Donald Hilvert

发表

Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting.

Richard Obexer, Moritz Pott, Cathleen Zeymer, 2016, Protein engineering, design & selection : PEDS.

Directed Evolution of Protein Catalysts.

Cathleen Zeymer, Donald Hilvert, D. Hilvert, 2018, Annual review of biochemistry.

Non-uniform HYSCORE: Measurement, processing and analysis with Hyscorean.

Donald Hilvert, Gunnar Jeschke, Matthias Tinzl, 2019, Journal of magnetic resonance.

Speeding up enzyme discovery and engineering with ultrahigh-throughput methods.

Moritz Pott, Donald Hilvert, Hans Adrian Bunzel, 2018, Current opinion in structural biology.

Catalysis on the coastline: Theozyme, molecular dynamics, and free energy perturbation analysis of antibody 21D8 catalysis of the decarboxylation of 5‐nitro‐3‐carboxybenzisoxazole

Yunfeng Hu, Donald Hilvert, Kinya Hotta, 2003, J. Comput. Chem..

Evolution-based design of chorismate mutase enzymes

Simona Cocco, Donald Hilvert, Rama Ranganathan, 2020, bioRxiv.

Proceedings du 23ème Conseil Solvay de Chimie "New Chemistry and New Opportunities from the Expanding Protein Universe": World Scientific Publishing

Kurt Wüthrich, Donald Hilvert, Ian A. Wilson, 2014 .

Using Evolutionary Strategies to Investigate the Structure and Function of Chorismate Mutases

Donald Hilvert, Peter Kast, Sean V. Taylor, 2003 .

Fast Knoevenagel Condensations Catalyzed by an Artificial Schiff-Base-Forming Enzyme.

Donald Hilvert, Xavier Garrabou, D. Hilvert, 2016, Journal of the American Chemical Society.

Directed Evolution of a Model Primordial Enzyme Provides Insights into the Development of the Genetic Code

Donald Hilvert, Jane R. Allison, Philippe Marlière, 2013, PLoS genetics.

Both the cis-trans equilibrium and isomerization dynamics of a single proline amide modulate β2-microglobulin amyloid assembly

Donald Hilvert, D. Hilvert, Vladimir Yu Torbeev, 2013, Proceedings of the National Academy of Sciences.

Relative tolerance of mesostable and thermostable protein homologs to extensive mutation

Donald Hilvert, Peter Kast, D. Hilvert, 2006, Proteins.

Transition State of the Base-Promoted Ring-Opening of Isoxazoles. Theoretical Prediction of Catalytic Functionalities and Design of Haptens for Antibody Production

Donald Hilvert, Kendall N. Houk, D. Hilvert, 1996 .

Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design.

David Baker, Liang Tong, Donald Hilvert, 2014, Journal of molecular biology.

A Noncanonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold.

Moritz Pott, Donald Hilvert, Takahiro Hayashi, 2018, Journal of the American Chemical Society.

Stereoselectivity and expanded substrate scope of an engineered PLP-dependent aldolase.

Donald Hilvert, Kim K Baldridge, Celine Amoreira, 2006, Angewandte Chemie.

A Chemically Programmed Proximal Ligand Enhances the Catalytic Properties of a Heme Enzyme.

Donald Hilvert, Takahiro Hayashi, Peer R. E. Mittl, 2016, Journal of the American Chemical Society.

Use of molecular dynamics in the design and structure determination of a photoinducible beta-hairpin.

Wilfred F van Gunsteren, Donald Hilvert, Vincent Kräutler, 2005, Journal of the American Chemical Society.

Selenosubtilisin as a glutathione peroxidase mimic

Donald Hilvert, D. Hilvert, Zhen Ping Wu, 1990 .

Active Site Plasticity of a Computationally Designed Retro‐Aldolase Enzyme

David Baker, Donald Hilvert, D. Hilvert, 2014 .

Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design.

David Baker, Donald Hilvert, Eric A. Althoff, 2011, Journal of molecular biology.

An enzymatic molten globule: efficient coupling of folding and catalysis.

Donald Hilvert, Konstantin Pervushin, Peter Kast, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Robust design and optimization of retroaldol enzymes

Daniel Herschlag, Donald Hilvert, Eric A. Althoff, 2012, Protein science : a publication of the Protein Society.

Searching sequence space for protein catalysts

Donald Hilvert, Sean V. Taylor, Peter Kast, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Investigating and Engineering Enzymes by Genetic Selection.

Donald Hilvert, Sean V. Taylor, Peter Kast, 2001, Angewandte Chemie.

