Rudi Pauwels

发表

On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data

Eddy Arnold, Paul J. Lewi, Kalyan Das, 2003, J. Comput. Aided Mol. Des..

Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.

Celia A Schiffer, Hilde Azijn, Rudi Pauwels, 2005, Journal of medicinal chemistry.

TMC125, a Novel Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor Active against Nonnucleoside Reverse Transcriptase Inhibitor-Resistant Human Immunodeficiency Virus Type 1

Koen Andries, Hilde Azijn, Theo Thielemans, 2004, Antimicrobial Agents and Chemotherapy.

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

Erik De Clercq, Jan Desmyter, Dominique Schols, 1990, Nature.

Design of HIV-1 protease inhibitors active on multidrug-resistant virus.

Celia A Schiffer, Hilde Azijn, Rudi Pauwels, 2005, Journal of medicinal chemistry.

Encoding microcarriers: present and future technologies

Kevin Braeckmans, Marc Leblans, Stefaan C. De Smedt, 2002, Nature Reviews Drug Discovery.

Encoding microcarriers by spatial selective photobleaching

Kevin Braeckmans, Marc Leblans, Rudi Pauwels, 2003, Nature materials.

4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains.

Christophe Meyer, Eddy Arnold, Koen Andries, 2005, Journal of medicinal chemistry.

TMC114, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor Active against Protease Inhibitor-Resistant Viruses, Including a Broad Range of Clinical Isolates

Dirk Jochmans, Hilde Azijn, Rudi Pauwels, 2005, Antimicrobial Agents and Chemotherapy.

A Rapid Method for Simultaneous Detection of Phenotypic Resistance to Inhibitors of Protease and Reverse Transcriptase in Recombinant Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Antiretroviral Drugs

Brendan Larder, Stuart Bloor, Frank Peeters, 1998, Antimicrobial Agents and Chemotherapy.

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of tetrahydro-imidazo[4,5,1-JK][1,4]-benzzodiazepin-2(1H)-one and -thione (TIBO) derivatives

J Desmyter, Rudi Pauwels, R. Pauwels, 1990 .

Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-ones (TIBO) analogues

Erik De Clercq, Koen Andries, Rudi Pauwels, 1999 .

New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections.

Rudi Pauwels, R. Pauwels, 2004, Current opinion in pharmacology.

Phenotypic and genotypic analysis of clinical HIV-1 isolates reveals extensive protease inhibitor cross-resistance: a survey of over 6000 samples

Brendan A. Larder, Stuart Bloor, Margriet Van Houtte, 2000, AIDS.

In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

Stephen H Hughes, Peter Williams, Paul J Lewi, 2005, Journal of medicinal chemistry.