David P Lane

发表

Rigorous Computational and Experimental Investigations on MDM2/MDMX-Targeted Linear and Macrocyclic Peptides

Jon Swanson, Alexander S. Bayden, Joseph Audie, 2019, Molecules.

Stapled peptide design: principles and roles of computation.

Chandra S Verma, Yaw Sing Tan, David P Lane, 2016, Drug Discovery Today.

Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents.

Peter M Fischer, Wayne Jackson, Campbell McInnes, 2010, Chemistry & biology.

Differential binding of p53 and nutlin to MDM2 and MDMX: Computational studies

Chandra S Verma, Christopher J Brown, David P Lane, 2010, Cell cycle.

On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: A Brownian dynamics study

Chandra S Verma, Reidun Twarock, Leo S D Caves, 2013, Cell cycle.

Small Molecular Weight Variants of p53 Are Expressed in Human Melanoma Cells and Are Induced by the DNA-Damaging Agent Cisplatin

Borivoj Vojtesek, Rodney J Scott, David P Lane, 2008, Clinical Cancer Research.

Differences in the transactivation domains of p53 family members: a computational study

Chandra Verma, David P Lane, Arumugam Madhumalar, 2010, BMC Genomics.

Cyclin-Dependent Kinase Inhibitors Sensitize Tumor Cells to Nutlin-Induced Apoptosis: a Potent Drug Combination

David P Lane, D. Lane, C. F. Cheok, 2007, Molecular Cancer Research.

p53-based cancer therapy.

David P Lane, Sonia Lain, D. Lane, 2010, Cold Spring Harbor perspectives in biology.

A generic scaffold for conversion of peptide ligands into homogenous biosensors.

David P Lane, D. Lane, F. Ghadessy, 2013, Biosensors & bioelectronics.

Chemical states of the N-terminal “lid” of MDM2 regulate p53 binding: Simulations reveal complexities of modulation

Chandra S Verma, Shubhra Ghosh Dastidar, David P Lane, 2011, Cell cycle.

Characterization of the Ligand Receptor Encounter Complex and Its Potential for in Silico Kinetics-Based Drug Development.

Chandra S Verma, Reidun Twarock, Leo S D Caves, 2012, Journal of chemical theory and computation.

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.

David P Lane, T. Stankovic, C. Fegan, 2005, Blood.

Rational design and biophysical characterization of thioredoxin-based aptamers: insights into peptide grafting.

Shubhra Ghosh Dastidar, Chandra Verma, Christopher J Brown, 2010, Journal of molecular biology.

MDM4 downregulates p53 transcriptional activity and response to stress during differentiation

Kee Woei Ng, David P Lane, D. Lane, 2011, Cell cycle.

p53 isoforms can regulate p53 transcriptional activity.

David P Lane, D. Lane, M. Saville, 2005, Genes & development.

Molecular simulations of protein dynamics: new windows on mechanisms in biology

David P Lane, C. Verma, G. Dodson, 2008, EMBO reports.