Linda V. Sinclair

发表

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

David K. Finlay, Linda V. Sinclair, Carmen Feijoo, 2009, The Journal of experimental medicine.

Differential regulation of T-cell growth by IL-2 and IL-15.

Linda V. Sinclair, D. Cantrell, L. Sinclair, 2006, Blood.

Nutrient sensing, signal transduction and immune responses.

David K. Finlay, Linda V. Sinclair, L. Sinclair, 2016, Seminars in immunology.

Antigen receptor control of methionine metabolism in T cells

Linda V. Sinclair, A. Lamond, J. Locasale, 2018, bioRxiv.

Control of amino acid transport coordinates metabolic reprogramming in T-cell malignancy

Linda V. Sinclair, K. Grzes, D. Cantrell, 2017, Leukemia.

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

Linda V. Sinclair, D. Cantrell, Yunbo Shi, 2013, Nature Immunology.

Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation

Linda V. Sinclair, A. Lamond, D. Cantrell, 2019, Nature Immunology.

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment–sensing programs

Linda V. Sinclair, D. Cantrell, H. Brady, 2018, Science Signaling.

Antigen receptor control of amino acid transport coordinates the metabolic re-programming that is essential for T cell differentiation

Linda V. Sinclair, D. Cantrell, Yunbo Shi, 2013, Nature immunology.

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

David K. Finlay, Linda V. Sinclair, K. Okkenhaug, 2012, The Journal of experimental medicine.

Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism

Linda V. Sinclair, K. Okkenhaug, D. Cantrell, 2011, Immunity.

Temporal Differences in the Dependency on Phosphoinositide-Dependent Kinase 1 Distinguish the Development of Invariant Vα14 NKT Cells and Conventional T Cells

Linda V. Sinclair, D. Alessi, D. Cantrell, 2010, The Journal of Immunology.

Single cell analysis of kynurenine and System L amino acid transport in T cells

Linda V. Sinclair, D. Cantrell, G. Ramsay, 2018, Nature Communications.

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

Linda V. Sinclair, D. V. van Aalten, K. Grzes, 2016, Nature Immunology.

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

Linda V. Sinclair, V. Cowling, H. Macdonald, 2015, The EMBO journal.

Glucose represses dendritic cell-induced T cell responses

Linda V. Sinclair, L. Sinclair, D. Finlay, 2017, Nature Communications.

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

David K. Finlay, Linda V. Sinclair, Thijs J. Hagenbeek, 2008, Nature Immunology.

Phosphoinositide (3,4,5)-Triphosphate Binding to Phosphoinositide-Dependent Kinase 1 Regulates a Protein Kinase B/Akt Signaling Threshold That Dictates T-Cell Migration, Not Proliferation

David K. Finlay, Linda V. Sinclair, D. Cantrell, 2009, Molecular and Cellular Biology.

A glutamine ‘tug-of-war’: targets to manipulate glutamine metabolism for cancer immunotherapy

Linda V. Sinclair, L. Sinclair, A. Schurich, 2021, Immunotherapy advances.

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

David K. Finlay, Linda V. Sinclair, P. Oefner, 2018, Nature Communications.

Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity.

David K. Finlay, Linda V. Sinclair, E. Ma, 2023, Cell metabolism.

Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses

Linda V. Sinclair, G. Besra, L. Sinclair, 2019, The Journal of Immunology.

Exhausted CD4+ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression

Graham M Lord, Richard G. Jenner, Linda V. Sinclair, 2020, The Journal of Immunology.

University of Dundee PDK 1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD 8 T cells

Linda V. Sinclair, K. Okkenhaug, D. Cantrell, 2012 .

University of Dundee PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

Linda V. Sinclair, K. Okkenhaug, D. Cantrell, 2012 .

Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses

Linda V. Sinclair, Maria Z. Krauss, M. Hepworth, 2022, bioRxiv.

Large Neutral Amino acid uptake and mTOR activation within CD4+ T cells coordinate Type 2 immunity and host resistance to Trichuris muris

Linda V. Sinclair, Maria Z. Krauss, K. Hayes, 2020, bioRxiv.

The cytotoxic T cell proteome and its shaping by mammalian Target of Rapamycin

Linda V. Sinclair, A. Lamond, P. Hawkins, 2015, Nature Immunology.

Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

Linda V. Sinclair, D. Cantrell, L. Sinclair, 2010, The Biochemical journal.

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

Linda V. Sinclair, M. Haniffa, A. Bertoletti, 2015, Nature Medicine.

Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

Linda V. Sinclair, D. Cantrell, L. Sinclair, 2019, bioRxiv.

Single Cell Glucose Uptake Assays: A Cautionary Tale

Linda V. Sinclair, D. Cantrell, L. Sinclair, 2020, Immunometabolism.

The Immunological Proteome Resource

David K. Finlay, Linda V. Sinclair, A. Lamond, 2022, bioRxiv.

Proteomic and functional comparison between human induced and embryonic stem cells

Linda V. Sinclair, J. Swedlow, A. Lamond, 2021, bioRxiv.