Mekala Gunaratnam

Structure-based design and evaluation of small molecules with selectivity for telomeric quadruplex nucleic acids

Andreas G. Schätzlein, Nancy H. Campbell, Stephen Neidle, 2010 .

Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands.

Stephen Neidle, Shozeb Haider, Mekala Gunaratnam, 2008, Molecular bioSystems.

Bioactive pyridine-N-oxide disulfides from Allium stipitatum.

Stephen Neidle, Simon Gibbons, Mekala Gunaratnam, 2009, Journal of natural products.

Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.

Stephen Neidle, Javier Cuesta, Mekala Gunaratnam, 2006, Journal of medicinal chemistry.

An evaluation cascade for G-quadruplex telomere targeting agents in human cancer cells.

Stephen Neidle, Mekala Gunaratnam, S. Neidle, 2010, Methods in molecular biology.

Mechanism of acridine-based telomerase inhibition and telomere shortening.

Stephen Neidle, Hamid Morjani, Mekala Gunaratnam, 2007, Biochemical pharmacology.

Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes.

Stephen Neidle, Mekala Gunaratnam, Silvia Sparapani, 2010, Journal of the American Chemical Society.

Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells.

Stephen Neidle, Mekala Gunaratnam, Stephan A. Ohnmacht, 2013, Journal of medicinal chemistry.

Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs.

Stephen Neidle, Mekala Gunaratnam, Gary N Parkinson, 2008, Journal of medicinal chemistry.