Eric Boerwinkle

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Exploring Genetic Epidemiology Data with Bayesian Networks

Andrei S. Rodin, Grigoriy Gogoshin, Anatoliy Litvinenko, 2012 .

ACAT: A Fast and Powerful P-value Combination Method for Rare-variant Analysis in Sequencing Studies

Xihong Lin, Eric Boerwinkle, Sixing Chen, 2018, bioRxiv.

An Empirical Comparison of Meta‐analysis and Mega‐analysis of Individual Participant Data for Identifying Gene‐Environment Interactions

Eric Boerwinkle, Sharon L R Kardia, Yun Ju Sung, 2014, Genetic epidemiology.

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

Seunggeun Lee, Brian E. Cade, Tamar Sofer, 2018, bioRxiv.

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

Giovanni Malerba, Jin Li, Rohit Varma, 2017, Nature Genetics.

Reproducibility of genotypes as measured by the affymetrix GeneChip® 100K Human Mapping Array set

Brooke L. Fridley, Andrei S. Rodin, Eric Boerwinkle, 2008, Comput. Stat. Data Anal..

Measuring Marker Information Content by the Ambiguity of Block Boundaries Observed in Dense SNP Data

Eric Boerwinkle, Kai Yu, C Charles Gu, 2007, Annals of human genetics.

xAtlas: scalable small variant calling across heterogeneous next-generation sequencing experiments

Donna M. Muzny, Eric Boerwinkle, Olga Krasheninina, 2018, bioRxiv.

Launching genomics into the cloud: deployment of Mercury, a next generation sequence analysis pipeline

Simon White, Donna M. Muzny, Narayanan Veeraraghavan, 2014, BMC Bioinformatics.

Statistical causal networks using multi-omics and the concept of granularity

Eric Boerwinkle, Azam Yazdani Akram Yazdani Ahmad Samiei, 2015 .

Fast implementation of a scan statistic for identifying chromosomal patterns of genome wide association studies

Eric Boerwinkle, Stephen T. Turner, Sharon L. R. Kardia, 2009, Comput. Stat. Data Anal..

A generalized weighted quantile sum approach for analyzing correlated data in the presence of interactions

Eric Boerwinkle, MinJae Lee, Mohammad H Rahbar, 2019, Biometrical journal. Biometrische Zeitschrift.

Mining genetic epidemiology data with Bayesian networks I: Bayesian networks and example application (plasma apoE levels)

Andrei S. Rodin, Eric Boerwinkle, E. Boerwinkle, 2005, Bioinform..

Parliament2: Fast Structural Variant Calling Using Optimized Combinations of Callers

Goo Jun, Eric Boerwinkle, Samantha Zarate, 2018, bioRxiv.

Rare variants analysis using penalization methods for whole genome sequence data

Eric Boerwinkle, Azam Yazdani, Akram Yazdani, 2015, BMC Bioinformatics.

Identification, analysis, and interpretation of a human serum metabolomics causal network in an observational study

Ahmad Samiei, Eric Boerwinkle, Azam Yazdani, 2016, J. Biomed. Informatics.

Pathway analysis with next-generation sequencing data

Momiao Xiong, Eric Boerwinkle, Jinying Zhao, 2014, European Journal of Human Genetics.

Hardy Weinberg Exact Test In Large Scale Variant Calling Quality Control

Degui Zhi, Navin Rustagi, Eric Boerwinkle, 2016, bioRxiv.

Evaluation of microarray-based DNA methylation measurement using technical replicates: the Atherosclerosis Risk In Communities (ARIC) Study

Yu Zhang, Chong Wu, Eric Boerwinkle, 2014, BMC Bioinformatics.

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

Seunggeun Lee, Tamar Sofer, Xihong Lin, 2018, bioRxiv.

Use of Wrapper Algorithms Coupled with a Random Forests Classifier for Variable Selection in Large-Scale Genomic Association Studies

Andrei S. Rodin, Anatoliy Litvinenko, Eric Boerwinkle, 2009, J. Comput. Biol..

Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo

Susan R. Heckbert, John Attia, M. Arfan Ikram, 2010, PLoS genetics.

Analysis of Sequence Data Under Multivariate Trait-Dependent Sampling

Ran Tao, Donglin Zeng, Dan-Yu Lin, 2015, Journal of the American Statistical Association.

A hybrid computational strategy to address WGS variant analysis in >5000 samples

Manjunath Gorentla Venkata, Narayanan Veeraraghavan, Navin Rustagi, 2016, BMC Bioinformatics.

New Algorithm and Software (BNOmics) for Inferring and Visualizing Bayesian Networks from Heterogeneous Big Biological and Genetic Data

Andrei S. Rodin, Grigoriy Gogoshin, Eric Boerwinkle, 2017, J. Comput. Biol..

