Ruth Brenk

发表

Here Be Dragons: Docking and Screening in an Uncharted Region of Chemical Space

John J Irwin, Brian K Shoichet, Ruth Brenk, 2005, Journal of biomolecular screening.

De Novo Design, Synthesis, and In Vitro Evaluation of Inhibitors for Prokaryotic tRNA‐Guanine Transglycosylase: A Dramatic Sulfur Effect on Binding Affinity

Gerhard Klebe, François Diederich, Ruth Brenk, 2002, Chembiochem : a European journal of chemical biology.

De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments

Daniel Rauh, Brad Sherborne, Michael Kiczun, 2013, ACS chemical biology.

Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry.

Torsten Luksch, Dominic J Campopiano, Ruth Brenk, 2010, Nature chemistry.

“Hot Spot” Analysis of Protein‐binding Sites as a Prerequisite for Structure‐based Virtual Screening and Lead Optimization

Gerhard Klebe, Ruth Brenk, 2006 .

Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis.

Gerhard Klebe, Klaus Reuter, Hans-Dieter Gerber, 2003, Journal of medicinal chemistry.

Flexible Adaptations in the Structure of the tRNA‐Modifying Enzyme tRNA–Guanine Transglycosylase and Their Implications for Substrate Selectivity, Reaction Mechanism and Structure‐Based Drug Design

Gerhard Klebe, Klaus Reuter, Ruth Brenk, 2003, Chembiochem : a European journal of chemical biology.

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness

Ian H. Gilbert, Chidochangu P. Mpamhanga, Michael Hodgkinson, 2010, Nature.

Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening.

Gerhard Klebe, Klaus Reuter, François Diederich, 2004, Journal of molecular biology.

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

Ian H. Gilbert, Chidochangu P. Mpamhanga, William N. Hunter, 2009, Journal of medicinal chemistry.

Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases

Daniel James, Agata Krasowski, Ruth Brenk, 2007, ChemMedChem.

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

Ian H Gilbert, Paul G Wyatt, Torsten Luksch, 2011, ChemMedChem.

To Hit or Not to Hit, That Is the Question – Genome-wide Structure-Based Druggability Predictions for Pseudomonas aeruginosa Proteins

Aurijit Sarkar, Ruth Brenk, R. Brenk, 2015, PloS one.

From Hit to Lead: De Novo Design Based on Virtual Screening Hits of Inhibitors of tRNA‐Guanine Transglycosylase, a Putative Target of Shigellosis Therapy

Gerhard Klebe, Klaus Reuter, Ruth Brenk, 2003 .

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Ian H. Gilbert, Irene Hallyburton, Alan H. Fairlamb, 2011, Journal of medicinal chemistry.