David S Nirschl

发表

End-to-End Sample Tracking in the Laboratory Using a Custom Internet of Things Device

William Neil, Greg Zipp, Gregory Nemeth, 2018, SLAS technology.

A Computational Method for Planning Complex Compound Distributions under Container, Liquid Handler, and Assay Constraints

William Neil, Daniel Wild, Mark F Russo, 2013, Journal of laboratory automation.

Synthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds.

David S Nirschl, Arthur M Doweyko, Arvind Mathur, 2007, Bioorganic & medicinal chemistry letters.

Pyrrolo[1,2-f]triazines as JAK2 inhibitors: achieving potency and selectivity for JAK2 over JAK3.

David S. Nirschl, Jonathan Lippy, John S Tokarski, 2011, Bioorganic & medicinal chemistry letters.

Application of lean manufacturing concepts to drug discovery: rapid analogue library synthesis.

Harold N Weller, John G Houston, David S. Nirschl, 2006, Journal of combinatorial chemistry.

Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

Akbar Nayeem, Haixia Wang, Steven Sheriff, 2008, Bioorganic & medicinal chemistry letters.

Addressing the medicinal chemistry bottleneck: a lean approach to centralized purification.

Harold N Weller, William H Bullock, David S Nirschl, 2012, ACS combinatorial science.

Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.

David S. Nirschl, David S Nirschl, A. Doweyko, 2013, Bioorganic & medicinal chemistry letters.

2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis.

David S. Taylor, David S Nirschl, C. Weigelt, 2008, Bioorganic & medicinal chemistry letters.

Efficient and library-friendly synthesis of furo- and thieno[2,3-d] pyrimidin-4-amine derivatives by microwave irradiation

David S Nirschl, Ying Han, H. Weller, 2010 .

Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase.

David S. Nirschl, David S Nirschl, J. Fargnoli, 2008, Bioorganic & medicinal chemistry letters.

Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.

David S. Nirschl, Kimberly A. Foster, David S Nirschl, 2017, Journal of medicinal chemistry.

Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors.

David S. Nirschl, David S Nirschl, Sidney Pitt, 2014, Bioorganic & medicinal chemistry letters.

Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors.

David S. Nirschl, David S. Taylor, David S Nirschl, 2014, Bioorganic & medicinal chemistry letters.

Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066).

David S. Nirschl, David S Nirschl, Michael A. Galella, 2011, Bioorganic & medicinal chemistry letters.

Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.

David S. Nirschl, David S Nirschl, S. Spergel, 2011, Bioorganic & medicinal chemistry letters.

Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors.

David S. Nirschl, David S. Taylor, David S Nirschl, 2012, Bioorganic & medicinal chemistry letters.

Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors.

David S. Nirschl, David S. Taylor, David S Nirschl, 2012, Journal of medicinal chemistry.

Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1).

David S. Nirschl, David S Nirschl, G. Trainor, 2012, Bioorganic & medicinal chemistry letters.

Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy- N-

David S Nirschl, Michael A. Galella, S. Spergel, 2012 .

Novel tricyclic inhibitors of IkappaB kinase.

David S Nirschl, S. Spergel, R. Moquin, 2009, Journal of medicinal chemistry.

Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.

David S Nirschl, P. Lam, S. Sheriff, 2019, Bioorganic & medicinal chemistry letters.