Ryan M. O’Connell

发表

CIPR: a web-based R/shiny app and R package to annotate cell clusters in single cell RNA sequencing experiments

H. Atakan Ekiz, Christopher J. Conley, W. Zac Stephens, 2020, BMC Bioinformatics.

miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response.

Ryan M. O’Connell, J. Round, M. Deininger, 2017, Blood.

NF-κB dysregulation in microRNA-146a–deficient mice drives the development of myeloid malignancies

Ryan M. O’Connell, D. Baltimore, K. Taganov, 2011, Proceedings of the National Academy of Sciences.

Inositol phosphatase SHIP1 is a primary target of miR-155

Ryan M. O’Connell, D. Baltimore, A. Chaudhuri, 2009, Proceedings of the National Academy of Sciences.

microRNA regulation of inflammatory responses.

Ryan M. O’Connell, D. Baltimore, D. Rao, 2012, Annual review of immunology.

Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A

Aadel A. Chaudhuri, David Baltimore, Ryan M. O’Connell, 2012, Proceedings of the National Academy of Sciences.

A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages

Ryan M. O’Connell, J. Round, W. Tang, 2021, Nature Communications.

Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity.

Ryan M. O’Connell, D. Baltimore, J. Round, 2012, Cell reports.

Type I Interferon Production Enhances Susceptibility to Listeria monocytogenes Infection

Ryan M. O’Connell, T. Taniguchi, G. Cheng, 2004, The Journal of experimental medicine.

MicroRNAs and the regulation of intestinal homeostasis

Ryan M. O’Connell, J. Round, M. Runtsch, 2014, Front. Genet..

Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine Coronavirus

Ryan M. O’Connell, T. Lane, H. A. Ekiz, 2020, Journal of Virology.

Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.

Ryan M. O’Connell, J. Round, J. Rutter, 2020, Cell reports.

MicroRNA-155 is induced during the macrophage inflammatory response

David Baltimore, Ryan M. O’Connell, Genhong Cheng, 2007, Proceedings of the National Academy of Sciences.

MicroRNAs and hematopoietic cell development.

Ryan M. O’Connell, D. Baltimore, Ryan M. O'Connell, 2012, Current topics in developmental biology.

MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output

Aadel A. Chaudhuri, David Baltimore, Ryan M. O’Connell, 2010, Proceedings of the National Academy of Sciences.

Single-cell RNA sequencing reveals the diversity of the immunological landscape following CNS infection 3

Ryan M. O’Connell, T. Lane, Ryan M. O'Connell, 2020 .

The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling

Ryan M. O’Connell, J. Round, R. Fujinami, 2019, eLife.

Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor

Ryan M. O’Connell, J. Round, R. Fujinami, 2017, Proceedings of the National Academy of Sciences.

A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice

Ryan M. O’Connell, D. Stillman, J. Round, 2017, Science Translational Medicine.

MicroRNA-125b Potentiates Macrophage Activation

Ryan M. O’Connell, D. Baltimore, A. Chaudhuri, 2011, The Journal of Immunology.

Adaptive immunity induces mutualism between commensal eukaryotes

Ryan M. O’Connell, J. Round, K. Christensen, 2021, Nature.

Function of MicroRNA-146 a and NF-κ B in Physiologic and Pathologic Hematopoiesis

Ryan M. O’Connell, Balázs, Devdoot Majumdar, 2013 .

MicroRNA function in myeloid biology.

Ryan M. O’Connell, D. Rao, Jimmy L. Zhao, 2011, Blood.

Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder

Aadel A. Chaudhuri, David Baltimore, Ryan M. O’Connell, 2008, The Journal of experimental medicine.

Physiological and pathological roles for microRNAs in the immune system

Ryan M. O’Connell, D. Baltimore, A. Chaudhuri, 2010, Nature Reviews Immunology.

Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease

Ryan M. O’Connell, M. Bronner, J. Round, 2019, PLoS genetics.

MicroRNA-155 coordinates the immunological landscape within murine melanoma and correlates with immunity in human cancers.

Ryan M. O’Connell, J. Round, Matthew A. Williams, 2019, JCI insight.

Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes.

Ryan M. O’Connell, D. Baltimore, Lili Yang, 2009, Blood.

