J. Christopher Fromme

发表

Decision letter: The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation

Cong Ma, J. Christopher Fromme, 2020 .

X-Ray Diffraction data from Sec7 (T. terrestris) DCB/HUS domain, source of 5HAS structure

J. Christopher Fromme, Brian C. Richardson, 2016 .

Structure of a trapped endonuclease III–DNA covalent intermediate

J. Christopher Fromme, G. Verdine, 2003, The EMBO journal.

GTPase cross talk regulates TRAPPII activation of Rab11 homologues during vesicle biogenesis

J. Christopher Fromme, Laura L Thomas, 2016, The Journal of cell biology.

Surpassing the physical Nyquist limit to produce super-resolution cryo-EM reconstructions

J. Christopher Fromme, J. Feathers, K. Spoth, 2019, bioRxiv.

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle

J. Christopher Fromme, N. Kelleher, P. Thomas, 2020, Nature Communications.

The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast.

J. Christopher Fromme, R. Schekman, Robyn M. Barfield, 2009, Molecular biology of the cell.

Capturing endosomal vesicles at the Golgi

J. Christopher Fromme, M. Munson, 2017, Nature Cell Biology.

Structural basis for activation of Arf1 at the Golgi complex

J. Christopher Fromme, A. Muccini, M. Gustafson, 2022, bioRxiv.

Structure of a TRAPPII-Rab11 activation intermediate reveals GTPase substrate selection mechanisms.

J. Christopher Fromme, S. Bagde, 2022, Science advances.

Distinct N-terminal regions of the exomer secretory vesicle cargo Chs3 regulate its trafficking itinerary

J. Christopher Fromme, A. M. Weiskoff, 2014, Front. Cell Dev. Biol..

Structural basis for the initiation of COPII vesicle biogenesis

J. Christopher Fromme, A. Joiner, 2020, bioRxiv.

Structure and mechanism of TRAPPIII-mediated Rab1 activation

Ethan J. Sanford, J. Christopher Fromme, Haiyuan Yu, 2020, bioRxiv.

COPII-coated vesicles: flexible enough for large cargo?

J. Christopher Fromme, R. Schekman, 2005, Current opinion in cell biology.

Structure of human cytidine deaminase bound to a potent inhibitor.

Sang J. Chung, J. Christopher Fromme, G. Verdine, 2005, Journal of medicinal chemistry.

The HUS box is required for allosteric regulation of the Sec7 Arf-GEF

J. Christopher Fromme, S. Halaby, Steve L. Halaby, 2018, The Journal of Biological Chemistry.

Extensive GTPase crosstalk regulates Golgi trafficking and maturation.

J. Christopher Fromme, Laura L Thomas, 2020, Current opinion in cell biology.

Analysis of Arf1 GTPase-Dependent Membrane Binding and Remodeling Using the Exomer Secretory Vesicle Cargo Adaptor.

J. Christopher Fromme, J. Paczkowski, 2016, Methods in molecular biology.

Activity-based directed evolution of a membrane editor in mammalian cells

J. Christopher Fromme, Jeremy M. Baskin, S. Bagde, 2022, bioRxiv.

Arf1 directly recruits the Pik1-Frq1 PI4K complex to regulate the final stages of Golgi maturation

J. Christopher Fromme, Carolyn M Highland, Carolyn M. Highland, 2021, Molecular biology of the cell.

Arf1 orchestrates Rab GTPase conversion at the trans-Golgi network

J. Christopher Fromme, Laura L Thomas, Carolyn M Highland, 2021, Molecular biology of the cell.

Membrane Trafficking: Licensing a Cargo Receptor for ER Export

J. Christopher Fromme, 2015, Current Biology.

DNA glycosylase recognition and catalysis.

J. Christopher Fromme, G. Verdine, A. Banerjee, 2004, Current opinion in structural biology.

The exomer cargo adaptor features a flexible hinge domain.

J. Christopher Fromme, B. Richardson, 2013, Structure.

Structures of core eukaryotic protein complexes

J. Christopher Fromme, S. Keeney, S. Biggins, 2021, bioRxiv.

Product-assisted catalysis in base-excision DNA repair

J. Christopher Fromme, M. Karplus, Wei Yang, 2003, Nature Structural Biology.

Base excision repair.

J. Christopher Fromme, G. Verdine, 2004, Advances in protein chemistry.

Regulation of Arf activation occurs via distinct mechanisms at early and late Golgi compartments

J. Christopher Fromme, M. Gustafson, 2017, Molecular biology of the cell.

Four GTPases differentially regulate the Sec7 Arf-GEF to direct traffic at the trans-golgi network.

J. Christopher Fromme, Caitlin M McDonold, 2014, Developmental cell.

Experimental evaluation of super-resolution imaging and magnification choice in single-particle cryo-EM

J. Christopher Fromme, J. Feathers, K. Spoth, 2021, Journal of structural biology: X.

The genetic basis of a craniofacial disease provides insight into COPII coat assembly.

