Christoph E. Dumelin

发表

Small-molecule discovery from DNA-encoded chemical libraries.

David R. Liu, Ralph E. Kleiner, Christoph E. Dumelin, 2011, Chemical Society reviews.

On the magnitude of the chelate effect for the recognition of proteins by pharmacophores scaffolded by self-assembling oligonucleotides.

Samu Melkko, Dario Neri, Christoph E Dumelin, 2006, Chemistry & biology.

Encoded self-assembling chemical libraries

Christoph E. Dumelin, S. Melkko, J. Scheuermann, 2004, Nature Biotechnology.

High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

Christoph E. Dumelin, E. Rizzi, G. De Bellis, 2008, Proceedings of the National Academy of Sciences.

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

Christoph E. Dumelin, A. Keefe, J. Cuozzo, 2015, Scientific Reports.

DNA-encoded chemistry: enabling the deeper sampling of chemical space

Anthony D. Keefe, Christoph E. Dumelin, A. Keefe, 2016, Nature Reviews Drug Discovery.

Isolation of a Small‐Molecule Inhibitor of the Antiapoptotic Protein Bcl‐xL from a DNA‐Encoded Chemical Library

Christoph E. Dumelin, M. Grütter, A. Villa, 2010, ChemMedChem.

Label‐free determination of protein–ligand binding constants using mass spectrometry and validation using surface plasmon resonance and isothermal titration calorimetry

Renato Zenobi, Stefan Schauer, Christoph E. Dumelin, 2009, Journal of molecular recognition : JMR.

DNA-encoded chemical libraries

Samu Melkko, Dario Neri, Christoph E Dumelin, 2022, Nature Reviews Methods Primers.

Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target

Christoph E. Dumelin, A. Keefe, R. Cooke, 2018, SLAS discovery : advancing life sciences R & D.

Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions.

Dario Neri, Christoph E Dumelin, Christoph E. Dumelin, 2008, Bioorganic & medicinal chemistry letters.

In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors

David R. Liu, Ralph E. Kleiner, Christoph E. Dumelin, 2010, Journal of the American Chemical Society.

A portable albumin binder from a DNA-encoded chemical library.

Christof Baltes, Samu Melkko, Susanne C. Beck, 2008, Angewandte Chemie.

Small-Molecule Discovery from DNA-Encoded Chemical Libraries

David R. Liu, Ralph E. Kleiner, Christoph E. Dumelin, 2012 .

Interaction-Dependent PCR: Identification of Ligand−Target Pairs from Libraries of Ligands and Libraries of Targets in a Single Solution-Phase Experiment

David R. Liu, Christoph E. Dumelin, L. M. McGregor, 2010, Journal of the American Chemical Society.

Structural insight into allosteric modulation of protease-activated receptor 2

Patrik Johansson, Ali Jazayeri, Christoph Grebner, 2017, Nature.

Diversity-oriented synthesis encoded by deoxyoligonucleotides

Connor W. Coley, John M. Knapp, Christoph E. Dumelin, 2023, Nature communications.

Compound Screening

Christoph E. Dumelin, Gianluca Etienne, S. Numao, 2021, Reference Module in Biomedical Sciences.

Advancements in assay technologies and strategies to enable drug discovery.

Scott A. Busby, Christoph E Dumelin, Christoph E. Dumelin, 2020, ACS chemical biology.

In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives.

Dario Neri, Christoph E Dumelin, Christoph E. Dumelin, 2009, Bioorganic & medicinal chemistry letters.

Discovery and biological characterization of geranylated RNA in bacteria

Aaron M. Leconte, David R. Liu, Christoph E. Dumelin, 2012, Nature chemical biology.

A DNA-based molecular probe for optically reporting cellular traction forces

David R. Liu, Brendon M. Baker, Colin K. Choi, 2014, Nature Methods.

Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors

Christoph E. Dumelin, Anselm F. L. Schneider, S. Hintermann, 2021, RSC chemical biology.

New strategy for the extension of the serum half-life of antibody fragments.

Alessandra Villa, Dario Neri, Christoph E. Dumelin, 2009, Bioconjugate chemistry.

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.

Christoph E. Dumelin, S. Kazmirski, A. Keefe, 2017, ACS medicinal chemistry letters.

Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery

Lukas Leder, Johannes Ottl, Jonas V Schaefer, 2019, Molecules.

Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa.

Christoph E. Dumelin, A. Keefe, S. Evans, 2021, Journal of medicinal chemistry.

Lead discovery by DNA-encoded chemical libraries.

Christoph E. Dumelin, S. Melkko, J. Scheuermann, 2007, Drug discovery today.

Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action

Christoph E. Dumelin, A. Keefe, O. Fedorov, 2017, ACS chemical biology.

Diversity-oriented synthesis encoded by deoxyoligonucleotides

Connor W. Coley, John M. Knapp, Christoph E. Dumelin, 2023, bioRxiv.

Isolation of high-affinity trypsin inhibitors from a DNA-encoded chemical library.

Christoph E. Dumelin, S. Melkko, J. Scheuermann, 2007, Angewandte Chemie.

Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology

Christoph E. Dumelin, A. Keefe, J. Breed, 2016, Proceedings of the National Academy of Sciences.

Isolation of potent and specific trypsin inhibitors from a DNA-encoded chemical library.

Christoph E. Dumelin, S. Melkko, J. Scheuermann, 2010, Bioconjugate chemistry.

Selection of streptavidin binders from a DNA-encoded chemical library.

Christoph E. Dumelin, S. Melkko, J. Scheuermann, 2006, Bioconjugate chemistry.

DNA-encoded chemical libraries for the discovery of MMP-3 inhibitors.

Samu Melkko, Jens Sobek, Dario Neri, 2008, Bioconjugate chemistry.

Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions.

Christoph E. Dumelin, D. Neri, Yixin Zhang, 2008, Bioorganic & medicinal chemistry letters.

Compound Screening

Christoph E. Dumelin, Shin Numao, Gianluca Etienne, 2021, Reference Module in Biomedical Sciences.

DNA-encoded chemical libraries.

Christoph E. Dumelin, Jörg Scheuermann, Samu Melkko, 2006, Journal of biotechnology.