Owen J Sansom

发表

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.

Ian P Newton, Hans Clevers, Owen J Sansom, 2004, Genes & development.

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.

Jennifer P Morton, Paul Timpson, Richard L Mort, 2011, Nature communications.

The APC network regulates the removal of mutated cells from colonic crypts.

Kwang-Hyun Cho, Walter Kolch, Je-Hoon Song, 2014, Cell reports.

The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively

Paul L Appleton, Ian P Newton, Inke S Näthke, 2012, Journal of Cell Science.

The Lgr 5 intestinal stem cell signature : robust expression of proposed quiescent ‘ þ 4 ’ cell markers

Alexander van Oudenaarden, Hans Clevers, Jan Koster, 2012 .

Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma.

Jennifer P Morton, Paul Timpson, Colin McKay, 2010, Gastroenterology.

Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron

Jamie A Davies, Peter Hohenstein, Owen J Sansom, 2015, eLife.

Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells.

Owen J Sansom, Bryan Serrels, O. Sansom, 2012, Carcinogenesis.

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer.

Neil O Carragher, Max Nobis, Jennifer P Morton, 2013, Cancer research.

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

Andreas Trumpp, Owen J Sansom, Alan R Clarke, 2008, Nature Genetics.

Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation.

Rosalie C Sears, Owen J Sansom, Jukka Westermarck, 2015, Cell reports.

Single cell tracking reveals that Msh2 is a key component of an early-acting DNA damage-activated G2 checkpoint

Owen J Sansom, Alan R Clarke, Nuria Marquez, 2003, Oncogene.

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

Karin Oien, Jennifer P Morton, Paul Timpson, 2015, EMBO molecular medicine.

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

Hans Clevers, Paul L Appleton, Inke S Näthke, 2010, Cell stem cell.

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth.

Hans Clevers, Kurt I Anderson, Paul Timpson, 2024, Cancer cell.

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

Sean C Warren, Max Nobis, Astrid Magenau, 2017, Cell reports.

MicroRNA Molecular Profiles Associated with Diagnosis, Clinicopathologic Criteria, and Overall Survival in Patients with Resectable Pancreatic Ductal Adenocarcinoma

Jennifer P Morton, Owen J Sansom, N. Jamieson, 2011, Clinical Cancer Research.