Bruce S. Edwards

发表

Integration of virtual and physical screening

Dan C. Fara, Tudor I. Oprea, Eric R. Prossnitz, 2006, Drug Discovery Today: Technologies.

Figure 5, Five analogues submitted to support probe SID 88095709 (CID 44640177)

Dan C. Fara, Tudor I. Oprea, Cristian G. Bologa, 2013 .

Figure 4, Screening and Hit advancement flowchart

Tudor I. Oprea, Bruce S. Edwards, Larry A. Sklar, 2013 .

Figure 15, Overlay of dose response curves for probe ML231 (SID 99300522, CID 3392161)

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, 2013 .

Flow cytometry systems for drug discovery and development

Eric R. Prossnitz, Bruce S. Edwards, Larry A. Sklar, 2000, Photonics West - Biomedical Optics.

Table 4, Summary of modifications for R2

Dan C. Fara, Tudor I. Oprea, Cristian G. Bologa, 2013 .

Table 2, Continuation of SAR expansion on initial hit SID 85240370

Dan C. Fara, Tudor I. Oprea, Cristian G. Bologa, 2013 .

Table 5, Summary of modifications for R4

Dan C. Fara, Tudor I. Oprea, Cristian G. Bologa, 2013 .

Figure 16, Validated hit and SAR strategy

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, 2013 .

Table 3, SAR summary for modification at R2

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, 2013 .

Figure 6, Screening flow chart

Dan C. Fara, Tudor I. Oprea, Cristian G. Bologa, 2013 .

Figure 5, TOR compound triage and flow chart

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, 2013 .

Figure 6, Schematic of screen strategy

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, 2013 .

Figure 11, [Detailed synthetic pathway for making probe].

Tudor I. Oprea, Bruce S. Edwards, Larry A. Sklar, 2010 .

[Table, Detailed synthetic pathway for making probe].

Tudor I. Oprea, Bruce S. Edwards, Larry A. Sklar, 2010 .

Table 3, Summary of modifications for R1

Dan C. Fara, Tudor I. Oprea, Cristian G. Bologa, 2013 .

High‐Throughput Flow Cytometry

Tudor I. Oprea, Eric R. Prossnitz, Cristian G. Bologa, 2010 .

Sample handling for kinetics and molecular assembly in flow cytometry

Eric R. Prossnitz, Bruce S. Edwards, Larry A. Sklar, 1998, Photonics West - Biomedical Optics.

Figure 9, Focus of SAR expansion efforts based on primary efflux data

Dan C. Fara, Tudor I. Oprea, Cristian G. Bologa, 2013 .

Figure 7, Validated hit resulting from the preliminary commercial SAR effort

Dan C. Fara, Tudor I. Oprea, Cristian G. Bologa, 2013 .

Table 1, SAR expansion on initial hit SID 85240370

Dan C. Fara, Tudor I. Oprea, Cristian G. Bologa, 2013 .

Figure 8, Sequence alignment of human Rac1 and Cdc42

Tudor I. Oprea, Bruce S. Edwards, Larry A. Sklar, 2010 .

[Table, Assay rationale and descriptions, table of reagents and source].

Tudor I. Oprea, Bruce S. Edwards, Larry A. Sklar, 2010 .

Figure 10, TORC1 bypass cell growth analysis on the probe ML231 and SID 96099781

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, 2013 .

Rapid Scanning Structure-Activity Relationships in Combinatorial Data Sets: Identification of Activity Switches

Clemencia Pinilla, Bruce S. Edwards, Larry A. Sklar, 2013, J. Chem. Inf. Model..

Table 2, Summary of modifications to R1

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, 2013 .

[Table, Summary of Results].

Tudor I. Oprea, Bruce S. Edwards, Larry A. Sklar, 2010 .

Mining large chemical spaces in lead and drug discovery

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, 2006 .

Flow Cytometry

Bruce S. Edwards, Larry A. Sklar, B. Edwards, 2015, Journal of biomolecular screening.

Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, 2013 .

High-Throughput Screening with HyperCyt® Flow Cytometry to Detect Small Molecule Formylpeptide Receptor Ligands

Tudor I. Oprea, Eric R. Prossnitz, Bruce S. Edwards, 2005, Journal of biomolecular screening.

Three small molecule pan activator families of Ras-related GTPases

Tudor I. Oprea, Cristian G. Bologa, Bruce S. Edwards, 2010 .

Selective Chemical Inhibition of agr Quorum Sensing in Staphylococcus aureus Promotes Host Defense with Minimal Impact on Resistance

Bruce S. Edwards, Larry A. Sklar, Michael Otto, 2014, PLoS pathogens.

Post-High-Throughput Screening Analysis: An Empirical Compound Prioritization Scheme

Tudor I. Oprea, Eric R. Prossnitz, Cristian G. Bologa, 2005, Journal of biomolecular screening.

Real-time Analysis of Very Late Antigen-4 Affinity Modulation by Shear*

Bruce S. Edwards, Larry A. Sklar, Terry D. Foutz, 2004, Journal of Biological Chemistry.

Selective Bcl-2 Inhibitor Probes

Tudor I. Oprea, Bruce S. Edwards, Larry A. Sklar, 2013 .

Real Time Analysis of the Affinity Regulation of α4-Integrin

Eric R. Prossnitz, Bruce S. Edwards, Larry A. Sklar, 2001, The Journal of Biological Chemistry.