John I. Clark

John I. Clark, G. Benedek, T. B. Sauke, 1979, Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences.

The occhiolino (occ) mutant Zebrafish, a model for development of the optical function in the biological lens

John I. Clark, D. Raible, Tor H. Linbo, 2017, Developmental dynamics : an official publication of the American Association of Anatomists.

The Cardiomyopathy and Lens Cataract Mutation in αB-crystallin Alters Its Protein Structure, Chaperone Activity, and Interaction with Intermediate Filaments in Vitro *

John I. Clark, P. Muchowski, P. van den Ijssel, 1999, The Journal of Biological Chemistry.

Characterization of the cellular microstructure of ocular lens using 2D power law analysis

John I. Clark, S. Vaezy, 1995, Annals of Biomedical Engineering.

Tmod1 and CP49 Synergize to Control the Fiber Cell Geometry, Transparency, and Mechanical Stiffness of the Mouse Lens

John I. Clark, Albert C. Chen, Roberta B. Nowak, 2012, PloS one.

Theoretical and experimental basis for the inhibition of cataract

John I. Clark, G. Benedek, J. Pande, 1999, Progress in Retinal and Eye Research.

Therapeutic applications of heat shock proteins and molecular chaperones

John I. Clark, 2001 .

Expression of the Matricellular Protein SPARC in Murine Lens: SPARC Is Necessary for the Structural Integrity of the Capsular Basement Membrane

John I. Clark, E. Sage, Q. Yan, 2003, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

The function of the β3 interactive domain in the small heat shock protein and molecular chaperone, human αB crystallin

John I. Clark, Scott A. Houck, J. Ghosh, 2006 .

protein and molecular chaperone, human aB crystallin

John I. Clark, Scott A. Houck, J. Ghosh, 2006 .

John I. Clark, P. Muchowski, M. M. Valdez, 2002, European journal of biochemistry.

Noninvasive Measurement of Protein Aggregation by Mutant Huntingtin Fragments or α-Synuclein in the Lens*

John I. Clark, P. Muchowski, R. Ramsden, 2008, Journal of Biological Chemistry.

Noninvasive Detection of Alzheimer’s Disease Lens Pathology in Down Syndrome by Quasi-Elastic Light Scattering

John I. Clark, Caitlin Rook, S. Sarangi, 2015 .

Self-assembly of protein aggregates in ageing disorders: the lens and cataract model

John I. Clark, 2013, Philosophical Transactions of the Royal Society B: Biological Sciences.

Automated, computerized, feature-based phenotype analysis of slit lamp images of the mouse lens.

John I. Clark, Jenny Yuen, L. Shapiro, 2008, Experimental eye research.

Cell fate and differentiation of the developing ocular lens.

John I. Clark, T. Greiling, M. Aose, 2010, Investigative ophthalmology & visual science.

Interactive sequences in the stress protein and molecular chaperone human alphaB crystallin recognize and modulate the assembly of filaments.

John I. Clark, Scott A. Houck, J. Ghosh, 2007, The international journal of biochemistry & cell biology.

Functional sequences in human alphaB crystallin.

John I. Clark, 2016, Biochimica et biophysica acta.

Targeted genomic deletion of the lens-specific intermediate filament protein CP49.

John I. Clark, J. Hess, T. Blankenship, 2002, Investigative ophthalmology & visual science.

Interactive Domains in the Molecular Chaperone Human aB Crystallin Modulate Microtubule Assembly and

John I. Clark, Scott A. Houck, D. Ghosh, 2007 .

IC-P-127 Non-invasive early detection of beta-amyloid molecular pathology by quasi-elastic light scattering in vivo

John I. Clark, W. Klunk, C. Mathis, 2006, Alzheimer's & Dementia.

Characterization of a mutation in the lens-specific CP49 in the 129 strain of mouse.

John I. Clark, J. Hess, T. Blankenship, 2004, Investigative ophthalmology & visual science.

The Functional Domains in Human B Crystallin in Development and Maintenance of Lens Transparency

John I. Clark, J. Ghosh, 2007 .

Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens

John I. Clark, R. Quinlan, 2022, The Journal of biological chemistry.

Characterization of the cellular microstructure of ocular lens using 2D power law analysis

John I. Clark, S. Vaezy, 1995, Annals of Biomedical Engineering.

