Jim X. Shen

发表

Fit-for-purpose bioanalytical cross-validation for LC-MS/MS assays in clinical studies.

Carol Gleason, Xiaohui Xu, Mohammed Jemal, 2013, Bioanalysis.

Complexation of polyethers and pyridyl ligands with monopositive transition metal ions in the gas phase

Jim X. Shen, J. Brodbelt, 1998 .

Strategies for improving sensitivity and selectivity for the quantitation of biotherapeutics in biological matrix using LC-MS/MS

Jim X. Shen, Guowen Liu, Yue Zhao, 2015, Expert review of proteomics.

Development and validation of a liquid chromatography tandem mass spectrometry assay for the quantitation of a protein therapeutic in cynomolgus monkey serum.

Jim X. Shen, B. Desilva, R. Pillutla, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL.

Jim X. Shen, R. Hayes, Haiping Wang, 2006, Journal of pharmaceutical and biomedical analysis.

Minimization of ion suppression in LC-MS/MS analysis through the application of strong cation exchange solid-phase extraction (SCX-SPE).

Jim X. Shen, R. Hayes, R. J. Motyka, 2005, Journal of pharmaceutical and biomedical analysis.

Analytical approaches to support microdose studies in drug discovery and development

Jim X. Shen, Yue Zhao, Xiaohui Xu, 2015 .

Overcoming bioanalytical challenges in an Onglyza(®) intravenous [(14)C]microdose absolute bioavailability study with accelerator MS.

Jim X. Shen, W. Humphreys, S. Dueker, 2012, Bioanalysis.

Sensitivity-based analytical approaches to support human absolute bioavailability studies.

Jim X. Shen, Hao Jiang, X. Xu, 2014, Bioanalysis.

Bioanalysis of propylparaben and p-hydroxybenzoic acid, and their sulfate conjugates in rat plasma by liquid chromatography-tandem mass spectrometry.

Jim X. Shen, L. Sivaraman, M. Arnold, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Highly selective and sensitive measurement of active forms of FGF21 using novel immunocapture enrichment with LC-MS/MS.

Jim X. Shen, Jane Liu, Jon E Peterson, 2018, Bioanalysis.

LC-MS/MS determination of apixaban (BMS-562247) and its major metabolite in human plasma: an application of polarity switching and monolithic HPLC column.

Jim X. Shen, A. Schuster, Oanh T Dang, 2014, Bioanalysis.

A UHPLC-MS/MS bioanalytical assay for the determination of BMS-911543, a JAK2 inhibitor, in human plasma.

Jim X. Shen, Jane Liu, Long Yuan, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Implementation of high-temperature superficially porous technologies for rapid LC-MS/MS diastereomer bioanalysis.

Jim X. Shen, R. Clement, J. M. Cunliffe, 2011, Bioanalysis.

Stereoselective quantitation of a serine protease inhibitor using LC-MS/MS at elevated column temperature.

Jim X. Shen, R. Clement, R. Hayes, 2008, Journal of separation science.

Dissociation of doubly charged transition metal/polyether/pyridyl ligand complexes in a quadrupole ion trap mass spectrometer

Jim X. Shen, J. Brodbelt, 1999 .

A high-throughput LC-MS/MS method for the quantitation of posaconazole in human plasma: Implementing fused core silica liquid chromatography.

Jim X. Shen, R. Clement, J. M. Cunliffe, 2009, Journal of pharmaceutical and biomedical analysis.

A sensitive liquid chromatography and mass spectrometry method for the determination of posaconazole in human plasma.

Jim X. Shen, G. Krishna, R. Hayes, 2007, Journal of pharmaceutical and biomedical analysis.

Simultaneous determination of desloratadine and pseudoephedrine in human plasma using micro solid-phase extraction tips and aqueous normal-phase liquid chromatography/tandem mass spectrometry.

Jim X. Shen, Yan Xu, R. Clement, 2007, Rapid communications in mass spectrometry : RCM.

Evaluation of automated micro solid phase extraction tips (micro-SPE) for the validation of a LC-MS/MS bioanalytical method.

