Tom L. Blundell

发表

PROVAT: a tool for Voronoi tessellation analysis of protein structures and complexes

David F. Burke, Swanand P. Gore, Tom L. Blundell, 2005, Bioinform..

Prediction by Graph Theoretic Measures of Structural Effects in Proteins Arising from Non-Synonymous Single Nucleotide Polymorphisms

Pietro Liò, Michele Vendruscolo, Tom L. Blundell, 2008, PLoS Comput. Biol..

Genome3D: exploiting structure to help users understand their sequences

Marco Punta, Sameer Velankar, Daniel W. A. Buchan, 2015, Nucleic Acids Res..

Polyphony: superposition independent methods for ensemble-based drug discovery

Tom L. Blundell, William R. Pitt, Rinaldo W. Montalvão, 2014, BMC Bioinformatics.

CHORAL: a differential geometry approach to the prediction of the cores of protein structures

Tom L. Blundell, Richard E. Smith, Rinaldo W. Montalvão, 2005, Bioinform..

Structural assembly of two-domain proteins by rigid-body docking

Juan Fernández-Recio, Tom L. Blundell, Tammy M. K. Cheng, 2008, BMC Bioinformatics.

Document S1. Figures S1–S5 and Supplemental Experimental Procedures

Ralf Kemkemer, Joachim P. Spatz, Brian Derby, 2013 .

Database update TIMBAL v2: update of a database holding small molecules modulating protein-protein interactions

Tom L. Blundell, Harry Jubb, Alicia P. Higueruelo, 2013 .

TIMBAL v2: update of a database holding small molecules modulating protein–protein interactions

Tom L. Blundell, Harry Jubb, Alicia P. Higueruelo, 2013, Database J. Biol. Databases Curation.

DDBASE2.0: updated domain database with improved identification of structural domains

Jiye Shi, Ramanathan Sowdhamini, Tom L. Blundell, 2003, Bioinform..

HOMSTRAD: adding sequence information to structure-based alignments of homologous protein families

Jiye Shi, Alex Bateman, Kenji Mizuguchi, 2001, Bioinform..

Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database

Tom L. Blundell, Alicia P. Higueruelo, George R. Bickerton, 2011, BMC Bioinformatics.

BIPA: a database for protein-nucleic acid interaction in 3D structures

Tom L. Blundell, Semin Lee, T. Blundell, 2009, Bioinform..

Utilising Graph Machine Learning within Drug Discovery and Development pdf

Jian Tang, Michael M. Bronstein, Jyothish Soman, 2020, ArXiv.

Knowledge‐based protein modelling and design

John P. Overington, Tom L. Blundell, Stephen P. Gardner, 1988 .

SInCRe—structural interactome computational resource for Mycobacterium tuberculosis

Nagasuma R. Chandra, Ramanathan Sowdhamini, Tom L. Blundell, 2015, Database J. Biol. Databases Curation.

Browsing the SLoop database of structurally classified loops connecting elements of protein secondary structure

Charlotte M. Deane, David F. Burke, Tom L. Blundell, 2000, Bioinform..

Graphein - a Python Library for Geometric Deep Learning and Network Analysis on Protein Structures and Interaction Networks

Tom L. Blundell, Pietro Lió, Arian R. Jamasb, 2020, bioRxiv.

DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach

Douglas E. V. Pires, Tom L. Blundell, David B. Ascher, 2014, Nucleic Acids Res..

Does a More Precise Chemical Description of Protein–Ligand Complexes Lead to More Accurate Prediction of Binding Affinity?

Tom L. Blundell, Pedro J. Ballester, Adrian Schreyer, 2014, J. Chem. Inf. Model..

PROVAT – a versatile tool for Voronoi tessellation analysis of protein structures and complexes

David F. Burke, Swanand P. Gore, Tom L. Blundell, 2005, BMC Bioinformatics.

Mabellini: a genome-wide database for understanding the structural proteome and evaluating prospective antimicrobial targets of the emerging pathogen Mycobacterium abscessus

Marcin J. Skwark, Tom L. Blundell, Pedro Henrique Monteiro Torres, 2019, Database J. Biol. Databases Curation.

Discarding Functional Residues from the Substitution Table Improves Predictions of Active Sites within Three-Dimensional Structures

Sungsam Gong, Tom L. Blundell, T. Blundell, 2008, PLoS Comput. Biol..

Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains

Sameer Velankar, James Smith, Daniel W. A. Buchan, 2012, Nucleic Acids Res..

CREDO: a structural interactomics database for drug discovery

Tom L. Blundell, Adrian Schreyer, T. Blundell, 2013, Database J. Biol. Databases Curation.

Computer graphics modelling and the subsite specificities of human and mouse renins

Tom L. Blundell, B. L. Sibanda, Andrew M. Hemmings, 1985 .

Ulla: a program for calculating environment-specific amino acid substitution tables

Tom L. Blundell, Semin Lee, T. Blundell, 2009, Bioinform..

