J. W. Flesher

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FEDERAL ASSISTANCE FOR BIOMEDICAL RESEARCH LABORATORIES. CITATIONS AND AREAS OF RESEARCH

J. W. Flesher, C. J. Peters, 1991 .

Phosphonic Acid Analogs of Nucleoside Phosphates. I. The Synthesis of 5″-Adenylyl Methylenediphosphonate, a Phosphonic Acid Analog of ATP

J. W. Flesher, T. Myers, Kaname. Nakamura, 1963 .

6-sulfooxymethylbenzo[a]pyrene is an ultimate electrophilic and carcinogenic form of the intermediary metabolite 6-hydroxymethylbenzo[a]pyrene.

J. W. Flesher, A. Lehner, J. Horn, 1997, Biochemical and biophysical research communications.

Possible role of 6‐hydroxymethylbenzo[a]pyrene as a proximate carcinogen of benzo[a]pyrene and 6‐methylbenzo[a]pyrene

J. W. Flesher, K. Sydnor, Katherine L. Sydnor, 1973, International journal of cancer.

The Meso-Region Theory of Aromatic Hydrocarbon Carcinogenesis

J. W. Flesher, A. Lehner, J. Horn, 2002 .

7-Sulfooxymethyl-12-methylbenz[a]anthracene is an exceptionally reactive electrophilic mutagen and ultimate carcinogen.

J. W. Flesher, A. Lehner, J. Horn, 1997, Biochemical and biophysical research communications.

7-Sulfooxymethylbenz[a]anthracene is an ultimate electrophilic and carcinogenic form of 7-hydroxymethylbenz[a]anthracene.

J. W. Flesher, A. Lehner, J. Horn, 1997, Biochemical and biophysical research communications.

One electron oxidation of 3-methylcholanthrene: A chemical model for its mechanism of carcinogenesis

J. W. Flesher, A. Lehner, J. Horn, 2017 .

Oxidative metabolism of 7-methylbenz[a]anthracene, 12-methylbenz[a]anthracene and 7,12-dimethylbenz[a]anthracene by rat liver cytosol.

J. W. Flesher, S. Myers, 1985, Cancer letters.

Carcinogenicity of derivatives of 7,12-dimethylbenz(a)anthracene.

J. W. Flesher, K. Sydnor, 1971, Cancer research.

Formation of benzylic-DNA adducts resulting from 7,12-dimethylbenz[a]anthracene in vivo.

J. W. Flesher, Ramesh C. Gupta, M. R. Ravi Kumar, 2005, Chemical research in toxicology.

Metabolism of chrysene, 5-methylchrysene, 6-methylchrysene and 5,6-dimethylchrysene in rat liver cytosol, in vitro, and in rat subcutaneous tissue, in vivo.

J. W. Flesher, S. Myers, 1991, Chemico-biological interactions.

Biosynthesis of the potent carcinogen 7,12-dimethylbenz[a]anthracene.

J. W. Flesher, J. Blake, S. Myers, 1984, Cancer letters.

Synthesis of metabolites of 7,12-dimethylbenz[a]anthracene. 4-Hydroxy-7,12-dimethylbenz[a]anthracene, 7-hydroxymethyl-12-methylbenz[a]anthracene, their methyl ethers, and acetoxy derivatives.

J. W. Flesher, D. R. Kelley, S. Soedigdo, 1967, Journal of medicinal chemistry.

The Structural Basis for the Production of Cancer and Detoxification by Oxidized Metabolites of Mesoanthracenic Methylated and Non-Methylated Polynuclear Hydrocarbons: a Paradigm Shift

J. W. Flesher, A. Lehner, 2019, Review Journal of Chemistry.

Structure, function and carcinogenicity of metabolites of methylated and non-methylated polycyclic aromatic hydrocarbons: a comprehensive review

J. W. Flesher, A. Lehner, 2016, Toxicology mechanisms and methods.

Role of Hydroxymethyl Sulfate Esters in Aromatic Hydrocarbon Carcinogenesis

J. W. Flesher, A. Lehner, J. Horn, 2000 .

Mass spectrometric analysis of 7-sulfoxymethyl-12-methylbenz[a]anthracene and related electrophilic polycyclic aromatic hydrocarbon metabolites.

J. W. Flesher, A. Lehner, J. Horn, 2004, Journal of mass spectrometry : JMS.

Detection of benzylic adducts in DNA and nucleotides from 7-sulfooxymethyl-12-methylbenz[a]anthracene and related compounds by 32P-postlabeling using new TLC systems.

J. W. Flesher, Ramesh C. Gupta, M. Vadhanam, 2003, Chemico-biological interactions.

The metabolism of formyl-substituted benzanthracenes to hydroxymethyl metabolites in rat liver in vitro and in vivo.

J. W. Flesher, A. Lehner, J. Horn, 2003, Chemico-biological interactions.

BENZYLIC CARBONIUM IONS AS ULTIMATE CARCINOGENS OF POLYNUCLEAR AROMATIC HYDROCARBONS

J. W. Flesher, A. Lehner, J. Horn, 1996 .

Molecular modeling of carcinogenic potential in polycyclic hydrocarbons

J. W. Flesher, A. Lehner, J. Horn, 1996 .

Complete Carcinogenic Potential of Polycyclic Fluoranthene Hydrocarbons in Relation to Their Center or Centers of Highest Electron Density

J. W. Flesher, 1995 .

Rules of molecular geometry for predicting carcinogenic activity of unsubstituted polynuclear aromatic hydrocarbons.

