Dario R Alessi

发表

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.

Hans C Clevers, Jérôme Boudeau, Annette F Baas, 2003, The EMBO journal.

LKB1-dependent signaling pathways.

Kei Sakamoto, Dario R Alessi, D. Alessi, 2006, Annual review of biochemistry.

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

Matthias Mann, Martin Steger, Dario R Alessi, 2017, eLife.

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

David Komander, Ricardo M Biondi, Maria Deak, 2002, The EMBO journal.

Kinase drug discovery--what's next in the field?

Dario R Alessi, P. Cohen, D. Alessi, 2013, ACS chemical biology.

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Jérôme Boudeau, Dario R Alessi, Tomi P Mäkelä, 2003, Journal of biology.

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.

David Komander, Dario R Alessi, D. V. van Aalten, 2003, The Biochemical journal.

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

Matthias Mann, Martin Steger, Stefanie Wachter, 2016, eLife.

Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia

Donna Neuberg, Kenneth J Livak, Shuqiang Li, 2017, Genome research.

Brain Penetrant LRRK2 Inhibitor.

Xianming Deng, Nathanael S Gray, Dario R Alessi, 2012, ACS medicinal chemistry letters.

Characterization of a Protein Kinase B Inhibitor In Vitro and in Insulin-Treated Liver Cells

Michael Keane, Dario R Alessi, D. Alessi, 2007, Diabetes.

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

Sebastian Alers, Mondira Kundu, Dario R Alessi, 2011, Autophagy.

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

Maria Deak, Dario R Alessi, D. V. van Aalten, 2009, Science.

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice.

Xu Huang, Kei Sakamoto, Stewart Fleming, 2008, The Biochemical journal.

Crystal Structure of the PTPL1/FAP-1 Human Tyrosine Phosphatase Mutated in Colorectal Cancer

Maria Deak, Dario R Alessi, D. V. van Aalten, 2004, Journal of Biological Chemistry.

High-Resolution Structure of the Pleckstrin Homology Domain of Protein Kinase B/Akt Bound to Phosphatidylinositol (3,4,5)-Trisphosphate

Maria Deak, Dario R Alessi, D. Alessi, 2002, Current Biology.

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

Justin Chapman, Laura Lingardo, Dario R Alessi, 2010, The Biochemical journal.

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.

Ayaz Najafov, Dario R Alessi, D. Alessi, 2011, The Biochemical journal.

Modulation of Insulin-stimulated Degradation of Human Insulin Receptor Substrate-1 by Serine 312 Phosphorylation*

Hiroshi Sakaue, Dario R Alessi, D. Alessi, 2003, The Journal of Biological Chemistry.

Discovery of potent and selective covalent inhibitors of JNK.

Taebo Sim, Mario Niepel, Scott B Ficarro, 2012, Chemistry & biology.

Metformin and reduced risk of cancer in diabetic patients

Dario R Alessi, A. Morris, L. Donnelly, 2005, BMJ : British Medical Journal.

Characterization of TAE684 as a potent LRRK2 kinase inhibitor.

Xianming Deng, Nathanael S Gray, Dario R Alessi, 2012, Bioorganic & medicinal chemistry letters.

Crystal structure of MO25α in complex with the C terminus of the pseudo kinase STE20-related adaptor

Jérôme Boudeau, Maria Deak, Dario R Alessi, 2004, Nature Structural &Molecular Biology.

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

Christian Veltkamp, Ruby Banerjee, Ignacio Varela, 2014, Nature Medicine.