James B. Mitchell

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SCORHE: A System for Automated Video-Based Assessment of Activity and Behavior for Mice Housed in a Home-Cage Environment

Tao Deng, James D. Malley, Ghadi Salem, 2013 .

Correction: Cellular Stress Induced Alterations in MicroRNA let-7a and let-7b Expression Are Dependent on p53

James B. Mitchell, N. Simone, C. Harris, 2012, PLoS ONE.

Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302

Shingo Matsumoto, Katarzyna A Rejniak, James B. Mitchell, 2015, Cancer & metabolism.

The chemistry and biology of nitroxide compounds.

James B. Mitchell, N. Simone, B. Soule, 2007, Free radical biology & medicine.

Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1‐13C]pyruvate and 13C magnetic resonance spectroscopic imaging

James B. Mitchell, James B. Mitchell, H. D. Morris, 2011, Magnetic resonance in medicine.

Intrapleural photodynamic therapy: Results of a phase I trial

James B. Mitchell, Harvey I. Pass, Walter S. Friauf, 2006, Annals of Surgical Oncology.

PX‐478, an inhibitor of hypoxia‐inducible factor‐1α, enhances radiosensitivity of prostate carcinoma cells

James B. Mitchell, C. N. Coleman, C. Coleman, 2008, International journal of cancer.

Absolute oxygen tension (pO2) in murine fatty and muscle tissue as determined by EPR

Shingo Matsumoto, James B. Mitchell, Murali C Krishna, 2005, Magnetic resonance in medicine.

Application of Functional Molecular Imaging in Radiation Oncology

James B. Mitchell, S. Naz, M. Krishna, 2017 .

Noninvasive in vivo oximetric imaging by radiofrequency FT EPR

James B. Mitchell, Murali C Krishna, Nallathamby Devasahayam, 2002, Magnetic resonance in medicine.

Prevention of Radiation-Induced Salivary Hypofunction Following hKGF Gene Delivery to Murine Submandibular Glands

James B. Mitchell, A. Rowzee, B. Baum, 2011, Clinical Cancer Research.

Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands.

James B. Mitchell, B. Baum, A. Cotrim, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction.

James B. Mitchell, G. Illei, C. Van Waes, 2006, Biochimica et biophysica acta.

Kinetics of Tempol for Prevention of Xerostomia Following Head and Neck Irradiation in a Mouse Model

James B. Mitchell, B. Baum, A. Cotrim, 2005, Clinical Cancer Research.

The Stable Nitroxide Tempol Facilitates Salivary Gland Protection during Head and Neck Irradiation in a Mouse Model

James B. Mitchell, S. Pillemer, B. Baum, 2004, Clinical Cancer Research.

Evaluation of Radiation-Induced Oral Mucositis by Optical Coherence Tomography

Anastasia L. Sowers, James B. Mitchell, Bruce J. Baum, 2005, Clinical Cancer Research.

Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite.

James B. Mitchell, C. Colton, D. Wink, 2002, Archives of biochemistry and biophysics.

Metabolomics Reveals That Tumor Xenografts Induce Liver Dysfunction*

James B. Mitchell, F. Gonzalez, A. Patterson, 2013, Molecular & Cellular Proteomics.

Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI

Shingo Matsumoto, James B. Mitchell, Marcelino Bernardo, 2009, Proceedings of the National Academy of Sciences.

Mass Spectrometry-Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer.

Anastasia L. Sowers, James B. Mitchell, John A. Cook, 2016, Cancer research.

Taxol in combination with doxorubicin or etoposide possible antagonism in vitro

James B. Mitchell, S. Hahn, D. Venzon, 1993, Cancer.

Pyruvate Induces Transient Tumor Hypoxia by Enhancing Mitochondrial Oxygen Consumption and Potentiates the Anti-Tumor Effect of a Hypoxia-Activated Prodrug TH-302

Robert J. Gillies, Shingo Matsumoto, Masayuki Matsuo, 2014, PloS one.

Ionizing Radiation-Induced Oxidative Stress Alters miRNA Expression

James B. Mitchell, Curtis C. Harris, Nicole L. Simone, 2009, PloS one.

Potential Use of Nitroxides in Radiation Oncology 1

James B. Mitchell, S. Hahn, W. Degraff, 2006 .

Nitroxides as antioxidants: Tempol protects against EO9 cytotoxicity

James B. Mitchell, W. Degraff, M. Krishna, 2004, Molecular and Cellular Biochemistry.

Nitroxides as antioxidants: Tempol protects against EO9 cytotoxicity.

James B. Mitchell, W. Degraff, M. Krishna, 2002 .

Do Nitroxide Antioxidants Act as Scavengers of O2 or as SOD Mimics?*

James B. Mitchell, S. Goldstein, M. Krishna, 1996, The Journal of Biological Chemistry.

Monitoring redox-sensitive paramagnetic contrast agent by EPRI, OMRI and MRI.

James B. Mitchell, M. Krishna, F. Hyodo, 2008, Journal of magnetic resonance.

Brain redox imaging.

James B. Mitchell, H. Utsumi, M. Krishna, 2011, Methods in molecular biology.

Time-Domain Radio Frequency EPR Imaging

James B. Mitchell, M. Krishna, S. Subramanian, 2003 .

Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor.

James B. Mitchell, C. Barlow, A. Wynshaw-Boris, 2005, Human molecular genetics.

Researchof the fullerene compound DF-1 as a radiation protector

James B. Mitchell, U. Shankavaram, D. Citrin, 2010 .

Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin.

James B. Mitchell, K. Flanders, A. Roberts, 2003, The American journal of pathology.

In Vitro and In Vivo Radiation Sensitization of Human Tumor Cells by a Novel Checkpoint Kinase Inhibitor

James B. Mitchell, D. Citrin, W. Degraff, 2009 .

Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma.

James B. Mitchell, E. Sausville, K. Camphausen, 2005, International journal of radiation oncology, biology, physics.

Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol.

James B. Mitchell, A. Nakamura, C. Redon, 2014, Cancer letters.

Combustion products of 1,3-butadiene inhibit catalase activity and induce expression of oxidative DNA damage repair enzymes in human bronchial epithelial cells

James B. Mitchell, V. L. Wilson, V. Wilson, 2009, Cell Biology and Toxicology.

Pulsed EPR imaging of nitroxides in mice.