Hemoglobin Interactions with αB Crystallin: A Direct Test of Sensitivity to Protein Instability

John I. Clark, Tyler J. W. Clark, Scott A. Houck, 2012, PloS one.

Alterations in the lens capsule contribute to cataractogenesis in SPARC-null mice.

John I. Clark, John I Clark, E Helene Sage, 2002, Journal of cell science.

An in vitro model of posterior capsular opacity: SPARC and TGF-beta2 minimize epithelial-to-mesenchymal transition in lens epithelium.

John I. Clark, John I Clark, Hiroyuki Matsushima, 2007, Investigative ophthalmology & visual science.

Ultrasound-Enhanced Transcorneal Drug Delivery

John I. Clark, V. Zderic, S. Vaezy, 2004, Cornea.

Drug Delivery Into the Eye With the Use of Ultrasound

John I. Clark, Vesna Zderic, John I Clark, 2004, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

The effects of drug delivery via hydrophilic acrylic (hydrogel) intraocular lens systems on the epithelial cells in culture.

John I. Clark, Y. Obara, T. Senoo, 2005, Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye.

Analysis of cytoskeletal proteins in posterior capsule opacification after implantation of acrylic and hydrogel intraocular lenses

John I. Clark, Y. Obara, H. Matsushima, 2004, Journal of cataract and refractive surgery.

Insights into the domains required for dimerization and assembly of human αB crystallin

John I. Clark, J. Ghosh, 2005, Protein science : a publication of the Protein Society.

Multiple Sites in αB-Crystallin Modulate Its Interactions with Desmin Filaments Assembled In Vitro

John I. Clark, Scott A. Houck, R. Quinlan, 2011, PloS one.

Interactive domains for chaperone activity in the small heat shock protein, human alphaB crystallin.

John I. Clark, J. Ghosh, Marcus R. Estrada, 2005, Biochemistry.

Biology of the Lens: Lens Transparency as a Function of Embryology, Anatomy, and Physiology

John I. Clark, J. Kuszak, K. Cooper, 2008 .

Biology of the Transparent Lens and Changes with Age

John I. Clark, 2020 .

Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy

John I. Clark, S. Tapscott, Philippe Soriano, 2000, Nature Genetics.

Alzheimer’s disease amyloid-β pathology in the lens of the eye

John I. Clark, R. Tanzi, A. McKee, 2022, Experimental eye research.

New insights into the mechanism of lens development using zebra fish.

John I. Clark, T. Greiling, 2012, International review of cell and molecular biology.

Alzheimer's Disease Amyloid-\(\beta\) Links Lens and Brain Pathology in Down Syndrome

John I. Clark, J. Kuszak, R. Tanzi, 2010 .

Inhibition of Lens Opocificotion in X-lrrodioted Rots Treoted With WR-77913

John I. Clark, K. Krohn, T. Menard, 2005 .

Genome Sequencing of Idiopathic Pulmonary Fibrosis in Conjunction with a Medical School Human Anatomy Course

John I. Clark, J. Shendure, Gregory M. Findlay, 2014, PloS one.

Targeted deletion of the lens fiber cell-specific intermediate filament protein filensin.

John I. Clark, J. Hess, T. Blankenship, 2003, Investigative ophthalmology & visual science.

Interactive sequences in the molecular chaperone, human alphaB crystallin modulate the fibrillation of amyloidogenic proteins.

John I. Clark, Scott A. Houck, J. Ghosh, 2008, The international journal of biochemistry & cell biology.

In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans and Mice

John I. Clark, R. Tanzi, M. Ericsson, 2018, The journals of gerontology. Series A, Biological sciences and medical sciences.

Studies of αB crystallin subunit dynamics by surface plasmon resonance

John I. Clark, Shaoyi Jiang, J. Ghosh, 2006 .

Human αB-Crystallin

John I. Clark, P. Muchowski, N. Lubsen, 1997, The Journal of Biological Chemistry.

N- and C-Terminal motifs in human alphaB crystallin play an important role in the recognition, selection, and solubilization of substrates.

John I. Clark, J. Ghosh, A. Shenoy, 2006, Biochemistry.

The function of the beta3 interactive domain in the small heat shock protein and molecular chaperone, human alphaB crystallin.

John I. Clark, Scott A. Houck, J. Ghosh, 2006, Cell stress & chaperones.