An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene‐Lifestyle Interactions Working Group

Claude Bouchard, Xiaofeng Zhu, Eric Boerwinkle, 2016, Genetic epidemiology.

ACAT: A Fast and Powerful p Value Combination Method for Rare-Variant Analysis in Sequencing Studies.

Xihong Lin, Eric Boerwinkle, Sixing Chen, 2019, American journal of human genetics.

Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

Åsa Johansson, Morris Swertz, John Attia, 2017, Scientific Reports.

Generating a robust statistical causal structure over 13 cardiovascular disease risk factors using genomics data

Ahmad Samiei, Eric Boerwinkle, Azam Yazdani, 2016, J. Biomed. Informatics.

Conceptual Aspects of Causal Networks in an Applied Context

Eric Boerwinkle, Azam Yazdani, Akram Yazdani, 2016 .

Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole Genome Sequencing Studies

Xihong Lin, Eric Boerwinkle, Yaowu Liu, 2019, bioRxiv.

Genome-wide association and functional follow-up reveals new loci for kidney function | NOVA. The University of Newcastle's Digital Repository

Yurii S. Aulchenko, Albert Hofman, Qiong Yang, 2012 .

Diagnostic tools in linkage analysis for quantitative traits

Eric Boerwinkle, Mariza de Andrade, Brooke Fridley, 2003, Genetic epidemiology.

Discovery and Refinement Supplementary

Christian Gieger, Cisca Wijmenga, Inês Barroso, 2015 .

Atlas-CNV: a validated approach to call single-exon CNVs in the eMERGESeq gene panel

Alexander Fedotov, Simon White, Eric Boerwinkle, 2018, Genetics in Medicine.

Mining Genetic Epidemiology Data with Bayesian Networks Application to APOE Gene Variation and Plasma Lipid Levels

Andrew G. Clark, Andrei S. Rodin, Eric Boerwinkle, 2005, J. Comput. Biol..

Predictive Analytics for Glaucoma using Data from the All of Us Research Program.

Lucila Ohno-Machado, Eric Boerwinkle, Tsung-Ting Kuo, 2021, American journal of ophthalmology.

Knowledge-Driven Analysis Identifies a Gene–Gene Interaction Affecting High-Density Lipoprotein Cholesterol Levels in Multi-Ethnic Populations

Andrew G. Clark, Eric Boerwinkle, Charles F. Sing, 2012, PLoS genetics.

Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction

Udo Hoffmann, David M Herrington, Eric Boerwinkle, 2011, Circulation.

Genome-wide association study identiﬁes novel loci for plasma levels of protein C: the ARIC study

Eric Boerwinkle, Mary Cushman, Xiaoxiao Kong, 2022 .

Trans-ethnic meta-analysis of white blood cell phenotypes.

Yusuke Nakamura, Ming-Huei Chen, Rehan Qayyum, 2014, Human molecular genetics.

Cardiac Troponin T Measured by a Highly Sensitive Assay Predicts Coronary Heart Disease, Heart Failure, and Mortality in the Atherosclerosis Risk in Communities Study

Eric Boerwinkle, Ron C. Hoogeveen, Vijay Nambi, 2011, Circulation.

Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program

James A Perry, Eric Boerwinkle, Josée Dupuis, 2019, bioRxiv.

In silico prediction of splice-altering single nucleotide variants in the human genome

Eric Boerwinkle, Xueqiu Jian, E. Boerwinkle, 2014, Nucleic acids research.

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Eden R Martin, Seth Love, Brian Lawlor, 2019, Nature Genetics.

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Thomas Meitinger, Inês Barroso, Peter Kraft, 2010, Nature Genetics.

Determinants of the success of whole-genome association testing.

Eric Boerwinkle, Andrew G Clark, E. Boerwinkle, 2005, Genome research.

On Robust Association Testing for Quantitative Traits and Rare Variants

Wei Pan, Eric Boerwinkle, Il-Youp Kwak, 2016, G3: Genes, Genomes, Genetics.

Analysis of Rare, Exonic Variation amongst Subjects with Autism Spectrum Disorders and Population Controls

Kathryn Roeder, Stephan Ripke, Shannon Gross, 2013, PLoS genetics.

A causal network analysis in an observational study identifies metabolomics pathways influencing plasma triglyceride levels

Eric Boerwinkle, Azam Yazdani, Akram Yazdani, 2016, Metabolomics.

Peroxisome proliferator–activated receptor α genetic variation interacts with n−6 and long-chain n−3 fatty acid intake to affect total cholesterol and LDL-cholesterol concentrations in the Atherosclerosis Risk in Communities Study

Eric Boerwinkle, Christie M. Ballantyne, Kelly A. Volcik, 2008 .

