Michael G. Yang

发表

Using Arden Syntax to Handle Alert Escalation

Jiang Wu, Sheldon Wang, Roger Corman, 1998, AMIA.

The Transfer of Adverse Clinical Events Rules with an Arden-Based Decision Support System

Jiang Wu, Sheldon Wang, Nancy Thalman, 1997, AMIA.

A Stereochemical Model for Merged 1,2- and 1,3-Asymmetric Induction in Diastereoselective Mukaiyama Aldol Addition Reactions and Related Processes

Michael G. Yang, Davidr . Evans, M. Dart, 1996 .

Arginine-based molecular transporters: the synthesis and chemical evaluation of releasable taxol-transporter conjugates.

Michael G. Yang, J. Rothbard, P. Wender, 2003, Organic letters.

Sequential diastereoselective addition and allylic azide isomerization of syn- and anti-.alpha.-azido-.beta.-(dimethylphenylsilyl)-(E)-hex-4-enoates with acetals: asymmetric synthesis of .gamma.-hydroxy-.alpha.-amino acid synthons

Michael G. Yang, J. Panek, I. Muler, 1992 .

Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists.

Michael G. Yang, J. Barrish, S. Mandlekar, 2014, Bioorganic & medicinal chemistry letters.

Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials.

Michael G. Yang, K. McIntyre, D. Shen, 2019, Journal of medicinal chemistry.

Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2.

Michael G. Yang, S. Mandlekar, A. Mathur, 2021, ACS medicinal chemistry letters.

Tricyclic Sulfones as Potent, Selective and Efficacious RORγt Inverse Agonists - Exploring C6 and C8 SAR Using Late-Stage Functionalization.

Michael G. Yang, D. Shuster, C. Weigelt, 2020, Bioorganic & medicinal chemistry letters.

Improving the pharmacokinetic and CYP inhibition profiles of azaxanthene-based glucocorticoid receptor modulators-identification of (S)-5-(2-(9-fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)-5H-chromeno[2,3-b]pyridin-5-yl)-2-methylpropanamido)-N-(tetrahydro-2H-pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide

Michael G. Yang, Michael A. Galella, K. McIntyre, 2015, Journal of medicinal chemistry.

Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator.

Michael G. Yang, K. McIntyre, D. Shen, 2016, Journal of medicinal chemistry.

Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists.

Michael G. Yang, A. Doweyko, D. Shuster, 2014, Bioorganic & medicinal chemistry letters.

Sequential Diastereoselective Addition and Allylic Azide Isomerization of syn‐ and anti‐α‐Azido‐β‐(dimethylphenylsilyl)‐E‐hex‐4‐ enoates with Acetals: Asymmetric Synthesis of γ‐Hydroxy‐α‐ amino Acid Synthons.

Michael G. Yang, J. Panek, I. Muler, 1992 .

Cycloadditions in heterocycle and alkaloid synthesis

Michael G. Yang, P. Wipf, Yongzhao Yan, 2013 .

Diastereofacial selectivity with optically active .alpha.-substituted .beta.-silyl-(E)-hexenoates. Enantioselective construction of homoallylic ethers via reaction with aryl acetals

Michael G. Yang, J. Panek, 1991 .

Synthesis of 3-substituted-4(3H)-quinazolinones via HATU-mediated coupling of 4-hydroxyquinazolines with amines.

Michael G. Yang, P. Li, P. Carter, 2009, Organic letters.

Total Synthesis of (+)-Mycotrienol and (+)-Mycotrienin I: Application of Asymmetric Crotylsilane Bond Constructions

Michael G. Yang, C. Masse, J. Panek, 1998 .

gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.

Michael G. Yang, J. Barrish, S. Mandlekar, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2).

Michael G. Yang, J. Barrish, A. Tebben, 2012, Bioorganic & medicinal chemistry letters.

Remote asymmetric induction in diastereoface selective addition reactions of optically active .alpha.-substituted-.beta.-silyl (E)-hexenoates with achiral .alpha.-alkoxy and .beta.-alkoxy acetals

Michael G. Yang, J. Panek, 1991 .

Synthesis of Chiral (E)‐Crotylsilanes: [3R‐ and 3S‐]‐(4E)‐Methyl 3‐(Dimethylphenylsilyl)‐4‐Hexenoate

Michael G. Yang, J. Panek, R. Beresis, 2003 .

Diastereoselective Aldol and Allylstannane Addition Reactions. The Merged Stereochemical Impact of .alpha. and .beta. Aldehyde Substituents

Michael G. Yang, Davidr . Evans, M. Dart, 1995 .

Sequential diastereoselective addition and palladium(II)-catalyzed allylic acetate transposition of syn- and anti-.alpha.-acetoxy-.beta.-silyl-(E)-hex-4-enoates with achiral acetals. Asymmetric synthesis of differentiated syn and anti 1,3-diol synthons

Michael G. Yang, J. Panek, J. S. Solomon, 1993 .

Diastereoselective additions of chiral (E)-crotylsilanes to in situ generated oxonium ions : a direct asymmetric synthesis of functionalized homoallylic ethers

Michael G. Yang, J. Panek, Feng Xu, 1992 .

Diastereoselective electrophilic addition reactions to chiral .beta.-dimethylphenylsilyl ester enolates. Synthesis of 2,3-anti-.alpha.-substituted-.beta.-silyl-(E)-hex-4-enoates

Michael G. Yang, J. Panek, Feng Xu, 1991 .

Diastereoselective additions of chiral (E)-crotylsilanes to .alpha.-alkoxy and .beta.-alkoxy aldehydes. A one-step, silicon-directed tetrahydrofuran synthesis

Michael G. Yang, J. Panek, 1991 .

Chelate-controlled carbonyl addition reactions. The exceptional chelating abilityof dimethylaluminum chloride and methylaluminum dichloride

Michael G. Yang, Davidr . Evans, B. Allison, 1999 .

DOUBLE STEREODIFFERENTIATING LEWIS ACID-PROMOTED (MUKAIYAMA) ALDOL BOND CONSTRUCTIONS

Michael G. Yang, Davidr . Evans, M. Dart, 1995 .

Studies directed toward the synthesis of (+)-mycotrienin I. Asymmetric synthesis of the C9N21 aromatic synthon

Michael G. Yang, J. Panek, J. S. Solomon, 1995 .

Cyclic derivatives as modulators of chemokine receptor

Michael G. Yang, A. Srivastava, P. Carter, 2004 .

Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis.

Michael G. Yang, D. Shuster, C. Weigelt, 2021, ACS medicinal chemistry letters.

Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672.

Michael G. Yang, Michael A. Galella, J. Barrish, 2019, ACS medicinal chemistry letters.

Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent γ-secretase inhibitors

Michael G. Yang, R. Olson, D. Robertson, 2007 .

The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression*

Michael G. Yang, J. Macor, M. Ford, 2008, Journal of Biological Chemistry.

Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P1) Modulators: Optimization of the PK, PD, and Safety Profiles.

Michael G. Yang, K. McIntyre, D. Shen, 2020, ACS medicinal chemistry letters.

Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.

Michael G. Yang, D. Shuster, C. Weigelt, 2021, Journal of medicinal chemistry.

DOUBLE STEREODIFFERENTIATING ALDOL REACTIONS OF (E) AND (Z) LITHIUM ENOLATES. MODEL REACTIONS FOR POLYPROPIONATE ASSEMBLAGE

Michael G. Yang, M. Dart, J. L. Duffy, 1996 .