Paul W Smith

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Sustainment in the Army 2020: Using the Army's Sustainment Principles to Identify and Mitigate Risks Associated with Organizational Change

Paul W Smith, 2015 .

Design, synthesis, and biological evaluation of indole-2-carboxamides: a promising class of antituberculosis agents.

Paul W Smith, K. Kuhen, P. Bifani, 2013, Journal of medicinal chemistry.

The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists.

Paul W Smith, I. Forbes, P. Wyman, 2010, Bioorganic & medicinal chemistry letters.

Novel inhibitors of influenza sialidase related to GG167 Synthesis of 4-amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza a virus sialidase

Paul W Smith, R. Bethell, S. Sollis, 1996 .

Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides

Paul W Smith, P. Colman, J. Varghese, 1996 .

The identification of novel orally active mGluR5 antagonist GSK2210875.

Paul W Smith, M. Pilla, B. Tehan, 2010, Bioorganic & medicinal chemistry letters.

Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis.

Kelly Chibale, Paul W Smith, K. Chibale, 2014, Chemical reviews.

Therapeutics for Neglected Infectious Diseases: Progress and Challenge.

Paul W Smith, Pei-Yong Shi, P. Shi, 2015, ACS infectious diseases.

Novel 5-HT(1A/1B/1D) receptors antagonists with potent 5-HT reuptake inhibitory activity.

Paul W Smith, C. Scott, F. Blaney, 2008, Bioorganic & medicinal chemistry letters.

Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.

Paul W Smith, C. Scott, K. Thewlis, 2008, Journal of medicinal chemistry.

Radiosynthesis and in vivo evaluation of [(11)C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A.

Richard E Carson, Steen Jakobsen, David Weinzimmer, 2011, Nuclear medicine and biology.

Structure- and property-based design of factor Xa inhibitors: pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs.

Stefan Senger, Matthew Campbell, Savvas Kleanthous, 2006, Bioorganic & medicinal chemistry letters.

SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2′methyl-4′-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): A novel, potent and selective 5-HT1B receptor antagonist

Paul W Smith, C. Langmead, J. Hagan, 2006, Neuropharmacology.

Lead optimization of spiropyrazolopyridones: a new and potent class of dengue virus inhibitors.

Paul W Smith, P. Shi, A. Chao, 2015, ACS medicinal chemistry letters.

An efficient synthesis of 4,6-dihydrospiro[azepino[4,3,2-cd]indole-3,3′-indoline]-2′,5(1H)-diones via multi-component reaction

Paul W Smith, B. Zou, Mei Ding, 2014 .

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration.

Paul W Smith, K. Chibale, Dale Taylor, 2015, Journal of medicinal chemistry.

Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases.

Paul W Smith, D. Minnikin, G. Besra, 2004, The Biochemical journal.

Discovery of Dengue Virus NS4B Inhibitors

Paul W Smith, P. Shi, J. Lescar, 2015, Journal of Virology.

An Efficient Synthesis of Spiroquinoxalinones via Tandem Reactions

Paul W Smith, B. Zou, S. Y. Leong, 2014 .

Imaging Mass Cytometry and Single-Cell Genomics Reveal Differential Depletion and Repletion of B-Cell Populations Following Ofatumumab Treatment in Cynomolgus Monkeys

Paul W Smith, M. Stoeckli, P. Couttet, 2019, Front. Immunol..

4-Acetylamino-3-(imidazol-1-yl)-benzoic acids as novel inhibitors of influenza sialidase

Paul W Smith, A. Wonacott, N. Taylor, 1999 .

Novel inhibitors of influenza sialidases related to zanamivir. Heterocyclic replacements of the glycerol sidechain

Paul W Smith, N. Taylor, S. Sollis, 1997 .

Sialidase inhibitors related to GG167: Synthesis of analogues via an inverse demand hetero Diels Alder reaction

Paul W Smith, P. Howes, 1996 .

Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-guanidino-Neu5Ac2en (GG167) with modified 5-substituents

Paul W Smith, M. Itzstein, Wen-Yang Wu, 1996 .

Synthesis and influenza virus sialidase inhibitory activity of the 5-desacetamido analogue of 2,3-didehydro-2,4-dideoxy-4-guanidinyl-N-acetylneuraminic acid (GG167)

Paul W Smith, I. D. Starkey, D. Noble, 1995 .

Therapeutic utility of NK3 receptor antagonists for the treatment of schizophrenia.

Paul W Smith, L. Dawson, 2010, Current pharmaceutical design.

