Bernd Kuhn

发表

Rationalizing Tight Ligand Binding through Cooperative Interaction Networks

Martin Stahl, Michael Reutlinger, Julian E. Fuchs, 2011, J. Chem. Inf. Model..

D3R Grand Challenge 2: blind prediction of protein–ligand poses, affinity rankings, and relative binding free energies

Shuai Liu, Huanwang Yang, Stephen K. Burley, 2017, Journal of Computer-Aided Molecular Design.

Small Molecule Conformational Preferences Derived from Crystal Structure Data. A Medicinal Chemistry Focused Analysis

Martin Stahl, Bernd Kuhn, Ken A. Brameld, 2008, J. Chem. Inf. Model..

Corrections to A Medicinal Chemist’s Guide to Molecular Interactions

Martin Stahl, Caterina Bissantz, Bernd Kuhn, 2010, Journal of Medicinal Chemistry.

Systematic investigation of halogen bonding in protein-ligand interactions.

François Diederich, Jörg Benz, Bernd Kuhn, 2011, Angewandte Chemie.

A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Recruits PPARγ-Coactivator-1α, Prevents Triglyceride Accumulation, and Potentiates Insulin Signaling in Vitro

Armin Ruf, Hans Peter Märki, Jörg Benz, 2006 .

Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes.

Franz Schuler, Rainer E. Martin, Rainer E Martin, 2011, Bioorganic & medicinal chemistry letters.

Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist.

Hans Richter, Rainer E. Martin, Rainer E Martin, 2009, Bioorganic & medicinal chemistry letters.

Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.

Martin Stahl, Jörg Benz, Daniel Schlatter, 2009, European journal of medicinal chemistry.

Structure-based design of indole propionic acids as novel PPARα/γ co-agonists

Hans Peter Märki, Jörg Benz, Bernd Kuhn, 2006 .

Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors.

Daniel Hunziker, Holger Fischer, Bernd Kuhn, 2010, Bioorganic & medicinal chemistry letters.

Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists

Armin Ruf, Jörg Benz, Daniel Schlatter, 2009, ChemMedChem.

Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents.

Silja Weber, Jens-Uwe Peters, Bernd Kuhn, 2004, Bioorganic & medicinal chemistry letters.

A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro.

Armin Ruf, Hans Peter Märki, Jörg Benz, 2006, Molecular endocrinology.

Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments

Nobuo Shimma, François Diederich, Jörg Benz, 2011, ChemMedChem.

Fluorine in Medicinal Chemistry

Martin Stahl, Manfred Kansy, Hans-Joachim Böhm, 2004, Chembiochem : a European journal of chemical biology.

Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate.

Martin Stahl, Walter Huber, Jörg Benz, 2010, Bioorganic & medicinal chemistry letters.

Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

Holger Fischer, Bernd Kuhn, B. Kuhn, 2010, Bioorganic & medicinal chemistry letters.

Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors.

Jérôme Hert, Robert Abel, Lingle Wang, 2017, Journal of medicinal chemistry.

Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.

François Diederich, Bernd Kuhn, F. Diederich, 2016, Chemistry.

1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors.

Jens-Uwe Peters, Bernd Löffler, Daniel Hunziker, 2007, Bioorganic & medicinal chemistry letters.

Comparative Molecular Profiling of the PPARα/γ Activator Aleglitazar: PPAR Selectivity, Activity and Interaction with Cofactors

Armin Ruf, Jörg Benz, Bernd Kuhn, 2012, ChemMedChem.

Molecular recognition of ligands in dipeptidyl peptidase IV.

Bernd Kuhn, B. Kuhn, P. Mattei, 2007, Current topics in medicinal chemistry.

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery.

Manfred Kansy, Björn Wagner, Erick M Carreira, 2015, Journal of medicinal chemistry.

Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRα and β

Jörg Benz, Bernd Kuhn, B. Kuhn, 2006 .

Ligand channel in pharmacologically stabilized rhodopsin

Gebhard F. X. Schertler, Markus G. Rudolph, Andre Alker, 2018, Proceedings of the National Academy of Sciences.