Dustin J Maly

发表

Multi-input chemical control of protein dimerization for programming graded cellular responses

William Sheffler, Zhizhi Wang, David Baker, 2019, Nature Biotechnology.

Peptide microarrays for the determination of protease substrate specificity.

Dustin J Maly, J. Ellman, Cleo M. Salisbury, 2002, Journal of the American Chemical Society.

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds

Gregory J. Crowther, Dustin J Maly, G. Drewes, 2016, PloS one.

Sequence determinants of a specific inactive protein kinase conformation.

Ethan A Merritt, Dustin J Maly, E. Merritt, 2013, Chemistry & biology.

Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors.

Dustin J Maly, J. Ellman, I. C. Choong, 2000, Proceedings of the National Academy of Sciences of the United States of America.

A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent Functions.

Alan F. Rubin, Ethan A Merritt, Douglas M Fowler, 2019, Molecular cell.

Altered Substrate Specificity of Drug-Resistant Human Immunodeficiency Virus Type 1 Protease

Sami Mahrus, Neil Parkin, Dustin J Maly, 2002, Journal of Virology.

Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations.

John Kuriyan, Yibing Shan, Dustin J Maly, 2009, Cancer research.

Profiling serine protease substrate specificity with solution phase fluorogenic peptide microarrays

Scott L Diamond, Dustin J Maly, S. Diamond, 2005, Proteomics.

A computationally engineered RAS rheostat reveals RAS/ERK signaling dynamics

David Baker, Alejandro Wolf-Yadlin, Inna Goreshnik, 2016, Nature chemical biology.

Rapid profiling of protein kinase inhibitors by quantitative proteomics.

Dustin J Maly, Martin Golkowski, Shao-En Ong, 2014, MedChemComm.

Intracellular delivery of bioactive molecules using light-addressable nanocapsules.

Daniel T Chiu, Jennifer C. Gadd, Dustin J Maly, 2010, ACS nano.

Kinome chemoproteomics characterization of pyrrolo[3,4-c]pyrazoles as potent and selective inhibitors of glycogen synthase kinase 3.

Dustin J Maly, S. Ong, W. V. Van Voorhis, 2018, Molecular omics.

Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.

Dustin J Maly, W. V. Van Voorhis, K. Ojo, 2016, The Journal of infectious diseases.

Tuning a three-component reaction for trapping kinase substrate complexes.

Dustin J Maly, D. Lockhart, P. Zarrinkar, 2008, Journal of the American Chemical Society.

One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases.

Dustin J Maly, W. V. Voorhis, S. Tzipori, 2020, Veterinary parasitology.

A chemically-controlled system for activating RAS GTPases.

Dustin J Maly, E. M. Dieter, E. Dieter, 2020, Methods in enzymology.

Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays

Dustin J Maly, M. Parsons, E. Merritt, 2018, Antimicrobial Agents and Chemotherapy.

Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung

Dustin J Maly, R. Ghosh, F. R. Papa, 2018, bioRxiv.

Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung

Dustin J Maly, R. Ghosh, F. R. Papa, 2018, bioRxiv.

Rheostatic Control of Cas9-Mediated DNA Double Strand Break (DSB) Generation and Genome Editing

John C. Rose, Cindy T. Wei, Dustin J Maly, 2017, ACS chemical biology.

Pharmacoproteomics Identifies Kinase Pathways that Drive the Epithelial-Mesenchymal Transition and Drug Resistance in Hepatocellular Carcinoma.

Dustin J Maly, S. Ong, Ho-Tak Lau, 2020, Cell systems.

Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.

Dustin J Maly, C. Craik, B. J. Backes, 2002, The Journal of organic chemistry.

Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.

Dustin J Maly, J. Bluestone, R. Ghosh, 2017, Cell metabolism.

5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents.

Dustin J Maly, S. Lindner, W. V. Van Voorhis, 2016, Bioorganic & medicinal chemistry letters.

Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.

Steven M. Johnson, Dustin J Maly, C. Verlinde, 2014, European journal of medicinal chemistry.

Biochemical mechanisms of resistance to small-molecule protein kinase inhibitors.

Dustin J Maly, R. Krishnamurty, 2010, ACS chemical biology.

In vitro growth inhibition of Theileria equi by bumped kinase inhibitors.

Dustin J Maly, R. Evanoff, W. V. Van Voorhis, 2018, Veterinary parasitology.

Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned.

Dustin J Maly, D. Kempf, R. Hackman, 2020, International journal for parasitology.

Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy

Dustin J Maly, B. Striepen, A. White, 2017, The Journal of infectious diseases.

