Kenneth A Jacobson

发表

Crystal structures of the A2A adenosine receptor and their use in medicinal chemistry

Kenneth A Jacobson, 2013, In Silico Pharmacology.

Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor Agonists.

David Rodríguez, Jens Carlsson, Saibal Chakraborty, 2016, ACS chemical biology.

Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists.

Sang Kook Lee, Kenneth A Jacobson, K. Jacobson, 2009, Bioorganic & medicinal chemistry.

Computational studies to predict or explain G protein coupled receptor polypharmacology.

Stefano Costanzi, Silvia Paoletta, Kenneth A Jacobson, 2014, Trends in pharmacological sciences.

Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.

Francesca Deflorian, Kenneth A Jacobson, K. Jacobson, 2012, Journal of medicinal chemistry.

A Region in the Seven-transmembrane Domain of the Human Ca2+ Receptor Critical for Response to Ca2+*

Kenneth A Jacobson, K. Jacobson, Stuart J McLarnon, 2005, Journal of Biological Chemistry.

Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.

Kenneth A Jacobson, K. Jacobson, C. Müller, 2002, Journal of medicinal chemistry.

Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.

Carl R. Johnson, Dov Barak, Kenneth A Jacobson, 2002, Journal of medicinal chemistry.

Rapid identification of functionally critical amino acids in a G protein–coupled receptor

Bo Li, Kenneth A Jacobson, J. Wess, 2007, Nature Methods.

Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor.

Johannes Brussee, Kenneth A Jacobson, Kai Ye, 2006, Journal of medicinal chemistry.

Interactions of flavones and other phytochemicals with adenosine receptors.

Kenneth A Jacobson, S. Moro, K. Jacobson, 2002, Advances in experimental medicine and biology.

Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor.

T Kendall Harden, Stefano Costanzi, Kenneth A Jacobson, 2006, Journal of medicinal chemistry.

Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling.

Francesca Deflorian, Barbara Cacciari, Giampiero Spalluto, 2003, Chemical communications.

Docking studies of agonists and antagonists suggest an activation pathway of the A3 adenosine receptor.

Kenneth A Jacobson, K. Jacobson, Zhang-Guo Gao, 2006, Journal of molecular graphics & modelling.

Techniques: Recent developments in computer-aided engineering of GPCR ligands using the human adenosine A3 receptor as an example.

Giampiero Spalluto, Kenneth A Jacobson, S. Moro, 2005, Trends in pharmacological sciences.

Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety.

Kenneth A Jacobson, Zhan-Guo Gao, Hea Ok Kim, 2006, Bioorganic & medicinal chemistry letters.

Functionally biased modulation of A(3) adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers.

Kenneth A Jacobson, Kai Ye, K. Jacobson, 2011, Biochemical pharmacology.

Breakthrough in GPCR Crystallography and Its Impact on Computer-Aided Drug Design.

Antonella Ciancetta, Kenneth A Jacobson, K. Jacobson, 2018, Methods in molecular biology.

Molecular architecture of G protein‐coupled receptors

Kenneth A Jacobson, K. Jacobson, A. V. van Rhee, 1996, Drug development research.

Identification of essential residues involved in the allosteric modulation of the human A(3) adenosine receptor.

Kenneth A Jacobson, K. Jacobson, Zhang-Guo Gao, 2003, Molecular pharmacology.

Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists.

Sang Kook Lee, Kenneth A Jacobson, Zhan-Guo Gao, 2008, Journal of medicinal chemistry.

Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor.

Fei Xu, Francesca Deflorian, Vsevolod Katritch, 2012, Journal of medicinal chemistry.

Evaluation of homology modeling of G-protein-coupled receptors in light of the A(2A) adenosine receptor crystallographic structure.

Dov Barak, Kenneth A Jacobson, K. Jacobson, 2009, Journal of medicinal chemistry.

Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.

Silvia Paoletta, Steven M. Moss, Kenneth A Jacobson, 2013, Journal of medicinal chemistry.

Molecular modeling as a tool to investigate molecular recognition in P2Y receptors.

Kenneth A Jacobson, Stefano Moro, 2002, Current pharmaceutical design.

Exploring distal regions of the A3 adenosine receptor binding site: sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands.

Kenneth A Jacobson, K. Jacobson, Zhang-Guo Gao, 2004, Bioorganic & medicinal chemistry.

Controlling murine and rat chronic pain through A3 adenosine receptor activation

Kenneth A Jacobson, K. Jacobson, D. Salvemini, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells.

Jian Zhang, Wei Huang, Kenneth A Jacobson, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors.

T Kendall Harden, Stefano Costanzi, Piet Herdewijn, 2004, Bioorganic & medicinal chemistry.

Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives.

Adriaan P IJzerman, Kenneth A Jacobson, K. Jacobson, 2002, Molecular pharmacology.

Recent developments in adenosine receptor ligands and their potential as novel drugs.

Kenneth A Jacobson, K. Jacobson, C. Müller, 2011, Biochimica et biophysica acta.

Progress in the pursuit of therapeutic adenosine receptor antagonists

Giampiero Spalluto, Kenneth A Jacobson, S. Moro, 2006, Medicinal research reviews.

Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models

Adriaan P IJzerman, Kenneth A Jacobson, Kai Ye, 2009, BMC pharmacology.

Allosteric modulation of the adenosine family of receptors.

Kenneth A Jacobson, K. Jacobson, A. IJzerman, 2005, Mini reviews in medicinal chemistry.

Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists

Gangadhar J Sanjayan, Kenneth A Jacobson, K. Jacobson, 2010, Journal of nanobiotechnology.

Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors.

Stefano Costanzi, Irina G Tikhonova, Kenneth A Jacobson, 2009, Current pharmaceutical design.

Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.

Silvia Paoletta, Kenneth A Jacobson, Zhan-Guo Gao, 2014, Bioorganic & medicinal chemistry letters.

Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists.

Silvia Paoletta, Kenneth A Jacobson, K. Jacobson, 2015, MedChemComm.

Structure-activity relationships and molecular modeling of 1,2,4-triazoles as adenosine receptor antagonists.

Jens Carlsson, Kenneth A Jacobson, K. Jacobson, 2012, ACS medicinal chemistry letters.

Identification of an Agonist-induced Conformational Change Occurring Adjacent to the Ligand-binding Pocket of the M3 Muscarinic Acetylcholine Receptor*

Bo Li, Sung-Jun Han, Kenneth A Jacobson, 2005, Journal of Biological Chemistry.

Modeling the adenosine receptors: comparison of the binding domains of A2A agonists and antagonists.

Kenneth A Jacobson, K. Jacobson, Philippe van Rompaey, 2003, Journal of medicinal chemistry.

Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.

Ruben Abagyan, Fei Xu, Francesca Deflorian, 2012, Journal of medicinal chemistry.

Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function after myocardial infarct.

Asher Shainberg, Edith Hochhauser, Kenneth A Jacobson, 2006, Biochemical pharmacology.

A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude.

Jan Balzarini, Stephen H Hughes, Clifford George, 2003, Journal of medicinal chemistry.

New paradigms in GPCR drug discovery.

Kenneth A Jacobson, K. Jacobson, 2015, Biochemical pharmacology.