Rohit Ramachandran

发表

Qualitative Assessment of a Multi-Scale, Compartmental PBM-DEM Model of a Continuous Twin-Screw Wet Granulation Process

Dana Barrasso, Rohit Ramachandran, 2015, Journal of Pharmaceutical Innovation.

Simulation-Based Design of an Efficient Control System for the Continuous Purification and Processing of Active Pharmaceutical Ingredients

Ravendra Singh, Rohit Ramachandran, Maitraye Sen, 2014, Journal of Pharmaceutical Innovation.

Parallelization methods for efficient simulation of high dimensional population balance models of granulation

Rohit Ramachandran, Franklin E. Bettencourt, Anik Chaturbedi, 2017, Comput. Chem. Eng..

Population Balance Model Validation and Predictionof CQAs for Continuous Milling Processes: toward QbDin Pharmaceutical Drug Product Manufacturing

Dana Barrasso, Carl Wassgren, Rohit Ramachandran, 2013, Journal of Pharmaceutical Innovation.

Development of a low-volume, highly sensitive microimmunoassay using computational fluid dynamics-driven multiobjective optimization

Rohit Ramachandran, Martin L Yarmush, Mehdi Ghodbane, 2015, Microfluidics and nanofluidics.

CFD-DEM-PBM coupled model development and validation of a 3D top-spray fluidized bed wet granulation process

Rohit Ramachandran, Ashutosh Tamrakar, R. Ramachandran, 2019, Comput. Chem. Eng..

A systematic framework for onsite design and implementation of a control system in a continuous tablet manufacturing process

Marianthi G. Ierapetritou, Ravendra Singh, Fernando J. Muzzio, 2014, Comput. Chem. Eng..

Flexible multipurpose Continuous processing: Integration of process flow modeling for continuous processing of pharmaceutical solid dosage forms

Fernando J. Muzzio, Fani Boukouvala, Rohit Ramachandran, 2012 .

Combined Feedforward/Feedback Control of an Integrated Continuous Granulation Process

Ravendra Singh, Fernando J. Muzzio, Rohit Ramachandran, 2018, Journal of Pharmaceutical Innovation.

An integrated approach for dynamic flowsheet modeling and sensitivity analysis of a continuous tablet manufacturing process

Marianthi G. Ierapetritou, Fernando J. Muzzio, Fani Boukouvala, 2012, Comput. Chem. Eng..

System-wide hybrid MPC-PID control of a continuous pharmaceutical tablet manufacturing process via direct compaction.

Marianthi Ierapetritou, Ravendra Singh, Rohit Ramachandran, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Model-Based Control-Loop Performance of a Continuous Direct Compaction Process

Rohit Ramachandran, Marianthi G. Ierapetritou, Jeyrathan Arjunan, 2011, Journal of Pharmaceutical Innovation.

Integrated Moving Horizon-Based Dynamic Real-Time Optimization and Hybrid MPC-PID Control of a Direct Compaction Continuous Tablet Manufacturing Process

Marianthi Ierapetritou, Ravendra Singh, Rohit Ramachandran, 2015, Journal of Pharmaceutical Innovation.

An engineering study on the enhanced control and operation of continuous manufacturing of pharmaceutical tablets via roller compaction.

Marianthi Ierapetritou, Ravendra Singh, Rohit Ramachandran, 2012, International journal of pharmaceutics.

Computer-Aided Flowsheet Simulation of a Pharmaceutical Tablet Manufacturing Process Incorporating Wet Granulation

Fani Boukouvala, Anwesha Chaudhury, Rohit Ramachandran, 2013, Journal of Pharmaceutical Innovation.

A parallel unidirectional coupled DEM-PBM model for the efficient simulation of computationally intensive particulate process systems

Shantenu Jha, Rohit Ramachandran, Ioannis Paraskevakos, 2018, Comput. Chem. Eng..

Closed-Loop Feedback Control of a Continuous Pharmaceutical Tablet Manufacturing Process via Wet Granulation

Ravendra Singh, Dana Barrasso, Rohit Ramachandran, 2014, Journal of Pharmaceutical Innovation.

Implementation of an advanced hybrid MPC-PID control system using PAT tools into a direct compaction continuous pharmaceutical tablet manufacturing pilot plant.

Marianthi Ierapetritou, Ravendra Singh, Rohit Ramachandran, 2014, International journal of pharmaceutics.

A Computationally Efficient Surrogate-Based Reduction of a Multiscale Comill Process Model

Marianthi Ierapetritou, Rohit Ramachandran, Nirupaplava Metta, 2019, Journal of Pharmaceutical Innovation.

Population Balance Model Development, Validation, and Prediction of CQAs of a High-Shear Wet Granulation Process: Towards QbD in Drug Product Pharmaceutical Manufacturing

Dana Barrasso, Rohit Ramachandran, Huiquan Wu, 2014, Journal of Pharmaceutical Innovation.

Recent advances in integrated process analytical techniques, modeling, and control strategies to enable continuous biomanufacturing of monoclonal antibodies

Ravendra Singh, Rohit Ramachandran, Haoran Zhang, 2021 .

Statistical analysis and comparison of a continuous high shear granulator with a twin screw granulator: Effect of process parameters on critical granule attributes and granulation mechanisms.

