Ralf Pörtner

发表

Model-based strategy for cell culture seed train layout verified at lab scale

Simon Kern, Oscar Platas-Barradas, Ralf Pörtner, 2015, Cytotechnology.

Ringvorlesung „Tissue Engineering – Regenerative Medizin“ WiSe 16/17

Ralf Pörtner, Michael M. Morlock, 2017 .

“BioProzessTrainer” as training tool for design of experiments

Oscar Platas-Barradas, Ralf Pörtner, Janosh Gradkowski, 2011, BMC proceedings.

Future aspects of bioprocess monitoring.

Thomas Becker, Roland Ulber, Ralf Pörtner, 2007, Advances in biochemical engineering/biotechnology.

Digital Twins and Their Role in Model-Assisted Design of Experiments.

Ralf Pörtner, Kim B Kuchemüller, Johannes Möller, 2020, Advances in biochemical engineering/biotechnology.

Bioreactor design for tissue engineering.

Ralf Pörtner, Norbert M Meenen, Stephanie Nagel-Heyer, 2005, Journal of bioscience and bioengineering.

Automation von Bioreaktoren

Volker C. Hass, Ralf Pörtner, 2009 .

Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes

Ralf Pörtner, Dieter Eibl, Matthias Kraume, 2017 .

Model-Based Design of Process Strategies for Cell Culture Bioprocesses

Ralf Pörtner, Johannes Möller, 2018 .

Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes

Ralf Pörtner, Björn Frahm, T. Hernández Rodríguez, 2020 .

Model-based design of the first steps of a seed train for cell culture processes

Simon Kern, Ralf Pörtner, Björn Frahm, 2013, BMC Proceedings.

Efficient Optimization of Process Strategies with Model-Assisted Design of Experiments.

Ralf Pörtner, Kim B Kuchemüller, Johannes Möller, 2020, Methods in molecular biology.

Model-based DoE for feed batch cultivation of a CHO cell line

Ralf Pörtner, Regine Eibl, Dieter Eibl, 2015, BMC Proceedings.

Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method

Claus Weihs, Ralf Pörtner, Björn Frahm, 2019, Biotechnology and bioengineering.

A modular flow-chamber bioreactor concept as a tool for continuous 2D- and 3D-cell culture

Ralf Pörtner, Jörg Müller, Janine Fischer, 2013, BMC Proceedings.

Advanced Process and Control Strategies for Bioreactors

Volker C. Hass, Ralf Pörtner, Björn Frahm, 2017 .

Model-based strategy for cell culture seed train layout verified at lab scale

Simon Kern, Ralf Pörtner, Björn Frahm, 2015, BMC Proceedings.

Expansion of Human Mesenchymal Stem Cells in a Fixed-Bed Bioreactor System Based on Non-Porous Glass Carrier – Part A: Inoculation, Cultivation, and Cell Harvest Procedures

Ralf Pörtner, Christian Weber, Christine Wallrapp, 2010, The International journal of artificial organs.

Seed train optimization for suspension cell culture

Ralf Pörtner, Björn Frahm, Tanja Hernández Rodríguez, 2013, BMC Proceedings.

Bioreactors for Mammalian Cells

Ralf Pörtner, R. Pörtner, 2015 .

„Design of Experiments” mit dem BioProzessTrainer

Volker C. Hass, Ralf Pörtner, F. Kuhnen, 2010 .

Estimation of Process Model Parameters.

Ralf Pörtner, Björn Frahm, Kim B Kuchemüller, 2020, Methods in molecular biology.

Evaluation of a Scalable Disposable Bioreactor System for Manufacturing of Mammalian Cell Based Biopharmaceuticals

Uwe Marx, Marco Riedel, Ralf Pörtner, 2007 .

DoE of fed-batch processes – model-based design and experimental evaluation

Ralf Pörtner, Volker Sandig, An-Ping Zeng, 2011, BMC proceedings.

Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culture

Udo Reichl, Ralf Pörtner, Uwe Jandt, 2011, BMC proceedings.

