A. J. Roman

发表

J. K. Nwude, A. J. Roman, 1973 .

Energy conservation systems analysis - food processing industry: Campbell Soup Co. Plant No. 2

B. B. Hamel, H. L. Brown, J. K. Nwude, 1975 .

Parametric study of prospective early commercial MHD power plants (PSPEC). General Electric Company, task 1: Parametric analysis

D. A. Rogers, C. H. Marston, D. J. Bender, 1980 .

Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year.

A. J. Roman, W. Hauswirth, T. Aleman, 2009, Human gene therapy.

Effect of an intravitreal antisense oligonucleotide on vision in Leber congenital amaurosis due to a photoreceptor cilium defect

A. J. Roman, Ian C. Han, A. Cideciyan, 2018, Nature Medicine.

TULP1 mutations causing early-onset retinal degeneration: preserved but insensitive macular cones.

A. J. Roman, A. Cideciyan, S. Schwartz, 2014, Investigative ophthalmology & visual science.

Treatment Potential for Macular Cone Vision in Leber Congenital Amaurosis Due to CEP290 or NPHP5 Mutations: Predictions From Artificial Intelligence

Alexander Sumaroka, Artur V. Cideciyan, Rebecca Sheplock, 2019, Investigative ophthalmology & visual science.

Pseudo-fovea formation after gene therapy for RPE65-LCA.

Omar H. Butt, A. J. Roman, W. Hauswirth, 2014, Investigative ophthalmology & visual science.

Intravitreal antisense oligonucleotide sepofarsen in Leber congenital amaurosis type 10: a phase 1b/2 trial

A. J. Roman, Ian C. Han, A. Cideciyan, 2022, Nature Medicine.

Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations.

A. J. Roman, T. Aleman, S. Kaushal, 2008, Investigative ophthalmology & visual science.

Retina Intervisit Variability of Visual Parameters in Leber Congenital Amaurosis Caused by RPE 65 Mutations

A. J. Roman, A. Cideciyan, S. Schwartz, 2013 .

Normal central retinal function and structure preserved in retinitis pigmentosa.

A. J. Roman, T. Aleman, A. Cideciyan, 2010, Investigative ophthalmology & visual science.

Automated Light- and Dark-Adapted Perimetry for Evaluating Retinitis Pigmentosa: Filling a Need to Accommodate Multicenter Clinical Trials.

A. V. Cideciyan, A. J. Roman, A. Cideciyan, 2016, Investigative ophthalmology & visual science.

Durable vision improvement after a single treatment with antisense oligonucleotide sepofarsen: a case report

A. J. Roman, A. Cideciyan, S. Jacobson, 2021, Nature Medicine.

Reading Performance in Blue Cone Monochromacy: Defining an Outcome Measure for a Clinical Trial

A. J. Roman, A. Cideciyan, S. Jacobson, 2020, Translational Vision Science & Technology.

Developing an Outcome Measure With High Luminance for Optogenetics Treatment of Severe Retinal Degenerations and for Gene Therapy of Cone Diseases

A. J. Roman, S. Nirenberg, A. Cideciyan, 2016, Investigative ophthalmology & visual science.

Mobility test to assess functional vision in dark-adapted patients with Leber congenital amaurosis

A. J. Roman, A. Cideciyan, S. Jacobson, 2022, BMC Ophthalmology.

Pupillary Light Reflexes in Severe Photoreceptor Blindness Isolate the Melanopic Component of Intrinsically Photosensitive Retinal Ganglion Cells

A. J. Roman, A. Cideciyan, S. Jacobson, 2017, Investigative ophthalmology & visual science.

Night vision restored in days after decades of congenital blindness

A. J. Roman, A. Cideciyan, S. Boye, 2022, iScience.

EYS Mutations Causing Autosomal Recessive Retinitis Pigmentosa: Changes of Retinal Structure and Function with Disease Progression

A. J. Roman, A. Cideciyan, S. Jacobson, 2017, Genes.

Intravitreal Sepofarsen for Leber Congenital Amaurosis Type 10 (LCA10)

A. J. Roman, Ian C. Han, A. Cideciyan, 2020 .

Late-onset retinal degeneration caused by C1QTNF5 mutation: sub-retinal pigment epithelium deposits and visual consequences.

A. J. Roman, A. Cideciyan, S. Jacobson, 2014, JAMA ophthalmology.

Blue Cone Monochromacy: Visual Function and Efficacy Outcome Measures for Clinical Trials

A. V. Cideciyan, A. J. Roman, A. Cideciyan, 2015, PloS one.

Molecular anthropology meets genetic medicine to treat blindness in the North African Jewish population: human gene therapy initiated in Israel.