Fernando J. Muzzio, Rohit Ramachandran, Maitraye Sen, 2016, International journal of pharmaceutics.

Multi-scale flowsheet simulation of an integrated continuous purification-downstream pharmaceutical manufacturing process.

Ravendra Singh, Anwesha Chaudhury, Rohit Ramachandran, 2013, International journal of pharmaceutics.

Near infrared spectroscopic calibration models for real time monitoring of powder density.

Marianthi Ierapetritou, Ravendra Singh, Rafael Méndez, 2016, International journal of pharmaceutics.

Real time monitoring of powder blend bulk density for coupled feed-forward/feed-back control of a continuous direct compaction tablet manufacturing process.

Marianthi Ierapetritou, Ravendra Singh, Rohit Ramachandran, 2015, International journal of pharmaceutics.

A quantitative assessment of the influence of primary particle size polydispersity on granule inhomogeneity

Anwesha Chaudhury, Rohit Ramachandran, Frantisek Stepanek, 2012 .

A Multi-Scale Hybrid CFD-DEM-PBM Description of a Fluid-Bed Granulation Process

Dana Barrasso, Rohit Ramachandran, Maitraye Sen, 2014 .

The effects of improper mixing and preferential wetting of active and excipient ingredients on content uniformity in high shear wet granulation

Fernando J. Muzzio, Rohit Ramachandran, Sarang Oka, 2015 .

Dynamic Flowsheet Model Development and Sensitivity Analysis of a Continuous Pharmaceutical Tablet Manufacturing Process Using the Wet Granulation Route

Marianthi G. Ierapetritou, Ingmar Nopens, Thomas De Beer, 2019, Processes.

Computational Approaches for Studying the Granular Dynamics of Continuous Blending Processes, 2 – Population Balance and Data‐Based Methods

Marianthi G. Ierapetritou, Fernando J. Muzzio, Atul Dubey, 2012 .

Experimental validation studies on a multi-dimensional and multi-scale population balance model of batch granulation

Francis J. Doyle, Ian T. Cameron, Charles D. Immanuel, 2009 .

Multi-dimensional population balance model development and validation for a twin screw granulation process

Dana Barrasso, Rohit Ramachandran, James D. Litster, 2015 .

Model Development and Validation of Fluid Bed Wet Granulation with Dry Binder Addition Using a Population Balance Model Methodology

Rohit Ramachandran, Ashutosh Tamrakar, Preetanshu Pandey, 2018, Processes.

A mechanistic model for breakage in population balances of granulation: Theoretical kernel development and experimental validation

Francis J. Doyle, Charles D. Immanuel, Rohit Ramachandran, 2009 .

Experimental studies on distributions of granule size, binder content and porosity in batch drum granulation: Inferences on process modelling requirements and process sensitivities

Francis J. Doyle, Ian T. Cameron, Charles D. Immanuel, 2008 .

Multi-dimensional mechanistic modeling of fluid bed granulation processes: An integrated approach

Alexander M. Niziolek, Anwesha Chaudhury, Rohit Ramachandran, 2013 .

A comparison of model order reduction techniques for a four-dimensional population balance model describing multi-component wet granulation processes

Dana Barrasso, Rohit Ramachandran, R. Ramachandran, 2012 .

Compartment based population balance model development of a high shear wet granulation process via dry and wet binder addition

Rohit Ramachandran, Anik Chaturbedi, Ajit S. Narang, 2017 .

Effects of Process and Design Parameters on Granule Size Distribution in a Continuous High Shear Granulation Process

Fernando J. Muzzio, Rohit Ramachandran, Sarang Oka, 2017, Journal of Pharmaceutical Innovation.

A systematic framework to monitor mulling processes using Near Infrared spectroscopy

Jun Zhang, Benjamin J. Glasser, Rohit Ramachandran, 2016 .

Quantitative validation and analysis of the regime map approach for the wet granulation of industrially relevant zirconium hydroxide powders

Fernando J. Muzzio, Benjamin J. Glasser, Rohit Ramachandran, 2016 .

Multi-scale modeling of granulation processes: Bi-directional coupling of PBM with DEM via collision frequencies

Dana Barrasso, Rohit Ramachandran, R. Ramachandran, 2015 .

Distribution and accessibility of binder in wet granules

Rohit Ramachandran, Rey T. Chern, František Štěpánek, 2009 .

Integrated Population Balance Model Development and Validation of a Granulation Process

Anwesha Chaudhury, Rohit Ramachandran, R. Ramachandran, 2013 .

Flowsheet models modernize pharmaceutical manufacturing design and risk assessment

Fernando J. Muzzio, Rohit Ramachandran, Maitraye Sen, 2015 .

Model development and prediction of particle size distribution, density and friability of a comilling operation in a continuous pharmaceutical manufacturing process

Marianthi Ierapetritou, Ingmar Nopens, Ravendra Singh, 2018, International journal of pharmaceutics.

Advanced process design and understanding of continuous twin-screw granulation via implementation of in-line process analytical technologies

Fernando J. Muzzio, Rohit Ramachandran, Andrés D. Román-Ospino, 2019, Advanced Powder Technology.