A Structural Bioinformatics Approach to the Analysis of nonsynonymous Single nucleotide polymorphisms (nsSNPS) and their Relation to Disease

Sungsam Gong, David F. Burke, Tom L. Blundell, 2007, J. Bioinform. Comput. Biol..

Sequences and topology—An inverse approach to the old folding problem: Editorial overview

Russell F. Doolittle, Tom L. Blundell, 1992 .

XSuLT: a web server for structural annotation and representation of sequence-structure alignments

Tom L. Blundell, Bernardo Ochoa-Montaño, T. Blundell, 2017, Nucleic Acids Res..

JOY: protein sequence-structure representation and analysis

Charlotte M. Deane, Kenji Mizuguchi, John P. Overington, 1998, Bioinform..

TIBLE: a web-based, freely accessible resource for small-molecule binding data for mycobacterial species

Tom L. Blundell, Alicia P. Higueruelo, Grace Mugumbate, 2017, Database J. Biol. Databases Curation.

Andante: reducing side-chain rotamer search space during comparative modeling using environment-specific substitution probabilities

David F. Burke, Tom L. Blundell, Richard E. Smith, 2007, Bioinform..

Structure-based identification and clustering of protein families and superfamilies

Tom L. Blundell, Stephen D. Rufino, T. Blundell, 1994, J. Comput. Aided Mol. Des..

USRCAT: real-time ultrafast shape recognition with pharmacophoric constraints

Tom L. Blundell, Adrian Schreyer, T. Blundell, 2012, Journal of Cheminformatics.

BMC Bioinformatics BioMed Central Methodology article Genome bioinformatic analysis of nonsynonymous SNPs

David F. Burke, Tom L. Blundell, Catherine L. Worth, 2006 .

Platinum: a database of experimentally measured effects of mutations on structurally defined protein–ligand complexes

Douglas E. V. Pires, Tom L. Blundell, David B. Ascher, 2014, Nucleic Acids Res..

Analysis of conservation and substitutions of secondary structure elements within protein superfamilies

Kenji Mizuguchi, Tom L. Blundell, 2000, Bioinform..

SCORE: predicting the core of protein models

Charlotte M. Deane, Tom L. Blundell, Quentin Kaas, 2001, Bioinform..

mCSM: predicting the effects of mutations in proteins using graph-based signatures

Douglas E. V. Pires, Tom L. Blundell, David B. Ascher, 2013, Bioinform..

High-throughput crystallography for lead discovery in drug design

Harren Jhoti, Tom L. Blundell, Chris Abell, 2002, Nature Reviews Drug Discovery.

Computational Deorphaning of Mycobacterium tuberculosis Targets

Tom L. Blundell, Grace Mugumbate, Lorraine Yamurai Bishi, 2019, Drug Discovery and Development - New Advances.

The pattern of common supersecondary structure (motifs) in protein database

Tom L. Blundell, Zhirong Sun, T. Blundell, 1995, Proceedings of the Twenty-Eighth Annual Hawaii International Conference on System Sciences.

SDM: a server for predicting effects of mutations on protein stability

Tom L. Blundell, David B. Ascher, Bernardo Ochoa-Montaño, 2017, Nucleic Acids Res..

CHOPIN: a web resource for the structural and functional proteome of Mycobacterium tuberculosis

Tom L. Blundell, Bernardo Ochoa-Montaño, Nishita Mohan, 2015, Database J. Biol. Databases Curation.

A base measure of precision for protein stability predictors: structural sensitivity

Tom L. Blundell, Octav Caldararu, Kasper P. Kepp, 2021, BMC Bioinform..

COSMIC Cancer Gene Census 3D database: understanding the impacts of mutations on cancer targets

Tom L. Blundell, Ismail Moghul, Sundeep Chaitanya Vedithi, 2021, Briefings Bioinform..

Three Simple Properties Explain Protein Stability Change upon Mutation

Tom L. Blundell, Octav Caldararu, Kasper P. Kepp, 2021, J. Chem. Inf. Model..

18TH KREBS,HANS LECTURE - KNOWLEDGE-BASED PROTEIN MODELING AND DESIGN

John P. Overington, Tom L. Blundell, Stephen P. Gardner, 1988 .

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.

Thomas R. Ioerger, Travis Hartman, Tom L. Blundell, 2017, ACS infectious diseases.

Analysis of HGD Gene Mutations in Patients with Alkaptonuria from the United Kingdom: Identification of Novel Mutations.

Douglas E. V. Pires, Tom L. Blundell, David B. Ascher, 2015, JIMD reports.

DNA REPAIR: DNA‐PKcs structure suggests an allosteric mechanism modulating DNA double‐strand break repair

Tom L. Blundell, David B. Ascher, Dimitri Y. Chirgadze, 2017 .

X-RAY STRUCTURE OF GELATINASE A CATALYTIC DOMAIN COMPLEXED WITH A HYDROXAMATE INHIBITOR

Tom L. Blundell, Christine Humblet, Daniel F. Ortwine, 1999 .

X-ray analysis of the eye lens protein γ-II crystallin at 1·9 Å resolution

Graeme Wistow, David S. Moss, Tom L. Blundell, 1983 .

pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

Douglas E. V. Pires, Tom L. Blundell, David B. Ascher, 2015, Journal of medicinal chemistry.