A. V. Cideciyan, A. J. Roman, W. Hauswirth, 2010, Human gene therapy.

Color Vision in Blue Cone Monochromacy: Outcome Measures for a Clinical Trial

A. V. Cideciyan, A. J. Roman, A. Cideciyan, 2023, Translational vision science & technology.

Lifespan and mitochondrial control of neurodegeneration

A. V. Cideciyan, A. J. Roman, A. Cideciyan, 2004, Nature Genetics.

Retina Automated Light-and Dark-Adapted Perimetry for Evaluating Retinitis Pigmentosa : Filling a Need to Accommodate Multicenter Clinical Trials

A. V. Cideciyan, A. J. Roman, A. Cideciyan, 2016 .

Postretinal Structure and Function in Severe Congenital Photoreceptor Blindness Caused by Mutations in the GUCY2D Gene

Omar H. Butt, A. V. Cideciyan, A. J. Roman, 2017, Investigative ophthalmology & visual science.

Childhood-onset genetic cone-rod photoreceptor diseases and underlying pathobiology.

A. V. Cideciyan, A. J. Roman, A. Cideciyan, 2021, EBioMedicine.

Short-Wavelength Sensitive Cone (S-cone) Testing as an Outcome Measure for NR2E3 Clinical Treatment Trials

A. V. Cideciyan, A. J. Roman, A. Cideciyan, 2019, International journal of molecular sciences.

Defective photoreceptor phagocytosis in a mouse model of enhanced S‐cone syndrome causes progressive retinal degeneration

A. V. Cideciyan, A. J. Roman, M. Adams, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Nuclear receptor NR2E3 gene mutations distort human retinal laminar architecture and cause an unusual degeneration.

Edwin M Stone, Val C Sheffield, Alexander Sumaroka, 2004, Human molecular genetics.

Probing Mechanisms of Photoreceptor Degeneration in a New Mouse Model of the Common Form of Autosomal Dominant Retinitis Pigmentosa due to P23H Opsin Mutations*♦

A. J. Roman, A. Cideciyan, S. Jacobson, 2011, The Journal of Biological Chemistry.

Electroretinographic analyses of Rpe65-mutant rd12 mice: developing an in vivo bioassay for human gene therapy trials of Leber congenital amaurosis.

A. J. Roman, W. Hauswirth, T. Aleman, 2007, Molecular vision.

Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis.

A. J. Roman, W. Hauswirth, T. Aleman, 2006, Human gene therapy.

Genetics and Disease Expression in the CNGA3 Form of Achromatopsia: Steps on the Path to Gene Therapy.

A. J. Roman, A. Cideciyan, S. Schwartz, 2015, Ophthalmology.

Improvement and decline in vision with gene therapy in childhood blindness.

A. J. Roman, W. Hauswirth, A. Cideciyan, 2015, The New England journal of medicine.

Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement

Alexander Sumaroka, Artur V. Cideciyan, Samuel G. Jacobson, 2013, Proceedings of the National Academy of Sciences.

Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years.

William J Feuer, Edwin M Stone, Alexander Sumaroka, 2012, Archives of ophthalmology.

Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

Edwin M Stone, Terence R Flotte, Alexander Sumaroka, 2008, Proceedings of the National Academy of Sciences.

Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection.

A. J. Roman, W. Hauswirth, T. Aleman, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

RDH12 and RPE65, visual cycle genes causing leber congenital amaurosis, differ in disease expression.

A. J. Roman, T. Aleman, A. Cideciyan, 2007, Investigative ophthalmology & visual science.

Human cone photoreceptor dependence on RPE65 isomerase

A. J. Roman, T. Aleman, A. Cideciyan, 2007, Proceedings of the National Academy of Sciences.

Variegated yet non-random rod and cone photoreceptor disease patterns in RPGR-ORF15-associated retinal degeneration.

A. J. Roman, A. Cideciyan, S. Schwartz, 2016, Human molecular genetics.

ABCA4 disease progression and a proposed strategy for gene therapy.

A. J. Roman, T. Aleman, A. Cideciyan, 2009, Human molecular genetics.

Vision 1 year after gene therapy for Leber's congenital amaurosis.

Alexander Sumaroka, A. J. Roman, W. Hauswirth, 2009, The New England journal of medicine.

Retinal disease expression in Bardet-Biedl syndrome-1 (BBS1) is a spectrum from maculopathy to retina-wide degeneration.

A. J. Roman, V. Sheffield, T. Aleman, 2006, Investigative ophthalmology & visual science.

Determining consequences of retinal membrane guanylyl cyclase (RetGC1) deficiency in human Leber congenital amaurosis en route to therapy: residual cone-photoreceptor vision correlates with biochemical properties of the mutants.

