John S Lazo

发表

Identifying Actives from HTS Data Sets

Paul A Johnston, Tong Ying Shun, John S Lazo, 2011, Journal of biomolecular screening.

The Benzo[c]phenanthridine Alkaloid, Sanguinarine, Is a Selective, Cell-active Inhibitor of Mitogen-activated Protein Kinase Phosphatase-1*

Andreas Vogt, John S Lazo, John Skoko, 2005, Journal of Biological Chemistry.

Systems cell biology knowledge created from high content screening.

Dennis P Curran, Billy W Day, John S Lazo, 2005, Assay and drug development technologies.

Building a Pharmacological Lexicon: Small Molecule Discovery in Academia

John S Lazo, R. Dingledine, L. Brady, 2007, Molecular Pharmacology.

Improved low molecular weight Myc-Max inhibitors

John S Lazo, Ariele Viacava Follis, E. Prochownik, 2007, Molecular Cancer Therapeutics.

Four diterpenoid inhibitors of Cdc25B phosphatase from a marine anemone.

David G I Kingston, John S Lazo, Shugeng Cao, 2005, Bioorganic & medicinal chemistry.

microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.

Zhenghe Wang, Peng Wang, John S Lazo, 2009, Cancer research.

Chemical complementation: a definitive phenotypic strategy for identifying small molecule inhibitors of elusive cellular targets.

Andreas Vogt, John S Lazo, J. Lazo, 2005, Pharmacology & therapeutics.

Compound acquisition and prioritization algorithm for constructing structurally diverse compound libraries.

Xiang-Qun Xie, John S Lazo, Chao Ma, 2011, ACS combinatorial science.

Redox Regulation of Cdc25B by Cell-Active Quinolinediones

Peter Wipf, Billy W Day, John S Lazo, 2005, Molecular Pharmacology.

Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor.

Xiang-Qun Xie, Lirong Wang, Zhaojun Xie, 2011, International immunopharmacology.

Development and validation of a high-content screening assay to identify inhibitors of cytoplasmic dynein-mediated transport of glucocorticoid receptor to the nucleus.

Paul A Johnston, Billy W Day, Tong Ying Shun, 2012, Assay and drug development technologies.

Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments.

Peter Wipf, Paul A Johnston, Tong Ying Shun, 2010, Assay and drug development technologies.

Discovery and Characterization of Novel Small Molecule Inhibitors of Human Cdc25B Dual Specificity Phosphatase

Ivet Bahar, Peter Wipf, Dror Tobi, 2004, Molecular Pharmacology.

Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1

Peter Wipf, John S Lazo, P. Wipf, 2010, BMC chemical biology.

Low molecular weight inhibitors of Myc–Max interaction and function

John S Lazo, E. Prochownik, J. Lazo, 2003, Oncogene.

Toward a Molecular Understanding of the Interaction of Dual Specificity Phosphatases with Substrates: Insights from Structure-Based Modeling and High Throughput Screening

Ivet Bahar, Ahmet Bakan, Peter Wipf, 2008, Current medicinal chemistry.

Synthesis and Biological Activity of a Focused Library of Mitogen‐activated Protein Kinase Phosphatase Inhibitors

Peter Wipf, Paul A Johnston, Donna M Huryn, 2007, Chemical biology & drug design.

Identification of Survival Genes in Human Glioblastoma Cells by Small Interfering RNA Screening

Fang Zhang, Nikhil G Thaker, Peter R McDonald, 2009, Molecular Pharmacology.

Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1.

Peter Wipf, Andreas Vogt, John S Lazo, 2006, Bioorganic & medicinal chemistry.

Cell-active dual specificity phosphatase inhibitors identified by high-content screening.

Peter Wipf, Andreas Vogt, John S Lazo, 2003, Chemistry & biology.

Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D.

Peter Wipf, John S Lazo, Elizabeth R Sharlow, 2011, ACS medicinal chemistry letters.

Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents.

Peter Wipf, Paul A Johnston, Tong Ying Shun, 2008, Assay and drug development technologies.

Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors.

Peter Wipf, Rick Gussio, William Furey, 2002, Molecular pharmacology.