Katherine R. Singleton

发表

Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy

Jaewoo Kang, Minjae Yoo, Aik Choon Tan, 2014, Bioinform..

Systematic identification of signaling pathways with potential to confer anticancer drug resistance

Donald P. McDonnell, Tim Wang, Jeff S. Jasper, 2014, Science Signaling.

Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence.

Jason W. Locasale, Sayan Mukherjee, Lorin Crawford, 2017, Cell reports.

A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop

Katherine R. Singleton, A. Tan, L. Heasley, 2013, Oncogenesis.

Drug dependence in cancer is exploitable by optimally constructed treatment holidays

Kevin B. Wood, Katherine R. Singleton, K. Wood, 2022, bioRxiv.

An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases

Katherine R. Singleton, A. Jimeno, Jihye Kim, 2015, PloS one.

Fibroblast Growth Factor Receptors Are Components of Autocrine Signaling Networks in Head and Neck Squamous Cell Carcinoma Cells

Katherine R. Singleton, D. Raben, L. Heasley, 2011, Clinical Cancer Research.

Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC.

Katherine R. Singleton, Jihye Kim, A. Tan, 2015, Cancer research.

A Receptor Tyrosine Kinase Network Composed of Fibroblast Growth Factor Receptors, Epidermal Growth Factor Receptor, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, and Hepatocyte Growth Factor Receptor Drives Growth and Survival of Head and Neck Squamous Carcinoma Cell Lines

Katherine R. Singleton, Jihye Kim, A. Tan, 2013, Molecular Pharmacology.

A Receptor Tyrosine Kinase Network Composed of Fibroblast Growth Factor Receptors, Epidermal Growth Factor Receptor, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, and Hepatocyte Growth Factor Receptor Drives Growth and Survival of Head and Neck Squamous Carcinoma Cell Lines s

Katherine R. Singleton, Jihye Kim, A. Tan, 2013 .

Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes

Katherine R. Singleton, K. Wood, K. R. Singleton, 2016, Genes & cancer.

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer

Amy E. Decker, Katherine R. Singleton, Emily T. Winn, 2020, Nature Genetics.

Melanoma Therapeutic St rategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence Graphical

Katherine R. Singleton, Sayan Mukherjee, K. Flaherty, 2017 .

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer

Katherine R. Singleton, Emily T. Winn, Lorin Crawford, 2020, Nature Genetics.

MCB-613 exploits a collateral sensitivity in drug resistant EGFR-mutant non-small cell lung cancer through covalent inhibition of KEAP1

Katherine R. Singleton, K. Wood, G. Robert, 2023, bioRxiv.

Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis

Katherine R. Singleton, Jun O. Liu, J. Locasale, 2019, The Journal of Biological Chemistry.

ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer

Katherine R. Singleton, R. Doebele, Jihye Kim, 2018, Oncotarget.

Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines

Katherine R. Singleton, Jihye Kim, A. Tan, 2019, Molecular Pharmacology.

Cancer Therapy : Preclinical Fibroblast Growth Factor Receptors Are Components of Autocrine Signaling Networks in Head and Neck Squamous Cell Carcinoma Cells

Katherine R. Singleton, D. Raben, L. Heasley, 2011 .

Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC.

Katherine R. Singleton, Jihye Kim, L. Heasley, 2015, Cancer research.