Review: Anti-infectives Developments in viral hepatitis during 1994

Paul W Smith, J. Coates, 1995 .

Inhibition of HIV replication by amino‐sugar derivatives

Paul W Smith, R. Dwek, N. Ramsden, 1988, FEBS letters.

Synthesis of (2R,3S,4R)-3,4-dihydroxyproline from D-ribonolactone; an approach to the synthesis of polyfunctionalised D-amino acids from sugar lactones. X-Ray molecular structures of 2-azido-3,4-O-(R)-benzylidene-2-deoxy-D-ribono-1,5-lactone, 2-azido-2-deoxy-D-ribono-1,4-lactone, and (2R,3S,3R)-3,4-

Paul W Smith, G. Fleet, K. Prout, 1987 .

A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening*

Paul W Smith, P. Shi, S. Lim, 2016, The Journal of Biological Chemistry.

The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist.

Paul W Smith, S. Gul, M. Caivano, 2010, Bioorganic & medicinal chemistry letters.

Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery

Paul W Smith, G. Sandford, J. Christopher, 2009 .

New quinoline NK3 receptor antagonists with CNS activity.

Paul W Smith, P. Wyman, Zining Wu, 2009, Bioorganic & medicinal chemistry letters.

Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator.

Paul W Smith, K. Thewlis, S. Ward, 2010, Journal of medicinal chemistry.

Effects of the α-mannosidase inhibitors, 1,4-dideoxy-1,4-imino-d-mannitol and swainsonine, on glycoprotein catabolism in cultured macrophages

Paul W Smith, D. Newburg, G. Fleet, 2005, Glycoconjugate Journal.

Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents.

Paul W Smith, S. Peukert, N. Ma, 2015, European journal of medicinal chemistry.

Synthesis and crystal structure of a complex in which a single macrocyclic ligand binds six cuII centres in a cyclohexane boat arrangement

Paul W Smith, R. Robson, B. F. Hoskins, 1990 .

Molecular complex evaluation. A simultaneous assay of binding using substrate mixtures

Paul W Smith, G. Chang, W. C. Still, 1988 .

Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents.

Shi Hua Ang, Paul W Smith, K. Kuhen, 2013, ACS medicinal chemistry letters.

Synthesis of (4R*,5S*)-5-acetylamino-4-diethylcarbamoyl-5,6-dihydro-4H-pyran- 2-carboxylic acid and its inhibitory action against influenza virus sialidases

Paul W Smith, R. Pritchard, R. J. Stoodley, 2001 .

Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future

Paul W Smith, Robert H Bates, K. Read, 2018, ACS infectious diseases.

Synthesis of the α-Mannosidase inhibitors swainsonine [(1S, 2R, 8R, 8aR)-1,2,8-trihydroxyoctahydroindolizine] and 1,4-dideoxy-1,4-imino-d-mannitol from mannose

Paul W Smith, P. Smith, G. Fleet, 1987 .

Synthesis of (4R*,5R*)-4-acetylamino-5-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid and (3R*,4R*)-4-acetylamino-3-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid: new inhibitors of influenza virus sialidases

Paul W Smith, R. J. Stoodley, Sean A. Kerrigan, 2001 .

Synthesis of Deoxymannojirimycin, Fagomine, Deoxynojirimycin, 2-Acetamido-1,5-imino-1,2,5-trideoxy-D-mannitol, 2-Acetamido-1,5-imino-1,2,5-trideoxy-D-glucitol, 2S,3R,4R,5R-Trihydroxypipecolic Acid and 2S,3R,4R,5S-Trihydroxypipecolic A

Paul W Smith, G. Fleet, L. Fellows, 1987 .

Methyl 2-azido-3-O-benzyl-2-deoxy-α-D-mamnofuranoside as a divergent intermediate for the synthesis of polyhydroxylated piperidines and pyrrolidines: synthesis of 2,5-dideoxy-2,5-imino-D-mannitol [2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine]

Paul W Smith, P. Smith, G. Fleet, 1987 .

Synthesis of 2-Acetamido-1,5-imino-1,2,5-trideoxy-D-mannitol and of 2-Acetamido-1,5-imino-1,2,5-trideoxy-D-glucitol, a Potent and Specific Inhibitor of a Number of β-N-Acetylglucosaminidases

Paul W Smith, T. Rademacher, R. Parekh, 1986 .

Enantiomerically pure amines by a new method: biotransformation of oxalamic esters using the lipase from Candida antarctica

Paul W Smith, D. Scopes, D. Crout, 1996 .