Shingo Matsumoto, James B. Mitchell, Murali C Krishna, 2009, Journal of magnetic resonance.

Cancer esearch rated Systems and Technologies-Field Magnetic Resonance Imaging to Visualize Chronic R Cycling Hypoxia in Tumor-Bearing Mice

James B. Mitchell, S. Matsumoto, M. Krishna, 2010 .

Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice.

James B. Mitchell, S. Matsumoto, M. Krishna, 2010, Cancer research.

A Phase I Study of Topical Tempol for the Prevention of Alopecia Induced by Whole Brain Radiotherapy

James B. Mitchell, S. Hahn, J. Metz, 2004, Clinical Cancer Research.

Brain Redox Imaging Using Blood—Brain Barrier-Permeable Nitroxide MRI Contrast Agent

James B. Mitchell, K. Chuang, A. Koretsky, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation.

James B. Mitchell, K. Flanders, A. Roberts, 2002, The American journal of pathology.

Longitudinal Imaging Studies of Tumor Microenvironment in Mice Treated with the mTOR Inhibitor Rapamycin

James B. Mitchell, S. Matsumoto, J. Gutkind, 2012, PloS one.

The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation.

James B. Mitchell, D. Wink, M. Krishna, 2009, Free radical biology & medicine.

Dose-dependent enhancement of T-lymphocyte priming and CTL lysis following ionizing radiation in an engineered model of oral cancer.

James B. Mitchell, J. Friedman, R. Hodge, 2017, Oral oncology.

Semiquinone radical intermediate in catecholic estrogen-mediated cytotoxicity and mutagenesis: Chemoprevention strategies with antioxidants

James B. Mitchell, W. Degraff, E. Chuang, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Neuroprotection by the stable nitroxide 3-carbamoyl-proxyl during reperfusion in a rat model of transient focal ischemia.

James B. Mitchell, B. Lyeth, J. C. Watson, 2003, Journal of neurosurgery.

Co-imaging of the tumor oxygenation and metabolism using electron paramagnetic resonance imaging and 13-C hyperpolarized magnetic resonance imaging before and after irradiation

James B. Mitchell, M. Matsuo, T. Kawai, 2018, Oncotarget.

Nitroxides as radiation protectors.

James B. Mitchell, M. Krishna, 2002, Military medicine.

Factors influencing nitroxide reduction and cytotoxicity in vitro.

James B. Mitchell, M. Krishna, Ken‐ichi Yamada, 2004, Antioxidants & redox signaling.

Therapeutic and clinical applications of nitroxide compounds.

James B. Mitchell, N. Simone, B. Soule, 2007, Antioxidants & redox signaling.

Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice

James B. Mitchell, Anamika Singh, T. Rouault, 2008, Proceedings of the National Academy of Sciences.

Wireless implantable coil with parametric amplification for in vivo electron paramagnetic resonance oximetric applications

James B. Mitchell, A. Koretsky, C. Qian, 2018, Magnetic resonance in medicine.

Echo-based Single Point Imaging (ESPI): a novel pulsed EPR imaging modality for high spatial resolution and quantitative oximetry.

James B. Mitchell, S. Matsumoto, M. Krishna, 2012, Journal of magnetic resonance.

Halofuginone enhances the radiation sensitivity of human tumor cell lines.

James B. Mitchell, W. Degraff, J. Cook, 2010, Cancer letters.

Absence of Smad3 induces neutrophil migration after cutaneous irradiation: possible contribution to subsequent radioprotection.

James B. Mitchell, K. Flanders, A. Roberts, 2008, The American journal of pathology.

Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice.

James B. Mitchell, C. Barlow, A. Wynshaw-Boris, 2004, Human molecular genetics.

Altering the response to radiation: sensitizers and protectors.

James B. Mitchell, D. Citrin, 2014, Seminars in oncology.

Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology.

James B. Mitchell, Fei Li, F. Gonzalez, 2013, Journal of proteome research.

Spin-Labeled Dendrimers in EPR Imaging with Low Molecular Weight Nitroxides.

James B. Mitchell, M. Brechbiel, M. Krishna, 2001, Angewandte Chemie.

Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice.

James B. Mitchell, C. Van Waes, M. Grompe, 2008, Cancer research.

The influence of tumor oxygenation on 18F-FDG (Fluorine-18 Deoxyglucose) uptake: A mouse study using positron emission tomography (PET)

James B. Mitchell, Michael V. Green, J. Seidel, 2006, Radiation oncology.

Phase I study of weekly gemcitabine as a radiation sensitizer for unresectable pancreatic cancer.

James B. Mitchell, J. Cook, Judith A. Smith, 2002, International journal of radiation oncology, biology, physics.

Truncated Plasminogen Activator Inhibitor-1 Protein Protects From Pulmonary Fibrosis Mediated by Irradiation in a Murine Model.

James B. Mitchell, D. Citrin, E. Chung, 2016, International journal of radiation oncology, biology, physics.

Mammalian Target of Rapamycin Inhibition With Rapamycin Mitigates Radiation-Induced Pulmonary Fibrosis in a Murine Model.

James B. Mitchell, D. Citrin, E. Chung, 2016, International journal of radiation oncology, biology, physics.

Workshop Report for Cancer Research: Defining the Shades of Gy: Utilizing the Biological Consequences of Radiotherapy in the Development of New Treatment Approaches-Meeting Viewpoint.

James B. Mitchell, C. N. Coleman, R. Mohan, 2018, Cancer research.

SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2.

James B. Mitchell, C. Van Waes, Zhong Chen, 2016, Cancer research.

Quantitative imaging of pO2 in orthotopic murine gliomas: hypoxia correlates with resistance to radiation

James B. Mitchell, K. Camphausen, S. Matsumoto, 2017, Free radical research.

The influence of Cremophor EL on the cell cycle effects of paclitaxel (Taxol®) in human tumor cell lines

James B. Mitchell, C. Lipschultz, J. Cook, 2004, Cancer Chemotherapy and Pharmacology.

Radiation and the Apo 2 L / TRAIL Apoptotic Pathway Preferentially Inhibit the Colonization of Premalignant Human Breast Cells Overexpressing

James B. Mitchell, P. Steeg, W. Degraff, 2000 .