Interactive Domains in the Molecular Chaperone Human αB Crystallin Modulate Microtubule Assembly and Disassembly

John I. Clark, Scott A. Houck, J. Ghosh, 2007, PloS one.

ATP and the Core “α-Crystallin” Domain of the Small Heat-shock Protein αB-crystallin*

John I. Clark, J. Yates, P. Muchowski, 1999, The Journal of Biological Chemistry.

Site-directed mutations within the core “α-crystallin” domain of the small heat-shock protein, human αB-crystallin, decrease molecular chaperone functions

John I. Clark, P. Muchowski, E. Adman, 1999 .

The β4-β8 Groove Is an ATP-interactive Site in the α Crystallin Core Domain of the Small Heat Shock Protein, Human αB Crystallin

John I. Clark, Scott A. Houck, J. Ghosh, 2006 .

Absence of SPARC leads to impaired lens circulation.

John I. Clark, John I Clark, T. Greiling, 2009, Experimental eye research.

2 – Surgical Anatomy for the Implanting Physician

John I. Clark, C. Fligner, J. Poole, 2018 .

P Nuclear Magnetic Resonance and Laser Spectroscopic Analyses of Lens Transparency During Calcium-Induced Opacificafion

John I. Clark, C. Beaulieu, 2005 .

Scanning Electron Microscopy of Opaque and Transparent States in Reversible Calf Lens Cataracts

John I. Clark, G. Benedek, L. Mengel, 1980 .

Interactions between Important Regulatory Proteins and Human αB Crystallin

John I. Clark, J. Ghosh, A. Shenoy, 2007 .

Structure-based analysis of the β8 interactive sequence of human αB crystallin

John I. Clark, J. Ghosh, Marcus R. Estrada, 2006 .

Dynamic Subunit Exchange and the Regulation of Microtubule Assembly by the Stress Response Protein Human αB Crystallin

John I. Clark, Scott A. Houck, 2010, PloS one.

Structure-based analysis of the beta8 interactive sequence of human alphaB crystallin.

John I. Clark, J. Ghosh, Marcus R. Estrada, 2006, Biochemistry.

Assigning in vivo carbamylation and acetylation in human lens proteins using tandem mass spectrometry and database searching

John I. Clark, J. Yates, R. Sadygov, 2007 .

A new method for study of normal lens developmentin vitro using pulsatile delivery of PDGF or EGF in HL-1 serum-free medium

John I. Clark, B. Brewitt, 1990, In Vitro Cellular & Developmental Biology.

John I. Clark, Andrew D. Brown, Ruiyu Zeng, 2021, Hearing Research.

Evolution of the vertebrate beaded filament protein, Bfsp2; comparing the in vitro assembly properties of a "tailed" zebrafish Bfsp2 to its "tailless" human orthologue.

John I. Clark, A. Prescott, Yizhi Liu, 2012, Experimental eye research.

Order and disorder in the transparent media of the eye.

John I. Clark, John I Clark, 2004, Experimental eye research.

Effect of selected anti-cataract agents on opacification in the selenite cataract model.

John I. Clark, J. I. Clark, T. Hiraoka, 1996, Experimental eye research.

Small heat-shock proteins and their potential role in human disease.

John I. Clark, P. Muchowski, J. I. Clark, 2000, Current opinion in structural biology.

Fibroblast growth factor-2 selectively stimulates angiogenesis of small vessels in arterial tree.

John I. Clark, P. Parsons-Wingerter, J. I. Clark, 2000, Arteriosclerosis, thrombosis, and vascular biology.

The Cardiomyopathy and Lens Cataract Mutation in αB-crystallin Alters Its Protein Structure, Chaperone Activity, and Interaction with Intermediate Filaments in Vitro *

John I. Clark, P. Muchowski, P. van den Ijssel, 1999, The Journal of Biological Chemistry.

In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans.

John I. Clark, R. Tanzi, M. Ericsson, 2020, The journals of gerontology. Series A, Biological sciences and medical sciences.

Relaxometry of lens homogenates. II. temperature dependence and comparison with other proteins

John I. Clark, C. Beaulieu, S. H. Koenig, 1989, Magnetic resonance in medicine.

Noninvasive Measurement of Protein Aggregation by Mutant Huntingtin Fragments or α-Synuclein in the Lens*

John I. Clark, P. Muchowski, R. Ramsden, 2008, Journal of Biological Chemistry.