Scott W. Lowe

发表

Prediction of ultra-potent shRNAs with a sequential classification algorithm

Gunnar Rätsch, Christina S. Leslie, Christian Widmer, 2017, Nature Biotechnology.

microRNAs join the p53 network — another piece in the tumour-suppression puzzle

Gregory J. Hannon, Scott W. Lowe, S. Lowe, 2007, Nature Reviews Cancer.

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions

Michael Wigler, Johannes Zuber, Stephanie Roessler, 2012, Proceedings of the National Academy of Sciences.

Abstract 4188: RNAi and CRISPR/Cas9 basedin vivomodels for drug discovery

Johannes Zuber, Lukas E. Dow, Prem K. Premsrirut, 2016 .

mTORC1 promotes survival through translational control of Mcl-1

David E. Housman, Robert Nadon, John R. Mills, 2008, Proceedings of the National Academy of Sciences.

Chelator-Free Radiolabeling of SERRS Nanoparticles for Whole-Body PET and Intraoperative Raman Imaging

Travis M. Shaffer, Moritz F. Kircher, Darjus F. Tschaharganeh, 2017, Theranostics.

p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state

Adrian Krainer, Scott W. Lowe, Matthew J. Lazzara, 2014, Proceedings of the National Academy of Sciences.

Abstract B37: RNAi and CRISPR/Cas9-based in vivo models for drug discovery

Christof Fellmann, Johannes Zuber, Lukas E. Dow, 2015 .

Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

Mark J. Smyth, Scott W. Lowe, Ricky W. Johnstone, 2007, Proceedings of the National Academy of Sciences.

Convergent loss of PTEN leads to clinical resistance to a PI3Kα inhibitor

Obi L. Griffith, Malachi Griffith, Benjamin J. Ainscough, 2014, Nature.

Role of genomic instability and p53 in AID-induced c-myc–Igh translocations

Michel C. Nussenzweig, Scott W. Lowe, Mila Jankovic, 2006, Nature.

Corrigendum: In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system

Joana A. Vidigal, Andrea Ventura, Elisa de Stanchina, 2015, Nature.

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Carlos Cordon-Cardo, Scott W. Lowe, S. Lowe, 2007, Nature.

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer

Hans Clevers, Lukas E. Dow, Darjus F. Tschaharganeh, 2015, Cell.

Direct coupling of the cell cycle and cell death machinery by E2F

Ramana V. Davuluri, Michael Q. Zhang, Masashi Narita, 2002, Nature Cell Biology.

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference

Johannes Zuber, Lukas E. Dow, Gregory J. Hannon, 2011, Cell.

RNAi and CRISPR/Cas9 based in vivo models for drug discovery

Johannes Zuber, Lukas E. Dow, Gregory J. Hannon, 2016 .

Stable RNA interference rules for silencing

Christof Fellmann, Scott W. Lowe, S. Lowe, 2013, Nature Cell Biology.

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

Jianmin Wu, Sean M. Grimmond, Christian Pilarsky, 2014, Cell.

Tumor Promotion by Mdm 2 Splice Variants Unable to Bind p 531

Elisa de Stanchina, Carlos Cordon-Cardo, Scott W. Lowe, 2003 .

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

David E. Housman, Scott W. Lowe, D. Housman, 1996, Nature.

Regulation of p53 by Hypoxia: Dissociation of Transcriptional Repression and Apoptosis from p53-Dependent Transactivation

Yoichi Taya, Scott W. Lowe, S. Lowe, 2001, Molecular and Cellular Biology.

Stem cells: The promises and perils of p53

Scott W. Lowe, S. Lowe, V. Krizhanovsky, 2009, Nature.

Abstract C54: Pdgfrb is an essential mediator of p53(mut)-driven metastasis in pancreatic cancer

Vishal Thapar, Scott W. Lowe, Susann Weissmueller, 2013 .

A rectal cancer model establishes a platform to study individual responses to chemoradiation

Hans Clevers, Lukas E. Dow, Jinru Shia, 2019, bioRxiv.

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

Patrick J. Paddison, Carlos Cordon-Cardo, Gregory J. Hannon, 2003, Nature Genetics.

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

John T. Poirier, Charles M. Rudin, Amanda R. Kulick, 2018, Science.

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

Jeffrey R. Marks, Ken C. Q. Nguyen, Jing Li, 2002, Nature Genetics.

Topoisomerase levels determine chemotherapy response in vitro and in vivo

W. Richard McCombie, Gregory J. Hannon, Scott W. Lowe, 2008, Proceedings of the National Academy of Sciences.

p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer

Matthias Evert, Lukas E. Dow, Thomas Longerich, 2014, Cell.

Quantitative Self-Assembly Prediction Yields Targeted Nanomedicines

John D. Chodera, Mehtap Işık, Januka Budhathoki-Uprety, 2017, Nature Materials.

Putting p53 in Context

Scott W. Lowe, S. Lowe, Edward R. Kastenhuber, 2017, Cell.

Apoptosis A Link between Cancer Genetics and Chemotherapy

Scott W. Lowe, Ricky W. Johnstone, S. Lowe, 2002, Cell.

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system

Joana A. Vidigal, Andrea Ventura, Elisa de Stanchina, 2014, Nature.

Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas

Lukas E. Dow, Maurizio Scaltriti, Scott W. Lowe, 2016, Proceedings of the National Academy of Sciences.

p53 is required for radiation-induced apoptosis in mouse thymocytes

Scott W. Lowe, S. Lowe, T. Jacks, 1993, Nature.

Transforming Big Data into Cancer-Relevant Insight: An Initial, Multi-Tier Approach to Assess Reproducibility and Relevance

Ken Chen, Chris Sander, Olivier Gevaert, 2016, Molecular Cancer Research.