An efficient synthesis of 3-(N-piperidinemethyl)-2, 2, 5, 5-tetramethyl-1-oxy-3-pyrroline, a promising radioprotector for cancer radiotherapy.

James B. Mitchell, M. Krishna, R. Swenson, 2014, Tetrahedron letters.

ContRoVeRSY And ConSenSuS Meeting Viewpoint Workshop Report for Cancer Research : defining the Shades of Gy : utilizing the Biological Consequences of Radiotherapy in the development of new treatment Approaches

James B. Mitchell, C. N. Coleman, R. Mohan, 2018 .

Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma

James B. Mitchell, P. Choyke, J. Brender, 2020, Cancer Research.

Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice.

James B. Mitchell, R. Gillies, S. Matsumoto, 2018, Cancer research.

Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma.

James B. Mitchell, C. Van Waes, Zhong Chen, 2004, Cancer research.

Erratum: Nuclear factor-κB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma (Cancer Research (September 2004) 64 (6511-6523)

James B. Mitchell, C. Waes, Zhong Chen, 2004 .

The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation.

James B. Mitchell, P. Rosenberg, P. Albert, 2012, Cancer research.

A low molecular weight antioxidant decreases weight and lowers tumor incidence.

James B. Mitchell, S. Hahn, A. Deluca, 2003, Free radical biology & medicine.

Mitchell-Transferases S Human and Rodent Glutathione Differential Specificity of Monochlorobimane for Isozymes of Updated

James B. Mitchell, J. Cook, Susan N. lype, 1991 .

Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells.

James B. Mitchell, Mong-Hsun Tsai, Shuping Zhao, 2002, Cancer research.

Effect of amifostine, a radiation-protecting drug, on oxygen concentration in tissue measured by EPR oximetry and imaging

James B. Mitchell, S. Matsumoto, I. Nakanishi, 2017, Journal of clinical biochemistry and nutrition.

The effects of antioxidants on radiation-induced apoptosis pathways in TK6 cells.

James B. Mitchell, W. Degraff, M. Krishna, 2004, Free radical biology & medicine.

The influence of tumor oxygenation on hypoxia imaging in murine squamous cell carcinoma using [64Cu]Cu-ATSM or [18F]Fluoromisonidazole positron emission tomography.

James B. Mitchell, Michael V. Green, J. Seidel, 2007, International journal of oncology.

Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin: Efficacy of Recoupling Nitric Oxide Synthase as a Therapeutic Strategy

James B. Mitchell, D. Kass, M. Halushka, 2008, Circulation.

Halofuginone mediated protection against radiation-induced leg contracture.

James B. Mitchell, K. Flanders, J. Cook, 2009, International journal of oncology.

Radiosensitization and Proteasome Inhibition

James B. Mitchell, C. Waes, W. Degraff, 2004 .

Magnetic resonance imaging of organic contrast agents in mice: capturing the whole-body redox landscape.

James B. Mitchell, M. Bernardo, S. Matsumoto, 2011, Free radical biology & medicine.

High-ResolutionMapping of Tumor Redox Status byMagnetic Resonance Imaging Using Nitroxides as Redox-Sensitive Contrast

James B. Mitchell, A. Koretsky, C. Krishna, 2006 .

Comparative studies with EPR and MRI on the in vivo tissue redox status estimation using redox-sensitive nitroxyl probes: influence of the choice of the region of interest

James B. Mitchell, M. Krishna, Ken-ichiro Matsumoto, 2018, Free radical research.

Iron Insufficiency Compromises Motor Neurons and Their Mitochondrial Function in Irp2-Null Mice

James B. Mitchell, R. Sougrat, C. Beaumont, 2011, PloS one.

mTOR Inhibition With Rapamycin Mitigates Radiation-Induced Pulmonary Fibrosis in a Murine Model

James B. Mitchell, D. Citrin, E. Chung, 2015 .

Acyl-protected hydroxylamines as spin label generators for EPR brain imaging.

James B. Mitchell, M. Brechbiel, S. English, 2002, Journal of medicinal chemistry.

Mechanisms underlying the cytotoxic effects of Tachpyr--a novel metal chelator.

James B. Mitchell, M. Brechbiel, W. Degraff, 2002, Biochimica et biophysica acta.

Kinetics and mechanism of hydroxyl radical and OH-adduct radical reactions with nitroxides and with their hydroxylamines.

James B. Mitchell, P. Neta, S. Goldstein, 2002, Journal of the American Chemical Society.

Cellular Stress Induced Alterations in MicroRNA let-7a and let-7b Expression Are Dependent on p53

James B. Mitchell, N. Simone, Anthony D. Saleh, 2011, PloS one.

High-Resolution Mapping of Tumor Redox Status by Magnetic Resonance Imaging Using Nitroxides as Redox-Sensitive Contrast Agents

James B. Mitchell, Murali C Krishna, Fuminori Hyodo, 2006, Clinical Cancer Research.

Effects of oxygen challenging to tissue redox and pO2 status

James B. Mitchell, M. Krishna, Ken-ichiro Matsumoto, 2019, Free radical biology & medicine.

Chasing Free Radicals in Cells and Tissues

James B. Mitchell, 2011, Radiation research.

Nitroxides as cancer imaging agents.

James B. Mitchell, M. Krishna, Ryan M Davis, 2011, Anti-cancer agents in medicinal chemistry.

Detection of free radical reactions in an aqueous sample induced by low linear-energy-transfer irradiation.

James B. Mitchell, W. Degraff, I. Nakanishi, 2009, Biological & pharmaceutical bulletin.

High and low let particle-emitting isotopes for therapy: A comparison of cytotoxicity and dose-rate effects

James B. Mitchell, W. Degraff, J. Hines, 1994 .

Intracellular hypoxia of tumor tissue estimated by noninvasive electron paramagnetic resonance oximetry technique using paramagnetic probes.

James B. Mitchell, S. Matsumoto, M. Krishna, 2011, Biological & pharmaceutical bulletin.

Novel functional imaging for tissue oxygen concentration and redox status.

James B. Mitchell, M. Krishna, J. Cook, 2004, The Journal of nutrition.

Profiling toxic oxygen related-species–induced gene expression using cDNA microarrays

James B. Mitchell, A. Russo, Y. E. Chuang, 1999 .