B lymphocytes. broadly neutralizing anti-HIV antibody after in vitro maturation to human Engineering human hematopoietic stem/progenitor cells to produce a

Ryan M. O’Connell, D. Baltimore, Lili Yang, 2009 .

MicroRNA-34a perturbs B lymphocyte development by repressing the forkhead box transcription factor Foxp1.

Ryan M. O’Connell, D. Baltimore, A. Chaudhuri, 2010, Immunity.

MicroRNA-34 a Perturbs B Lymphocyte Development by Repressing the Forkhead Box Transcription Factor Foxp 1

Ryan M. O’Connell, D. Baltimore, A. Chaudhuri, 2010 .

No small matter: emerging roles for exosomal miRNAs in the immune system

Ryan M. O’Connell, J. Round, Ryan M. O'Connell, 2021, The FEBS journal.

microRNAs in Psoriasis.

Ryan M. O’Connell, S. Florell, G. Krueger, 2016, The Journal of investigative dermatology.

MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis

Ryan M. O’Connell, Noah C. Welker, Daniel Patrick Smith, 2015, Oncotarget.

MicroRNAs: new regulators of immune cell development and function

Ryan M. O’Connell, D. Baltimore, K. Taganov, 2008, Nature Immunology.

Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs

Ryan M. O’Connell, Jason Gertz, A. Welm, 2023, bioRxiv.

MicroRNA 155 and viral-induced neuroinflammation

Ryan M. O’Connell, T. Lane, Andrew G. Ramstead, 2017, Journal of Neuroimmunology.

Noncoding RNAs and chronic inflammation: Micro‐managing the fire within

Ryan M. O’Connell, Margaret Alexander, 2015, BioEssays : news and reviews in molecular, cellular and developmental biology.

MicroRNAs in Hematopoietic Stem Cell Biology

Ryan M. O’Connell, Dominique A. Kagele, 2015 .

miR-aculous new avenues for cancer immunotherapy

Ryan M. O’Connell, Ryan M. O'Connell, H. A. Ekiz, 2022, Frontiers in Immunology.

MicroRNAs and acute myeloid leukemia: therapeutic implications and emerging concepts.

Ryan M. O’Connell, Jared A. Wallace, 2017, Blood.

Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.

Ryan M. O’Connell, N. Ajami, J. Round, 2019, Cell host & microbe.

Lentiviral Vector Delivery of Human Interleukin-7 (hIL-7) to Human Immune System (HIS) Mice Expands T Lymphocyte Populations

Ryan M. O’Connell, D. Baltimore, A. Balazs, 2010, PloS one.

IRF3 mediates a TLR3/TLR4-specific antiviral gene program.

Govinda Rao, Sagar Vaidya, Ryan M. O’Connell, 2002, Immunity.

MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice

Ryan M. O’Connell, D. Baltimore, D. Rao, 2013, eLife.

Cutting Edge: TLR4 Activation Mediates Liver Ischemia/Reperfusion Inflammatory Response via IFN Regulatory Factor 3-Dependent MyD88-Independent Pathway1

Ryan M. O’Connell, F. Gao, G. Cheng, 2004, The Journal of Immunology.

Inflammasome-mediated production of IL-1β is required for neutrophil recruitment against Staphylococcus aureus in vivo.

Lawrence H. Uricchio, Ryan M. O’Connell, E. Pietras, 2008, The Journal of Immunology.

Inflammasome-Mediated Production of IL-1β Is Required for Neutrophil Recruitment against Staphylococcus aureus In Vivo1

Lawrence H. Uricchio, Ryan M. O’Connell, E. Pietras, 2007, The Journal of Immunology.

MicroRNAs: At the Interface of Metabolic Pathways and Inflammatory Responses by Macrophages

Ryan M. O’Connell, Morgan C. Nelson, 2020, Frontiers in Immunology.

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

Ryan M. O’Connell, J. Round, T. Tolmachova, 2015, Nature Communications.

MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health.

Ryan M. O’Connell, J. Round, W. Stephens, 2015, Cell host & microbe.

MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development.

Ryan M. O’Connell, D. Baltimore, A. Chaudhuri, 2010, Immunity.

MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus.

Ryan M. O’Connell, E. Pietras, A. Shahangian, 2006, Immunity.

MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection

Ryan M. O’Connell, W. Potts, N. Ajami, 2015, Nature Communications.

Immune Activation of Type I IFNs by Listeria monocytogenes Occurs Independently of TLR4, TLR2, and Receptor Interacting Protein 2 but Involves TANK-Binding Kinase 11

Ryan M. O’Connell, G. Cheng, Andrea K. Perry, 2005, The Journal of Immunology.

Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli

Ryan M. O’Connell, J. Round, T. Tolmachova, 2017, The Journal of Immunology.

MicroRNAs function on a new level.

Ryan M. O’Connell, Ryan M. O'Connell, 2012, Blood.

The miR-26b-5p/KPNA2 Axis Is an Important Regulator of Burkitt Lymphoma Cell Growth

Ryan M. O’Connell, K. Kok, I. Nolte, 2020, Cancers.

miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation.

Margaret Alexander, Thomas Möller, Ryan M. O’Connell, 2014, Immunity.

Toll-like Receptors Induce a Phagocytic Gene Program through p38

Ryan M. O’Connell, G. Cheng, W. Yeh, 2004, The Journal of experimental medicine.

Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system

Ryan M. O’Connell, K. Green, T. Lane, 2020, Glia.

Antagonistic Interplay between MicroRNA-155 and IL-10 during Lyme Carditis and Arthritis

Ryan M. O’Connell, J. Zachary, J. Weis, 2015, PloS one.

MicroRNA-146a Provides Feedback Regulation of Lyme Arthritis but Not Carditis during Infection with Borrelia burgdorferi

Ryan M. O’Connell, D. Baltimore, J. Zachary, 2014, PLoS pathogens.

Toll-Like Receptor 3 Mediates a More Potent Antiviral Response Than Toll-Like Receptor 41

Ryan M. O’Connell, G. Cheng, E. Chow, 2003, The Journal of Immunology.

Antiviral Response Than Toll-Like Receptor Toll-Like Receptor 3 Mediates a More Potent

Ryan M. O’Connell, G. Cheng, Ryan M. O'Connell, 2003 .

Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response.

Ryan M. O’Connell, R. Sun, G. Cheng, 2009, Cell host & microbe.

TLR agonists regulate PDGF‐B production and cell proliferation through TGF‐β/type I IFN crosstalk

Ryan M. O’Connell, G. Cheng, Xiao-Fan Wang, 2005, The EMBO journal.

Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis.

Ryan M. O’Connell, J. Heath, D. Baltimore, 2014, Cell stem cell.

A role for IRF3-dependent RXRα repression in hepatotoxicity associated with viral infections

Ryan M. O’Connell, A. Shahangian, G. Cheng, 2006, The Journal of experimental medicine.

3-Dependent MyD88-Independent Pathway Response via IFN Regulatory Factor Liver Ischemia/Reperfusion Inflammatory Cutting Edge: TLR4 Activation Mediates

Ryan M. O’Connell, F. Gao, G. Cheng, 2004 .

Coordination of tolerogenic immune responses by the commensal microbiota.

Ryan M. O’Connell, S. Mazmanian, J. Round, 2010, Journal of autoimmunity.

miR-125a-5p Regulates Megakaryocyte Proplatelet Formation Via the Actin Bundling Protein L-Plastin.

Ryan M. O’Connell, Robert A. Campbell, L. Edelstein, 2020, Blood.

Maternal schistosomiasis impairs offspring Interleukin-4 production and B cell expansion

Ryan M. O’Connell, Bartek Rajwa, Keke C. Fairfax, 2021, PLoS pathogens.

Antitumor immunity is defective in T cell–specific microRNA-155–deficient mice and is rescued by immune checkpoint blockade

Ryan M. O’Connell, J. Round, Margaret Alexander, 2017, The Journal of Biological Chemistry.

T cell expressed miR-155 promotes antitumor immunity

Ryan M. O’Connell, J. Round, Margaret Alexander, 2017 .

Inhibition of SHP-1 Expands the Repertoire of Antitumor T Cells Available to Respond to Immune Checkpoint Blockade

Ryan M. O’Connell, Matthew A. Williams, Ryan M. O'Connell, 2020, Cancer Immunology Research.

