Ian R Baxendale

发表

Achieving Continuous Manufacturing: Technologies and Approaches for Synthesis, Workup, and Isolation of Drug Substance May 20-21, 2014 Continuous Manufacturing Symposium.

Paul Sharratt, Martin D. Johnson, Richard D Braatz, 2015, Journal of pharmaceutical sciences.

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

Marcus Baumann, Ian R Baxendale, M. Baumann, 2015, Beilstein journal of organic chemistry.

Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations.

Steven V Ley, Ian R Baxendale, S. Ley, 2006, Chemistry.

A machine-assisted flow synthesis of SR48692: a probe for the investigation of neurotensin receptor-1.

Claudio Battilocchio, Steven V Ley, Ian R Baxendale, 2013, Chemistry.

Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines.

Marcus Baumann, Ian R Baxendale, M. Baumann, 2015, Organic & biomolecular chemistry.

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.

Steven V Ley, Ian R Baxendale, S. Ley, 2006, Chemical communications.

A continuous flow process using a sequence of microreactors with in-line IR analysis for the preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a potent and highly selective δ-opioid receptor agonist.

Steven V Ley, Ian R Baxendale, S. Ley, 2010, Chemistry.

Microwave assisted Leimgruber-Batcho reaction for the preparation of indoles, azaindoles and pyrroylquinolines.

Steven V Ley, Ian R Baxendale, S. Ley, 2004, Organic & biomolecular chemistry.

Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles.

Steven V Ley, Marcus Baumann, Ian R Baxendale, 2006, Organic letters.

Microwave reactions under continuous flow conditions.

Steven V Ley, Ian R Baxendale, S. Ley, 2007, Combinatorial chemistry & high throughput screening.

[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor.

Steven V Ley, Ian R Baxendale, S. Ley, 2007, Organic & biomolecular chemistry.

A "catch-react-release" method for the flow synthesis of 2-aminopyrimidines and preparation of the Imatinib base.

Richard J Ingham, Steven V Ley, Ian R Baxendale, 2012, Organic letters.

Multi-step synthesis by using modular flow reactors: the preparation of yne--ones and their use in heterocycle synthesis.

Steven V Ley, Ian R Baxendale, S. Ley, 2010, Chemistry.

A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor.

Steven V Ley, Lucia Tamborini, Ian R Baxendale, 2008, Journal of combinatorial chemistry.

The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib.

Steven V Ley, Mark D. Hopkin, Ian R Baxendale, 2013, Organic & biomolecular chemistry.

The oxygen-mediated synthesis of 1,3-butadiynes in continuous flow: using Teflon AF-2400 to effect gas/liquid contact.

Steven V Ley, Anastasios Polyzos, Trond Ulven, 2012, ChemSusChem.

Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds.

Ian R Baxendale, I. Baxendale, D. Ron, 2012, Chemistry.

Continuous flow based catch and release protocol for the synthesis of α-ketoesters

Alessandro Palmieri, Steven V Ley, Anastasios Polyzos, 2009, Beilstein journal of organic chemistry.

An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles

Marcus Baumann, Ian R Baxendale, M. Baumann, 2013, Beilstein journal of organic chemistry.

KMnO(4)-Mediated oxidation as a continuous flow process.

Steven V Ley, Marcus Baumann, Ian R Baxendale, 2010, Organic letters.

Organic synthesis in a changing world.

Steven V Ley, Ian R Baxendale, S. Ley, 2002, Chemical record.

Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assembly.

Daiki Sakai, Steven V Ley, Heiko Lange, 2011, Chemistry.

Continuous flow reaction monitoring using an on-line miniature mass spectrometer.

Steven V Ley, Ian R Baxendale, Duncan L Browne, 2012, Rapid communications in mass spectrometry : RCM.

Non-metal-catalysed intramolecular alkyne cyclotrimerization reactions promoted by focussed microwave heating in batch and flow modes.

Steven V Ley, Ian R Baxendale, S. Ley, 2005, Organic & biomolecular chemistry.

Synthesis of acetal protected building blocks using flow chemistry with flow I.R. analysis: preparation of butane-2,3-diacetal tartrates.

Steven V Ley, Catherine F. Carter, Ian R Baxendale, 2009, Organic & biomolecular chemistry.

Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor.

Steven V Ley, Julia Madrzak, Ian R Baxendale, 2010, Organic & biomolecular chemistry.

Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines.

Steven V Ley, Ian R Baxendale, S. Ley, 2007, Organic & biomolecular chemistry.

Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions.

Steven V Ley, Marcus Baumann, Ian R Baxendale, 2008, Organic & biomolecular chemistry.

Solid-supported reagents for multi-step organic synthesis: preparation and application.

S V Ley, Ian R Baxendale, S. Ley, 2002, Farmaco.

Achieving continuous manufacturing: technologies and approaches for synthesis, workup, and isolation of drug substance. May 20-21, 2014 Continuous Manufacturing Symposium.

Paul Sharratt, Richard D Braatz, Klavs F Jensen, 2015, Journal of pharmaceutical sciences.

Multi-step application of immobilized reagents and scavengers: a total synthesis of epothilone C.

Steven V Ley, Ian R Baxendale, S. Ley, 2004, Chemistry.

Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods.

Steven V Ley, Rainer E. Martin, Rainer E Martin, 2011, ACS combinatorial science.

The application of flow microreactors to the preparation of a family of casein kinase I inhibitors.

Steven V Ley, Ian R Baxendale, S. Ley, 2010, Organic & biomolecular chemistry.

A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures.

Steven V Ley, Marcus Baumann, Ian R Baxendale, 2011, Organic letters.

A flow-based synthesis of imatinib: the API of Gleevec.

Steven V Ley, Mark D. Hopkin, Ian R Baxendale, 2010, Chemical communications.

Multistep synthesis using modular flow reactors: Bestmann-Ohira reagent for the formation of alkynes and triazoles.

Steven V Ley, Ian R Baxendale, S. Ley, 2009, Angewandte Chemie.

Total synthesis of the amaryllidaceae alkaloid (+)-plicamine and its unnatural enantiomer by using solid-supported reagents and scavengers in a multistep sequence of reactions.

Steven V Ley, Ian R Baxendale, S. Ley, 2002, Angewandte Chemie.

The continuous-flow synthesis of carboxylic acids using CO2 in a tube-in-tube gas permeable membrane reactor.

Steven V Ley, Anastasios Polyzos, Ian R Baxendale, 2011, Angewandte Chemie.

An expeditious synthesis of imatinib and analogues utilising flow chemistry methods.

Steven V Ley, Mark D. Hopkin, Ian R Baxendale, 2013, Organic & biomolecular chemistry.

Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor.

Steven V Ley, Ian R Baxendale, S. Ley, 2011, Organic letters.

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles.

Steven V Ley, Heiko Lange, Ian R Baxendale, 2011, Organic & biomolecular chemistry.

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Steven V Ley, Anastasios Polyzos, Heiko Lange, 2011, Beilstein journal of organic chemistry.

Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating.

Steven V Ley, Ian R Baxendale, S. Ley, 2005, Journal of combinatorial chemistry.

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent.

Steven V Ley, Ian R Baxendale, S. Ley, 2011, Organic & biomolecular chemistry.