K Dane Wittrup

发表

Practical theoretic guidance for the design of tumor-targeting agents.

K Dane Wittrup, Greg M Thurber, Michael M Schmidt, 2012, Methods in enzymology.

Equilibrium and dynamic design principles for binding molecules engineered for reagentless biosensors.

K Dane Wittrup, Seymour de Picciotto, Barbara Imperiali, 2014, Analytical biochemistry.

Biophysical properties of the clinical-stage antibody landscape

K Dane Wittrup, Yingda Xu, Michael Brown, 2017, Proceedings of the National Academy of Sciences.

Target-independent variable region mediated effects on antibody clearance can be FcRn independent

K Dane Wittrup, Ryan L Kelly, Yingda Xu, 2016, mAbs.

Identification of the Epitope for the Epidermal Growth Factor Receptor-specific Monoclonal Antibody 806 Reveals That It Preferentially Recognizes an Untethered Form of the Receptor*

K Dane Wittrup, Gerd Ritter, Nathan E Hall, 2004, Journal of Biological Chemistry.

Fine epitope mapping of anti-epidermal growth factor receptor antibodies through random mutagenesis and yeast surface display.

K Dane Wittrup, Jennifer R Cochran, J. Cochran, 2004, Journal of molecular biology.

An engineered protein antagonist of K-Ras/B-Raf interaction

K Dane Wittrup, Carla Mattos, Ryan Knihtila, 2017, Scientific Reports.

Structural model of the mAb 806-EGFR complex using computational docking followed by computational and experimental mutagenesis.

Jeffrey J. Gray, K Dane Wittrup, Jeffrey J Gray, 2006, Structure.

A modular IgG-scFv bispecific antibody topology.

K Dane Wittrup, John V Frangioni, Kelly Davis Orcutt, 2010, Protein engineering, design & selection : PEDS.

Localized immunotherapy via liposome-anchored Anti-CD137 + IL-2 prevents lethal toxicity and elicits local and systemic antitumor immunity.

K Dane Wittrup, Jamal Elkhader, Darrell J Irvine, 2013, Cancer research.

A high affinity human antibody antagonist of P-selectin mediated rolling.

K Dane Wittrup, T. Springer, K. Wittrup, 2006, Biochemical and biophysical research communications.

Tumor cells are dislodged into the pulmonary vein during lobectomy.

K Dane Wittrup, J Christopher Love, Viktor A Adalsteinsson, 2014, The Journal of thoracic and cardiovascular surgery.

Isolating and engineering human antibodies using yeast surface display

K Dane Wittrup, Benjamin J Hackel, Shaun M Lippow, 2006, Nature Protocols.

High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice

K Dane Wittrup, Ryan L Kelly, Yingda Xu, 2015, mAbs.

Single cells from human primary colorectal tumors exhibit polyfunctional heterogeneity in secretions of ELR+ CXC chemokines.

K Dane Wittrup, Douglas S Kwon, J Christopher Love, 2013, Integrative biology : quantitative biosciences from nano to macro.

Monovalent, reduced-size quantum dots for imaging receptors on living cells

K Dane Wittrup, Michael M Schmidt, Michael M. Schmidt, 2008, Nature Methods.

Evolution of an interloop disulfide bond in high-affinity antibody mimics based on fibronectin type III domain and selected by yeast surface display: molecular convergence with single-domain camelid and shark antibodies.

K Dane Wittrup, Benjamin J Hackel, Shaun M Lippow, 2007, Journal of molecular biology.

Engineering an antibody with picomolar affinity to DOTA chelates of multiple radionuclides for pretargeted radioimmunotherapy and imaging.

K Dane Wittrup, Benjamin Ruiz-Yi, John V Frangioni, 2011, Nuclear medicine and biology.

Yeast surface display for protein engineering and characterization

K Dane Wittrup, K. Wittrup, S Annie Gai, 2007, Current Opinion in Structural Biology.

Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool.

K Dane Wittrup, Yingda Xu, Tingwan Sun, 2013, Protein engineering, design & selection : PEDS.

Stochastic kinetics of intracellular huntingtin aggregate formation

K Dane Wittrup, David W. Colby, John P. Cassady, 2006, Nature chemical biology.

Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance.

K Dane Wittrup, Greg M Thurber, Michael M Schmidt, 2008, Advanced drug delivery reviews.

Quantitative spatiotemporal analysis of antibody fragment diffusion and endocytic consumption in tumor spheroids.

K Dane Wittrup, Greg M Thurber, Greg M. Thurber, 2008, Cancer research.

Development of a human light chain variable domain (V(L)) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display.

K Dane Wittrup, Payal Garg, David W. Colby, 2004, Journal of molecular biology.

Effect of Small-Molecule–Binding Affinity on Tumor Uptake In Vivo: A Systematic Study Using a Pretargeted Bispecific Antibody

K Dane Wittrup, John J Rhoden, Benjamin Ruiz-Yi, 2012, Molecular Cancer Therapeutics.