Role of Metabolic Genes in Blood Arsenic Concentrations of Jamaican Children with and without Autism Spectrum Disorder

Eric Boerwinkle, Megan L. Grove, Katherine A. Loveland, 2014, International journal of environmental research and public health.

Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans.

Mengmeng Du, Charles Kooperberg, Eric Boerwinkle, 2014, Human molecular genetics.

Inferring population mutation rate and sequencing error rate using the SNP frequency spectrum in a sample of DNA sequences.

Taylor J. Maxwell, Eric Boerwinkle, Yun-Xin Fu, 2009, Molecular biology and evolution.

Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder.

Eric Boerwinkle, Mohammad H Rahbar, Maureen Samms-Vaughan, 2015, Research in autism spectrum disorders.

Causal inference at the population level

Eric Boerwinkle, Azam Yazdani, E. Boerwinkle, 2014 .

The landscape of recombination in African Americans

Xiaofeng Zhu, Alex P. Reiner, Jasmin Divers, 2011, Nature.

Moderate mutation rate in the SARS coronavirus genome and its implications

Zhongming Zhao, Eric Boerwinkle, Yun-Xin Fu, 2004, BMC Evolutionary Biology.

Resolution of Disease Phenotypes Resulting from Multilocus Genomic Variation

Donna M. Muzny, Yan Ding, Eric Boerwinkle, 2017, The New England journal of medicine.

A meta-analysis of genome-wide linkage scans for hypertension: the National Heart, Lung and Blood Institute Family Blood Pressure Program.

Eric Boerwinkle, Stephen T Turner, Steven C Hunt, 2003, American journal of hypertension.

Independent Susceptibility Markers for Atrial Fibrillation on Chromosome 4q25

Eric Boerwinkle, Annette Peters, John Barnard, 2010, Circulation.

Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

Sylvia Stracke, Alex Doney, Yurii S. Aulchenko, 2012, PLoS genetics.

Genome-wide association analysis identifies multiple loci related to resting heart rate.

Christian Gieger, Thomas Meitinger, Henry Völzke, 2010, Human molecular genetics.

Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies

Mark I. McCarthy, Deborah A. Nickerson, Xiaowu Gai, 2008, PloS one.

Sequence Variations in PCSK 9 , Low LDL , and Protection against Coronary Heart Disease

Eric Boerwinkle, Jonathan C. Cohen, Helen H. Hobbs, 2006 .

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Inês Barroso, Jiyoung Heo, Beverley Balkau, 2015, Nature communications.

Pleiotropic genes for metabolic syndrome and inflammation.

Eric Boerwinkle, Josée Dupuis, Sharon L R Kardia, 2014, Molecular genetics and metabolism.

Understanding the accuracy of statistical haplotype inference with sequence data of known phase

Eric Boerwinkle, Andrew G Clark, E. Boerwinkle, 2007, Genetic epidemiology.

Metabolomics Identifies Novel Blood Biomarkers of Pulmonary Function and COPD in the General Population

Christian Gieger, Gabi Kastenmüller, Eric Boerwinkle, 2019, Metabolites.

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

Christian Gieger, Ming-Huei Chen, Luigi Ferrucci, 2009, Nature Genetics.

Seafood Consumption and Blood Mercury Concentrations in Jamaican Children With and Without Autism Spectrum Disorders

Eric Boerwinkle, Megan L. Grove, Katherine A. Loveland, 2012, Neurotoxicity Research.

Multiple Loci Are Associated with White Blood Cell Phenotypes

Christian Gieger, Yusuke Nakamura, Kazuhiko Yamamoto, 2011, PLoS genetics.

Practical Approaches for Whole-Genome Sequence Analysis of Heart- and Blood-Related Traits.

Navin Rustagi, Eric Boerwinkle, Fuli Yu, 2017, American journal of human genetics.

Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.

Eric Boerwinkle, Len A Pennacchio, Jonathan C. Cohen, 2008, The Journal of clinical investigation.

Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping

Xiaofeng Zhu, Eric Boerwinkle, Hua Tang, 2012, Journal of hypertension.

An exome array study of the plasma metabolome

Qiong Yang, Eric Boerwinkle, Susan Cheng, 2016, Nature Communications.

Strategies to Design and Analyze Targeted Sequencing Data: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study

Eric Boerwinkle, Mayetri Gupta, Thomas Lumley, 2014, Circulation. Cardiovascular genetics.

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL

Eric Boerwinkle, Yunxin Fu, Len A Pennacchio, 2007, Nature Genetics.

