Megan L. McCain

发表

Optical Clearing of Skeletal Muscle Bundles Engineered in 3-D Printed Templates

Divya Gupta, Nethika R. Ariyasinghe, Jeffrey W. Santoso, 2020, Annals of Biomedical Engineering.

Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip.

Megan L. McCain, K. Parker, A. Grosberg, 2011, Lab on a chip.

A tissue-engineered jellyfish with biomimetic propulsion

Megan L. McCain, J. Nawroth, A. Feinberg, 2012, Nature Biotechnology.

Micropatterning Alginate Substrates for In Vitro Cardiovascular Muscle on a Chip

Kevin Kit Parker, Ashutosh Agarwal, Alexander P Nesmith, 2013, Advanced functional materials.

Muscle on a chip: in vitro contractility assays for smooth and striated muscle.

Josue A. Goss, Alexander P Nesmith, Megan L. McCain, 2012, Journal of pharmacological and toxicological methods.

Microfluidic heart on a chip for higher throughput pharmacological studies.

Josue A. Goss, Megan L. McCain, K. Parker, 2013, Lab on a chip.

Cooperative coupling of cell-matrix and cell–cell adhesions in cardiac muscle

Kevin Kit Parker, Hyungsuk Lee, Megan L. McCain, 2012, Proceedings of the National Academy of Sciences.

Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function

Kevin Kit Parker, Megan L. McCain, K. Parker, 2011, Pflügers Archiv - European Journal of Physiology.

Modeling the mitochondrial cardiomyopathy of Barth syndrome with iPSC and heart-on-chip technologies

Gang Wang, Ronald J A Wanders, Kevin Kit Parker, 2014 .

Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes

Sean P Sheehy, Mackenzie A. Eagleson, Anna Grosberg, 2017, Experimental biology and medicine.

Title Toward improved myocardial maturity in an organon-chip platform with immature cardiac myocytes

Mackenzie A. Eagleson, Alexander P Nesmith, Megan L. McCain, 2017 .

Coupling primary and stem cell – derived cardiomyocytes in an in vitro model of cardiac cell therapy

Megan L. McCain, S. Sheehy, K. Parker, 2022 .

Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip

Kevin Kit Parker, Anna Grosberg, Sean P. Sheehy, 2013, Proceedings of the National Academy of Sciences.

Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues.

Kevin Kit Parker, Ashutosh Agarwal, Alexander P Nesmith, 2014, Biomaterials.

Matrix elasticity regulates the optimal cardiac myocyte shape for contractility.

Megan L. McCain, K. Parker, F. Pasqualini, 2014, American journal of physiology. Heart and circulatory physiology.

Chapter 2 In Vitro Tools for Quantifying Structure – Function Relationships in Cardiac Myocyte Cells and Tissues

Megan L. McCain, A. Grosberg, M. B. Knight, 2019 .

Fabrication of Micromolded Gelatin Hydrogels for Long-Term Culture of Aligned Skeletal Myotubes.

Jeffrey W. Santoso, Megan L. McCain, Gio C. Suh, 2017, Methods in molecular biology.

Prolonged Culture of Aligned Skeletal Myotubes on Micromolded Gelatin Hydrogels

Megan L. McCain, N. Geisse, Gio C. Suh, 2016, Scientific Reports.

Engineering cardiac microphysiological systems to model pathological extracellular matrix remodeling.

Davi M. Lyra-Leite, Nethika R. Ariyasinghe, Megan L. McCain, 2018, American journal of physiology. Heart and circulatory physiology.

Featured Article: TGF-β1 dominates extracellular matrix rigidity for inducing differentiation of human cardiac fibroblasts to myofibroblasts

Megan L. McCain, Nathan Cho, Shadi Razipour, 2018, Experimental biology and medicine.

Modeling Patient-Specific Muscular Dystrophy Phenotypes and Therapeutic Responses in Reprogrammed Myotubes Engineered on Micromolded Gelatin Hydrogels

Jeffrey W. Santoso, Megan L. McCain, Laura Rabichow, 2022, Frontiers in cell and developmental biology.

Extended culture and imaging of normal and regenerating adult zebrafish hearts in a fluidic device.

Megan L. McCain, G. E. Fernandez, C. Lien, 2019, Lab on a chip.

Coupling primary and stem cell–derived cardiomyocytes in an in vitro model of cardiac cell therapy

Megan L. McCain, S. Sheehy, K. Parker, 2016 .

Immunity Protective and Therapeutic Antitumor T Cell-Mediated + CCR 6 Elicit Potent CD 8 Antigen-Expressing Vaccines that Target Tumor-Associated Embryonic

Megan L. McCain, R. Schiavo, A. Biragyn, 2007 .

Tumor-Associated Embryonic Antigen-Expressing Vaccines that Target CCR6 Elicit Potent CD8+ T Cell-Mediated Protective and Therapeutic Antitumor Immunity1

Megan L. McCain, R. Schiavo, A. Biragyn, 2007, The Journal of Immunology.

Engineering the Cellular Microenvironment of Post-infarct Myocardium on a Chip

Megan L. McCain, Natalie N. Khalil, 2021, Frontiers in Cardiovascular Medicine.

Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes

Josue A. Goss, Megan L. McCain, A. Feinberg, 2015, Experimental biology and medicine.

Heterogeneous pdgfrβ+ cells regulate coronary vessel development and revascularization during heart regeneration

Megan L. McCain, M. Pellegrini, C. Lien, 2021, bioRxiv.

Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current.

Megan L. McCain, A. Kleber, K. Parker, 2012, Cardiovascular research.

