Ralph E. Kleiner

发表

Small-molecule discovery from DNA-encoded chemical libraries.

David R. Liu, Ralph E. Kleiner, Christoph E. Dumelin, 2011, Chemical Society reviews.

An In Vitro Translation, Selection, and Amplification System for Peptide Nucleic Acids

David R. Liu, Michael E. Birnbaum, Ralph E. Kleiner, 2009, Nature chemical biology.

In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors

David R. Liu, Ralph E. Kleiner, Christoph E. Dumelin, 2010, Journal of the American Chemical Society.

Small-Molecule Discovery from DNA-Encoded Chemical Libraries

David R. Liu, Ralph E. Kleiner, Christoph E. Dumelin, 2012 .

Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends.

Scott Forth, Ralph E. Kleiner, Eva Nogales, 2016, Developmental cell.

Bumping Up Kinase Activity with an ATP-Derived Neo-Substrate

Ralph E. Kleiner, T. Kapoor, 2013, Cell.

Mechanisms of epitranscriptomic gene regulation

Ralph E. Kleiner, Kyung W. Seo, 2020, Biopolymers.

Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases

Ralph E. Kleiner, E. Mairhofer, Ang Li, 2022, Nature Communications.

Live-cell RNA imaging with metabolically incorporated fluorescent nucleosides

Ralph E. Kleiner, B. Purse, Danyang Wang, 2022, bioRxiv.

Reading the RNA Code.

Ralph E. Kleiner, 2018, Biochemistry.

YTHDF2 recognition of N1-methyladenosine (m1A)-modified RNA is associated with transcript destabilization.

Ralph E. Kleiner, Kyung W. Seo, 2019, ACS chemical biology.

DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes.

David R. Liu, Ralph E. Kleiner, Y. Brudno, 2008, Journal of the American Chemical Society.

Profiling dynamic RNA–protein interactions using small-molecule-induced RNA editing

Ralph E. Kleiner, Kyung W. Seo, 2022, bioRxiv.

Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation

Ralph E. Kleiner, M. Wühr, Ang Li, 2021, Nature Chemical Biology.

Cell- and polymerase-selective metabolic labeling of cellular RNA with 2'-azidocytidine.

Ralph E. Kleiner, Danyang Wang, Yu Zhang, 2020, Journal of the American Chemical Society.

RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein-RNA Interactome.

Ralph E. Kleiner, Amanda N. DeLiberto, A. E. Arguello, 2017, Journal of the American Chemical Society.

Interrogating the transcriptome with metabolically incorporated ribonucleosides.

Ralph E. Kleiner, 2021, Molecular omics.

Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response

Ralph E. Kleiner, B. Chait, T. Kapoor, 2015, Nature chemical biology.

Highly Specific, Bi-substrate-Competitive Src Inhibitors from DNA-Templated Macrocycles

David R. Liu, Ralph E. Kleiner, M. Seeliger, 2011, Nature chemical biology.

Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles.

David R. Liu, Ralph E. Kleiner, M. García-Díaz, 2016, Cell chemical biology.

High-throughput approaches to profile RNA-protein interactions.

Ralph E. Kleiner, Misha Nechay, 2019, Current opinion in chemical biology.

A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells.

Ralph E. Kleiner, Brian T Chait, B. Chait, 2017, Cell chemical biology.

A neural m6A/Ythdf pathway is required for learning and memory in Drosophila

Ralph E. Kleiner, Adam Claridge‐Chang, E. Lai, 2020, Nature Communications.

Chemical Method to Sequence 5-Formylcytosine on RNA.

Ralph E. Kleiner, Xuemeng Sun, Ang Li, 2022, ACS chemical biology.

A chemical method to sequence 5-formylcytosine on RNA

Ralph E. Kleiner, Ang Li, Xuemeng Sun, 2021, bioRxiv.

In vitro selection with a site-specifically modified RNA library reveals the binding preferences of N6-methyladenosine (m6A) reader proteins.

Ralph E. Kleiner, Robert W. Leach, A. E. Arguello, 2019, Biochemistry.

An intein-based genetic selection allows the construction of a high-quality library of binary patterned de novo protein sequences.

David W Wood, Ralph E. Kleiner, Michael H Hecht, 2005, Protein engineering, design & selection : PEDS.

Tracking chromatin state changes using nanoscale photo-proximity labelling

Ralph E. Kleiner, T. Muir, D. MacMillan, 2023, Nature.

A Metabolic Engineering Approach to Incorporate Modified Pyrimidine Nucleosides into Cellular RNA.

Ralph E. Kleiner, Yu Zhang, 2019, Journal of the American Chemical Society.

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

David R. Liu, Ralph E. Kleiner, A. Saghatelian, 2014, Nature.

Site-specific chemistry on the microtubule polymer.

Ralph E. Kleiner, T. Kapoor, S. Ti, 2013, Journal of the American Chemical Society.

Oxaliplatin Inhibits RNA Polymerase I via DNA Damage Signaling Targeted to the Nucleolus

Ralph E. Kleiner, Misha Nechay, 2023, bioRxiv.

Inhibition of nucleolar transcription by oxaliplatin involves ATM/ATR kinase signaling.

Ralph E. Kleiner, Danyang Wang, Misha Nechay, 2023, Cell chemical biology.

Global Discovery of Covalent Modulators of Ribonucleoprotein Granules.

Ralph E. Kleiner, Dina L. Bai, Adam L. Borne, 2023, Journal of the American Chemical Society.

Chemical Approaches To Investigate Post-transcriptional RNA Regulation.

Ralph E. Kleiner, 2023, ACS chemical biology.

Chemoproteomic profiling of 8-oxoguanosine-sensitive RNA-protein interactions

Ralph E. Kleiner, Amanda N. DeLiberto, A. E. Arguello, 2023, bioRxiv.

Transcriptome-wide RNA structure probing with temporal resolution

Ralph E. Kleiner, Danyang Wang, Yongkang Tang, 2023, bioRxiv.

Oxaliplatin Inhibits RNA Polymerase I via ATM- and ATR-Dependent Signaling Targeted to the Nucleolus

Ralph E. Kleiner, Danyang Wang, Misha Nechay, 2023 .

Chemoproteomic Approaches to Studying RNA Modification-Associated Proteins.

Ralph E. Kleiner, Wei Dai, Nathan J. Yu, 2023, Accounts of chemical research.

Reading the RNA Code.

Ralph E. Kleiner, 2018, Biochemistry.

A Photocrosslinking‐Based RNA Chemical Proteomics Approach to Profile m6A‐Regulated Protein‐RNA Interactions

Ralph E. Kleiner, A. E. Arguello, Tharan Srikumar, 2018, Current protocols in nucleic acid chemistry.