P-Glycoprotein–Mediated Efflux Reduces the In Vivo Efficacy of a Therapeutic Targeting the Gastrointestinal Parasite Cryptosporidium

Dustin J Maly, W. V. Van Voorhis, N. Yarlett, 2019, The Journal of infectious diseases.

The Right Tool for the Job: A Chemical and Genetic Toolkit for Interrogating DCLK1 Function.

Dustin J Maly, L. Fang, 2020, Cell chemical biology.

A versatile, chemically-controlled DNA binding switch enables temporal modulation of Cas9-based effectors

Cindy T. Wei, Dustin J Maly, E. Borenstein, 2022, bioRxiv.

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.

Dustin J Maly, W. Hol, M. Parsons, 2016, Journal of medicinal chemistry.

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

Dustin J Maly, W. Hol, M. Parsons, 2015, ACS medicinal chemistry letters.

Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis.

Dustin J Maly, M. Parsons, A. DeRocher, 2018, The Journal of infectious diseases.

5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum

Dustin J Maly, W. V. Van Voorhis, K. Ojo, 2017, Antimicrobial Agents and Chemotherapy.

Extended-spectrum antiprotozoal bumped kinase inhibitors: A review.

Dustin J Maly, M. Parsons, E. Merritt, 2017, Experimental parasitology.

7 H-Pyrrolo[2,3- d]pyrimidin-4-amine-Based Inhibitors of Calcium-Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared with 1 H-Pyrazolo[3,4- d]pyrimidin-4-amine-Based Inhibitors.

Dustin J Maly, E. Merritt, W. V. Van Voorhis, 2018, ACS infectious diseases.

Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis.

Dustin J Maly, D. Kempf, Joachim Müller, 2017, International journal for parasitology.

A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.

Dustin J Maly, X. Su, K. Comess, 2014, The Journal of infectious diseases.

Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection

Dustin J Maly, B. Striepen, W. V. Van Voorhis, 2017, The Journal of infectious diseases.

Bumped kinase inhibitor prohibits egression in Babesia bovis.

Dustin J Maly, W. V. Van Voorhis, Molly C. Reid, 2016, Veterinary parasitology.

SH2-Catalytic Domain Linker Heterogeneity Influences Allosteric Coupling across the SFK Family

Dustin J Maly, S. Leonard, A. Register, 2014, Biochemistry.

Combinatorial Strategies for Targeting Protein Families: Application to the Proteases

Dustin J Maly, J. Ellman, L. Huang, 2002, Chembiochem : a European journal of chemical biology.

Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly.

Dustin J Maly, C. Bertozzi, J. Kehoe, 2002, Bioorganic & medicinal chemistry letters.

A novel protein kinase is essential in bloodstream Trypanosoma brucei.

Dustin J Maly, M. Parsons, B. Jensen, 2016, International journal for parasitology.

Title: Designed sensors reveal normal and oncogenic Ras signaling in endomembranes and condensates

John C. Rose, Dustin J Maly, D. Baker, 2022 .

An integrated approach reveals a regulatory mechanism coupling Src’s kinase activity, localization, and phosphotransferase-independent functions

Dustin J Maly, E. Merritt, D. Fowler, 2019 .

ACombined Approach Reve als a RegulatoryMechanism Coupling Src ’ s Kinase Activity , Localization , and Phosphotransferase-Independent Functions Graphical Abstract Highlights

Alan F. Rubin, Dustin J Maly, E. Merritt, 2019 .

How ATP-competitive inhibitors allosterically modulate tyrosine kinases that contain a Src-like regulatory architecture.

Dustin J Maly, M. Seeliger, Zachary E. Potter, 2020, ACS chemical biology.

Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.

Steven M. Johnson, Dustin J Maly, C. Verlinde, 2012, Bioorganic & medicinal chemistry letters.

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

Dustin J Maly, E. Snapp, R. Ghosh, 2014, Cell.

Divergent Modulation of Src-Family Kinase Regulatory Interactions with ATP-Competitive Inhibitors

Dustin J Maly, S. Leonard, Gabriel J. Brighty, 2014, ACS chemical biology.

Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src.

Dustin J Maly, M. Seeliger, S. Hari, 2013, ACS chemical biology.

Active site profiling reveals coupling between domains in SRC-family kinases

Dustin J Maly, E. Merritt, E. Larson, 2012, Nature chemical biology.

Bumped kinase inhibitor 1369 is effective against Cystoisospora suis in vivo and in vitro

Dustin J Maly, W. V. Van Voorhis, Aruna Shrestha, 2019, International Journal for Parasitology: Drugs and Drug Resistance.

Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.

Dustin J Maly, F. R. Papa, Michael Tong, 2016, ACS chemical biology.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

Dustin J Maly, Ho-Tak Lau, Martin Golkowski, 2023, Molecular cell.

Affinity-based probes based on type II kinase inhibitors.

Dustin J Maly, J. Villén, E. Merritt, 2012, Journal of the American Chemical Society.

Allosteric Modulation of JNK Docking Site Interactions with ATP-Competitive Inhibitors.

Dustin J Maly, Audrey L Davis, C. Lombard, 2018, Biochemistry.

Bivalent inhibitors of protein kinases

Dustin J Maly, Carrie M. Gower, Matthew E K Chang, 2014, Critical reviews in biochemistry and molecular biology.

A mechanism-based cross-linker for the identification of kinase-substrate pairs.

Dustin J Maly, K. Shokat, Jasmina A Allen, 2004, Journal of the American Chemical Society.

Radiotherapy Followed by Aurora Kinase Inhibition Targets Tumor-Propagating Cells in Human Glioblastoma

Dustin J Maly, M. Berger, C. James, 2014, Molecular Cancer Therapeutics.

Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1.

Dustin J Maly, F. R. Papa, B. J. Backes, 2019, ACS chemical biology.

Druggable sensors of the unfolded protein response.

Dustin J Maly, F. R. Papa, F. Papa, 2014, Nature chemical biology.

Allosteric Inhibition of the IRE 1 a RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

Dustin J Maly, E. Snapp, R. Ghosh, 2014 .

Subcellular drug targeting illuminates local kinase action

Dustin J Maly, John D. Scott, H. Hehnly, 2019, eLife.

Kinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors.

Dustin J Maly, Hyong Won Suh, Martin Golkowski, 2017, Journal of proteome research.

Bivalent inhibitors of the tyrosine kinases ABL and SRC: determinants of potency and selectivity.

Dustin J Maly, Z. Hill, B. G. K. Perera, 2011, Molecular bioSystems.

Design, synthesis and characterization of "clickable" 4-anilinoquinazoline kinase inhibitors.

Dustin J Maly, B. G. K. Perera, 2008, Molecular bioSystems.

Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity.

Dustin J Maly, M. Schirle, Edmund M. Harrington, 2016, ACS chemical biology.

Calcium‐Dependent Protein Kinases of Apicomplexan Parasites as Drug Targets

Dustin J Maly, W. V. Voorhis, E. Merritt, 2013 .

Targeting diverse signaling interaction sites allows the rapid generation of bivalent kinase inhibitors.

Simeon S. Andrews, Dustin J Maly, Z. Hill, 2012, ACS chemical biology.

Affinity purification of protein kinases that adopt a specific inactive conformation.

Dustin J Maly, Pratistha Ranjitkar, 2012, Methods in molecular biology.

Protein kinase affinity reagents based on a 5-aminoindazole scaffold.

Amanda M. Brock, Dustin J Maly, R. Krishnamurty, 2011, Bioorganic & medicinal chemistry letters.

Affinity reagents that target a specific inactive form of protein kinases.

Amanda M. Brock, Dustin J Maly, Pratistha Ranjitkar, 2010, Chemistry & biology.

In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum

Dustin J Maly, Joachim Müller, W. V. Van Voorhis, 2015, Antimicrobial Agents and Chemotherapy.

Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy

Dustin J Maly, W. Hol, E. Merritt, 2014, PloS one.

In vitro efficacy of bumped kinase inhibitors against Besnoitia besnoiti tachyzoites.

Dustin J Maly, A. Hehl, W. V. Van Voorhis, 2017, International journal for parasitology.

Multiplexed profiling of kinase interactomes quantifies cellular network plasticity

Dustin J Maly, Ho-Tak Lau, Andrea Lius, 2021, bioRxiv.

Kinome-centric pharmacoproteomics identifies signaling pathways underlying cellular responses to targeted cancer drugs

Dustin J Maly, Ho-Tak Lau, R. Yeung, 2019, bioRxiv.

Profiling of the drug resistance of thousands of Src tyrosine kinase mutants uncovers a regulatory network that couples autoinhibition to catalytic domain dynamics

Dustin J Maly, D. Fowler, Jason J. Stephany, 2021, bioRxiv.

Conformation-selective ATP-competitive inhibitors control regulatory interactions and noncatalytic functions of mitogen-activated protein kinases.

Dustin J Maly, E. Merritt, S. Hari, 2014, Chemistry & biology.