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

Tom L. Blundell, Menico Rizzi, Stewart T. Cole, 2016, ACS infectious diseases.

Patterns of Sequence and 3-D Structure Variation in Families of Homologous Proteins: Lessons for Tertiary Templates and Comparative Modelling

Tom L. Blundell, T. Blundell, 1992 .

Molecular anatomy: Phyletic relationships derived from three-dimensional structures of proteins

Tom L. Blundell, T. Blundell, M. Sutcliffe, 2005, Journal of Molecular Evolution.

A six-stranded double-psi β barrel is shared by several protein superfamilies

Kenji Mizuguchi, Alexey G. Murzin, Tom L. Blundell, 1999 .

erratum: Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

Manuel Serrano, Tom L. Blundell, Ernest D. Laue, 1998, Nature.

Flexibility and small pockets at protein–protein interfaces: New insights into druggability

Tom L. Blundell, David B. Ascher, Harry Jubb, 2015, Progress in biophysics and molecular biology.

Evolutionary Trace analysis of TGF-β and related growth factors

Jiye Shi, Tom L. Blundell, C. A. Innis, 2000 .

High resolution structure of an oligomeric eye lens β-crystallin

Tom L. Blundell, H. P. C. Driessen, Christine Slingsby, 1991 .

PATTERNS OF SEQUENCE VARIATION IN FAMILIES OF HOMOLOGOUS PROTEINS

John P. Overington, Andrej Sali, Tom L. Blundell, 1991 .

Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach

George Papadatos, John P. Overington, Tom L. Blundell, 2017, Front. Pharmacol..

In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity

Douglas E. V. Pires, Tom L. Blundell, David B. Ascher, 2016, Scientific Reports.

The Effects of Local Environments on the Pattern of Amino-Acid Substitution in Homologous Prote Instructures: the Role of Side-Chain to Main-Chain Van Der Waals Interactions

David S. Moss, Tom L. Blundell, T. Blundell, 1994 .

New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor

Tom L. Blundell, Alexander Wlodawer, Jennifer Gunning, 1991, Nature.

Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis

Tom L. Blundell, Bernardo Ochoa-Montaño, Clifton E. Barry, 2014, Antimicrobial Agents and Chemotherapy.

PDBe-KB: a community-driven resource for structural and functional annotations

Alfonso Valencia, Karel Berka, Jaroslav Koča, 2019, Nucleic Acids Res..

PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

Tom L. Blundell, Viji M. Draviam, Qian Wu, 2015, Science.

Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product

Tom L. Blundell, Carlos F. Ibáñez, T. Blundell, 1992, Cell.

mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance

Douglas E. V. Pires, Tom L. Blundell, David B. Ascher, 2016, Scientific Reports.

A Personal History of Using Crystals and Crystallography to Understand Biology and Advanced Drug Discovery

Tom L. Blundell, T. Blundell, 2020, Crystals.

Genomes, structural biology and drug discovery: combating the impacts of mutations in genetic disease and antibiotic resistance

Tom L. Blundell, David B. Ascher, Arun Prasad Pandurangan, 2017, Biochemical Society transactions.

Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches

Tom L. Blundell, Chris Abell, Alexander Fanourakis, 2019, Journal of medicinal chemistry.

Model-building strategies for low-resolution X-ray crystallographic data

Nicholas Furnham, Tom L. Blundell, T. Blundell, 2009, Acta crystallographica. Section D, Biological crystallography.

Keynote review: Structural biology and drug discovery

Tom L. Blundell, Miles Congreve, Christopher W. Murray, 2005 .

ARABESQUE: A TOOL FOR PROTEIN STRUCTURAL COMPARISON USING DIFFERENTIAL GEOMETRY AND KNOT THEORY

Michele Vendruscolo, Tom L. Blundell, Rinaldo W. Montalvao, 2012 .

Biophysical and computational fragment-based approaches to targeting protein–protein interactions: applications in structure-guided drug discovery

Tom L. Blundell, Alicia P. Higueruelo, Anja Winter, 2012, Quarterly Reviews of Biophysics.

Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

Manuel Serrano, Tom L. Blundell, Ernest D. Laue, 1998, Nature.

Multiprotein Systems As Targets for Drug Discovery : Opportunities and Challenges

Tom L. Blundell, Luca Pellegrini, B. L. Sibanda, 2007 .

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

David F. Burke, Tom L. Blundell, Barbara Mulloy, 2000, Nature.

Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by

Tom L. Blundell, Dorothy Crowfoot Hodgkin, Dan Mercola, 1972 .

Phosducin induces a structural change in transducin βγ

Tom L. Blundell, Andreas Loew, T. Blundell, 1998 .

Cell biology: Brief encounters bolster contacts

Juan Fernández-Recio, Tom L. Blundell, T. Blundell, 2006, Nature.

Insights into DNA recombination from the structure of a RAD51–BRCA2 complex

Tom L. Blundell, Luca Pellegrini, Ashok R. Venkitaraman, 2002, Nature.