J. W. Flesher, S. Myers, 1991, Teratogenesis, carcinogenesis, and mutagenesis.

Carcinogenicity of 1-hydroxy-3-methylcholanthrene and its electrophilic sulfate ester 1-sulfooxy-3-methylcholanthrene in Sprague-Dawley rats.

J. W. Flesher, A. Lehner, J. Horn, 1998, Biochemical and biophysical research communications.

Synthesis and carcinogenicity of compounds related to 6-hydroxymethylbenzo(a)pyrene.

J. W. Flesher, R. Natarajan, 1973, Journal of medicinal chemistry.

Formation of radical cations in a model for the metabolism of aromatic hydrocarbons.

J. W. Flesher, A. Lehner, J. Horn, 2004, Biochemical and biophysical research communications.

Distribution of radioactivity in the tissues of rats after oral administration of 7,12-dimethylbenz(A)anthracene-3H.

J. W. Flesher, 1967, Biochemical pharmacology.

Mechanism of aralkyl-DNA adduct formation from benzo[a]pyrene in vivo.

J. W. Flesher, R. Gupta, K. Stansbury, 1994, Chemical research in toxicology.

1-Sulfooxymethylpyrene is an electrophilic mutagen and ultimate carcinogen of 1-methyl- and 1-hydroxymethylpyrene.

J. W. Flesher, A. Lehner, J. Horn, 1996, Biochemical and biophysical research communications.

9-Sulfooxymethylanthracene is an ultimate electrophilic and carcinogenic form of 9-hydroxymethylanthracene.

J. W. Flesher, A. Lehner, J. Horn, 1998, Biochemical and biophysical research communications.

Metabolism of the carcinogen 3-methylcholanthrene in human bone marrow preparations.

J. W. Flesher, S. Myers, 1990, Drug Metabolism And Disposition.

Metabolism of 3-methylcholanthrene in rat liver cytosol.

J. W. Flesher, J. Blake, S. Myers, 1989, Chemico-biological interactions.

S-Adenosyl-L-methionine is a carbon donor in the conversion of benzo[alpha]pyrene to 6-hydroxymethylbenzo[alpha]pyrene by rat liver S-9.

J. W. Flesher, K. Stansbury, K. Sydnor, 1982, Cancer letters.

Bioalkylation and biooxidation of anthracene, in vitro and in vivo.

J. W. Flesher, J. Blake, S. Myers, 1988, Biochemical and biophysical research communications.

Bioalkylation of dibenz[a,b]anthracene in rat liver cytosol.

J. W. Flesher, J. Blake, S. Myers, 1986, Chemico-biological interactions.

Methyl-substitution of benzene and toluene in preparations of human bone marrow.

J. W. Flesher, S. Myers, 1991, Life sciences.

DNA binding and mutagenicity of 7-substituted derivatives of benz[A]anthracene.

J. W. Flesher, M. Chien, J. Wettstein, 1979, Drug and chemical toxicology.

Role of the Bay- and L-Regions in the Metabolic Activation and Carcinogenicity of Picene and Dibenz[ a,h ]anthracene

J. W. Flesher, A. Lehner, J. Horn, 2002 .

Mass Spectral Analysis of Unstable N7-Aralkyl DNA Adducts Resulting from Reaction of 7-Sulfooxymethyl-12-methylbenz[ a ]anthracene (SMBA) with DNA and Deoxynucleotides

J. W. Flesher, A. Lehner, J. Horn, 2002 .

Effect of various substituents in the 6-position on the relative carcinogenic activity of a series of benzo[a]pyrene derivatives.

J. W. Flesher, K. Sydnor, C. H. Bergo, 1980, Chemico-biological interactions.

High-pressure liquid chromatography of polycyclic aromatic hydrocarbons and some of their derivatives.

J. W. Flesher, W. Angus, S. Soedigdo, 1975, Analytical biochemistry.

Rapid induction of mammary cancer by repeated subcutaneous injection of the trans-3,4-dihydrodiol of 7,12-dimethylbenz[a]anthracene in the female Sprague-Dawley rat.

J. W. Flesher, A. Lehner, J. Horn, 2005, Cancer letters.

Oncogenicity of k‐region epoxides of benzo(a)pyrene and 7,12‐dimethylbenz(a)anthracene

J. W. Flesher, R. Harvey, K. Sydnor, 1976, International journal of cancer.

Binding of the carcinogens 5-fluoro-7-hydroxymethyl-12-methylbenz(a)anthracene and its acetate ester to DNA in vitro.

J. W. Flesher, M. Chien, 1981, Life sciences.

Binding of 6-hydroxymethylbenzo[a]pyrene and 6-acetoxymethylbenzo[a]pyrene to DNA.

J. W. Flesher, L. Tay, K. Sydnor, 1979, Chemico-biological interactions.

Comparative studies on distribution of DMBA‐3H and 7‐hydroxy‐DMBA‐3H and their carcinogenic activity

J. W. Flesher, Katherine L. Syndor, 1970, International Journal of Cancer.

Comparative biologic activities of 7,12-dimethylbenz(a)anthracene, 7-hydroxymethyl-12-methylbenz(a)anthracene, 7,12-dehydroxy-methylbenz(a)anthracene, and 4-methoxy-7,12-dimethylbenz(a)anthracene in the Sprague-Dawley female rat.

J. W. Flesher, K. Sydnor, 1969, Cancer research.

Mutagenic activity of biliary metabolites of 6-hydroxymethylbenzo[a]pyrene.

J. W. Flesher, C. Gairola, M. Hughes, 1986, Mutation research.