D. L. Cole

发表

Sequencing of oligonucleotide phosphorothioates based on solid- supported desulfurization

T. K. Wyrzykiewicz, D. L. Cole, T. Wyrzykiewicz, 1994, Nucleic Acids Res..

Preclinical development of antisense therapeutics

D. L. Cole, G. Hardee, A. Levin, 1999 .

Application of sample displacement techniques to the purification of synthetic oligonucleotides and nucleic acids: a mini-review with experimental results

D. L. Cole, W. Leitch, R. R. Deshmukh, 1998 .

A novel solid support for synthesis of oligonucleotide 3'-phosphorothioate monoesters.

D. L. Cole, Z. Cheruvallath, V. Ravikumar, 2003, Bioorganic & medicinal chemistry letters.

A CASE STUDY: OLIGONUCLEOTIDE PURIFICATION FROM GRAM TO HUNDRED GRAM SCALE

D. L. Cole, K. Eriksson, P. Moore, 2001, Nucleosides, nucleotides & nucleic acids.

Selectivity of anion exchange chromatography and capillary gel electrophoresis for the analysis of phosphorothioate oligonucleotides.

R. H. Carlson, D. L. Cole, G. Srivatsa, 1997, Journal of pharmaceutical and biomedical analysis.

Determination of free and encapsulated oligonucleotides in liposome formulated drug product.

D. L. Cole, G. Srivatsa, D. Chen, 2000, Journal of pharmaceutical and biomedical analysis.

Large-scale purification of antisense oligonucleotides by high-performance membrane adsorber chromatography.

D. L. Cole, G. Srivatsa, M. Murphy, 2000, Journal of chromatography. A.

Synthesis of High Quality Phosphorothioate Oligonucleotides as Antisense Drugs. Use of I-Linker in the Elimination of 3′-Terminal Phosphorothioate Monoesters

D. L. Cole, V. Ravikumar, D. Capaldi, 2003, Nucleosides, nucleotides & nucleic acids.

Stability of phosphorothioate oligonucleotides in aqueous ammonia in presence of stainless steel.

D. L. Cole, Z. Cheruvallath, V. Ravikumar, 1999, Nucleosides & nucleotides.

Influence of Diastereomeric Ratios of Deoxyribonucleoside Phosphoramidites on the Synthesis of Phosphorothioate Oligonucleotides

D. L. Cole, H. Sasmor, Z. Cheruvallath, 2000, Nucleosides, nucleotides & nucleic acids.

Diastereomeric Process Control in the Synthesis of Oligodeoxyribonucleotide Phosphorothioates

D. L. Cole, T. Wyrzykiewicz, Z. Cheruvallath, 1999 .

Solution Phase Synthesis of an Oligodeoxyribonucleotide Phosphorothioate for Therapeutic Applications

D. L. Cole, Z. Cheruvallath, V. Ravikumar, 1997 .

2-Diphenylmethylsilylethyl (DPSE): a versatile protecting group for oligodeoxyribonucleotide synthesis.

D. L. Cole, V. Ravikumar, 1994, Gene.

Synthesis of oligonucleotides via phosphoramidite approach utilizing 2-diphenylmethylsilylethyl (DPSE) as a phosphorus protecting group

D. L. Cole, T. Wyrzykiewicz, V. Ravikumar, 1994 .

Controlled Detritylation of Antisense Oligonucleotides

D. L. Cole, V. Ravikumar, A. Krotz, 2003 .

Synthesis of Dimer Phosphoramidite Synthons for Oligodeoxyribonucleotide Phosphorothioates Using Diethyldithiocarbonate Disulfide as an Efficient Sulfurizing Reagent.

D. L. Cole, Z. Cheruvallath, V. Ravikumar, 1999 .

Improved Impurity Profile of Phosphorothioate Oligonucleotides Through the Use of Dimeric Phosphoramidite Synthons

D. L. Cole, V. Ravikumar, P. Klopchin, 1997 .

Highly efficient solid phase synthesis of oligonucleotide analogs containing phosphorodithioate linkages.

D. L. Cole, V. Ravikumar, D. Capaldi, 2000, Nucleic acids research.

Chemical Synthesis and Purification of Phosphorothioate Antisense Oligonucleotides

D. L. Cole, L. Holmberg, Y. Sanghvi, 1999 .

Use of Phenylacetyl Disulfide (PADS) in the Synthesis of Oligodeoxyribonucleotide Phosphorothioates

D. L. Cole, P. Wheeler, Z. Cheruvallath, 1999 .

2-Methyl-5-tert-butylthiophenol—An Odorless Deprotecting Reagent Useful in Synthesis of Oligonucleotides and Their Analogs

D. L. Cole, R. K. Kumar, V. Ravikumar, 2003, Nucleosides, nucleotides & nucleic acids.

Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides: Adduct Characterization and Avoidance

Jim Arnold, D. L. Cole, H. Gaus, 2003 .

Analysis of internal (n-1)mer deletion sequences in synthetic oligodeoxyribonucleotides by hybridization to an immobilized probe array.

D. L. Cole, G. Srivatsa, D Chen, 1999, Nucleic Acids Research.

Preparation of oligonucleotides without aldehyde abasic sites.

D. L. Cole, H. Gaus, V. Ravikumar, 2001, Bioorganic & medicinal chemistry letters.

4-Cyano-2-butenyl Group: A New Type of Protecting Group in Oligonucleotide Synthesis via Phosphoramidite Approach

D. L. Cole, Z. Cheruvallath, V. Ravikumar, 1996 .

Special Issues for Synthetic Antisense Oligonucleotides

D. L. Cole, G. Srivatsa, V. Ravikumar, 2000 .

Large-Scale Synthesis of Oligodeoxyribonucleotide Phosphorothioate Using Controlled-Pore Glass as Support

D. L. Cole, T. Wyrzykiewicz, V. Ravikumar, 1995 .

Development and validation of a method for routine base composition analysis of phosphorothioate oligonucleotides.

