Chuang Lu

发表

PBPK modeling and simulation in drug research and development

Xiaomei Zhuang, Chuang Lu, Chuang Lu, 2016, Acta pharmaceutica Sinica. B.

Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective

David Moore, Yuan Chen, Louis Leung, 2016, Drug Metabolism and Disposition.

Enzyme inhibition in drug discovery and development

Chuang Lu, Chuang Lu, Albert P. Li, 2009 .

Comparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in Hepatocytes

Chuang Lu, Ping Li, Suresh K Balani, 2006, Drug Metabolism and Disposition.

Identification and Characterization of Psoralen and Isopsoralen as Potent CYP1A2 Reversible and Time-Dependent Inhibitors in Human and Rat Preclinical Studies

Chuang Lu, Chuang Lu, Xiao-Mei Zhuang, 2013, Drug Metabolism and Disposition.

A Novel Model for the Prediction of Drug-Drug Interactions in Humans Based on in Vitro Cytochrome P450 Phenotypic Data

Chuang Lu, Suresh K Balani, Gerald T Miwa, 2007, Drug Metabolism and Disposition.

Prediction of Pharmacokinetic Drug-Drug Interactions Using Human Hepatocyte Suspension in Plasma and Cytochrome P450 Phenotypic Data. II. In Vitro-in Vivo Correlation with Ketoconazole

Chuang Lu, Suresh K Balani, Frank W Lee, 2008, Drug Metabolism and Disposition.

Quantitative Prediction and Clinical Observation of a CYP3A Inhibitor-Based Drug-Drug Interactions with MLN3897, a Potent C-C Chemokine Receptor-1 Antagonist

Chuang Lu, Suresh K Balani, L. V. von Moltke, 2010, Journal of Pharmacology and Experimental Therapeutics.

RELATIVE CONTRIBUTIONS OF THE FIVE MAJOR HUMAN CYTOCHROMES P450, 1A2, 2C9, 2C19, 2D6, AND 3A4, TO THE HEPATIC METABOLISM OF THE PROTEASOME INHIBITOR BORTEZOMIB

Chuang Lu, Liang-Shang Gan, Chuang Lu, 2005, Drug Metabolism and Disposition.

Assessment of cytochrome P450‐mediated drug–drug interaction potential of orteronel and exposure changes in patients with renal impairment using physiologically based pharmacokinetic modeling and simulation

Chuang Lu, Wen Chyi Shyu, Chuang Lu, 2014, Biopharmaceutics & drug disposition.

Prediction of Pharmacokinetic Drug-Drug Interactions Using Human Hepatocyte Suspension in Plasma and Cytochrome P450 Phenotypic Data. III. In Vitro-in Vivo Correlation with Fluconazole

Chuang Lu, Suresh K Balani, Frank W Lee, 2008, Drug Metabolism and Disposition.

Characterization of preclinical in vitro and in vivo ADME properties and prediction of human PK using a physiologically based pharmacokinetic model for YQA‐14, a new dopamine D3 receptor antagonist candidate for treatment of drug addiction

Xiaomei Zhuang, Chuang Lu, Jin Li, 2014, Biopharmaceutics & drug disposition.

JPET #161893 1 QUANTITATIVE PREDICTION AND CLINICAL OBSERVATION OF A CYP3A INHIBITOR-BASED DRUG-DRUG INTERACTIONS WITH MLN3897, A POTENT CCR1 ANTAGONIST

Chuang Lu, Lisa L. von Moltke, Suresh K. Balani, 2009 .

Preclinical experimental models of drug metabolism and disposition in drug discovery and development

Chuang Lu, Donglu Zhang, Xinxin Ding, 2012 .

The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America

Chuang Lu, Heidi J Einolf, Y. Wong, 2009, Drug Metabolism and Disposition.