Roy J. Vaz

发表

Evaluation of proposed modes of binding of (2S)-2-[4-[[(3S)-1-acetimidoyl-3-pyrrolidinyl]oxy]phenyl]-3-(7-amidino-2-naphthyl)propanoic acid hydrochloride and some analogs to Factor Xa using a comparative molecular field analysis

Larry R. McLean, Roy J. Vaz, John T. Pelton, 1998, J. Comput. Aided Mol. Des..

Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches.

Roy J. Vaz, M. Preobrazhenskaya, R. Pearlstein, 2003, Bioorganic & medicinal chemistry letters.

The challenges of in silico contributions to drug metabolism in lead optimization

Roy J. Vaz, G. Cruciani, I. Zamora, 2010, Expert opinion on drug metabolism & toxicology.

Antitargets : prediction and prevention of drug side effects

Roy J. Vaz, T. Klabunde, Thomas Klabunde, 2008 .

Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic

Roy J. Vaz, D. R. Compton, Jiesheng Kang, 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

Human ether-a-go-go related gene (HERG): a chemist's perspective.

Roy J Vaz, Roy J. Vaz, D. Rampe, 2005, Progress in medicinal chemistry.

Predictive models for hERG potassium channel blockers.

Gabriele Cruciani, Roy J Vaz, Arnaldo Fravolini, 2005, Bioorganic & medicinal chemistry letters.

Structure-based design, synthesis, and profiling of a β-tryptase inhibitor with a spiro-piperidineamide scaffold, benzylamine P1 group, and a substituted indole P4 group

Roy J. Vaz, Xin Chen, Qingping Wang, 2011 .

A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR.

Gabriele Cruciani, Meng Zhang, Roy J Vaz, 2005, Journal of medicinal chemistry.

Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.

Yi Li, Stephan Reiling, Ying Zhang, 2009, Bioorganic & Medicinal Chemistry Letters.

Molecular Interaction Fields in ADME and Safety

Yi Li, Meng Zhang, Roy J. Vaz, 2006 .

Use of Electron Densities in Comparative Molecular Field Analysis (CoMFA): A Quantitative Structure Activity Relationship (QSAR) for Electronic Effects of Groups

Roy J. Vaz, 1997 .

Use of CoMFA in validating the conformation used in designing 4-(1H-benzimidazole-2-carbonyl)piperidines with H1/NK1 receptor antagonist activity

Roy J. Vaz, John M. Kane, J. Kane, 1997 .

A crowdsourcing evaluation of the NIH chemical probes.

Tudor I. Oprea, Scott Boyer, Herbert Waldmann, 2009, Nature chemical biology.

Erratum: A crowdsourcing evaluation of the NIH chemical probes

Yvonne C. Martin, Roy J. Vaz, R. Glen, 2009 .

Fingerprints, Facial Recognition and Cancer

Roy J. Vaz, 2016 .

Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site.

Roy J. Vaz, Yi Li, L. McLean, 2010, Bioorganic & medicinal chemistry letters.

Fingerprints, Facial Recognition and Cancer

Roy J. Vaz, 2016 .

Amelioration of mechanism-based inactivation of CYP3A4 by a H-PGDS inhibitor.

Roy J. Vaz, Yi Li, M. Munson, 2018, Bioorganic & medicinal chemistry letters.

5 Drug-Induced Liver Injury : Clinical and Diagnostic Aspects

Roy J. Vaz, L. Urban, J. Senior, 2015 .

Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human β-tryptase

Roy J. Vaz, Xin Chen, F. Liu, 2004 .

Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists.

J. Y. Roberge, Roy J. Vaz, R. Seethala, 2005, Bioorganic & medicinal chemistry letters.

Metallocenes for polypropylene: Polymerization performance and computer modeling

Roy J. Vaz, T. Burkhardt, M. Murata, 1995 .

Hydroxyoxazolidines as α-aminoacetaldehyde equivalents: Novel inhibitors of calpain

Roy J. Vaz, N. Peet, D. Friedrich, 1999 .

