James A. Wells

[Table, Identification of lead].

Douglas S. Auld, Matthew B. Boxer, Craig J. Thomas, 2011 .

Prediction of protease substrates using sequence and structure features

Ursula Pieper, Andrej Sali, Sami Mahrus, 2010, Bioinform..

Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis

Alma L. Burlingame, Sami Mahrus, James A. Wells, 2012, Proceedings of the National Academy of Sciences.

Small-Molecule Activators of a Proenzyme

James A. Wells, Dennis W. Wolan, D. Wolan, 2009, Science.

Hot-spot mimicry of a cytokine receptor by a small molecule

Christopher D. Thanos, James A. Wells, W. Delano, 2006, Proceedings of the National Academy of Sciences.

Direct activation of the apoptosis machinery as a mechanism to target cancer cells

James A. Wells, J. Nguyen, Jack T. Nguyen, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Binding of small molecules to an adaptive protein–protein interface

Michelle R. Arkin, Jennifer Hyde, Robert S. McDowell, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity

Bruce R. Conklin, Luke A. Gilbert, Jonathan S. Weissman, 2016, Nature Communications.

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Kevan M. Shokat, James A. Wells, K. Shokat, 2013, Nature.

Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor

Charles Eigenbrot, Christian Wiesmann, James A. Wells, 1997, Cell.

Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease

Sami Mahrus, James A. Wells, Daniel C Gray, 2010, Cell.