David R. Croucher

发表

Computational survey of peptides derived from disulphide-bonded protein loops that may serve as mediators of protein-protein interactions

Marc Devocelle, Denis C. Shields, Fergal J. Duffy, 2014, BMC Bioinformatics.

Understanding Cell Fate Decisions by Identifying Crucial System Dynamics

Boris N. Kholodenko, Dirk Fey, Walter Kolch, 2012 .

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer

Sean C. Warren, Max Nobis, Astrid Magenau, 2018, Cell reports.

Temporal regulation of EGF signaling networks by the scaffold protein Shc1

Tony Pawson, Anne-Claude Gingras, Karen Colwill, 2013, Nature.

Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades

Boris N. Kholodenko, Walter Kolch, Dirk Fey, 2012, Front. Physiol..

Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2

David R. Croucher, David E. James, D. Croucher, 2023, The Journal of experimental medicine.

Mepolizumab decreases tissue eosinophils while increasing type‐2 cytokines in eosinophilic chronic rhinosinusitis

David R. Croucher, D. Croucher, S. L. Van Es, 2022, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells.

David R. Croucher, A. Biankin, D. Croucher, 2010, Cancer research.

Cancer esearch or and Stem Cell Biology sine Phosphorylation Profiling Reveals the Signaling R work Characteristics of Basal Breast Cancer Cells

David R. Croucher, D. Croucher, S. O'toole, 2010 .

The extracellular matrix as a key regulator of intracellular signalling networks

Jordan F Hastings, David R. Croucher, D. Croucher, 2019, British journal of pharmacology.

Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling

David R. Croucher, D. Croucher, R. Daly, 2008, Science Signaling.

Revisiting the biological roles of PAI2 (SERPINB2) in cancer

David R. Croucher, D. Croucher, S. Lobov, 2008, Nature Reviews Cancer.

Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients

Walter Kolch, Dirk Fey, Matthias Fischer, 2015, Science Signaling.

Defining the mechanism and functional consequences of PAI-2-mediated uPA/uPAR endocytosis

David R. Croucher, D. Croucher, 2006 .

A zebrafish functional genomics model to investigate the role of human A20 variants in vivo

David R. Croucher, D. Croucher, S. Grey, 2020, Scientific Reports.

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer

David M. Thomas, David R. Croucher, J. Blay, 2020, Science.

Applications of personalised signalling network models in precision oncology.

Dirk Fey, Jordan F Hastings, Yolande O'Donnell, 2020, Pharmacology & therapeutics.

t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions

David R. Croucher, D. Croucher, L. Pedersen, 2014, Brain Research.

Tissue‐type plasminogen activator requires a co‐receptor to enhance NMDA receptor function

David R. Croucher, D. Croucher, D. Lawrence, 2008, Journal of neurochemistry.

Personalized Medicine for Neuroblastoma: Moving from Static Genotypes to Dynamic Simulations of Drug Response

Jordan F Hastings, David R. Croucher, W. Kolch, 2021, Journal of personalized medicine.

Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis

Jordan F Hastings, David R. Croucher, D. Croucher, 2022, Nature Communications.

The Under-Appreciated Promiscuity of the Epidermal Growth Factor Receptor Family

Jordan F Hastings, David R. Croucher, D. Croucher, 2016, Front. Cell Dev. Biol..

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma

David R. Croucher, D. Croucher, Sharissa L. Latham, 2020, Frontiers in Cell and Developmental Biology.

A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers

David R. Croucher, D. Croucher, C. Day, 2020, Proceedings of the National Academy of Sciences.

A cryptic tubulin-binding domain links MEKK1 to microtubule remodelling

David R. Croucher, D. Croucher, C. Day, 2020, bioRxiv.

Myosin-18B Regulates Higher-Order Organization of the Cardiac Sarcomere through Thin Filament Cross-Linking and Thick Filament Dynamics.

David R. Croucher, D. Croucher, D. Manstein, 2020, Cell reports.

Cortactin Modulates RhoA Activation and Expression of Cip/Kip Cyclin-Dependent Kinase Inhibitors To Promote Cell Cycle Progression in 11q13-Amplified Head and Neck Squamous Cell Carcinoma Cells

David R. Croucher, D. Croucher, E. Musgrove, 2010, Molecular and Cellular Biology.

A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma

Jordan F Hastings, David R. Croucher, D. Croucher, 2021, eLife.

Resistance to platinum chemotherapy in lung adenocarcinoma is driven by a non-genetic, cell-cycle dependent mechanism

Jordan F Hastings, David R. Croucher, D. Croucher, 2020, bioRxiv.

Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development

David R. Croucher, D. Croucher, S. O'toole, 2010, International journal of cancer.

Dependence on Endocytic Receptor Binding via a Minimal Binding Motif Underlies the Differential Prognostic Profiles of SerpinE1 and SerpinB2 in Cancer*

David R. Croucher, D. Croucher, B. Cochran, 2011, The Journal of Biological Chemistry.

Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments

David R. Croucher, D. Croucher, Sharissa L. Latham, 2022, Biochemical Society transactions.

Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers

Jordan F Hastings, David R. Croucher, S. Aparicio, 2016, Science Signaling.

Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging.

David R. Croucher, D. Croucher, P. Timpson, 2021, Cell reports.

Signalling by protein phosphatases and drug development: a systems‐centred view

David R. Croucher, B. Kholodenko, L. K. Nguyen, 2012, The FEBS journal.

Signalling by protein and drug development: a systems-centred view

David R. Croucher, D. Matallanas, D. Croucher, 2017 .

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

David R. Croucher, J. Kench, L. Andrews, 2019, Nature Communications.

PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells

David R. Croucher, David E. James, D. James, 2016, Journal of Cell Science.

MASTL overexpression promotes chromosome instability and metastasis in breast cancer

David R. Croucher, D. James, D. Croucher, 2018, Oncogene.

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy

Jordan F Hastings, David R. Croucher, D. Croucher, 2018, Science Translational Medicine.

Breathing New Life into the Mechanisms of Platinum Resistance in Lung Adenocarcinoma

Jordan F Hastings, David R. Croucher, D. Croucher, 2020, Frontiers in Cell and Developmental Biology.

CAN-10-0911 Cancer esearch or and Stem Cell Biology sine Phosphorylation Profiling Reveals the Signaling R work Characteristics of Basal Breast Cancer Cells

David R. Croucher, D. Croucher, S. O'toole, 2010 .

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer

Amaya Garcia Munoz, Jordan F Hastings, David R. Croucher, 2019, Breast Cancer Research.

Relationship between Circulating Lipids and Cytokines in Metastatic Castration-Resistant Prostate Cancer

Jordan F Hastings, David R. Croucher, M. Stockler, 2021, Cancers.

A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer

Jordan F Hastings, David R. Croucher, J. Kench, 2023, Nature Cancer.

Structure-based mechanism of preferential complex formation by apoptosis signal–regulating kinases

David R. Croucher, D. Croucher, R. Dobson, 2020, Science Signaling.

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

Shereen R Kadir, David R. Croucher, D. Croucher, 2015, Cell reports.

Intravital FRAP Imaging us ing an E-cadherin-GFP Mouse Reveals Disease-and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue Graphical

Shereen R Kadir, David R. Croucher, D. Croucher, 2015 .

Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma

Jordan F Hastings, David R. Croucher, F. Speleman, 2023, Science advances.

Activin A Is Essential for Neurogenesis Following Neurodegeneration

David R. Croucher, B. Vissel, D. Croucher, 2009, Stem cells.

Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse

David R. Croucher, D. Croucher, T. Phan, 2023, Science advances.

Functional characterization of cancer-associated Gab1 mutations

David R. Croucher, D. Croucher, R. Daly, 2013, Oncogene.

Kinetic analysis of plasminogen activator inhibitor type-2: urokinase complex formation and subsequent internalisation by carcinoma cell lines.

David R. Croucher, D. Croucher, F. Al-Ejeh, 2004, Experimental cell research.

A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells.

David R. Croucher, D. Croucher, D. Saunders, 2007, The Biochemical journal.

Preclinical evaluation of 213Bi-labeled plasminogen activator inhibitor type 2 in an orthotopic murine xenogenic model of human breast carcinoma

David R. Croucher, D. Croucher, F. Al-Ejeh, 2007, Molecular Cancer Therapeutics.

The Urokinase/PAI-2 Complex

Darren N Saunders, David R. Croucher, D. Croucher, 2006, Journal of Biological Chemistry.

Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

Jordan F Hastings, David R. Croucher, D. Croucher, 2020, eLife.

Dynamic analysis of pulsed cisplatin identifies effectors of resistance in lung adenocarcinoma

Jordan F Hastings, David R. Croucher, A. Nagrial, 2019 .

Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients

Amaya Garcia Munoz, Jordan F Hastings, David R. Croucher, 2015, Science Signaling.

Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes

David R. Croucher, D. Croucher, M. Ranson, 2010, Thrombosis and Haemostasis.

Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

David R. Croucher, D. Croucher, J. Center, 2021, eLife.

Bisphosphonate drugs have actions outside the skeleton and inhibit the mevalonate pathway in alveolar macrophages

David R. Croucher, D. Croucher, J. Center, 2021, bioRxiv.

Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro

David R. Croucher, D. Croucher, S. Lobov, 2008, Thrombosis and Haemostasis.

t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions

David R. Croucher, L. Pedersen, R. Medcalf, 2014, Brain Research.

Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway.

Naveid A Ali, David R. Croucher, D. Croucher, 2013, Cancer research.

Involvement of Lyn and the Atypical Kinase in a Basal Breast Cancer Signaling Pathway

Naveid A Ali, David R. Croucher, D. Croucher, 2017 .

as biomarkers: Patient-specific

Amaya Garcia Munoz, Jordan F Hastings, David R. Croucher, 2017 .

In Vitro 3D Models of Tunable Stiffness.

David R. Croucher, D. Croucher, T. Cox, 2021, Methods in molecular biology.

Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells

David R. Croucher, D. Croucher, S. Kennedy, 2016, Oncogenesis.

Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism

David R. Croucher, L. Quek, P. Timpson, 2024, Advanced science.