Shailesh N Mistry

发表

27th Annual GP2A Medicinal Chemistry Conference

Barrie Kellam, Shailesh N Mistry, Pascal Marchand, 2019, Pharmaceuticals.

Molecular Determinants of Allosteric Modulation at the M1 Muscarinic Acetylcholine Receptor*

Arthur Christopoulos, Patrick M Sexton, Laura López, 2014, The Journal of Biological Chemistry.

Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease

Shailesh N Mistry, P. Fischer, S. Gardiner, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.

Arthur Christopoulos, Patrick M Sexton, Ben Capuano, 2016, Journal of Medicinal Chemistry.

GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors

Shailesh N Mistry, C. Laughton, P. Fischer, 2017, Journal of biomolecular structure & dynamics.

Novel selective b1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease

Shailesh N Mistry, P. Fischer, S. Gardiner, 2017 .

Synthesis and Characterization of High-Affinity 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene-Labeled Fluorescent Ligands for Human β-Adrenoceptors

Shailesh N Mistry, S. Hill, J. Baker, 2011, Journal of medicinal chemistry.

Development of fluorescent peptide G Protein Coupled Receptor activation biosensors for NanoBRET characterisation of intracellular allosteric modulators

Shailesh N Mistry, C. Laughton, N. Holliday, 2022, bioRxiv.

Synthesis and in vitro antimicrobial activity of new steroidal hydrazone derivatives

Shailesh N Mistry, A. Singh, 2022, Future Journal of Pharmaceutical Sciences.

Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors

Shailesh N Mistry, P. Sexton, A. Christopoulos, 2018, Molecular Pharmacology.

Abdul-Ridha, Alaa and Lane, J. Robert and Mistry, Shailesh N. and Lopez, Laura and Sexton, Patrick M. and Scammells, Peter J. and Christopoulos, Arthur and Canals, Meritxell (2014) Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine

Shailesh N Mistry, P. Sexton, A. Christopoulos, 2016 .

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

Shailesh N Mistry, K. Gregory, A. Christopoulos, 2015, British journal of pharmacology.

M1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease

Shailesh N Mistry, P. Sexton, A. Christopoulos, 2022, Science Signaling.

Structure-activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor.

Shailesh N Mistry, A. Christopoulos, P. Scammells, 2015, Journal of medicinal chemistry.

Triphenylphosphonium Anhydride Trifluoromethanesulfonate

Shailesh N Mistry, J. B. Hendrickson, J. Hendrickson, 2011 .

Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor.

Shailesh N Mistry, S. Charlton, D. Sykes, 2019, Journal of medicinal chemistry.

4,5‐Dihydro‐1‐[(1S)‐1‐(hydroxymethyl)‐2,2‐dimethylpropyl]‐3‐(2,4,6‐trimethylphenyl)‐1H‐imidazolium Hexafluorophosphate

Shailesh N Mistry, 2012 .

Synthesis and in Vitro and in Vivo Characterization of Highly β1-Selective β-Adrenoceptor Partial Agonists

Shailesh N Mistry, P. Fischer, S. Gardiner, 2013, Journal of medicinal chemistry.

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.

Shailesh N Mistry, S. McGowan, A. Paiardini, 2016, European journal of medicinal chemistry.

Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.

Shailesh N Mistry, P. Sexton, A. Christopoulos, 2013, Journal of medicinal chemistry.

Positive Allosteric Modulation of the Muscarinic M1 Receptor Improves Efficacy of Antipsychotics in Mouse Glutamatergic Deficit Models of Behavior

David M. Shackleford, Shailesh N Mistry, C. Langmead, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

Christel A. S. Bergström, Shailesh N Mistry, I. Kukavica-Ibrulj, 2020, Frontiers in Chemistry.

Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.

Shailesh N Mistry, A. Christopoulos, P. Scammells, 2016, ACS chemical neuroscience.

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.

Shailesh N Mistry, S. McGowan, A. Paiardini, 2014, Journal of medicinal chemistry.

Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D2 receptor.

Shailesh N Mistry, P. Scammells, J. R. Lane, 2019, European journal of medicinal chemistry.

Activation of M1 muscarinic receptors reduce pathology and slow progression of neurodegenerative disease

Shailesh N Mistry, P. Sexton, A. Christopoulos, 2021, bioRxiv.

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18

Shailesh N Mistry, S. McGowan, A. Paiardini, 2015, PloS one.

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

Shailesh N Mistry, K. Gregory, A. Christopoulos, 2015, British journal of pharmacology.

Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H1 Receptor

Leigh A. Stoddart, Shailesh N Mistry, R. Leurs, 2022, Journal of medicinal chemistry.

Mechanistic Insights into Allosteric Structure-Function Relationships at the M1 Muscarinic Acetylcholine Receptor*

Arthur Christopoulos, Laura López, Patrick M. Sexton, 2014, The Journal of Biological Chemistry.

Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand.

Shailesh N Mistry, A. Christopoulos, Lei Shi, 2015, Journal of medicinal chemistry.

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.

Shailesh N Mistry, P. Sexton, A. Christopoulos, 2017 .

Acetylcholine Receptor Muscarinic 1 Modulation at the M Molecular Determinants of Allosteric Signal Transduction

Shailesh N Mistry, P. Sexton, A. Christopoulos, 2016 .

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.

Shailesh N Mistry, S. McGowan, A. Paiardini, 2016, European journal of medicinal chemistry.

Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2

Shailesh N Mistry, C. Laughton, N. Holliday, 2023, Journal of medicinal chemistry.

Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors

Shailesh N Mistry, P. Sexton, A. Christopoulos, 2018, Molecular Pharmacology.

A Thieno[2,3- d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor.

Shailesh N Mistry, P. Scammells, J. R. Lane, 2019, Journal of Medicinal Chemistry.

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.

Shailesh N Mistry, S. McGowan, A. Paiardini, 2014, Journal of medicinal chemistry.

Molecular Determinants of Allosteric Modulation at the M1 Muscarinic Acetylcholine Receptor*

Shailesh N Mistry, P. Sexton, A. Christopoulos, 2014, The Journal of Biological Chemistry.