Julian Blagg

发表

Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors

Sarah R. Langdon, Isaac M. Westwood, Rob L. M. van Montfort, 2013, J. Chem. Inf. Model..

MOARF, an Integrated Workflow for Multiobjective Optimization: Implementation, Synthesis, and Biological Evaluation

Nathan Brown, Julian Blagg, Nicholas C. Firth, 2015, J. Chem. Inf. Model..

The promise and peril of chemical probes.

John P. Overington, Jian Jin, Matthieu Schapira, 2015, Nature chemical biology.

Donated chemical probes for open science

Anton Simeonov, Steve Hitchcock, Stefan Laufer, 2018, eLife.

Plane of Best Fit: A Novel Method to Characterize the Three-Dimensionality of Molecules

Nathan Brown, Julian Blagg, Nicholas C. Firth, 2012, J. Chem. Inf. Model..

Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology

Julian Blagg, Paul Workman, P. Workman, 2017, Cancer cell.

Mapping the 3D structures of small molecule binding sites

Nathan Brown, Julian Blagg, Joshua Meyers, 2016, Journal of Cheminformatics.

Scaffold Diversity of Exemplified Medicinal Chemistry Space

Sarah R. Langdon, Nathan Brown, Julian Blagg, 2011, J. Chem. Inf. Model..

Bioisosteres in De Novo Design

Julian Blagg, Nicholas C. Firth, Nathan J. Brown, 2013 .

Author response: Donated chemical probes for open science

Adriaan P. IJzerman, Bryan L. Roth, Anton Simeonov, 2018 .

Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.

Julian Blagg, Djordje Musil, Paul Czodrowski, 2016, Journal of medicinal chemistry.

Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Isaac M. Westwood, Julian Blagg, Florence I. Raynaud, 2013, Journal of medicinal chemistry.

Potent and selective nonpeptidic inhibitors of procollagen C-proteinase.

Julian Blagg, P. Fish, R. Butt, 2007, Journal of medicinal chemistry.

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease

Gary Box, Julian Blagg, Paul Workman, 2015, Nature chemical biology.

Structural Alerts for Toxicity

Julian Blagg, J. Blagg, 2010, Medicinal Chemistry for Practitioners.

The Metabolism and Toxicity of Furosemide in the Wistar Rat and CD-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore

Julian Blagg, Iain Gardner, Dominic P. Williams, 2007, Journal of Pharmacology and Experimental Therapeutics.

Scaffold Diversity in Medicinal Chemistry Space

Sarah R. Langdon, Julian Blagg, J. Blagg, 2013 .

Physicochemical drug properties associated with in vivo toxicological outcomes: a review

Nigel Greene, Julian Blagg, David A. Price, 2009, Expert opinion on drug metabolism & toxicology.

A public-private partnership to unlock the untargeted kinome.

Julian Blagg, Paul Workman, Bernhard Kuster, 2013, Nature chemical biology.

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor

Nathan Brown, Julian Blagg, Paul Workman, 2018, Molecular oncology.

Optimization of imidazo [4, 5-b] pyridine-based kinase inhibitors: identification of a dual FLT3/aur

Gary Box, Nathan Brown, Julian Blagg, 2012 .

1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity.

Julian Blagg, P. Fish, J. Blagg, 2008, Bioorganic & medicinal chemistry letters.

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

Julian Blagg, Paul Workman, Florence I. Raynaud, 2016, Journal of medicinal chemistry.

Chemical biology approaches to target validation in cancer.

Julian Blagg, Paul Workman, P. Workman, 2014, Current opinion in pharmacology.

Analysis of water patterns in protein kinase binding sites

Caterina Barillari, Julian Blagg, Anna L. Duncan, 2011, Proteins.

Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2

Ian Collins, Isaac M. Westwood, Nathan Brown, 2013, PloS one.

Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore.

Julian Blagg, Djordje Musil, Paul Czodrowski, 2016, Bioorganic & medicinal chemistry letters.

Structure–Activity Relationships for In vitro and In vivo Toxicity

Julian Blagg, J. Blagg, 2006 .

Evaluation of Germline BMP4 Mutation as a Cause of Colorectal Cancer

Nathan Brown, Julian Blagg, Richard S Houlston, 2011, Human mutation.