Matts Kågedal

Extension of the simplified reference tissue model, to allow different non-specific concentrations in the brain region of interest and the reference region. Application to PET with the radioligand [11C]AZ10419369 displaced by AZD3783 at the serotonin 5HT1B receptor.

Andrew C. Hooker, Mats O. Karlsson, Matts Kågedal, 2014 .

Non-linear mixed effects modelling of positron emission tomography data for simultaneous estimation of radioligand kinetics and occupancy in healthy volunteers

Andrew C. Hooker, Siv Jönsson, Mats O. Karlsson, 2012, NeuroImage.

A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066 — Estimating occupancy in the absence of a reference region

Andrew C. Hooker, Christer Halldin, Mats O. Karlsson, 2013, NeuroImage.

Improved precision of exposure–response relationships by optimal dose-selection. Examples from studies of receptor occupancy using PET and dose finding for neuropathic pain treatment

Andrew C. Hooker, Mats O. Karlsson, Matts Kågedal, 2015, Journal of Pharmacokinetics and Pharmacodynamics.

Modelling a Spontaneously Reported Side Effect by Use of a Markov Mixed-Effects Model

Matts Kågedal, Mats O Karlsson, M. Karlsson, 2005, Journal of Pharmacokinetics and Pharmacodynamics.