J. Christopher Fromme, R. Schekman, L. Orci, 2007, Developmental cell.

Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking

J. Christopher Fromme, R. Schekman, L. Orci, 2006, Nature Genetics.

Coordination of COPII vesicle trafficking by Sec23.

Randy Schekman, J. Christopher Fromme, R. Schekman, 2008, Trends in cell biology.

The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase

J. Christopher Fromme, B. Richardson, M. Gustafson, 2016, eLife.

Structure of the RhlR-PqsE complex from Pseudomonas aeruginosa reveals mechanistic insights into quorum-sensing gene regulation.

J. Christopher Fromme, J. Feathers, J. Paczkowski, 2022, Structure.

Structure of a TRAPPII-Rab11 activation intermediate reveals GTPase substrate selection mechanisms

J. Christopher Fromme, S. Bagde, 2021, bioRxiv.

Structural basis of TRAPPIII‐mediated Rab1 activation

Ethan J. Sanford, J. Christopher Fromme, Haiyuan Yu, 2021, The EMBO journal.

Structural basis for the initiation of COPII vesicle biogenesis.

J. Christopher Fromme, A. Joiner, 2021, Structure.

Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase

J. Christopher Fromme, G. Verdine, A. Banerjee, 2004, Nature.

In‐depth and 3‐dimensional exploration of the budding yeast phosphoproteome

Ethan J. Sanford, J. Christopher Fromme, Haiyuan Yu, 2021, EMBO reports.

The TRAPPIII complex activates the GTPase Ypt1 (Rab1) in the secretory pathway

J. Christopher Fromme, Laura L Thomas, A. Joiner, 2018, The Journal of cell biology.

Golgi membrane protein Erd1 Is essential for recycling a subset of Golgi glycosyltransferases

J. Christopher Fromme, S. Emr, Richa Sardana, 2021, eLife.

DNA Lesion Recognition by the Bacterial Repair Enzyme MutM*

J. Christopher Fromme, G. Verdine, 2003, Journal of Biological Chemistry.

Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM

J. Christopher Fromme, G. Verdine, 2002, Nature Structural Biology.

Structural characterization of NrnC identifies unifying features of dinucleases

J. Christopher Fromme, H. Sondermann, W. Winkler, 2021, eLife.

Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments

J. Christopher Fromme, J. Freed, S. Emr, 2015, eLife.

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle

J. Christopher Fromme, N. Kelleher, P. Thomas, 2020, Nature Communications.

A Steric Gating Mechanism Dictates the Substrate Specificity of a Rab-GEF.

J. Christopher Fromme, Laura L Thomas, Solveig A. van der Vegt, 2019, Developmental cell.

The Sec7 Arf-GEF is recruited to the trans-Golgi network by positive feedback.

J. Christopher Fromme, B. Richardson, Caitlin M McDonold, 2012, Developmental cell.

Structural and mechanistic studies on repair of 8-oxoguanine in mammalian cells.

J. Christopher Fromme, G. Verdine, S. Bruner, 2000, Cold Spring Harbor symposia on quantitative biology.

Cargo adaptors: structures illuminate mechanisms regulating vesicle biogenesis.

J. Christopher Fromme, B. Richardson, J. Paczkowski, 2015, Trends in cell biology.

The structural basis of Salmonella A2B5 toxin neutralization by antibodies targeting the glycan-receptor binding subunits

J. Christopher Fromme, N. Mantis, J. Feathers, 2021, Cell reports.

Author response: Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments

J. Christopher Fromme, J. Freed, S. Emr, 2015 .

Structural basis for membrane binding and remodeling by the exomer secretory vesicle cargo adaptor.

J. Christopher Fromme, J. Paczkowski, 2014, Developmental cell.

C. elegans SMOC-1 interacts with both BMP and glypican to regulate BMP signaling

J. Christopher Fromme, Jun Liu, B. Williams, 2023, bioRxiv.

The Arf-GAP Age2 localizes to the late-Golgi via a conserved amphipathic helix

J. Christopher Fromme, Kaitlyn M. Manzer, 2023, bioRxiv.

The exomer cargo adaptor structure reveals a novel GTPase‐binding domain

J. Christopher Fromme, B. Richardson, J. Paczkowski, 2012, The EMBO journal.

Biochemical methods for studying kinetic regulation of Arf1 activation by Sec7.

J. Christopher Fromme, B. Richardson, 2015, Methods in cell biology.

SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans.

J. Christopher Fromme, Jun Liu, B. Williams, 2023, PLoS biology.

Autoregulation of Sec7 Arf-GEF activity and localization by positive feedback

J. Christopher Fromme, B. Richardson, 2012, Small GTPases.

The TRAPP complexes: discriminating GTPases in context

J. Christopher Fromme, S. Bagde, J. Fromme, 2022, FEBS letters.

Four GTPases differentially regulate the Sec7 Arf-GEF to direct traffic at the trans-golgi network.

J. Christopher Fromme, Caitlin M McDonold, 2014, Developmental cell.