Genomic Susceptibility Loci for Brain Atrophy in Hypertensive Sibships From the GENOA Study

Clifford R Jack, Eric Boerwinkle, Mariza de Andrade, 2005, Hypertension.

Fine Mapping and Identification of BMI Loci in African Americans.

Eric Farber-Eger, Dana C Crawford, Stephanie Rosse, 2013, American journal of human genetics.

CUBN is a gene locus for albuminuria.

Sylvia Stracke, Ming-Huei Chen, Luigi Ferrucci, 2011, Journal of the American Society of Nephrology : JASN.

Genomic Association Analysis Suggests Chromosome 12 Locus Influencing Antihypertensive Response to Thiazide Diuretic

Brooke L. Fridley, Hugues Sicotte, Eric Boerwinkle, 2008, Hypertension.

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Thomas Meitinger, Inês Barroso, Peter Kraft, 2011, Nature Genetics.

Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease: A Scientific Statement From the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group

David M Herrington, Eric Boerwinkle, Donna K Arnett, 2007, Circulation.

Tree Scanning

Alan R. Templeton, David Posada, Taylor J. Maxwell, 2005, Genetics.

Blood Lead Concentrations in Jamaican Children with and without Autism Spectrum Disorder

Eric Boerwinkle, Megan L. Grove, Katherine A. Loveland, 2014, International journal of environmental research and public health.

Rare Complete Knockouts in Humans: Population Distribution and Significant Role in Autism Spectrum Disorders

Kathryn Roeder, Stephan Ripke, Shannon Gross, 2013, Neuron.

Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) study.

Eric Boerwinkle, Vijay Nambi, Christie M. Ballantyne, 2010, Journal of the American College of Cardiology.

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes

Sylvia Stracke, Christian Gieger, Joshua C. Denny, 2015, Diabetes.

Association of exome sequences with plasma C-reactive protein levels in >9000 participants.

Pierre Fontanillas, Charles Kooperberg, Eric Boerwinkle, 2015, Human molecular genetics.

Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE Consortium

Ming-Huei Chen, Qiong Yang, Nicole Soranzo, 2010 .

FTO genotype is associated with phenotypic variability of body mass index

Joel Eriksson, Joseph E. Powell, Andres Metspalu, 2012, Nature.

β-Fibrinogen gene -455G/A polymorphism and coronary heart disease incidence: The Atherosclerosis Risk in Communities (ARIC) Study

Eric Boerwinkle, Chul Ahn, E. Boerwinkle, 2001 .

Epistasis analysis for quantitative traits by functional regression model

Momiao Xiong, Eric Boerwinkle, Futao Zhang, 2014, Genome research.

Autosomal Genome-Wide Scan for Coronary Artery Calcification Loci in Sibships at High Risk for Hypertension

Patrick Royston, Eric Boerwinkle, Stephen T Turner, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits : (Nature Genetics, (2018), 50, 10, (1412-1425), 10.1038/s41588-018-0205-x)

Christian Gieger, Ian J. Deary, He Gao, 2018 .

Mapping and characterization of structural variation in 17,795 human genomes

Eric S. Lander, Haley J. Abel, Yeting Zhang, 2020, Nature.

From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II.

Antonio Colombo, Chun Yuan, Morteza Naghavi, 2003, Circulation.

Common variants in the GDF5-UQCC region are associated with variation in human height

Shah Ebrahim, Debbie A Lawlor, Yoav Ben-Shlomo, 2008, Nature Genetics.

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits.

He Gao, Tim Kacprowski, Andres Metspalu, 2016, American journal of human genetics.

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.

Christian Gieger, Xiaofeng Zhu, Tom R. Gaunt, 2014, American journal of human genetics.

NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium

Suzette J. Bielinski, Yurii S. Aulchenko, Jeffrey R. O'Connell, 2009, PLoS genetics.

Novel Genetic Loci Associated With Retinal Microvascular Diameter

Paul Mitchell, Ching-Yu Cheng, Eric Boerwinkle, 2016, Circulation. Cardiovascular genetics.

Interaction between manganese and GSTP1 in relation to autism spectrum disorder while controlling for exposure to mixture of lead, mercury, arsenic, and cadmium.

Eric Boerwinkle, Mohammad H Rahbar, Maureen Samms-Vaughan, 2018, Research in autism spectrum disorders.

Common and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI Exome Sequencing Project.

Eric Boerwinkle, Deborah A Nickerson, David Green, 2013, Blood.

Novel Associations of Multiple Genetic Loci With Plasma Levels of Factor VII, Factor VIII, and von Willebrand Factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium

Ming-Huei Chen, Qiong Yang, Nicole Soranzo, 2010, Circulation.

Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes.

Peter Kraft, Eric Boerwinkle, Josée Dupuis, 2010, Human molecular genetics.

Generalized T2 test for genome association studies.

Momiao Xiong, Eric Boerwinkle, E. Boerwinkle, 2002, American journal of human genetics.

Genomic Association Analysis Reveals Variants Associated With Blood Pressure Response to Beta‐Blockers in European Americans

Eric Boerwinkle, Stephen T Turner, Kent R Bailey, 2019, Clinical and translational science.

Loss-of-function variants influence the human serum metabolome

Eric Boerwinkle, Alexander Hanbo Li, Richard A Gibbs, 2016, Science Advances.

Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk

Christian Gieger, Xiaofeng Zhu, Paolo Vineis, 2011, Nature.

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

Jianwen Cai, Tao Wang, Charles Kooperberg, 2019, PLoS genetics.

Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Christian Gieger, Jason Carey, Steven Wiltshire, 2016 .

Common variants at ten loci modulate the QT interval duration in the QTSCD Study

Christian Gieger, Thomas Meitinger, Raimund Erbel, 2009, Nature Genetics.

Whole-genome sequencing study of serum peptide levels: the Atherosclerosis Risk in Communities study

Eric Boerwinkle, Richard A Gibbs, Paul S de Vries, 2017, Human molecular genetics.

Demographic, environmental, and genetic predictors of metabolic side effects of hydrochlorothiazide treatment in hypertensive subjects.

Eric Boerwinkle, Stephen T Turner, E. Boerwinkle, 2005, American journal of hypertension.

Directional dominance on stature and cognition in diverse human populations

Laura J. Scott, Claude Bouchard, Christian Gieger, 2015, Nature.

Population Genomic Analysis of 962 Whole Genome Sequences of Humans Reveals Natural Selection in Non-Coding Regions

Andrew G. Clark, Jian Lu, Eric Boerwinkle, 2015, PloS one.

Multiple rare alleles at LDLR and APOA5 confer risk for early-onset myocardial infarction

David M. Herrington, Adam Kiezun, Peter Donnelly, 2014, Nature.

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

Tom H. Lindner, Eric Boerwinkle, Naoko Iwasaki, 2000, Nature Genetics.

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Alexander Pertsemlidis, Eric Boerwinkle, Chao Xing, 2008, Nature Genetics.

Molecular Diagnostic Experience of Whole-Exome Sequencing in Adult Patients

Chad A Shaw, Eric Boerwinkle, Fan Xia, 2015, Genetics in Medicine.

Genetic Determinants Influencing Human Serum Metabolome among African Americans

Eric Boerwinkle, Danny Alexander, Alanna C. Morrison, 2014, PLoS genetics.

Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

Claude Bouchard, Christian Gieger, Tuija Tammelin, 2017 .

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

Matti Pirinen, David M. Herrington, Alex Doney, 2014, Nature Communications.

Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence.

Hongyu Zhao, Eric Boerwinkle, Joel Gelernter, 2013, American journal of human genetics.

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Christian Gieger, Alex Doney, Inês Barroso, 2010, Nature Genetics.

Associations Between Lipoprotein(a) Levels and Cardiovascular Outcomes in Black and White Subjects: The Atherosclerosis Risk in Communities (ARIC) Study

Eric Boerwinkle, Thomas H Mosley, Diane J Catellier, 2011, Circulation.

Evaluating the Context-Dependent Effect of Family History of Stroke in a Genome Scan for Hypertension

Eric Boerwinkle, Stephen T Turner, Sharon L R Kardia, 2003, Stroke.

Comparison of strategies for selecting single nucleotide polymorphisms for case/control association studies

Eric Boerwinkle, Qiqing Huang, Yun-Xin Fu, 2003, Human Genetics.

Troponin T and NT–Pro B-Type Natriuretic Peptide: A Biomarker Approach to Predict Heart Failure Risk—the Atherosclerosis Risk in Communities Study

Eric Boerwinkle, Thomas H Mosley, Anita Deswal, 2014 .

Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism.

Eric Boerwinkle, Deborah A Nickerson, Veikko Salomaa, 2002, American journal of human genetics.

Personalized medicine for high blood pressure.

Eric Boerwinkle, Stephen T Turner, E. Boerwinkle, 2007, Hypertension.

Scott T. Weiss, Hemant K. Tiwari, Donald W. Bowden, 2019, bioRxiv.

In silico tools for splicing defect prediction - A survey from the viewpoint of end-users

Eric Boerwinkle, Xueqiu Jian, E. Boerwinkle, 2013, Genetics in Medicine.

Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project

Donald W. Bowden, Eric Boerwinkle, Christopher A. Haiman, 2011, PLoS genetics.

Association studies for next-generation sequencing.

Momiao Xiong, Eric Boerwinkle, Li Luo, 2011, Genome research.

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

Tom R. Gaunt, Fotios Drenos, Meena Kumari, 2012, American journal of human genetics.

Positional Identification of Hypertension Susceptibility Genes on Chromosome 2

Eric Boerwinkle, Stephen T Turner, Steven C Hunt, 2004, Hypertension.

The performance of deleteriousness prediction scores for rare non-protein-changing single nucleotide variants in human genes

Eric Boerwinkle, Chang Li, E. Boerwinkle, 2016, Journal of Medical Genetics.

Genome-wide association study of PR interval

Christian Gieger, Thomas Meitinger, Jan A. Kors, 2010, Nature Genetics.

New loci associated with kidney function and chronic kidney disease

Uwe Völker, Luigi Ferrucci, Reinhold Schmidt, 2010, Nature Genetics.

Strategic transformation of population studies: recommendations of the working group on epidemiology and population sciences from the National Heart, Lung, and Blood Advisory Council and Board of External Experts.

Eric Boerwinkle, Isaac Kohane, Bruce M Psaty, 2015, American journal of epidemiology.

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Christian Gieger, Gonçalo Abecasis, He Gao, 2018, Nature Genetics.

Replicating genotype – phenotype associations What constitutes replication of a genotype – phenotype association , and how best can it be achieved ?

Peter Donnelly, Lon R. Cardon, Ellen M. Wijsman, 2007 .

Genetic Predisposition to Higher Blood Pressure Increases Coronary Artery Disease Risk

Michael J Pencina, Eric Boerwinkle, Themistocles L Assimes, 2013, Hypertension.

Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies.

Eric Boerwinkle, Walter Palmas, Andrew D. Johnson, 2016, American heart journal.

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Christian Gieger, Jianxin Shi, Inês Barroso, 2013, Nature Genetics.

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

Jingyuan Fu, Thomas Meitinger, Jan A. Kors, 2010, Nature Genetics.

Whole-exome sequencing reveals an inherited R566X mutation of the epithelial sodium channel β-subunit in a case of early-onset phenotype of Liddle syndrome

Eric Boerwinkle, Richard A. Gibbs, Sanjay Shete, 2016, Cold Spring Harbor molecular case studies.

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

Fernando Pires Hartwig, Claude Bouchard, Christian Gieger, 2018, American journal of human genetics.

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

Claude Bouchard, Uwe Völker, Todd L Edwards, 2016, Nature Genetics.

The Challenges of Genome-Wide Interaction Studies: Lessons to Learn from the Analysis of HDL Blood Levels

Eric Boerwinkle, Vilmundur Gudnason, Tony Kam-Thong, 2014, PloS one.

Creating a data resource: what will it take to build a medical information commons?

John Wilbanks, Robert Gentleman, Isaac S. Kohane, 2017, Genome Medicine.

The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster

Andrew G. Clark, Deborah A. Nickerson, Stephanie M. Fullerton, 2004, Human Genetics.

Genome-Wide Association Studies of Serum Magnesium, Potassium, and Sodium Concentrations Identify Six Loci Influencing Serum Magnesium Levels

Christian Gieger, Thomas Meitinger, Qiong Yang, 2010, PLoS genetics.

Analysis commons, a team approach to discovery in a big-data environment for genetic epidemiology

Andrew Carroll, Eric Boerwinkle, Andrew D. Johnson, 2017, Nature Genetics.

Discovery and fine mapping of serum protein loci through transethnic meta-analysis.

Christian Gieger, Yusuke Nakamura, Luigi Ferrucci, 2012, American journal of human genetics.

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

Brian E. Cade, Zachary A. Szpiech, Shannon Kelly, 2019, Nature.

Estimating population genetic parameters and comparing model goodness-of-fit using DNA sequences with error.

Taylor J. Maxwell, Eric Boerwinkle, Yun-Xin Fu, 2010, Genome research.

Coronary heart disease and genetic variants with low phospholipase A2 activity.

Eric Boerwinkle, Richard A Gibbs, R. Gibbs, 2015, The New England journal of medicine.

Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases

Laura J. Scott, Christian Gieger, Peter Kraft, 2012, PLoS genetics.

Analysis of loss-of-function variants and 20 risk factor phenotypes in 8,554 individuals identifies loci influencing chronic disease

Eric Boerwinkle, Thomas Lumley, Alexander Hanbo Li, 2015, Nature Genetics.

A multilocus approach to the antihypertensive pharmacogenetics of hydrochlorothiazide

Eric Boerwinkle, Stephen T Turner, E. Boerwinkle, 2005, Pharmacogenetics and genomics.