Nucleic Acids Research Induction of B 2 RNA polymerase III transcription by heat shock : enrichment for heat shock induced sequences in rodent cells by hybridization subtraction

James B. Mitchell, A. Fornace, 2005 .

The relationship between tissue oxygenation and redox status using magnetic resonance imaging

James B. Mitchell, S. Matsumoto, M. Krishna, 2012, International journal of oncology.

Radiation-Induced Microvascular Injury as a Mechanism of Salivary Gland Hypofunction and Potential Target for Radioprotectors

James B. Mitchell, N. Katabi, A. Haimovitz-Friedman, 2016, Radiation Research.

Nitroxide derivatives of non‐steroidal anti‐inflammatory drugs exert anti‐inflammatory and superoxide dismutase scavenging properties in A459 cells

James B. Mitchell, T. Moody, D. Wink, 2012, British journal of pharmacology.

EPR imaging of vascular changes in oxygen in response to carbogen breathing.

James B. Mitchell, M. Krishna, S. Subramanian, 2003, Advances in experimental medicine and biology.

Fluorine electron double resonance imaging for 19F MRI in low magnetic fields

James B. Mitchell, S. English, M. Krishna, 2002, Magnetic resonance in medicine.

Radiation Sensitization of Mammalian Cells by Metal Chelators

James B. Mitchell, W. Degraff, J. Cook, 2001, Radiation research.

Inhibition of adipogenesis by Tempol in 3T3-L1 cells.

James B. Mitchell, W. Degraff, M. Krishna, 2010, Free radical biology & medicine.

Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice.

Shingo Matsumoto, James B. Mitchell, Murali C Krishna, 2008, The Journal of clinical investigation.

Inhibition of radiation-induced skin fibrosis with imatinib

James B. Mitchell, D. Citrin, E. Chung, 2013, International journal of radiation biology.

Glutathione, a Determinant of Response to Cancer Treatment

James B. Mitchell, A. Russo, D. Kaufman, 1991 .

Effect of body temperature on the pharmacokinetics of a triarylmethyl‐type paramagnetic contrast agent used in EPR oximetry

James B. Mitchell, M. Krishna, F. Hyodo, 2018, Magnetic resonance in medicine.

Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs.

James B. Mitchell, Murali C Krishna, Fuminori Hyodo, 2010, Free radical biology & medicine.

Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers.

James B. Mitchell, A. Vissink, L. Elting, 2010, International journal of radiation oncology, biology, physics.

Taxol in Combination with Doxorubicin or Etoposide

James B. Mitchell, S. Hahn, D. Venzon, 1993 .

Nitroxide tempo, a small molecule, induces apoptosis in prostate carcinoma cells and suppresses tumor growth in athymic mice

James B. Mitchell, U. Kasid, S. Suy, 2005, Cancer.

Single‐point (constant‐time) imaging in radiofrequency Fourier transform electron paramagnetic resonance †

Andrew G. Taube, James B. Mitchell, Murali C Krishna, 2002, Magnetic resonance in medicine.

Suberoylanilide hydroxamic acid radiosensitizes tumor hypoxic cells in vitro through the oxidation of nitroxyl to nitric oxide.

James B. Mitchell, D. Wink, S. Goldstein, 2014, Free radical biology & medicine.

PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation

James B. Mitchell, C. Van Waes, J. Friedman, 2018, Oncoimmunology.

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

James B. Mitchell, D. Urban, W. Linehan, 2020, Cell reports.

Improvement and induction property of radiation-responsive promoter through DNA shuffling of 5'-flanking regions of the human p21 gene.

James B. Mitchell, Yoshikazu Tanaka, M. Hatashita, 2010, Journal of bioscience and bioengineering.

Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction

James B. Mitchell, Y. Mori, Xibao Liu, 2013, Nature Communications.

Nuclear Factor-κB is an Important Modulator of the Altered Gene Expression Profile and Malignant Phenotype in Squamous Cell Carcinoma

James B. Mitchell, C. Van Waes, Zhong Chen, 2004, Cancer Research.

HSP90 Inhibitor SNX5422/2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma.

James B. Mitchell, C. Van Waes, Zhong Chen, 2013, Translational oncology.

Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.

James B. Mitchell, W. Linehan, R. Srinivasan, 2014, Cancer cell.

Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration

James B. Mitchell, Murali C Krishna, Nallathamby Devasahayam, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.

James B. Mitchell, E. Shacter, C. Corpe, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Radiation-induced Adaptive Response: New Potential for Cancer Treatment

James B. Mitchell, C. N. Coleman, C. Coleman, 2020, Clinical Cancer Research.

Preclinical Data on Efficacy of 10 Drug-Radiation Combinations: Evaluations, Concerns, and Recommendations

James B. Mitchell, James Deye, Jacek Capala, 2016, Translational oncology.

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

James B. Mitchell, Vyomesh Patel, J. Gutkind, 2012, Cell stem cell.

Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury

James B. Mitchell, D. Citrin, B. Baum, 2010, The oncologist.

Radio frequency continuous‐wave and time‐domain EPR imaging and Overhauser‐enhanced magnetic resonance imaging of small animals: instrumental developments and comparison of relative merits for functional imaging

James B. Mitchell, Sankaran Subramanian, M. Krishna, 2004, NMR in biomedicine.

Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction

James B. Mitchell, G. Illei, Shuying Liu, 2012, Proceedings of the National Academy of Sciences.

Synthesis and evaluation of 13C‐labeled 5‐5‐dimethyl‐1‐pyrroline‐N‐oxide aimed at in vivo detection of reactive oxygen species using hyperpolarized 13C‐MRI

James B. Mitchell, J. Brender, S. Matsumoto, 2019, Free radical biology & medicine.

Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels.

James B. Mitchell, Murali C Krishna, Jay L Zweier, 2002, Cancer research.

Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade

James B. Mitchell, J. Brender, M. Krishna, 2021, Cancer Research.

Amelioration of Radiation-induced Fibrosis

James B. Mitchell, M. Reiss, K. Flanders, 2004, Journal of Biological Chemistry.

Molecular and Cellular Biology of Moderate-Dose (1–10 Gy) Radiation and Potential Mechanisms of Radiation Protection: Report of a Workshop at Bethesda, Maryland, December 17–18, 20011

James B. Mitchell, Rosemary S. L. Wong, C. N. Coleman, 2003, Radiation research.

