J Brian Houston

发表

Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: comparison of dynamic and static models.

Amin Rostami-Hodjegan, Aleksandra Galetin, Eleanor J Guest, 2009, British journal of clinical pharmacology.

Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data

Michael Gertz, Aleksandra Galetin, J Brian Houston, 2013, Drug Metabolism and Disposition.

UTILITY OF RECOMBINANT ENZYME KINETICS IN PREDICTION OF HUMAN CLEARANCE: IMPACT OF VARIABILITY, CYP3A5, AND CYP2C19 ON CYP3A4 PROBE SUBSTRATES

Aleksandra Galetin, Kiyomi Ito, J Brian Houston, 2004, Drug Metabolism and Disposition.

Prediction of Human Pharmacokinetics in 2013 and Beyond

J Brian Houston, J. Houston, 2013, Drug Metabolism and Disposition.

BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT

J Brian Houston, J. Houston, D. Hallifax, 2006, Drug Metabolism and Disposition.

Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data

Michael Gertz, Aleksandra Galetin, J Brian Houston, 2010, Drug Metabolism and Disposition.

Kinetic Characterization of Rat Hepatic Uptake of 16 Actively Transported Drugs

Aleksandra Galetin, J Brian Houston, A. Galetin, 2011, Drug Metabolism and Disposition.

PREDICTION OF TIME-DEPENDENT CYP3A4 DRUG-DRUG INTERACTIONS: IMPACT OF ENZYME DEGRADATION, PARALLEL ELIMINATION PATHWAYS, AND INTESTINAL INHIBITION

Aleksandra Galetin, J Brian Houston, A. Galetin, 2006, Drug Metabolism and Disposition.

In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises.

J Brian Houston, J. Houston, K. Knights, 2006, Biochemical pharmacology.

Modelling atypical CYP3A4 kinetics: principles and pragmatism.

Aleksandra Galetin, J Brian Houston, A. Galetin, 2005, Archives of biochemistry and biophysics.

Simultaneous Assessment In Vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a Media Loss Approach

Adam S Darwich, J Brian Houston, J. Houston, 2018, Drug Metabolism and Disposition.

Database analyses for the prediction of in vivo drug-drug interactions from in vitro data.

Kiyomi Ito, J Brian Houston, Hayley S. Brown, 2004, British journal of clinical pharmacology.

Methods for predicting in vivo pharmacokinetics using data from in vitro assays.

Aleksandra Galetin, J Brian Houston, A. Galetin, 2008, Current drug metabolism.

Physiologically Based Pharmacokinetic Modeling of Intestinal First-Pass Metabolism of CYP3A Substrates with High Intestinal Extraction

Michael Gertz, Aleksandra Galetin, J Brian Houston, 2011, Drug Metabolism and Disposition.

Hepatic, Intestinal, Renal, and Plasma Hydrolysis of Prodrugs in Human, Cynomolgus Monkey, Dog, and Rat: Implications for In Vitro–In Vivo Extrapolation of Clearance of Prodrugs

Aleksandra Galetin, J Brian Houston, A. Galetin, 2014, Drug Metabolism and Disposition.

Saturable Uptake of Lipophilic Amine Drugs into Isolated Hepatocytes: Mechanisms and Consequences for Quantitative Clearance Prediction

J Brian Houston, J. Houston, D. Hallifax, 2007, Drug Metabolism and Disposition.

Prediction of In Vivo Drug-Drug Interactions from In Vitro Data

Aleksandra Galetin, J Brian Houston, Hayley S. Brown, 2006, Clinical pharmacokinetics.

Potential role of intestinal first-pass metabolism in the prediction of drug-drug interactions.

Michael Gertz, Aleksandra Galetin, J Brian Houston, 2008, Expert opinion on drug metabolism & toxicology.

Predictive Models of CYP3A4 Heteroactivation: In Vitro-in Vivo Scaling and Pharmacophore Modeling

Ann-Charlotte Egnell, J Brian Houston, J. Houston, 2005, Journal of Pharmacology and Experimental Therapeutics.

Use of Mechanistic Modeling to Assess Interindividual Variability and Interspecies Differences in Active Uptake in Human and Rat Hepatocytes

Aleksandra Galetin, J Brian Houston, A. Galetin, 2012, Drug Metabolism and Disposition.

Hepatocellular Binding of Drugs: Correction for Unbound Fraction in Hepatocyte Incubations Using Microsomal Binding or Drug Lipophilicity Data

Michael Gertz, Aleksandra Galetin, J Brian Houston, 2008, Drug Metabolism and Disposition.

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

John C Lipscomb, Amin Rostami-Hodjegan, Alan R Boobis, 2007, Current drug metabolism.

Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance.

J Brian Houston, J. Houston, Sarah J Griffin, 2004, Drug metabolism and disposition: the biological fate of chemicals.

IMPACT OF PARALLEL PATHWAYS OF DRUG ELIMINATION AND MULTIPLE CYTOCHROME P450 INVOLVEMENT ON DRUG-DRUG INTERACTIONS: CYP2D6 PARADIGM

Kiyomi Ito, J Brian Houston, Kiyomi Ito, 2005, Drug Metabolism and Disposition.

Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs.

Aleksandra Galetin, J Brian Houston, A. Galetin, 2007, Current drug metabolism.

Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance

J Brian Houston, Hayley S. Brown, J. Houston, 2007, Drug Metabolism and Disposition.

In Vitro and in Silico Tools To Assess Extent of Cellular Uptake and Lysosomal Sequestration of Respiratory Drugs in Human Alveolar Macrophages.

Michael Gertz, Aleksandra Galetin, J Brian Houston, 2017, Molecular pharmaceutics.

SUBSTRATE DEPLETION APPROACH FOR DETERMINING IN VITRO METABOLIC CLEARANCE: TIME DEPENDENCIES IN HEPATOCYTE AND MICROSOMAL INCUBATIONS

Hannah M Jones, J Brian Houston, J. Houston, 2004, Drug Metabolism and Disposition.

Prediction of in vitro intrinsic clearance from hepatocytes: comparison of suspensions and monolayer cultures.

J Brian Houston, J. Houston, Sarah J Griffin, 2005, Drug metabolism and disposition: the biological fate of chemicals.