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.

Xiaofeng Zhu, Todd L Edwards, Dana C Crawford, 2016, American journal of human genetics.

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Claude Bouchard, Beverley Balkau, Bengt Sennblad, 2012, Nature Genetics.

Translational Genomics is Not a Spectator Sport: A Call to Action

Eric Boerwinkle, E. Boerwinkle, 2012, Genetic epidemiology.

Whole genome sequencing of Caribbean Hispanic families with late‐onset Alzheimer's disease

James Jaworski, Mohamad Saad, Eric Boerwinkle, 2018, Annals of clinical and translational neurology.

Genetic Structure, Self-identified Race/ethnicity, and Confounding in Case-control Association Studies

Xiaofeng Zhu, Eric Boerwinkle, Sharon L R Kardia, 2022 .

Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations

Xiaofeng Zhu, Tamar Sofer, Joshua C Denny, 2017, PLoS genetics.

Gene‐environment interplay in common complex diseases: forging an integrative model—recommendations from an NIH workshop

Peter Kraft, Kimberly McAllister, Eric Boerwinkle, 2011, Genetic epidemiology.

WGSA: an annotation pipeline for human genome sequencing studies

Andrew Carroll, Eric Boerwinkle, Bo Peng, 2015, Journal of Medical Genetics.

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Christian Gieger, Gonçalo Abecasis, He Gao, 2017, bioRxiv.

Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence

Steven M. Southwick, Henry R. Kranzler, Eric Boerwinkle, 2017, JAMA psychiatry.

Role of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder.

Eric Boerwinkle, Mohammad H Rahbar, Maureen Samms-Vaughan, 2014, Research in autism spectrum disorders.

Replication of the Wellcome Trust genome-wide association study of essential hypertension: the Family Blood Pressure Program

Eric Boerwinkle, Karen Schwander, Steven C Hunt, 2008, European Journal of Human Genetics.

Application of machine learning algorithms to predict coronary artery calcification with a sibship‐based design

Eric Boerwinkle, Yan V. Sun, E. Boerwinkle, 2008, Genetic epidemiology.

Inactivating mutations in NPC1L1 and protection from coronary heart disease.

John Spertus, Thomas Meitinger, Joshua C Denny, 2014, The New England journal of medicine.

The Atherosclerosis Risk in Communities (ARIC) Study

Eric Boerwinkle, Bruce A. Wasserman, Patrick T. Bradshaw, 2011 .

Association of Genome-Wide Variation With the Risk of Incident Heart Failure in Adults of European and African Ancestry: A Prospective Meta-Analysis From the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

Eric Boerwinkle, Thomas Lumley, Wolfgang Lieb, 2010, Circulation. Cardiovascular genetics.

A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease

Olli Saarela, Frank Kee, Kaisa Silander, 2011, Circulation. Cardiovascular genetics.

Genotype Imputation of MetabochipSNPs Using a Study‐Specific Reference Panel of ∼4,000 Haplotypes in African Americans From the Women's Health Initiative

Wei Wang, Dana C Crawford, Eric Yi Liu, 2012, Genetic epidemiology.

Neighboring-nucleotide effects on single nucleotide polymorphisms: a study of 2.6 million polymorphisms across the human genome.

Zhongming Zhao, Eric Boerwinkle, Zhongming Zhao, 2002, Genome research.

An assessment of incremental coronary risk prediction using C-reactive protein and other novel risk markers: the atherosclerosis risk in communities study.

Eric Boerwinkle, Lloyd E Chambless, Josef Coresh, 2006, Archives of internal medicine.

Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation

Thomas Meitinger, Andres Metspalu, Dan M. Roden, 2010, Nature Genetics.

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Christian Gieger, Jingyuan Fu, Thomas Meitinger, 2011, Nature Genetics.

Blood manganese concentrations in Jamaican children with and without autism spectrum disorders

Eric Boerwinkle, Mohammad H Rahbar, Maureen Samms-Vaughan, 2014, Environmental Health.

The gene, environment association studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions

Eric Boerwinkle, Eleanor Feingold, Myriam Fornage, 2010, Genetic epidemiology.

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.

Sylvia Stracke, Christian Gieger, Alex Doney, 2012, Human molecular genetics.

Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.

Yoav Ben-Shlomo, Eric Boerwinkle, Nilesh J Samani, 2012, American journal of human genetics.

PacBio-LITS: a large-insert targeted sequencing method for characterization of human disease-associated chromosomal structural variations

Eric Boerwinkle, Christian Buhay, Fuli Yu, 2015, BMC Genomics.