Differential Radiation Protection of Salivary Glands versus Tumor by Tempol with Accompanying Tissue Assessment of Tempol by Magnetic Resonance Imaging

James B. Mitchell, B. Baum, A. Cotrim, 2007, Clinical Cancer Research.

Tempol protects cardiomyocytes from nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity.

James B. Mitchell, M. Poirier, P. Nguyen, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Selective protection of zidovudine‐induced DNA‐damage by the antioxidants WR‐1065 and tempol

James B. Mitchell, M. Poirier, O. Olivero, 2014, Environmental and molecular mutagenesis.

Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response.

Ash A. Alizadeh, James B. Mitchell, L. Staudt, 2004, Blood.

DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer.

James B. Mitchell, G. Sledge, M. Aladjem, 2014, Journal of the National Cancer Institute.

Abemaciclib, a Selective CDK4/6 Inhibitor, Enhances the Radiosensitivity of Non–Small Cell Lung Cancer In Vitro and In Vivo

James B. Mitchell, S. Naz, J. Cook, 2018, Clinical Cancer Research.

Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition

James B. Mitchell, C. Van Waes, J. Friedman, 2019, Oncoimmunology.

Caloric restriction augments radiation efficacy in breast cancer

James B. Mitchell, N. Simone, K. Camphausen, 2013, Cell cycle.

Magnitude and specificity of temporal gene expression during HIV-1 infection of a CD4+ T cell

James B. Mitchell, A. Russo, Y. E. Chuang, 1999, Nature Genetics.

Radiation biology of lung cancer

James B. Mitchell, J. Carmichael, E. Glatstein, 1996, Journal of cellular biochemistry. Supplement.

PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer

James B. Mitchell, A. Kulkarni, C. Van Waes, 2013, Clinical Cancer Research.

In vivo imaging of tumor physiological, metabolic, and redox changes in response to the anti-angiogenic agent sunitinib: longitudinal assessment to identify transient vascular renormalization.

James B. Mitchell, H. D. Morris, H. Merkle, 2014, Antioxidants & redox signaling.

Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach.

James B. Mitchell, A. Feinberg, P. Munson, 2004, Cancer cell.

Radiation-Induced Senescence Reprograms Secretory and Metabolic Pathways in Colon Cancer HCT-116 Cells

James B. Mitchell, J. Brender, S. Naz, 2021, International journal of molecular sciences.

Imaging cycling tumor hypoxia.

James B. Mitchell, S. Matsumoto, M. Krishna, 2010, Cancer research.

Reduced hematopoietic function and enhanced radiosensitivity of transforming growth factor‐β1 transgenic mice

James B. Mitchell, Y. Vodovotz, J. Kopp, 2000, International journal of cancer.

Combined Inhibition of IAPs and WEE1 Enhances TNFα- and Radiation-Induced Cell Death in Head and Neck Squamous Carcinoma

James B. Mitchell, Ramya Viswanathan, C. Van Waes, 2023, Cancers.

Multimodal Functional Imaging for Cancer/Tumor Microenvironments Based on MRI, EPRI, and PET

James B. Mitchell, M. Krishna, Ken-ichiro Matsumoto, 2021, Molecules.

Cancer Incidence in C3H Mice Protected from Lethal Total-Body Radiation after Amifostine

James B. Mitchell, Kristin M. Fabre, S. Naz, 2018, Radiation Research.

Acute antihypertensive action of nitroxides in the spontaneously hypertensive rat.

James B. Mitchell, Yifan Chen, W. Welch, 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

Experimental Models for Ionizing Radiation Research

James B. Mitchell, Kristin M. Fabre, W. Degraff, 2011 .

Enhancement of 5-Fluorouracil-induced In Vitro and In Vivo Radiosensitization with MEK Inhibition

James B. Mitchell, K. Camphausen, D. Citrin, 2011, Clinical Cancer Research.

Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc

James B. Mitchell, W. Linehan, M. Wei, 2019, Scientific Reports.

Continuous wave EPR oximetric imaging at 300 MHz using radiofrequency power saturation effects.

James B. Mitchell, Y. Hama, M. Krishna, 2007, Antioxidants & redox signaling.

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

James B. Mitchell, Kristin M. Fabre, I. Albert, 2013, Nature Communications.

Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.

James B. Mitchell, M. Brechbiel, L. Neckers, 2003, Cancer research.

Oral Pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study

James B. Mitchell, N. Simone, R. Altemus, 2007, Radiation oncology.

Mechanisms of Normal Tissue Injury From Irradiation.

James B. Mitchell, D. Citrin, 2017, Seminars in radiation oncology.

Gene expression profiling of breast, prostate, and glioma cells following single versus fractionated doses of radiation.

James B. Mitchell, C. N. Coleman, W. Degraff, 2007, Cancer research.

Application of a Macromolecular Contrast Agent for Detection of Alterations of Tumor Vessel Permeability Induced by Radiation

James B. Mitchell, T. Waldmann, M. Brechbiel, 2004, Clinical Cancer Research.

Effects of hypoxia on radiation-responsive stress-activated protein kinase, p53, and caspase 3 signals in TK6 human lymphoblastoid cells.

James B. Mitchell, W. Degraff, E. Chuang, 2005, Cancer research.

Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis

James B. Mitchell, D. Raben, P. Dijke, 2013, Nature Medicine.

DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16(ink4A) down-regulation.

James B. Mitchell, J. Little, E. Chuang, 2008, Journal of biomedical science.

induces a p 53-dependent gene expression response Fludarabine treatment of patients with chronic lymphocytic leukemia

Ash A. Alizadeh, James B. Mitchell, Arthur, 2004 .

Abnormal gene expression profiles in unaffected parents of patients with hereditary-type retinoblastoma.

James B. Mitchell, X. Chen, J. Little, 2006, Cancer research.

Superoxide Fluxes Limit Nitric Oxide-induced Signaling*

James B. Mitchell, C. Harris, S. Ambs, 2006, Journal of Biological Chemistry.

NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay.

James B. Mitchell, J. Weiss, G. Trinchieri, 2015, Cancer research.

Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF‐κB

James B. Mitchell, C. Van Waes, G. Dong, 2000, Head & neck.

Nitric oxide and cancer: an introduction.

James B. Mitchell, D. Wink, 2003, Free radical biology & medicine.