Jim X. Shen, R. Hayes, C. Tama, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Selective reaction monitoring of negative electrospray ionization acetate adduct ions for the bioanalysis of dapagliflozin in clinical studies.

Jim X. Shen, D. Boulton, Jane Liu, 2015, Analytical chemistry.

Formation of doubly charged transition metal–polyether–pyridyl mixed‐ligand complexes by electrospray ionization

Jim X. Shen, J. Brodbelt, 1999 .

Characterization of ionophore–metal complexes by infrared multiphoton photodissociation and collision activated dissociation in a quadrupole ion trap mass spectrometer

Jim X. Shen, J. Brodbelt, 2000 .

A validated LC-MS/MS method for the quantitative measurement of creatinine as an endogenous biomarker in human plasma.

Jim X. Shen, Zhaoqing Wang, M. Arnold, 2016, Bioanalysis.

Improved ruggedness of an ion-pairing liquid chromatography/tandem mass spectrometry assay for the quantitative analysis of the triphosphate metabolite of a nucleoside reverse transcriptase inhibitor in peripheral blood mononuclear cells.

Jim X. Shen, M. Guha, Long Yuan, 2013, Rapid communications in mass spectrometry : RCM.

Sp E cial Focu S: e-S olution S in bioanaly S i S

Jim X. Shen, 2011 .

Determination of a novel thrombin receptor antagonist (SCH 530348) in human plasma: evaluation of Ultra Performance Liquid Chromatography™-tandem mass spectrometry for routine bioanalytical analysis.

Jim X. Shen, R. Clement, James E. Schiller, 2011, Journal of pharmaceutical and biomedical analysis.

Reactions of Hydantoin and Succinimide Anticonvulsants with Dimethyl Ether Ions in a Quadrupole Ion Trap Mass Spectrometer

Jim X. Shen, J. Brodbelt, 1996 .

A novel and cost effective method of removing excess albumin from plasma/serum samples and its impacts on LC-MS/MS bioanalysis of therapeutic proteins.

Jim X. Shen, M. Arnold, Guowen Liu, 2014, Analytical chemistry.

Using temperature to optimize resolution and reduce analysis times for bioanalytical diastereomer LC-MS/MS separations.

Jim X. Shen, R. Clement, R. Hayes, 2011, Journal of pharmaceutical and biomedical analysis.

Strategy for the Quantitation of a Protein Conjugate via Hybrid Immunocapture-Liquid Chromatography with Sequential HRMS and SRM-Based LC-MS/MS Analyses.

Jinping Gan, Jim X Shen, Guowen Liu, 2017, Analytical chemistry.

Dried blood spot analysis without dilution: Application to the LC-MS/MS determination of BMS-986001 in rat dried blood spot.

Jim X. Shen, A. Schuster, Long Yuan, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A multiplexed immunocapture liquid chromatography tandem mass spectrometry assay for the simultaneous measurement of myostatin and GDF-11 in rat serum using an automated sample preparation platform.

Jim X. Shen, Yan J. Zhang, A. Kozhich, 2017, Analytica chimica acta.

Medical Science and the Serials Crisis: Is Open Access a Viable Solution?

Jim X. Shen, 2011 .

LC-MS/MS Method for the Quantitative Determination of Tanespimycin and its Active Metabolite in Human Plasma: Method Validation and Overcoming an Insidious APCI Source Phenomenon

Jim X. Shen, V. Roongta, Morse Faria, 2020 .

A multiplexed immunocapture liquid chromatography tandem mass spectrometry assay for the simultaneous measurement of myostatin and GDF-11 in rat serum using an automated sample preparation platform.

Jim X. Shen, Yan J. Zhang, A. Kozhich, 2017, Analytica chimica acta.

Bioanalysis and where does it fit into the drug development process

Anne-Françoise Aubry, Jim X Shen, Jim X. Shen, 2013 .

Evaluation of proton‐binding capabilities of polyether and pyridyl ligands

Jim X. Shen, J. Brodbelt, 1998 .