglas A. Lauffenburger, John A. Quinn, Peter O Staffeld, 1987 .

Erratum: Bioengineering and systems biology (Annals of Biomedical Engigeering (2006) DOI: 10.1007/s10439-005-9047-7)

Douglas A. Lauffenburger, Trey Ideker, Douglas A. Lauffenburger, 2006 .

Molecular Network Analysis of Endometriosis Reveals a Role for c-Jun–Regulated Macrophage Activation

Linda G. Griffith, Douglas A. Lauffenburger, Keith B. Isaacson, 2014, Science Translational Medicine.

A unifying hypothesis for leukocyte random motility and chemotaxis based on stochastic cell-receptor sensing

Douglas A. Lauffenburger, Robert T. Tranquillo, 1987 .

Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics

Douglas A. Lauffenburger, Andrew Sawyer, Andreas Raue, 2018, Cell reports.

Epidermal Growth Factor Induces Fibroblast Contractility and Motility via a Protein Kinase C δ-dependent Pathway*

Alan Wells, Douglas A. Lauffenburger, Akihiro Iwabu, 2004, Journal of Biological Chemistry.

Membrane Proximal ERK Signaling Is Required for M-calpain Activation Downstream of Epidermal Growth Factor Receptor Signaling*

Alan Wells, Douglas A. Lauffenburger, Angela Glading, 2001, The Journal of Biological Chemistry.

Nature's Complex Copolymers: Engineering Design of Oligopeptide Materials

Michael R. Caplan, Douglas A. Lauffenburger, 2002 .

Molecular Signatures of Immune Activation and Epithelial Barrier Remodeling Are Enhanced during the Luteal Phase of the Menstrual Cycle: Implications for HIV Susceptibility

Douglas A. Lauffenburger, Richard M. Novak, D. Lauffenburger, 2015, Journal of Virology.

Erratum: Integrin–ligand binding properties govern cell migration speed through cell–substratum adhesiveness

Sean P. Palecek, Douglas A. Lauffenburger, Joseph C. Loftus, 1997, Nature.

Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAFV600E melanoma cells

Peter K. Sorger, Douglas A. Lauffenburger, Jia-Yun Chen, 2019, bioRxiv.