Electron Paramagnetic Resonance Imaging of Tumor Heterogeneity and OxygÃ © nationin a Murine Model 1

James B. Mitchell, S. Hahn, J. Zweier, 2006 .

Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage.

James B. Mitchell, W. Degraff, S. Xavier, 2002, Biochimica et biophysica acta.

In vitro and In vivo Radiation Sensitization of Human Tumor Cells by a Novel Checkpoint Kinase Inhibitor, AZD7762

James B. Mitchell, Kristin M. Fabre, D. Citrin, 2010, Clinical Cancer Research.

A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector.

James B. Mitchell, M. Bernardo, W. Degraff, 2011, Free radical biology & medicine.

TLR-Mediated Mast Cell Activation RI and ε Effects of Gamma Radiation on Fc

James B. Mitchell, N. Simone, B. Soule, 2013 .

Effects of Gamma Radiation on FcεRI and TLR-Mediated Mast Cell Activation1

James B. Mitchell, N. Simone, B. Soule, 2007, The Journal of Immunology.

Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect

James B. Mitchell, D. Citrin, M. Matsuo, 2018, Clinical Cancer Research.

13C-MR Spectroscopic Imaging with Hyperpolarized [1-13C]pyruvate Detects Early Response to Radiotherapy in SCC Tumors and HT-29 Tumors

James B. Mitchell, H. D. Morris, M. Matsuo, 2015, Clinical Cancer Research.

Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384

James B. Mitchell, C. Van Waes, W. Degraff, 2014, Clinical Cancer Research.

Distinct signaling pathways after higher or lower doses of radiation in three closely related human lymphoblast cell lines.

James B. Mitchell, H. Liber, T. Hsiao, 2010, International journal of radiation oncology, biology, physics.

Evaluation of the fullerene compound DF-1 as a radiation protector

James B. Mitchell, U. Shankavaram, D. Citrin, 2010, Radiation oncology.

Detecting Early Response to Immune Checkpoint Blockade by Multimodal Molecular Imaging

James B. Mitchell, M. Krishna, S. Kishimoto, 2020, bioRxiv.

Prevention of Radiation-Induced Oral Mucositis after Adenoviral Vector–Mediated Transfer of the Keratinocyte Growth Factor cDNA to Mouse Submandibular Glands

James B. Mitchell, B. Baum, C. Zheng, 2009, Clinical Cancer Research.

Beating Cardiomyocytes against Oxidative Damage

James B. Mitchell, S. Hahn, A. Samuni, 1991 .

Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.

James B. Mitchell, A. Harris, G. Semenza, 2004, Cancer research.

The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE-/- mice.

James B. Mitchell, Christine H. J. Kim, M. Davies, 2015, Atherosclerosis.

The antioxidant tempol transforms gut microbiome to resist obesity in female C3H mice fed a high fat diet

James B. Mitchell, M. Krishna, J. Cook, 2021, Free radical biology & medicine.

Title: Oral Administration of the Nitroxide Radical Tempol Exhibits Immunomodulatory and Therapeutic Properties in Multiple Sclerosis Models Running Title: Oral Tempol Limits Disease in Models of Ms

James B. Mitchell, H. McFarland, M. Cherukuri, 2022 .

Novel Pharmacokinetic Measurement Using Electron Paramagnetic Resonance Spectroscopy and Simulation of in Vivo Decay of Various Nitroxyl Spin Probes in Mouse Blood

James B. Mitchell, M. Krishna, Ken-ichiro Matsumoto, 2004, Journal of Pharmacology and Experimental Therapeutics.

Competition of nitroxyl contrast agents as an in vivo tissue redox probe: Comparison of pharmacokinetics by the bile flow monitoring (BFM) and blood circulating monitoring (BCM) methods using X‐band EPR and simulation of decay profiles

James B. Mitchell, K. Endo, M. Krishna, 2006, Magnetic resonance in medicine.

Development of investigational radiation modifiers.

James B. Mitchell, C. N. Coleman, K. Camphausen, 2003, Journal of the National Cancer Institute.

Implications for tumor control during protection of normal tissues with antioxidants.

James B. Mitchell, K. Camphausen, D. Citrin, 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Oxidative stress, redox, and the tumor microenvironment.

James B. Mitchell, Murali C Krishna, D. Wink, 2004, Seminars in radiation oncology.

Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines

James B. Mitchell, N. Simone, B. Soule, 2010, Radiation oncology.

Radiation-induced changes in gene-expression profiles for the SCC VII tumor cells grown in vitro and in vivo.

James B. Mitchell, W. Degraff, E. Chuang, 2006, Antioxidants & redox signaling.

Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.

James B. Mitchell, H. Pass, C. H. Kennedy, 2003, Free radical biology & medicine.

Spatially resolved biologic information from in vivo EPRI, OMRI, and MRI.

James B. Mitchell, Murali C Krishna, Sankaran Subramanian, 2007, Antioxidants & redox signaling.

Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents.

James B. Mitchell, Murali C Krishna, Fuminori Hyodo, 2006, Cancer research.

Tumor hypoxia: chicken, egg, or a piece of the farm?

James B. Mitchell, C. N. Coleman, K. Camphausen, 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Photochemistry of Roussin's Red Salt, Na2[Fe2S2(NO)4], and of Roussin's Black Salt, NH4[Fe4S3(NO)7]. In Situ Nitric Oxide Generation To Sensitize γ-Radiation Induced Cell Death1

James B. Mitchell, Peter C. Ford, D. Wink, 1997 .

Low-energy X-radiation for prevention of restenosis results in localized inhibition of V79 fibroblast cell proliferation.

James B. Mitchell, Y. Vodovotz, W. Degraff, 1998, International journal of cardiovascular interventions.

Estimation of tumor microvessel density by MRI using a blood pool contrast agent.

James B. Mitchell, S. Matsumoto, M. Krishna, 2009, International journal of oncology.

The Chemical Biology of Nitric Oxide. Balancing Nitric Oxide with Oxidative and Nitrosative Stress

James B. Mitchell, D. Wink, M. Grisham, 2000 .

Antiangiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia.

Shingo Matsumoto, James B. Mitchell, Murali C Krishna, 2011, Cancer research.