Impact of Haplotype-Frequency Estimation Error on Test Statistics in Association Studies

Momiao Xiong, Eric Boerwinkle, Jinying Zhao, 2006 .

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Xiaofeng Zhu, Vladan Mijatovic, Inês Barroso, 2016, Nature Genetics.

Predictors of antihypertensive response to a standard dose of hydrochlorothiazide for essential hypertension.

Eric Boerwinkle, Stephen T Turner, E. Boerwinkle, 2002, Kidney international.

Gene expression profiling and functional proteomic analysis reveal perturbed kinase-mediated signaling in genetic stroke susceptibility.

Eric Boerwinkle, Myriam Fornage, M. Fornage, 2003, Physiological genomics.

Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits

Jia Jia, Ming-Huei Chen, Eric Boerwinkle, 2016, Nature Genetics.

Hypertension in pregnancy as a risk factor for cardiovascular disease later in life

Eric Boerwinkle, E. Boerwinkle, K. Bailey, 2010, Journal of hypertension.

Loss-of-function mutations in APOC3, triglycerides, and coronary disease.

He Zhang, Thomas Meitinger, Raimund Erbel, 2014, The New England journal of medicine.

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Claude Bouchard, Christian Gieger, Joel Eriksson, 2016, Nature communications.

A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels.

Eric Boerwinkle, Chao Xing, Jonathan C. Cohen, 2010, American journal of human genetics.

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

John Spertus, Markus Perola, Eric Boerwinkle, 2012, The Lancet.

An entropy-based genome-wide transmission/disequilibrium test

Momiao Xiong, Eric Boerwinkle, E. Boerwinkle, 2007, Human Genetics.

An entropy-based statistic for genomewide association studies.

Momiao Xiong, Eric Boerwinkle, E. Boerwinkle, 2005, American journal of human genetics.

Multiple loci associated with indices of renal function and chronic kidney disease

Yurii S. Aulchenko, Ingo Ruczinski, Qiong Yang, 2009, Nature Genetics.

Best Practices and Joint Calling of the HumanExome BeadChip: The CHARGE Consortium

Eric Boerwinkle, Vilmundur Gudnason, Lenore J. Launer, 2013, PloS one.

Carotid Arterial Wall Characteristics Are Associated With Incident Ischemic Stroke But Not Coronary Heart Disease in the Atherosclerosis Risk in Communities (ARIC) Study

Eric Boerwinkle, Eric Y. Yang, Vijay Nambi, 2012, Stroke.

Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF.

Uwe Völker, Tim Kacprowski, Ming-Huei Chen, 2015, Blood.

The role of drinking water sources, consumption of vegetables and seafood in relation to blood arsenic concentrations of Jamaican children with and without Autism Spectrum Disorders.

Eric Boerwinkle, Megan L. Grove, Katherine A. Loveland, 2012, The Science of the total environment.

Genetics of blood pressure, hypertensive complications, and antihypertensive drug responses.

Eric Boerwinkle, Stephen T Turner, E. Boerwinkle, 2003, Pharmacogenomics.

Major clinical trials of hypertension: what should be done next?

Thomas D. Giles, Eric Boerwinkle, John B. Kostis, 2005, Hypertension.

Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium.

Dana C Crawford, Florian Kronenberg, Eric Boerwinkle, 2012, Atherosclerosis.

Abstract 4238: COnsortium for METabolomics Studies (COMETS): leveraging resources to accelerate scientific discovery

Christian Gieger, David M. Herrington, Mukesh Verma, 2016 .

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Hynek Pikhart, Tom R. Gaunt, Meena Kumari, 2014, BMJ : British Medical Journal.

Multi-center genetic study of hypertension: The Family Blood Pressure Program (FBPP).

Steven C. Hunt, Eric Boerwinkle, Nicholas J. Schork, 2002, Hypertension.

Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation

Gonçalo Abecasis, Dan M Roden, Christopher M Haggerty, 2018, JAMA.

A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases

Eric Boerwinkle, William B. Dobyns, Tomasz Gambin, 2014, Cell.

Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.

Xiaofeng Zhu, Todd L Edwards, Wei Guo, 2013, American journal of human genetics.

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

Joshua C Denny, Wei-Qi Wei, Fredrik Nyberg, 2016, Journal of Medical Genetics.

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Christian Gieger, Inês Barroso, Peter Kraft, 2010, Nature Genetics.

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

Eric Boerwinkle, Vilmundur Gudnason, Thomas Lumley, 2009, Nature Genetics.

Predicting Stroke Through Genetic Risk Functions: The CHARGE Risk Score Project

Sudha Seshadri, Eric Boerwinkle, Martin Dichgans, 2014, Stroke.