Shane M. Devine

发表

Engaging students with multiple problem-solving pathways for complex problems

Christopher Thompson, Elizabeth Yuriev, Kimberly Vo, 2019 .

A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors

Shane M. Devine, R. Norton, R. Anders, 2014 .

A Novel Highly Selective Adenosine A1 Receptor Agonist VCP28 Reduces Ischemia Injury in a Cardiac Cell Line and Ischemia–Reperfusion Injury in Isolated Rat Hearts at Concentrations That Do Not Affect Heart Rate

Shane M. Devine, P. White, C. Pouton, 2010, Journal of cardiovascular pharmacology.

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

Shane M. Devine, R. Norton, S. McGowan, 2019, ChemMedChem.

Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO.

Shane M. Devine, R. Norton, Wei Yang, 2014, Biochemistry.

Antimalarial drug discovery targeting apical membrane antigen 1.

Shane M. Devine, R. Norton, P. Scammells, 2017, MedChemComm.

VCP746, a novel A1 adenosine receptor biased agonist, reduces hypertrophy in a rat neonatal cardiac myocyte model

Shane M. Devine, H. Krum, P. White, 2016, Clinical and experimental pharmacology & physiology.

Full title : VCP 746 , a Novel A 1 Adenosine Receptor Biased Agonist , Reduces Hypertrophy in a Rat Neonatal Cardiac Myocyte Model Short title : VCP 746 and Cardiac Myocyte Hypertrophy

Shane M. Devine, H. Krum, P. White, 2016 .

Dual acting antioxidant A1 adenosine receptor agonists.

Shane M. Devine, P. White, S. Bottle, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A(1) receptor.

Shane M. Devine, P. Sexton, A. Christopoulos, 2012, Journal of medicinal chemistry.

Reverse Engineering of the Selective Agonist TBPB Unveils Both Orthosteric and Allosteric Modes of Action at the M1 Muscarinic Acetylcholine Receptor

Shane M. Devine, P. Sexton, A. Christopoulos, 2013, Molecular Pharmacology.

An Allosteric Modulator of the Adenosine A1 Receptor Improves Cardiac Function Following Ischaemia in Murine Isolated Hearts

Shane M. Devine, P. White, A. Butcher, 2013, Pharmaceuticals.

Current and emerging target identification methods for novel antimalarials

Shane M. Devine, D. Creek, Matthew P. Challis, 2022, International journal for parasitology. Drugs and drug resistance.

Development of inhibitors of Plasmodium falciparum apical membrane antigen 1 based on fragment screening

Shane M. Devine, R. Norton, R. Anders, 2013 .

Richter cyclization and co-cyclization reactions of triazene-masked diazonium ions

Shane M. Devine, P. Scammells, B. Flynn, 2010 .

Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents.

Shane M. Devine, R. Callaghan, C. Pouton, 2018, Journal of medicinal chemistry.

Novel annulated products from aminonaphthyridinones

Shane M. Devine, L. Deady, 2006 .

Synthesis and reactivity of some imidazo‐, triazolo‐ and tetrazolo‐isoquinoline derivatives

Shane M. Devine, L. Deady, 2004 .

A CONVENIENT PROCEDURE FOR INDIRECT OXIDATION OF AROMATIC METHYL GROUPS TO ALDEHYDES AND CARBOXYLIC ACIDS

Shane M. Devine, L. Deady, M. Rogers, 2003 .

An efficient convergent synthesis of adenosine-5′-N-alkyluronamides

Shane M. Devine, P. Scammells, 2008 .

Synthesis and Utility of 2-Halo-O6-(benzotriazol-1-yl)-Functionalized Purine Nucleosides

Shane M. Devine, P. Scammells, 2011 .

Linear and convergent approaches to 2-substituted adenosine-5′-N-alkylcarboxamides

Shane M. Devine, P. Scammells, Nicholas Hausler, 2009 .

Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists.

Shane M. Devine, P. White, S. Bottle, 2010, Bioorganic & medicinal chemistry.

Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR.

Shane M. Devine, M. Foley, R. Norton, 2014, Journal of medicinal chemistry.

Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum*

Shane M. Devine, G. Birrell, D. Creek, 2019, Molecular & Cellular Proteomics.

1,3‐Benzodioxole‐Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin‐Bound Structure

Shane M. Devine, M. Steinmetz, A. Prota, 2021, ChemMedChem.

A Novel Class of N‐Sulfonyl and N‐Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells

Shane M. Devine, R. Callaghan, P. Scammells, 2019, ChemMedChem.

Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists.

Shane M. Devine, P. White, S. Bottle, 2012, Journal of medicinal chemistry.

Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials

Shane M. Devine, R. Norton, H. Atreya, 2016, Journal of molecular recognition : JMR.

Discovery and development of 2-aminobenzimidazoles as potent antimalarials.

Shane M. Devine, R. Norton, V. Avery, 2021, European journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK

Shane M. Devine, H. Krum, D. Chalmers, 2014, ChemistryOpen.

Molecular Mechanisms of Bitopic Ligand Engagement with the M1 Muscarinic Acetylcholine Receptor*

Shane M. Devine, P. Sexton, A. Christopoulos, 2014, The Journal of Biological Chemistry.

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold.

J Willem M Nissink, Jonathan B Baell, Martin J Scanlon, 2015, Journal of medicinal chemistry.

The development process for discovery and clinical advancement of modern antimalarials.

Shane M. Devine, S. Charman, D. Creek, 2019, Journal of medicinal chemistry.

Antimalarial drug discovery targeting apical membrane antigen 1.

Shane M. Devine, R. Norton, P. Scammells, 2017, MedChemComm.

Multiplexed Native Mass Spectrometry Determination of Ligand Selectivity for Fatty Acid-Binding Proteins

Shane M. Devine, B. Doak, I. Chandrashekaran, 2024, ACS Medicinal Chemistry Letters.