Real-Time insight into in vivo redox status utilizing hyperpolarized [1-13C] N-acetyl cysteine

James B. Mitchell, P. Choyke, W. Linehan, 2021, Scientific Reports.

Magnetic resonance imaging of the tumor microenvironment in radiotherapy: perfusion, hypoxia, and metabolism.

James B. Mitchell, K. Camphausen, M. Matsuo, 2014, Seminars in radiation oncology.

Radiation Enhancement of Head and Neck SquamousCellCarcinomabytheDualPI3K/mTOR

James B. Mitchell, C. Waes, W. Degraff, 2015 .

Morphological Variants Cell Lines of Human Small Cell Lung Cancer and Its Large Cell Radiation and Chemotherapy Sensitivity of Established In Vitro Updated

James B. Mitchell, T. Kinsella, D. Carney, 2006 .

Principles of in Vivo EPR

James B. Mitchell, M. Krishna, S. Subramanian, 2003 .

Transforming growth factor-β improves healing of radiation-impaired wounds

James B. Mitchell, J. Norton, J. Uitto, 1991 .

Pulsed Electron Paramagnetic Resonance Imaging: Applications in the Studies of Tumor Physiology.

James B. Mitchell, S. Matsumoto, M. Krishna, 2017, Antioxidants & redox signaling.

HYPOXIC MAMMALIAN CELL RADIOSENSITIZATION BY NO To study the effects of NO and radiation in hypoxic cells

James B. Mitchell, D. Wink, W. Degraff, 2006 .

Cytoprotective Effects of NO against Oxidative Injury

James B. Mitchell, Y. Vodovotz, D. Wink, 2002 .

microRNA alterations driving acute and late stages of radiation-induced fibrosis in a murine skin model.

James B. Mitchell, N. Simone, K. Camphausen, 2014, International journal of radiation oncology, biology, physics.

n-Alkyl glucopyranosides completely inhibit ultrasound-induced cytolysis.

James B. Mitchell, Norio Miyoshi, Peter Riesz, 2005, Free radical biology & medicine.

Magnetic resonance imaging of tumor oxygenation and metabolic profile

Shingo Matsumoto, Masayuki Matsuo, James B. Mitchell, 2013, Acta oncologica.

Electron Paramagnetic Resonance Imaging of Tumor pO2

James B. Mitchell, S. Matsumoto, M. Krishna, 2012, Radiation research.

Evaluation and comparison of pulsed and continuous wave radiofrequency electron paramagnetic resonance techniques for in vivo detection and imaging of free radicals.

James B. Mitchell, Murali C Krishna, Nallathamby Devasahayam, 2002, Journal of magnetic resonance.

Pharmacological protection from radiation ± cisplatin-induced oral mucositis.

James B. Mitchell, B. Baum, C. Zheng, 2012, International journal of radiation oncology, biology, physics.

Reoxygenation after Evofosfamide Treatment in Pancreatic Ductal Adenocarcinoma Xenografts is due to Decreased Oxygen Consumption and not Increased Oxygen Supply

James B. Mitchell, J. Brender, M. Krishna, 2020, bioRxiv.

300 MHz continuous wave electron paramagnetic resonance spectrometer for small animal in vivo imaging

James B. Mitchell, Nallathamby Devasahayam, Sankaran Subramanian, 2000 .

An application system for automation of constant-time radio frequency electron paramagnetic resonance imaging

Andrew G. Taube, James B. Mitchell, Ramachandran Murugesan, 2003, Comput. Methods Programs Biomed..

Application of continuous‐wave EPR spectral‐spatial image reconstruction techniques for in vivo oxymetry: Comparison of projection reconstruction and constant‐time modalities

James B. Mitchell, Sankaran Subramanian, M. Krishna, 2003, Magnetic resonance in medicine.

Three‐dimensional whole body imaging of spin probes in mice by time‐domain radiofrequency electron paramagnetic resonance

James B. Mitchell, Nallathamby Devasahayam, Sankaran Subramanian, 2000, Magnetic resonance in medicine.

A broadband pulsed radio frequency electron paramagnetic resonance spectrometer for biological applications

James B. Mitchell, Nallathamby Devasahayam, Sankaran Subramanian, 1998 .

Imaging Metabolic Processes to Predict Radiation Responses.

James B. Mitchell, S. Naz, M. Krishna, 2019, Seminars in radiation oncology.

Absence of Smad3 confers radioprotection through modulation of ERK-MAPK in primary dermal fibroblasts.

James B. Mitchell, K. Flanders, A. Roberts, 2007, Journal of dermatological science.

Inhibition of USP14 promotes TNFα-induced cell death in head and neck squamous cell carcinoma (HNSCC)

James B. Mitchell, C. Van Waes, Zhong Chen, 2023, Cell Death & Differentiation.

Evaluation of a high-speed signal-averager for sensitivity enhancement in radio frequency Fourier transform electron paramagnetic resonance imaging

James B. Mitchell, Nallathamby Devasahayam, Sankaran Subramanian, 2002 .

Cardiovascular-Kidney Interactions in Health and Disease Acute antihypertensive action of nitroxides in the spontaneously hypertensive rat

James B. Mitchell, Yifan Chen, W. Welch, 2005 .

Nitric oxide modulation enhances the in vivo protection from lethal irradiation by stem cell factor

James B. Mitchell, D. Venzon, D. Wink, 1994 .

MR assessment of changes of tumor in response to hyperbaric oxygen treatment

James B. Mitchell, Marcelino Bernardo, Peter Choyke, 2006, Magnetic resonance in medicine.

Protection against Adriamycin cytotoxicity and inhibition of DNA topoisomerase II activity by 3,4-dihydroxybenzoic acid.

James B. Mitchell, S. Hahn, L. S. Myers, 2003, International Journal of Oncology.

Gadolinium-labeled dendrimers as biometric nanoprobes to detect vascular permeability

James B. Mitchell, M. Brechbiel, Hisataka Kobayashi, 2003 .

Hypoxia activated prodrug evofosfamide treatment in pancreatic ductal adenocarcinoma xenografts alters the tumor redox status to potentiate radiotherapy.

James B. Mitchell, J. Brender, M. Krishna, 2020, Antioxidants & redox signaling.

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

James B. Mitchell, J. Minna, A. Gazdar, 1987, Cancer research.

Rationale for hypoxia assessment and amelioration for precision therapy and immunotherapy studies.