A. J. Roman, A. Cideciyan, S. Schwartz, 2013, Human molecular genetics.

Defining Outcomes for Clinical Trials of Leber Congenital Amaurosis Caused by GUCY2D Mutations.

A. J. Roman, A. Cideciyan, S. Schwartz, 2017, American journal of ophthalmology.

A BSTRACT PURPOSE : To determine outcome measures for a clinical trial of Leber congenital amaurosis ( LCA ) associated with mutations in the GUCY 2 D gene

A. J. Roman, A. Cideciyan, S. Schwartz, 2017 .

Inner retinal abnormalities in X-linked retinitis pigmentosa with RPGR mutations.

A. J. Roman, T. Aleman, A. Cideciyan, 2007, Investigative ophthalmology & visual science.

Remodeling of the human retina in choroideremia: rab escort protein 1 (REP-1) mutations.

A. J. Roman, T. Aleman, A. Cideciyan, 2006, Investigative ophthalmology & visual science.

Relatively enhanced S cone function in the Goldmann-Favre syndrome.

A. J. Roman, S. Jacobson, J. Parker, 1991, American journal of ophthalmology.

Enhanced S cone syndrome: Evidence for an abnormally large number of S cones

A. J. Roman, A. Cideciyan, S. Jacobson, 1995, Vision Research.

S cone-driven but not S cone-type electroretinograms in the enhanced S cone syndrome.

A. J. Roman, S. Jacobson, 1991, Experimental eye research.

Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa

Hemant Khanna, Alexander Sumaroka, Artur V. Cideciyan, 2012, Proceedings of the National Academy of Sciences.

Measures of Function and Structure to Determine Phenotypic Features, Natural History, and Treatment Outcomes in Inherited Retinal Diseases.

A. J. Roman, A. Cideciyan, S. Jacobson, 2021, Annual review of vision science.

Rod function deficit in retained photoreceptors of patients with class B Rhodopsin mutations

A. J. Roman, A. Cideciyan, S. Jacobson, 2020, Scientific Reports.

Complexity of the Class B Phenotype in Autosomal Dominant Retinitis Pigmentosa Due to Rhodopsin Mutations

A. J. Roman, T. Aleman, A. Cideciyan, 2016, Investigative ophthalmology & visual science.

Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism.

A. J. Roman, K. Steel, T. Aleman, 2008, Human molecular genetics.

Usher syndromes due to MYO 7 A , PCDH 15 , USH 2 A or GPR 98 mutations share retinal disease mechanism

A. J. Roman, K. Steel, T. Aleman, 2008 .

Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype.

A. J. Roman, T. Aleman, A. Cideciyan, 2005, Investigative ophthalmology & visual science.

Human CRB1-associated retinal degeneration: comparison with the rd8 Crb1-mutant mouse model.

A. J. Roman, T. Aleman, A. Cideciyan, 2011, Investigative ophthalmology & visual science.

Retinal disease course in Usher syndrome 1B due to MYO7A mutations.

A. J. Roman, T. Aleman, A. Cideciyan, 2011, Investigative ophthalmology & visual science.

Variegated yet non-random rod and cone photoreceptor disease patterns in RPGR-ORF15-associated retinal degeneration.

A. J. Roman, A. Cideciyan, S. Schwartz, 2018, Human molecular genetics.

Progression in X-linked Retinitis Pigmentosa Due to ORF15-RPGR Mutations: Assessment of Localized Vision Changes Over 2 Years.

A. J. Roman, A. Cideciyan, S. Jacobson, 2018, Investigative ophthalmology & visual science.

Retina Progression in X-linked Retinitis Pigmentosa Due to ORF 15-RPGR Mutations : Assessment of Localized Vision Changes Over 2 Years

A. J. Roman, A. Cideciyan, S. Jacobson, 2018 .

RPGR-associated retinal degeneration in human X-linked RP and a murine model.

A. J. Roman, A. Cideciyan, S. Schwartz, 2012, Investigative ophthalmology & visual science.

X-linked retinitis pigmentosa: functional phenotype of an RP2 genotype.

A. J. Roman, A. Cideciyan, S. Jacobson, 1992, Investigative ophthalmology & visual science.

Blue Cone Monochromacy Caused by the C203R Missense Mutation or Large Deletion Mutations.

A. J. Roman, A. Cideciyan, S. Jacobson, 2018, Investigative ophthalmology & visual science.

Abnormal rod dark adaptation in autosomal dominant retinitis pigmentosa with proline-23-histidine rhodopsin mutation.