Model-assisted Design of Experiments as a concept for knowledge-based bioprocess development

Ralf Pörtner, Kim B Kuchemüller, Johannes Möller, 2019, Bioprocess and Biosystems Engineering.

Flexible Fed-Batch Process Control of Animal Cells

Ralf Pörtner, Björn Frahm, 2005 .

Evaluation of selected control strategies for fed‐batch cultures of a hybridoma cell line

Ralf Pörtner, Björn Frahm, Jan-Oliver Schwabe, 2004, Biotechnology and applied biochemistry.

Cell-surface interactions for tissue culture

Ivonne Bartsch, Frank Witte, Ralf Pörtner, 2012 .

Decision tree for selection of suitable cultivation parameters for mammalian cell culture processes

Simon Kern, Ralf Pörtner, Dieter Eibl, 2015, BMC Proceedings.

Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture

Udo Reichl, Thomas Noll, Ralf Pörtner, 2012 .

Long-term cultivation of immortalised mouse hepatocytes in a high cell density, fixed-bed reactor

Ralf Pörtner, D. Fassnacht, S. Rössing, 1998 .

Special Engineering Aspects

Ralf Pörtner, Peter Czermak, P. Czermak, 2009, Cell and Tissue Reaction Engineering.

High density fed-batch cultures for hybridoma cells performed with the aid of a kinetic model

Herbert Märkl, Ralf Pörtner, R. Pörtner, 1996 .

Perfusion cultures and modelling of oxygen uptake with three-dimensional chondrocyte pellets

Ralf Pörtner, Peter Adamietz, Dirk Nehring, 1999 .

Determination of dissolved CO(2) concentration and CO(2) production rate of mammalian cell suspension culture based on off-gas measurement.

Ralf Pörtner, Björn Frahm, Axel Munack, 2002, Journal of biotechnology.

Bioreactor cultivation of three-dimensional cartilage-carrier-constructs

Ralf Pörtner, Stephanie Nagel-Heyer, Christiane Goepfert, 2005, Bioprocess and biosystems engineering.

Cell and Tissue Reaction Engineering

Ralf Pörtner, Regine Eibl, Dieter Eibl, 2008 .

Expansion of Human Mesenchymal Stem Cells in a Fixed-Bed Bioreactor System Based on Non-Porous Glass Carrier – Part B: Modeling and Scale-up of the System

Ralf Pörtner, Christian Weber, Christine Wallrapp, 2010, The International journal of artificial organs.

3D-Bioreactor culture of human hepatoma cell line HepG2 as a promising tool for in vitro substance testing

Ralf Pörtner, Christiane Goepfert, Rolf Janßen, 2011, BMC proceedings.

Bioengineering of a Full-Thickness Skin Equivalent in a 96-Well Insert Format for Substance Permeation Studies and Organ-On-A-Chip Applications

Uwe Marx, Ralf Pörtner, Katharina Schimek, 2018, Bioengineering.

Redifferentiation of chondrocytes and cartilage formation under intermittent hydrostatic pressure

Udo Schumacher, Ralf Pörtner, Eduard Ilinich, 2006, Biotechnology Letters.

Bioreactor Design and Scale-Up

Ralf Pörtner, Regine Eibl, Dieter Eibl, 2009 .

A New Integrated Lab-on-a-Chip System for Fast Dynamic Study of Mammalian Cells under Physiological Conditions in Bioreactor

Ralf Pörtner, An-Ping Zeng, Janina Bahnemann, 2013, Cells.

Batch‐to‐batch variability of two human designer cell lines – AGE1.HN and AGE1.HN.AAT – carried out by different laboratories under defined culture conditions using a mathematical model

Udo Reichl, Thomas Rose, Ralf Pörtner, 2013 .

Effect of NH3 on the cell growth of a hybridoma cell line

Herbert Märkl, Ralf Pörtner, R. Pörtner, 2004, Cytotechnology.

Improvement of the culture stability of non-anchorage-dependent animal cells grown in serum-free media through immobilization

Michael Neumaier, Herbert Märkl, Ralf Pörtner, 1995, Cytotechnology.