D. L. Cole, G. Srivatsa, J. Schuette, 1994, Journal of pharmaceutical and biomedical analysis.

Quantitative capillary gel electrophoresis assay of phosphorothioate oligonucleotides in pharmaceutical formulations.

R. H. Carlson, D. L. Cole, G. Srivatsa, 1994, Journal of chromatography. A.

Large-Scale chromatographic purification of ougonucleotides

D. L. Cole, W. Leitch, R. R. Deshmukh, 2000 .

Purification of antisense oligonucleotides.

D. L. Cole, R. R. Deshmukh, Y. Sanghvi, 2000, Methods in enzymology.

Efficient Synthesis of Antisense Phosphorothioate Oligonucleotides: Evaluation of Dichloroacetic Acid at Higher Concentration to Reduce Cycle Time

D. L. Cole, C. Rentel, Z. Cheruvallath, 2003 .

Antisense Phosphorothioate Oligodeoxyribonucleotide Targeted against ICAM-1: Use of I-Linker to Eliminate 3‘-Terminal Phosphorothioate Monoester Formation

D. L. Cole, C. Rentel, R. K. Kumar, 2003 .

Synthesis of Antisense Oligonucleotides with Minimum Depurination

D. L. Cole, V. Ravikumar, A. Krotz, 2003, Nucleosides, nucleotides & nucleic acids.

Development of 2‘-O-Methoxyethyl Phosphorothioate Oligonucleotides as Antisense Drugs under Stereochemical Control

D. L. Cole, V. Ravikumar, 2002 .

Applications of green chemistry in the manufacture of oligonucleotide drugs

D. L. Cole, Y. Sanghvi, V. Ravikumar, 2001 .

Synthesis of an antisense oligonucleotide targeted against C-raf kinase: efficient oligonucleotide synthesis without chlorinated solvents.

D. L. Cole, V. Ravikumar, A. Krotz, 1999, Bioorganic & medicinal chemistry.

Synthesis of antisense oligonucleotides. using environmentally friendly and safe deprotection procedures

D. L. Cole, V. Ravikumar, A. Krotz, 1999 .

Efficient synthesis of deoxyribonucleotide phosphorothioates by the use of DMT cation scavenger1

D. L. Cole, V. Ravikumar, A. Krotz, 1995 .

Solid Phase Synthesis of Phosphorothioate Oligonucleotides Utilizing Diethyldithiocarbonate Disulfide (DDD) as an Efficient Sulfur Transfer Reagent

D. L. Cole, C. Rentel, R. K. Kumar, 2003, Nucleosides, nucleotides & nucleic acids.

Synthesis of Deoxyribonucleoside Phosphorodithioate Dimers by a Triester Method

D. L. Cole, V. Ravikumar, D. Capaldi, 1999 .

EFFICIENT SYNTHESIS OF ANTISENSE OLIGODEOXYRIBONUCLEOTIDE PHOSPHOROTHIOATES

D. L. Cole, V. Ravikumar, A. Scozzari, 1994 .

Sequence analysis of phosphorothioate oligonucleotides via matrix-assisted laser desorption ionization time-of-flight mass spectrometry.

D. L. Cole, N. Afeyan, G. Srivatsa, 1995, Journal of pharmaceutical and biomedical analysis.

Oligodeoxyribonucleotide Phosphorothioates: Substantial Reduction of (N-1)-mer Content Through the Use of Trimeric Phosphoramidite Synthons

D. L. Cole, V. Ravikumar, D. Capaldi, 1999 .

EFFORTS TOWARD SYNTHESIS OF OLIGONUCLEOTIDES FOR COMMERCIALIZATION

D. L. Cole, V. Ravikumar, A. Scozzari, 1997 .

Diastereomeric Process Control in the Synthesis of 2′-O-(2-Methoxyethyl) Oligoribonucleotide Phosphorothioates as Antisense Drugs

D. L. Cole, V. Ravikumar, 2003, Nucleosides, nucleotides & nucleic acids.

Synthesis of ISIS 2105 Containing the Abasic Site Model Compound 1,4-Anhydro-2-deoxy-D-Ribitol

D. L. Cole, T. Wyrzykiewicz, V. Ravikumar, 1994 .

Structural Investigation of Model Deadenylated Oligonucleotide Phosphorothioate Analog of Isis 2105

D. L. Cole, V. Mohan, T. Wyrzykiewicz, 1994 .

Phosphorothioate oligonucleotides: Largely reduced (N-1)-mer and phosphodiester content through the use of dimeric phosphoramidite synthons

D. L. Cole, V. Ravikumar, P. Klopchin, 1997 .

A Liquid-Phase Process Suitable for Large-Scale Synthesis of Phosphorothioate Oligonucleotides

D. L. Cole, G. Bonora, S. Zaramella, 2000 .

Stereo-Reproducibility of the Phosphoramidite Method in the Synthesis of Oligonucleotide Phosphorothioates

D. L. Cole, T. Wyrzykiewicz, 1995 .

Antisense phosphorothioate oligodeoxyribonucleotide targeted against ICAM-1: synthetic and biological characterization of a process-related impurity formed during oligonucleotide synthesis.

D. L. Cole, E. Lesnik, W. Lima, 2003, Bioorganic & medicinal chemistry.