Keith W Ward

Application of simple mathematical expressions to relate the half-lives of xenobiotics in rats to values in humans.

Paul Erhardt, Keith W Ward, Kenneth Bachmann, 2005, Journal of pharmacological and toxicological methods.

EXTRAPOLATION OF PRECLINICAL PHARMACOKINETICS AND MOLECULAR FEATURE ANALYSIS OF “DISCOVERY-LIKE” MOLECULES TO PREDICT HUMAN PHARMACOKINETICS

Christopher A Evans, Keith W Ward, K. Ward, 2006, Drug Metabolism and Disposition.

A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance.

Keith W Ward, B. Smith, K. Ward, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.

Keith W Ward, K. Ward, Larry J Jolivette, 2005, Journal of pharmaceutical sciences.

Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance.

Keith W Ward, K. Ward, R. Nagilla, 2006, Journal of pharmacological and toxicological methods.

4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.

Guang Yang, Keith W Ward, D. Veber, 2005, Journal of medicinal chemistry.

A comprehensive analysis of the role of correction factors in the allometric predictivity of clearance from rat, dog, and monkey to humans.

Keith W Ward, K. Ward, R. Nagilla, 2004, Journal of pharmaceutical sciences.

Protective effects of a coumarin derivative in diabetic rats.

Emanuela Mazzon, Keith W Ward, Salvatore Cuzzocrea, 2009, Investigative ophthalmology & visual science.

A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. II. Volume of distribution and mean residence time.

Keith W Ward, B. Smith, K. Ward, 2004, Drug metabolism and disposition: the biological fate of chemicals.