Connexin 43 Expression Delineates Two Discrete Pathways in the Human Atrioventricular Junction

Paul A Iaizzo, Igor R Efimov, Jacob I Laughner, 2008, Anatomical record.

Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation.

Kevin Kit Parker, Ashutosh Agarwal, Alexander P Nesmith, 2014, Lab on a chip.

Regulation of calcium dynamics and propagation velocity by tissue microstructure in engineered strands of cardiac tissue.

Davi M. Lyra-Leite, Nethika R. Ariyasinghe, Jeffrey W. Santoso, 2020, Integrative biology : quantitative biosciences from nano to macro.

Angiotensin II Induced Cardiac Dysfunction on a Chip

Megan L. McCain, S. Sheehy, K. Parker, 2016, PloS one.

Microenvironmental Modulation of Calcium Wave Propagation Velocity in Engineered Cardiac Tissues

Davi M. Lyra-Leite, Nethika R. Ariyasinghe, Megan L. McCain, 2018, Cellular and Molecular Bioengineering.

Cardiac tissue models

Megan L. McCain, J. K. Yip, J. Yip, 2019, Microfluidic Cell Culture Systems.

Contact photolithography-free integration of patterned and semi-transparent indium tin oxide stimulation electrodes into polydimethylsiloxane-based heart-on-a-chip devices for streamlining physiological recordings.

Megan L. McCain, Debarghya Sarkar, R. Kapadia, 2021, Lab on a chip.

Neuromuscular disease modeling on a chip

Jeffrey W. Santoso, Megan L. McCain, 2020, Disease Models & Mechanisms.

Characterization of Gelatin Hydrogels Cross-Linked with Microbial Transglutaminase as Engineered Skeletal Muscle Substrates

Jeffrey W. Santoso, Megan L. McCain, Divya Gupta, 2021, Bioengineering.

A myocardial infarct border-zone-on-a-chip demonstrates distinct regulation of cardiac tissue function by an oxygen gradient

Sarah J. Parker, Megan L. McCain, Hongyan Yuan, 2022, Science advances.

Matrix-Guided Control of Mitochondrial Function in Cardiac Myocytes.

Davi M. Lyra-Leite, Nethika R. Ariyasinghe, Megan L. McCain, 2019, Acta biomaterialia.

Mitochondrial division inhibitor 1 (mdivi‐1) increases oxidative capacity and contractile stress generated by engineered skeletal muscle

Megan L. McCain, Allen M. Andres, Megan L Rexius-Hall, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mitochondrial architecture in cardiac myocytes depends on cell shape and matrix rigidity.

Davi M. Lyra-Leite, Nethika R. Ariyasinghe, Megan L. McCain, 2020, Journal of molecular and cellular cardiology.

Mitochondrial function in engineered cardiac tissues is regulated by extracellular matrix elasticity and tissue alignment.

Davi M. Lyra-Leite, Nethika R. Ariyasinghe, Megan L. McCain, 2017, American journal of physiology. Heart and circulatory physiology.

Engineering micromyocardium to delineate cellular and extracellular regulation of myocardial tissue contractility.

Davi M. Lyra-Leite, Nethika R. Ariyasinghe, Megan L. McCain, 2017, Integrative biology : quantitative biosciences from nano to macro.

Engineering Shape-Controlled Microtissues on Compliant Hydrogels with Tunable Rigidity and Extracellular Matrix Ligands.

Nethika R. Ariyasinghe, Megan L. McCain, Megan L Rexius-Hall, 2020, Methods in molecular biology.

Engineering Cardiac Cell Junctions In Vitro to Study the Intercalated Disc

Megan L. McCain, A. Kleber, T. Desplantez, 2014, Cell communication & adhesion.

Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: relation between Cx43 immunofluorescence and intercellular electrical conductance.

Megan L. McCain, A. Kleber, K. Parker, 2012, American journal of physiology. Heart and circulatory physiology.

Electrical Coupling and Propagation in Engineered Ventricular Myocardium With Heterogeneous Expression of Connexin43

Megan L. McCain, A. Kleber, K. Parker, 2012, Circulation research.

conductancece and intercellular electrical ventricular cardiomyocytes: relation between Cx43 Cell-to-cell coupling in engineered pairs of rat

Megan L. McCain, A. Kleber, K. Parker, 2012 .

Engineering skeletal muscle tissues with advanced maturity improves synapse formation with human induced pluripotent stem cell-derived motor neurons

Jeffrey W. Santoso, Megan L. McCain, D. Dickman, 2021, APL bioengineering.

Engineering Programmable Material-To-Cell Pathways Via Synthetic Notch Receptors To Spatially Control Cellular Phenotypes In Multi-Cellular Constructs

Alexander R March, Megan L. McCain, Leonardo Morsut, 2023, bioRxiv.

Tools, techniques, and future opportunities for characterizing the mechanobiology of uterine myometrium

Megan L. McCain, Antonina P Maxey, Antonina P. Maxey, 2021, Experimental biology and medicine.

Modeling the mitochondrial cardiomyopathy of Barth syndrome with iPSC and heart-on-chip technologies

George A. Truskey, Megan L. McCain, George M. Church, 2014, Nature Medicine.

Heterogeneous pdgfrβ+ cells regulate coronary vessel development and revascularization during heart regeneration.

Megan L. McCain, M. Pellegrini, C. Lien, 2022, Development.

Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function.

Megan L. McCain, K. Parker, 2011 .

And the beat goes on

Megan L. McCain, 2019, Science Translational Medicine.