The synthesis of aminobenzazepinones as anti-phenylalanine dipeptide mimics and their use in nep inhibition

Roy J. Vaz, A. Warshawsky, G. Flynn, 1996 .

The synthesis of ketomethylene pseudopeptide analogues of dipeptide aldehyde inhibitors of calpain.

Roy J. Vaz, N. Peet, P. Bey, 1999, Bioorganic & medicinal chemistry letters.

On the mechanism of microsomal prostaglandin E synthase type-2--a theoretical study of endoperoxide reaction with MeS(-).

Roy J. Vaz, Yi Li, S. Reiling, 2010, Bioorganic & medicinal chemistry letters.

Effects of MTX-23, a Novel PROTAC of Androgen Receptor Splice Variant-7 and Androgen Receptor, on CRPC Resistant to Second-Line Antiandrogen Therapy

Roy J. Vaz, G. Cruciani, Wun-Jae Kim, 2020, Molecular Cancer Therapeutics.

Fingerprints, Facial Recognition and Cancer

Roy J Vaz, Roy J. Vaz, 2016 .

Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity.

Benjamin C. Tang, Roy J. Vaz, Nick A. Paras, 2020, ACS medicinal chemistry letters.

A conformationally constrained inhibitor with an enhanced potency for β-tryptase and stability against semicarbazide-sensitive amine oxidase (SSAO).

Roy J. Vaz, Xin Chen, Qingping Wang, 2010, Bioorganic & medicinal chemistry letters.

Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures.

Roy J. Vaz, Yi Li, L. McLean, 2010, Bioorganic & medicinal chemistry letters.

Selectivity in the Addition of Electron Deficient Radicals to the C2 Position of Indoles.

Roy J. Vaz, S. Olson, N. Paras, 2020, European journal of organic chemistry.

Identification of optimum computational protocols for modeling the aryl hydrocarbon receptor (AHR) and its interaction with ligands.

Roy J Vaz, Stephan Reiling, Roy J. Vaz, 2010, Bioorganic & medicinal chemistry letters.

Novel steroidal vinyl fluorides as inhibitors of steroid C17(20) lyase.

Roy J. Vaz, N. Peet, D. Friedrich, 2002, Bioorganic & medicinal chemistry.

Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic

Roy J. Vaz, D. R. Compton, Jiesheng Kang, 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

Structure-based design, synthesis, and profiling of potent and selective neuronal nitric oxide synthase (nNOS) inhibitors with an amidinothiophene hydroxypiperidine scaffold

Roy J. Vaz, I. Morize, Xin Chen, 2011 .

Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K+ channel.

Roy J Vaz, Roy J. Vaz, Jiesheng Kang, 2017, Bioorganic & medicinal chemistry letters.

Cardiac Side Effects Associated with Kinase Proteins and Their Signaling Pathways

Roy J. Vaz, V. Patel, 2015 .

Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulators.

Roy J. Vaz, Hong Shen, T. Kuntzweiler, 2018, Bioorganic & medicinal chemistry letters.

Hydroxyoxazolidines as alpha-aminoacetaldehye equivalents: novel inhibitors of calpain.

Roy J. Vaz, N. Peet, D. Friedrich, 1999, Bioorganic & Medicinal Chemistry Letters.

Understanding DP receptor antagonism using a CoMSIA approach.

Roy J. Vaz, I. Morize, R. Marcus, 2011, Bioorganic & medicinal chemistry letters.

A QSPR for the Tg of polymers: The Koehler‐Hopfinger approach using the tripos 5.2 force field

Roy J. Vaz, 1993 .

Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.

Roy J. Vaz, Yi Li, S. Reiling, 2009, Bioorganic & medicinal chemistry letters.

Derives d'acide propane phosphinique substitues

Roy J. Vaz, Y. M. Choi-Sledeski, G. Poli, 2005 .