James B. Mitchell, M. Dewhirst, T. Secomb, 2019, The Journal of clinical investigation.

Evaluation of oxygen dependence on in vitro and in vivo cytotoxicity of photoimmunotherapy using IR-700-antibody conjugates.

James B. Mitchell, P. Choyke, M. Bernardo, 2015, Free radical biology & medicine.

Abemaciclib: A multi-functional radiation modifier

James B. Mitchell, S. Naz, J. Cook, 2019, Oncotarget.

Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury

James B. Mitchell, D. Citrin, B. Baum, 2010, The oncologist.

The multifaceted roles of nitric oxide in cancer.

James B. Mitchell, M. Dewhirst, Y. Vodovotz, 1998, Carcinogenesis.

Strategies for improved temporal and spectral resolution in in vivo oximetric imaging using time‐domain EPR

James B. Mitchell, Nallathamby Devasahayam, Sankaran Subramanian, 2007, Magnetic resonance in medicine.

Parallel coil resonators for time-domain radiofrequency electron paramagnetic resonance imaging of biological objects.

James B. Mitchell, R Murugesan, J. Cook, 2000, Journal of magnetic resonance.

Biologically active metal-independent superoxide dismutase mimics.

James B. Mitchell, W. Degraff, U. Samuni, 1990, Biochemistry.

Reconstruction for Time-Domain In Vivo EPR 3D Multigradient Oximetric Imaging—A Parallel Processing Perspective

Shingo Matsumoto, James B. Mitchell, Calvin A. Johnson, 2009, Int. J. Biomed. Imaging.

In vivo electron paramagnetic resonance imaging of tumor heterogeneity and oxygenation in a murine model.

James B. Mitchell, S. Hahn, J. Zweier, 1998, Cancer research.

The effects of resveratrol and selected metabolites on the radiation and antioxidant response

James B. Mitchell, Kristin M. Fabre, W. Degraff, 2011, Cancer biology & therapy.

Pdfcrowd.com Open in Browser pro Version Are You a Developer? Try out the Html to Pdf Api Radioprotectors and Mitigators of Radiation-induced Normal Tissue Injury

James B. Mitchell, D. Citrin, B. Baum, 2022 .

Pharmacological inhibition of HSP90 radiosensitizes HNSCC xenograft by inhibition of DNA damage repair, nucleotide metabolism, and radiation-induced tumor vasculogenesis.

James B. Mitchell, C. Van Waes, S. Naz, 2021, International journal of radiation oncology, biology, physics.

Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers.

James B. Mitchell, A. Vissink, L. Elting, 2010, International journal of radiation oncology, biology, physics.

Targeting HIF2α Translation with Tempol in VHL-Deficient Clear Cell Renal Cell Carcinoma

James B. Mitchell, W. Linehan, W. Degraff, 2012, Oncotarget.

Quantitative imaging of pO2 in orthotopic murine gliomas: hypoxia correlates with resistance to radiation

James B. Mitchell, K. Camphausen, S. Matsumoto, 2017, Free radical research.

Iron Insufficiency Compromises Motor Neurons and Their Mitochondrial Function in Irp2-Null Mice

James B. Mitchell, R. Sougrat, C. Beaumont, 2011, PloS one.

Neuroprotection by the stable nitroxide Tempol during reperfusion in a rat model of transient focal ischemia.

James B. Mitchell, E. Oldfield, R. Pluta, 2000, Journal of neurosurgery.

Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology.

James B. Mitchell, Fei Li, F. Gonzalez, 2013, Journal of proteome research.

A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector.

James B. Mitchell, M. Bernardo, W. Degraff, 2011, Free radical biology & medicine.

A Phase I Study of Topical Tempol for the Prevention of Alopecia Induced by Whole Brain Radiotherapy

James B. Mitchell, S. Hahn, J. Metz, 2004, Clinical Cancer Research.

The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation.

James B. Mitchell, P. Rosenberg, P. Albert, 2012, Cancer research.

Imaging cycling tumor hypoxia.

James B. Mitchell, S. Matsumoto, M. Krishna, 2010, Cancer research.

Maximum Entropy Reconstruction Methods in Electron Paramagnetic Resonance Imaging

James B. Mitchell, Delia P. McGarry, Calvin A. Johnson, 2003, Ann. Oper. Res..

The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE-/- mice.

James B. Mitchell, Christine H. J. Kim, M. Davies, 2015, Atherosclerosis.

Brain Redox Imaging Using Blood—Brain Barrier-Permeable Nitroxide MRI Contrast Agent

James B. Mitchell, K. Chuang, A. Koretsky, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer

James B. Mitchell, A. Kulkarni, C. Van Waes, 2013, Clinical Cancer Research.

A Phase I study of intermittent intravenous bromodeoxyuridine (BUdR) with conventional fractionated irradiation.

James B. Mitchell, Barry H. Smith, J. Schwade, 1984, International journal of radiation oncology, biology, physics.

Photodynamic therapy of the canine peritoneum: Normal tissue response to intraperitoneal and intravenous photofrin followed by 630 nm light

James B. Mitchell, M. Manyak, H. Hoekstra, 1991, Lasers in surgery and medicine.

Oral administration of the nitroxide radical TEMPOL exhibits immunomodulatory and therapeutic properties in multiple sclerosis models

James B. Mitchell, H. McFarland, M. Cherukuri, 2017, Brain, Behavior, and Immunity.

Molecular imaging of tumor photoimmunotherapy: Evidence of photosensitized tumor necrosis and hemodynamic changes.

James B. Mitchell, P. Choyke, J. Ardenkjaer-Larsen, 2018, Free radical biology & medicine.

Reporting of quantitative oxygen mapping in EPR imaging.

James B. Mitchell, A. McMillan, S. Matsumoto, 2012, Journal of magnetic resonance.

A Phase I Trial of an Immune Checkpoint Inhibitor Plus Stereotactic Ablative Radiotherapy in Patients with Inoperable Stage I Non-Small Cell Lung Cancer

James B. Mitchell, K. Kelly, M. Daly, 2016 .

Kinetics of Tempol for Prevention of Xerostomia Following Head and Neck Irradiation in a Mouse Model

James B. Mitchell, B. Baum, A. Cotrim, 2005, Clinical Cancer Research.