T cells within the tumor microenvironment is essential for the control of tumor growth. Utilizing B16-F10 melanoma tumors that express altered peptide ligands of chicken ovalbumin, OVA257-264, we measured high- and low-affinity OVA-specific responses following adoptive transfer of OT-I

Ryan M. O’Connell, Matthew A. Williams, Ryan M. O'Connell, 2020 .

A MyD88-dependent IFNγR-CCR2 signaling circuit is required for mobilization of monocytes and host defense against systemic bacterial challenge

Ryan M. O’Connell, E. Pietras, G. Cheng, 2011, Cell Research.

Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition

Ryan M. O’Connell, J. Round, Allison M. Weis, 2021, Cell reports.

miR-155 promotes T reg cell development by safeguarding medullary thymic epithelial cell maturation

Ryan M. O’Connell, Ling-Li Lin, Li-Fan Lu, 2020, The Journal of experimental medicine.

T cell–mediated regulation of the microbiota protects against obesity

Ryan M. O’Connell, J. Round, S. Boudina, 2019, Science.

MicroRNA-155 Confers Encephalogenic Potential to Th17 Cells by Promoting Effector Gene Expression

Ryan M. O’Connell, A. Chaudhuri, J. Round, 2013, The Journal of Immunology.

miR-155-SOCS1 as a Functional Axis: Satisfying the Burden of Proof.

Ryan M. O’Connell, Ryan M. O'Connell, T. Huffaker, 2015, Immunity.

Aging impairs mouse skeletal muscle macrophage polarization and muscle-specific abundance during recovery from disuse.

Ryan M. O’Connell, M. Drummond, P. Reidy, 2019, American journal of physiology. Endocrinology and metabolism.

Clec12a tempers inflammation while restricting expansion of a colitogenic commensal

Ryan M. O’Connell, J. Round, Tyson R. Chiaro, 2023, bioRxiv.

MiR-23b is a safeguard against autoimmunity

Ryan M. O’Connell, Ruozhen Hu, 2012, Nature Medicine.

Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth

Ryan M. O’Connell, J. Round, D. Rao, 2016, PloS one.

Intramyocellular ceramides and skeletal muscle mitochondrial respiration are partially regulated by Toll-like receptor 4 during hindlimb unloading.

Ryan M. O’Connell, M. Drummond, Ryan M. O'Connell, 2016, American journal of physiology. Regulatory, integrative and comparative physiology.

T Cell–Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation

Ryan M. O’Connell, J. Round, J. Rutter, 2020, The Journal of Immunology.

MicroRNA control in the development of systemic autoimmunity

Ryan M. O’Connell, Ruozhen Hu, 2013, Arthritis Research & Therapy.

Absence of MyD88 from Skeletal Muscle Protects Female Mice from Inactivity‐Induced Adiposity and Insulin Resistance

Ryan M. O’Connell, M. Drummond, P. Reidy, 2020, Obesity.

Macrophage immunomodulation accelerates skeletal muscle functional recovery in aged mice following disuse atrophy.

Ryan M. O’Connell, M. Drummond, P. Reidy, 2022, Journal of applied physiology.

MicroRNA-155 enhances T cell trafficking and antiviral effector function in a model of coronavirus-induced neurologic disease

Ryan M. O’Connell, T. Lane, Ryan M. O'Connell, 2016, Journal of Neuroinflammation.

MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance.

Ryan M. O’Connell, M. Drummond, D. McClain, 2015, American journal of physiology. Endocrinology and metabolism.

CALL FOR PAPERS Endocrine and Metabolic Dysfunction during Aging and Senescence MyD88 regulates physical inactivity-induced skeletal muscle inﬂammation, ceramide biosynthesis signaling, and glucose intolerance

Ryan M. O’Connell, M. Drummond, D. McClain, 2015 .

Endocrine and Metabolic Dysfunction during Aging and Senescence MyD 88 regulates physical inactivity-induced skeletal muscle inflammation , ceramide biosynthesis signaling , and glucose intolerance

Ryan M. O’Connell, M. Drummond, D. McClain, 2015 .

Disrupted macrophage metabolic reprogramming in aged soleus muscle during early recovery following disuse atrophy

Ryan M. O’Connell, M. Drummond, Ziad S. Mahmassani, 2021, Aging cell.

