Sibylle Neuhoff

发表

New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment.

Bas J Blaauboer, Alicia Paini, Paul Jennings, 2020, ALTEX.

PBPK models for evaluating membrane transporter mediated DDIs: Current capabilities, case studies, future opportunities and recommendations.

Yuichi Sugiyama, Ming Zheng, Jan Snoeys, 2019, Clinical pharmacology and therapeutics.

Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data.

Lu Gaohua, Amin Rostami-Hodjegan, Masoud Jamei, 2016, Drug metabolism and pharmacokinetics.

Accounting for Transporters in Renal Clearance: Towards a Mechanistic Kidney Model (Mech KiM)

Lu Gaohua, Masoud Jamei, Amin Rostami-Hodjegan, 2013 .

In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects.

Talia Flanagan, Clive G. Wilson, Mai Anh Nguyen, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Population-Based Mechanistic Prediction of Oral Drug Absorption

Sebastian Polak, Masoud Jamei, Amin Rostami-Hodjegan, 2009, The AAPS Journal.

The Regional-Specific Relative and Absolute Expression of Gut Transporters in Adult Caucasians: A Meta-Analysis

Sibylle Neuhoff, S. Neuhoff, M. Harwood, 2019, Drug Metabolism and Disposition.

Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs

Masoud Jamei, David B. Turner, Sibylle Neuhoff, 2017, The AAPS Journal.

More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter‐Mediated Clearances

Khaled Abduljalil, Sibylle Neuhoff, S. Neuhoff, 2016, Journal of clinical pharmacology.

Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA method

Per Artursson, Sibylle Neuhoff, Alex Avdeef, 2005 .

pH-Dependent Bidirectional Transport of Weakly Basic Drugs Across Caco-2 Monolayers: Implications for Drug–Drug Interactions

Ismael Zamora, Per Artursson, Sibylle Neuhoff, 2003, Pharmaceutical Research.

Impact of Extracellular Protein Binding on Passive and Active Drug Transport Across Caco-2 Cells

Ismael Zamora, Per Artursson, Sibylle Neuhoff, 2005, Pharmaceutical Research.

Application of permeability-limited physiologically-based pharmacokinetic models: part I-digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux.

Masoud Jamei, David B Turner, Amin Rostami-Hodjegan, 2013, Journal of pharmaceutical sciences.

Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP2C8 and OATP1B Drug Substrates

Shiew-Mei Huang, Ping Zhao, Lei Zhang, 2018, Clinical pharmacology and therapeutics.

In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition

Amin Rostami-Hodjegan, Gordon Carlson, Brahim Achour, 2016, Drug Metabolism and Disposition.

Application of permeability-limited physiologically-based pharmacokinetic models: part II - prediction of P-glycoprotein mediated drug-drug interactions with digoxin.

Masoud Jamei, David B Turner, Amin Rostami-Hodjegan, 2013, Journal of pharmaceutical sciences.

pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers.

Ismael Zamora, Per Artursson, Sibylle Neuhoff, 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.