A. J. Roman, C. M. Kemp, J. Nathans, 1992, American journal of ophthalmology.

Autosomal dominant retinitis pigmentosa in a large family: a clinical and molecular genetic study.

A. J. Roman, J. Nathans, P. Weissbrod, 1994, Investigative ophthalmology & visual science.

Retina Blue Cone Monochromacy Caused by the C 203 R Missense Mutation or Large Deletion Mutations

A. J. Roman, A. Cideciyan, S. Jacobson, 2018 .

Full-field stimulus testing: Role in the clinic and as an outcome measure in clinical trials of severe childhood retinal disease

A. J. Roman, A. Cideciyan, S. Jacobson, 2021, Progress in Retinal and Eye Research.

A Novel ARL3 Gene Mutation Associated With Autosomal Dominant Retinal Degeneration

A. J. Roman, A. Cideciyan, S. Jacobson, 2021, Frontiers in Cell and Developmental Biology.

Quantifying rod photoreceptor-mediated vision in retinal degenerations: dark-adapted thresholds as outcome measures.

A. J. Roman, T. Aleman, A. Cideciyan, 2005, Experimental eye research.

Molecular Heterogeneity Within the Clinical Diagnosis of Pericentral Retinal Degeneration.

A. J. Roman, A. Cideciyan, S. Schwartz, 2015, Investigative ophthalmology & visual science.

Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290) blindness: generation of an all-cone Nphp6 hypomorph mouse that mimics the human retinal ciliopathy.

A. J. Roman, T. Aleman, A. Cideciyan, 2011, Human molecular genetics.

Efficacy Outcome Measures for Clinical Trials of USH2A Caused by the Common c.2299delG Mutation.

A. J. Roman, A. Cideciyan, S. Jacobson, 2018, American journal of ophthalmology.

Full-field stimulus testing (FST) to quantify visual perception in severely blind candidates for treatment trials

A. J. Roman, T. Aleman, A. Cideciyan, 2007, Physiological measurement.

CERKL mutations cause an autosomal recessive cone-rod dystrophy with inner retinopathy.

A. J. Roman, T. Aleman, A. Cideciyan, 2009, Investigative ophthalmology & visual science.

Human retinal disease from AIPL1 gene mutations: foveal cone loss with minimal macular photoreceptors and rod function remaining.

A. J. Roman, T. Aleman, A. Cideciyan, 2011, Investigative ophthalmology & visual science.

Inner and outer retinal changes in retinal degenerations associated with ABCA4 mutations.

A. J. Roman, A. Cideciyan, S. Schwartz, 2014, Investigative ophthalmology & visual science.

Cone Vision Changes in the Enhanced S-Cone Syndrome Caused by NR2E3 Gene Mutations.

A. J. Roman, A. Cideciyan, S. Jacobson, 2018, Investigative ophthalmology & visual science.

Canine and Human Visual Cortex Intact and Responsive Despite Early Retinal Blindness from RPE65 Mutation

Marc Korczykowski, James C Gee, David H Brainard, 2007, PLoS medicine.

Effect of an intravitreal antisense oligonucleotide on vision in Leber congenital amaurosis due to a photoreceptor cilium defect

A. J. Roman, Ian C. Han, A. Cideciyan, 2018, Nature Medicine.

Retina Cone Vision Changes in the Enhanced SCone Syndrome Caused by NR 2 E 3 Gene Mutations

A. J. Roman, A. Cideciyan, S. Jacobson, 2018 .

Macular Rod Function in Retinitis Pigmentosa Measured With Scotopic Microperimetry

A. J. Roman, A. Cideciyan, S. Jacobson, 2021, Translational vision science & technology.

Outcome measure for the treatment of cone photoreceptor diseases: orientation to a scene with cone-only contrast

A. J. Roman, A. Cideciyan, S. Schwartz, 2015, BMC Ophthalmology.

Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations.

A. J. Roman, T. Aleman, A. Cideciyan, 2009, Investigative ophthalmology & visual science.

Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept.

A. J. Roman, W. Hauswirth, T. Aleman, 2012, Human gene therapy.

Improvement in vision: a new goal for treatment of hereditary retinal degenerations

A. J. Roman, W. Hauswirth, A. Cideciyan, 2015, Expert opinion on orphan drugs.

Retinal disease in Rpe65-deficient mice: comparison to human leber congenital amaurosis due to RPE65 mutations.

A. J. Roman, W. Hauswirth, T. Aleman, 2010, Investigative ophthalmology & visual science.

Defining the residual vision in leber congenital amaurosis caused by RPE65 mutations.

