Amy S Espeseth

Integrating Experimental and Analytic Approaches to Improve Data Quality in Genome-wide RNAi Screens

Xiaohua Douglas Zhang, Marc Ferrer, Joseph F Heyse, 2008, Journal of biomolecular screening.

Identification of a small molecule beta-secretase inhibitor that binds without catalytic aspartate engagement.

Paul Zuck, Georgia McGaughey, Amy S. Espeseth, 2009, Bioorganic & medicinal chemistry letters.

Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

Amy S. Espeseth, Amy S Espeseth, D. Hazuda, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Robust statistical methods for hit selection in RNA interference high-throughput screening experiments.

Marc Ferrer, Amy S. Espeseth, Namjin Chung, 2006, Pharmacogenomics.

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.

Alison R. Gregro, Georgia B McGaughey, M Katharine Holloway, 2007, Bioorganic & medicinal chemistry letters.

Macrocyclic inhibitors of beta-secretase: functional activity in an animal model.

M Katharine Holloway, Lixia Jin, Michelle Crouthamel, 2006, Journal of medicinal chemistry.

Biochemical and cell-based assays for characterization of BACE-1 inhibitors.

Xiao-Ping Shi, Amy S Espeseth, Min Xu, 2005, Analytical biochemistry.

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.

Mark Embrey, Samson M Jolly, Wei Xu, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.

Paul Zuck, Georgia B McGaughey, M Katharine Holloway, 2008, Journal of medicinal chemistry.

The Use of Strictly Standardized Mean Difference for Hit Selection in Primary RNA Interference High-Throughput Screening Experiments

Marc Ferrer, Joseph F Heyse, Berta Strulovici, 2007, Journal of biomolecular screening.