A simple selection strategy for evolving highly efficient enzymes

Donald Hilvert, Peter Kast, Martin Neuenschwander, 2007, Nature Biotechnology.

Precision is essential for efficient catalysis in an evolved Kemp eliminase

Donald Hilvert, Stephen L. Mayo, Peer R. E. Mittl, 2013, Nature.

Iterative approach to computational enzyme design

Roberto A. Chica, Donald Hilvert, Stephen L. Mayo, 2012, Proceedings of the National Academy of Sciences.

Design of protein catalysts.

Donald Hilvert, D. Hilvert, 2013, Annual review of biochemistry.

De novo enzymes by computational design.

Donald Hilvert, Hajo Kries, D. Hilvert, 2013, Current opinion in chemical biology.

Enantiocomplementary Synthesis of γ-Nitroketones Using Designed and Evolved Carboligases.

Donald Hilvert, Xavier Garrabou, D. Hilvert, 2017, Journal of the American Chemical Society.

Consensus protein design without phylogenetic bias.

Frances H Arnold, Donald Hilvert, Christian Jäckel, 2010, Journal of molecular biology.

On the relationship between folding and chemical landscapes in enzyme catalysis

Arieh Warshel, Donald Hilvert, Maite Roca, 2008, Proceedings of the National Academy of Sciences.

Minimalist active-site redesign: teaching old enzymes new tricks.

Donald Hilvert, D. Hilvert, M. Toscano, 2007, Angewandte Chemie.

Efficientin VivoSynthesis and Rapid Purification of Chorismic Acid Using an EngineeredEscherichia coliStrain

Donald Hilvert, Peter Kast, D. Hilvert, 1997 .

Charge optimization increases the potency and selectivity of a chorismate mutase inhibitor.

Donald Hilvert, Ajay Mandal, 2003, Journal of the American Chemical Society.

Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase

David Baker, Clemens Mayer, Donald Hilvert, 2014, Proceedings of the National Academy of Sciences.

Is chorismate mutase a prototypic entropy trap? - Activation parameters for the Bacillus subtilis enzyme

Donald Hilvert, Peter Kast, D. Hilvert, 1996 .

Efficient in vitro encapsulation of protein cargo by an engineered protein container.

Donald Hilvert, D. Hilvert, Z. Pianowski, 2012, Journal of the American Chemical Society.

Evolution of a designed retro-aldolase leads to complete active site remodeling

David Baker, Donald Hilvert, Peter Kast, 2013, Nature chemical biology.

An Active Enzyme Constructed from a 9-Amino Acid Alphabet*

Donald Hilvert, D. Hilvert, Katherina Vamvaca, 2005, Journal of Biological Chemistry.

Computational design of catalytic dyads and oxyanion holes for ester hydrolysis.

Liang Tong, Gaetano T Montelione, Donald Hilvert, 2012, Journal of the American Chemical Society.

Biocatalysts by evolution.

Donald Hilvert, Christian Jäckel, D. Hilvert, 2010, Current opinion in biotechnology.

A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates.

Donald Hilvert, Xavier Garrabou, D. Hilvert, 2015, Angewandte Chemie.

Immunological Optimization of a Generic Hydrophobic Pocket for High Affinity Hapten Binding and Diels–Alder Activity

Donald Hilvert, D. Hilvert, Andrea Piatesi, 2004, Chembiochem : a European journal of chemical biology.

Structure and dynamics of a molten globular enzyme

Donald Hilvert, Konstantin Pervushin, Beat Vögeli, 2007, Nature Structural &Molecular Biology.

Structural origins of efficient proton abstraction from carbon by a catalytic antibody.

Donald Hilvert, Ian A Wilson, I. Wilson, 2005, Proceedings of the National Academy of Sciences of the United States of America.

New enzymes from combinatorial library modules.

Donald Hilvert, Peter Kast, D. Hilvert, 2004, Methods in enzymology.

Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting.

Moritz Pott, Andrew D Griffiths, Donald Hilvert, 2017, Protein engineering, design & selection : PEDS.

Stereodivergent Evolution of Artificial Enzymes for the Michael Reaction.

Donald Hilvert, Xavier Garrabou, D. Hilvert, 2018, Angewandte Chemie.

Directed Evolution of a Protein Container

Donald Hilvert, D. Hilvert, K. J. Woycechowsky, 2011, Science.

Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes.

Albert J R Heck, Donald Hilvert, Maria Reinhardt-Szyba, 2017, The Analyst.