Design synthesis and preliminary evaluation of a potent α- mannosidase inhibitor: 1,4-dideoxy-1,4-imino-D-mannitol

Paul W Smith, S. V. Evans, G. Fleet, 1984 .

The effect of substitution and stereochemistry on ion binding in the polyether ionophore monensin

Paul W Smith, W. C. Still, 1988 .

Synthesis of (3R*,4R*)-4-acetylamino-3-(pent-3-oxy)cyclohex-1-ene-1-carboxylic acid and its (3S*,4R*)-isomer and their inhibitory action against influenza virus sialidases

Paul W Smith, Paul W. Smith, R. Pritchard, 2001 .

Will Modulation of Neuropeptide Receptors Produce the Next Generation of Antipsychotic Drugs? A Focus on the Neurokinin and Neurotensin Systems

Paul W Smith, J. Watson, L. Dawson, 2012 .

Ten years of dengue drug discovery: progress and prospects.

David Beer, Hongping Dong, Shahul Nilar, 2013, Antiviral research.

A mild and efficient synthesis of spiroquinolinones via an unexpected rearrangement

Paul W Smith, B. Zou, Mei Ding, 2015 .

A Mild and Efficient Synthesis of Spiroquinolinones via an Unexpected Rearrangement.

Paul W Smith, B. Zou, Mei Ding, 2016 .

An approach to the synthesis of 5,5-trans-fused lactam analogues of β-lactam antibiotics

Paul W Smith, H. Finch, K. Cobley, 2001 .

Neurokinin 3 (NK3) receptor modulators for the treatment of psychiatric disorders.

Paul W Smith, L. Dawson, 2008, Recent patents on CNS drug discovery.

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.

Paul W Smith, P. Shi, R. Rao, 2016, Journal of medicinal chemistry.

Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.

Paul W Smith, K. Chibale, Dale Taylor, 2021, Journal of medicinal chemistry.

Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis

Paul W Smith, K. Kuhen, P. Bifani, 2013, Science Translational Medicine.

Perspective: Challenges and opportunities in TB drug discovery from phenotypic screening.

Paul W Smith, U. Manjunatha, 2015, Bioorganic & medicinal chemistry.

Progressing the global antimalarial portfolio: finding drugs which target multiple Plasmodium life stages

Paul W Smith, T. Diagana, B. Yeung, 2013, Parasitology.

Direct inhibitors of InhA are active against Mycobacterium tuberculosis

Paul W Smith, K. Kuhen, P. Tonge, 2015, Science Translational Medicine.

The identification of novel orally active mGluR5 antagonist GSK2210875.

Paul W Smith, M. Pilla, B. Tehan, 2010, Bioorganic & Medicinal Chemistry Letters.

In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics.

Paul W Smith, C. Langmead, C. Davies, 2010, European journal of pharmacology.

Synthesis of a Tetrasubstituted Bicyclo[2.2.2]octane as a Potential Inhibitor of Influenza Virus Sialidase.

Paul W Smith, R. Bethell, S. Lynn, 1999 .

The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2.

Paul W Smith, Emma L. Koppe, C. Corti, 2010, Bioorganic & medicinal chemistry letters.

Emerging therapeutic targets in tuberculosis: eradication of thecausative agent Mycobacterium tuberculosis

Paul W Smith, K. Duncan, 1998 .

3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors.

Paul W Smith, C. Scott, K. Thewlis, 2007, Bioorganic & medicinal chemistry letters.

Studies on a series of potent, orally bioavailable, 5-HT(1) receptor ligands.

Paul W Smith, C. Scott, K. Thewlis, 2007, Bioorganic & medicinal chemistry letters.

Identification of a potent and selective 5-HT1B receptor antagonist.

Paul W Smith, C. Scott, G. W. Price, 2005, Bioorganic & medicinal chemistry letters.

Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.

Paul W Smith, P. Colman, J. Varghese, 1998, Structure.

Progressing the global antimalarial portfolio: finding drugs which target multiple Plasmodium life stages

Paul W Smith, T. Diagana, B. Yeung, 2013, Parasitology.

Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages.

Paul W Smith, K. Kuhen, E. Winzeler, 2014, ACS medicinal chemistry letters.

Ten years of dengue drug discovery: progress and prospects.

Paul W Smith, Yen-Liang Chen, P. Shi, 2013, Antiviral research.

Paul W Smith, A. Mcelroy, J. Pritchard, 1994 .