Bob van de Water

发表

The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods

Alice Krebs, Barbara M. A. van Vugt-Lussenburg, Tanja Waldmann, 2020, Archives of Toxicology.

Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project

Barbara Zdrazil, Ciarán Fisher, Jan G. Hengstler, 2019, Archives of Toxicology.

A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity.

Bertrand Desprez, Martina Klaric, Gladys Ouédraogo, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

Functional analysis of high-content high-throughput imaging data

Annette Kopp-Schneider, Bob van de Water, Xiaoqi Jiang, 2017 .

Current approaches and future role of high content imaging in safety sciences and drug discovery.

Mardas Daneshian, Peter Macko, Imran Shah, 2014, ALTEX.

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

Bob van de Water, Steven Wink, B. van de Water, 2016, Archives of Toxicology.

Diclofenac inhibits tumor necrosis factor‐α‐induced nuclear factor‐κB activation causing synergistic hepatocyte apoptosis

Bob van de Water, Sanja Dragovic, Lisa Fredriksson, 2011, Hepatology.

Stem cell-derived systems in toxicology assessment.

Paul Jennings, Bob van de Water, Angelo Moretto, 2015, Stem cells and development.

Combining Doublecortin-Like Kinase Silencing and Vinca Alkaloids Results in a Synergistic Apoptotic Effect in Neuroblastoma Cells

Bob van de Water, E. Danen, B. van de Water, 2012, Journal of Pharmacology and Experimental Therapeutics.

Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells

Bas ter Braak, Bob van de Water, Jan Willem van der Laan, 2015, Breast Cancer Research.

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

Eytan Ruppin, Keren Yizhak, Bob van de Water, 2014, Molecular systems biology.

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

Eytan Ruppin, Keren Yizhak, Bob van de Water, 2014, Molecular Systems Biology.

Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

Eytan Ruppin, Keren Yizhak, Bob van de Water, 2014, eLife.

SYK is a candidate kinase target for the treatment of advanced prostate cancer.

Esther I Verhoef, Bob van de Water, Guido Jenster, 2015, Cancer research.

Finding synergies for the 3Rs - Repeated dose toxicity testing: Report from an EPAA partners' forum.

Bertrand Desprez, Gianni Dal Negro, Bob van de Water, 2019, Regulatory toxicology and pharmacology : RTP.

TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells.

Bob van de Water, Lisa Fredriksson, B. van de Water, 2013, Biochemical pharmacology.

High-Throughput Phenotypic Screening of Kinase Inhibitors to Identify Drug Targets for Polycystic Kidney Disease

Gerard J. P. van Westen, Bob van de Water, Kuan Yan, 2017, SLAS discovery : advancing life sciences R & D.

Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways.

Bob van de Water, Martijn H Breuning, Dorien J M Peters, 2009, Human molecular genetics.

Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants

Anna Forsby, Paul Jennings, Bob van de Water, 2019, Archives of Toxicology.

Aven‐mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma

Bob van de Water, Anne-Marie Cleton-Jansen, A. Cleton-Jansen, 2015, The Journal of pathology.

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk

Mardas Daneshian, Bob van de Water, Hennicke Kamp, 2016, Archives of Toxicology.

Automated Analysis of NF-κB Nuclear Translocation Kinetics in High-Throughput Screening

Fons J. Verbeek, Bob van de Water, Kuan Yan, 2012, PloS one.

Proteomic Analysis of Alternative Protein Tyrosine Phosphorylation in 1,2-Dichlorovinyl-Cysteine-Induced Cytotoxicity in Primary Cultured Rat Renal Proximal Tubular Cells

André M Deelder, Bob van de Water, Sylvia E. Le Dévédec, 2007, Journal of Pharmacology and Experimental Therapeutics.

MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation

Bob van de Water, Anne-Marie Cleton-Jansen, Marieke L. Kuijjer, 2015, Genes & cancer.

β1 Integrin Inhibition Elicits a Prometastatic Switch Through the TGFβ–miR-200–ZEB Network in E-Cadherin–Positive Triple-Negative Breast Cancer

Bob van de Water, Sylvia E. Le Dévédec, B. Ewa Snaar-Jagalska, 2014, Science Signaling.

Current EU research activities on combined exposure to multiple chemicals☆

Erik Lebret, Werner Brack, Bob van de Water, 2018, Environment international.

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment.

Bob van de Water, Harry Vrieling, Giel Hendriks, 2014, Chemical research in toxicology.

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq

Paul Jennings, Alice Limonciel, Bob van de Water, 2018, Archives of Toxicology.

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

Bob van de Water, Steven Wink, B. van de Water, 2018, Archives of Toxicology.

Focal adhesion kinase: a potential target in cancer therapy.

Bob van de Water, B. van de Water, Maroesja J van Nimwegen, 2007, Biochemical pharmacology.

The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals.

Bob van de Water, Harry Vrieling, Giel Hendriks, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant.

Benjamin Geiger, Bob van de Water, Gabriella Rustici, 2015, The Journal of clinical investigation.

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Ursula Klingmüller, Bob van de Water, K. G. Jensen, 2019, Nature Reviews Drug Discovery.

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

Giulia Callegaro, Bob van de Water, Maarten Coonen, 2019, Archives of Toxicology.

System Microscopy of Stress Response Pathways in Cholestasis Research.

Bob van de Water, Steven Wink, Marije Niemeijer, 2019, Methods in molecular biology.

An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2−/− γc−/− mouse

Bob van de Water, Sylvia E. Le Dévédec, B. van de Water, 2009, Clinical & Experimental Metastasis.

Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans.

Bob van de Water, Jeroen L A Pennings, Leo T M van der Ven, 2014, Toxicology letters.

Systems Biology Approach Identifies the Kinase Csnk1a1 as a Regulator of the DNA Damage Response in Embryonic Stem Cells

Jesper V Olsen, Bob van de Water, Harry Vrieling, 2013, Science Signaling.

Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

Carsten Kneuer, Giuseppe Testa, Thomas Backhaus, 2019, Environment international.