Edwin M Stone, Alexander Sumaroka, A. J. Roman, 2009, Investigative ophthalmology & visual science.

Safety and improved efficacy signals following gene therapy in childhood blindness caused by GUCY2D mutations

A. J. Roman, A. Cideciyan, S. Boye, 2021, iScience.

Retinal Disease in Rpe 65-Deficient Mice : Comparison to Human Leber Congenital Amaurosis Due to RPE 65 Mutations

A. J. Roman, W. Hauswirth, T. Aleman, 2010 .

Retina Pupillary Light Reflexes in Severe Photoreceptor Blindness Isolate the Melanopic Component of Intrinsically Photosensitive Retinal Ganglion Cells

A. J. Roman, A. Cideciyan, S. Jacobson, 2017 .

Transient pupillary light reflex in CEP290- or NPHP5-associated Leber congenital amaurosis: Latency as a potential outcome measure of cone function

A. J. Roman, A. Cideciyan, S. Jacobson, 2020, Vision Research.

Outcome Measures for Clinical Trials of Leber Congenital Amaurosis Caused by the Intronic Mutation in the CEP290 Gene.

A. J. Roman, A. Cideciyan, S. Schwartz, 2017, Investigative ophthalmology & visual science.

Intervisit variability of visual parameters in Leber congenital amaurosis caused by RPE65 mutations.

A. J. Roman, A. Cideciyan, S. Schwartz, 2013, Investigative ophthalmology & visual science.

Retina Outcome Measures for Clinical Trials of Leber Congenital Amaurosis Caused by the Intronic Mutation in the CEP 290 Gene

A. J. Roman, A. Cideciyan, S. Schwartz, 2017 .

Leber congenital amaurosis caused by an RPGRIP1 mutation shows treatment potential.

A. J. Roman, T. Aleman, A. Cideciyan, 2007, Ophthalmology (Rochester, Minn.).

Interocular asymmetry of visual function in heterozygotes of X-linked retinitis pigmentosa.

A. J. Roman, S. Jacobson, K. Yagasaki, 1989, Experimental eye research.

Durable vision improvement after a single intravitreal treatment with antisense oligonucleotide in CEP290-LCA: Replication in two eyes

A. J. Roman, A. Cideciyan, S. Jacobson, 2023, American journal of ophthalmology case reports.

Retina Pseudo-Fovea Formation After Gene Therapy for RPE 65-LCA

Omar H. Butt, A. J. Roman, W. Hauswirth, 2015 .

Retinal disease in Usher syndrome III caused by mutations in the clarin-1 gene.

A. J. Roman, T. Aleman, A. Cideciyan, 2008, Investigative ophthalmology & visual science.

Natural History of Cone Disease in the Murine Model of Leber Congenital Amaurosis Due to CEP290 Mutation: Determining the Timing and Expectation of Therapy

A. J. Roman, W. Hauswirth, A. Cideciyan, 2014, PloS one.

Leber Congenital Amaurosis Due to GUCY2D Mutations: Longitudinal Analysis of Retinal Structure and Visual Function

A. J. Roman, A. Cideciyan, S. Jacobson, 2021, International Journal of Molecular Sciences.

Improvement and decline in vision with gene therapy in childhood blindness.

A. J. Roman, W. Hauswirth, A. Cideciyan, 2015, The New England journal of medicine.

CERKL mutations cause an autosomal recessive cone-rod dystrophy with inner retinopathy.

A. J. Roman, T. Aleman, A. Cideciyan, 2009, Investigative ophthalmology & visual science.

Late-onset retinal degeneration caused by C1QTNF5 mutation: sub-retinal pigment epithelium deposits and visual consequences.

A. J. Roman, A. Cideciyan, S. Jacobson, 2014, JAMA ophthalmology.

Retinal disease course in Usher syndrome 1B due to MYO7A mutations.

A. J. Roman, T. Aleman, A. Cideciyan, 2011, Investigative ophthalmology & visual science.

Defining the residual vision in leber congenital amaurosis caused by RPE65 mutations.

A. J. Roman, T. Aleman, A. Cideciyan, 2009, Investigative ophthalmology & visual science.

Restoration of Cone Sensitivity to Individuals with Congenital Photoreceptor Blindness within the Phase 1/2 Sepofarsen Trial

A. J. Roman, A. Cideciyan, S. Jacobson, 2022, Ophthalmology science.

Outcome Measures for Clinical Trials of Leber Congenital Amaurosis Caused by the Intronic Mutation in the CEP290 Gene.

A. J. Roman, A. Cideciyan, S. Schwartz, 2017, Investigative ophthalmology & visual science.