CIPR: a web-based R/shiny app and R package to annotate cell clusters in single cell RNA sequencing experiments

Ryan M. O’Connell, W. Stephens, C. Conley, 2020, BMC Bioinformatics.

Intestinal epithelial cell-derived components regulate transcriptome of Lactobacillus rhamnosus GG

Ryan M. O’Connell, S. Rajagopala, S. Das, 2023, Frontiers in Microbiology.

Interferon Gamma-Inducible NAMPT in Melanoma Cells Serves as a Mechanism of Resistance to Enhance Tumor Growth

Ryan M. O’Connell, W. Voth, Soh-Hyun Lee, 2023, Cancers.

miRNA-1 promotes acute myeloid leukemia cell pathogenesis through metabolic regulation

Ryan M. O’Connell, Chris J. Stubben, D. Rao, 2023, Frontiers in Genetics.

MicroRNA-155 enhances T cell trafficking and antiviral effector function in a model of coronavirus-induced neurologic disease

Ryan M. O’Connell, T. Lane, J. Glover, 2016, Journal of Neuroinflammation.

Conversion of Danger Signals into Cytokine Signals By Hematopoietic Stem and Progenitor Cells for Regulation of Stress-Induced Hematopoiesis

Ryan M. O’Connell, J. Heath, D. Baltimore, 2014 .

LXR-Dependent Gene Expression Is Important for Macrophage Survival and the Innate Immune Response

Peter Tontonoz, Ryan M. O’Connell, Kevin W. Bruhn, 2004, Cell.

RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia

Ryan M. O’Connell, Jing Zhang, Ruoxing Wang, 2023, The Journal of clinical investigation.

Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1.

Ryan M. O’Connell, G. Cheng, Andrea K. Perry, 2005, Journal of immunology.

CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis

Ryan M. O’Connell, J. Round, Allison M. Weis, 2022, JCI insight.

Megakaryocyte-specific knockout of the Mir-99b/let7e/125a cluster lowers platelet count without altering platelet function.

Ryan M. O’Connell, Robert A. Campbell, I. Rigoutsos, 2021, Blood cells, molecules & diseases.

Targeting Human MicroRNA Genes Using Engineered Tal-Effector Nucleases (TALENs)

Ryan M. O’Connell, D. Grunwald, Ruozhen Hu, 2013, PloS one.

Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation.

Ryan M. O’Connell, M. Mokry, G. Geeven, 2023, Cell reports.

Pyruvate metabolism controls epigenome remodeling during CD4+ T cell activation

Ryan M. O’Connell, M. Mokry, G. Geeven, 2022 .

MicroRNA-155 Plays Selective Cell-Intrinsic Roles in Brain-Infiltrating Immune Cell Populations during Neuroinflammation.

Ryan M. O’Connell, J. Round, R. Fujinami, 2023, Journal of Immunology.

FLT 3-ITD-induced myeloproliferative disease through inhibition of the interferon response Short Title : miR-155 promotes FLT 3-ITD-induced myeloproliferative disease

Ryan M. O’Connell, J. Round, M. Deininger, 2017 .

Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs

Ryan M. O’Connell, Jason Gertz, A. Welm, 2023, bioRxiv.

Microsized inflammaging protects stem cells.

Ryan M. O’Connell, D. Rao, Ryan M. O'Connell, 2020, Blood.

Endogenous miR-29a regulates HSC function in mammals.

Ryan M. O’Connell, Ryan M. O'Connell, 2015, Blood.

A microRNA prevents resistance to targeted therapy in chronic myeloid leukemia

Ryan M. O’Connell, Charles B. Goodwin, A. Ghazaryan, 2020 .

MiR-125b potentiates macrophage activation1

Ryan M. O’Connell, D. Baltimore, A. Chaudhuri, 2011 .

TCGEx: A visual interface for multifaceted analyses of The Cancer Genome Atlas gene expression data

Ryan M. O’Connell, Huseyin Atakan Ekiz, M. E. Kus, 2023, bioRxiv.

Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response.

Ryan M. O’Connell, R. Sun, G. Cheng, 2009, Cell host & microbe.

A role for IRF3-dependent RXRα repression in hepatotoxicity associated with viral infections

Ryan M. O’Connell, A. Shahangian, G. Cheng, 2006, The Journal of Experimental Medicine.