Temporal and rheostatic control of genome editing with a chemically-inducible Cas9.

Cindy T. Wei, Dustin J Maly, D. Fowler, 2020, Methods in enzymology.

Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs

Douglas M. Fowler, John C. Rose, Nicholas A. Popp, 2019, Nature Communications.

Kinobead/LC-MS Phosphokinome Profiling Enables Rapid Analyses of Kinase-Dependent Cell Signaling Networks.

Dustin J Maly, J. Beavo, Ho-Tak Lau, 2019, Journal of proteome research.

Targeting Dynamic ATP-Binding Site Features Allows Discrimination between Highly Homologous Protein Kinases.

Dustin J Maly, Martin Golkowski, Sujata Chakraborty, 2019, ACS chemical biology.

Proteomic Profiling of Protein Kinase Inhibitor Targets by Mass Spectrometry.

Dustin J Maly, Martin Golkowski, Shao-En Ong, 2017, Methods in molecular biology.

A hexylchloride-based catch-and-release system for chemical proteomic applications.

Dustin J Maly, Jennifer L Brigham, B. G. K. Perera, 2013, ACS chemical biology.

Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival.

Dustin J Maly, R. Ghosh, F. R. Papa, 2019, Cancer research.

Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival

Dustin J Maly, R. Ghosh, F. R. Papa, 2019, bioRxiv.

Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics

John C. Rose, Dustin J Maly, W. J. Valente, 2017, Nature Methods.

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

Dustin J Maly, F. R. Papa, M. Seeliger, 2012, Nature chemical biology.

Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.

Steven M. Johnson, Dustin J Maly, M. Parsons, 2012, Journal of medicinal chemistry.

“Examining RAS pathway rewiring with a chemically inducible activator of RAS”

John C. Rose, Dustin J Maly, Daniel Cunningham-Bryant, 2018, Small GTPases.

Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy.

Dustin J Maly, M. Parsons, S. Dangoudoubiyam, 2016, International journal for parasitology.

Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

Dustin J Maly, F. Buckner, W. V. Voorhis, 2010, Nature Structural &Molecular Biology.

Probing Low Affinity and Multivalent Interactions with Surface Plasmon Resonance: Ligands for Concanavalin A

Dustin J Maly, M. Kanai, L. Kiessling, 1998 .

Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics.

Dustin J Maly, G. Kiss, A. Bridges, 2023, ACS chemical biology.

Allosteric Modulation of Src Family Kinases with ATP-Competitive Inhibitors.

Dustin J Maly, Sujata Chakraborty, A. Register, 2017, Methods in molecular biology.

Determination of the kinetics and thermodynamics of ligand binding to a specific inactive conformation in protein kinases.

Dustin J Maly, S. Hari, Pratistha Ranjitkar, 2012, Methods in molecular biology.

Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

Dustin J Maly, W. V. Voorhis, C. Verlinde, 2010 .

A chemical genetic method for generating bivalent inhibitors of protein kinases.

Dustin J Maly, Z. Hill, B. G. K. Perera, 2009, Journal of the American Chemical Society.

Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G

Dustin J Maly, Jianbing Mu, W. V. Van Voorhis, 2016, mBio.

Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.

Dustin J Maly, J. Bluestone, R. Ghosh, 2017, Cell metabolism.

Title Targeting ABL-IRE 1 alpha Signaling Spares ER-Stressed Pancreatic beta Cells to Reverse Autoimmune Diabetes

Dustin J Maly, J. Bluestone, R. Ghosh, 2022 .

Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis

Dustin J Maly, Joachim Müller, W. V. Van Voorhis, 2017, The Journal of antimicrobial chemotherapy.

A Chemically Disrupted Proximity System for Controlling Dynamic Cellular Processes.

John C. Rose, Dustin J Maly, Daniel Cunningham-Bryant, 2019, Journal of the American Chemical Society.

Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes.

Dustin J Maly, Zachary E. Potter, C. Lombard, 2019, Journal of the American Chemical Society.

Label Transfer Reagents to Probe p38 MAPK Binding Partners

Simeon S. Andrews, Dustin J Maly, Z. Hill, 2013, Chembiochem : a European journal of chemical biology.

Label Transfer Reagents for the Study of Protein Kinase Complexes

Simeon S. Andrews, Dustin J Maly, Gayani K Perera, 2012 .

Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold.

Dustin J Maly, K. Comess, C. Verlinde, 2014, ACS medicinal chemistry letters.

Comparative assessment of the effects of bumped kinase inhibitors on early zebrafish embryo development and pregnancy in mice

Dustin J Maly, Joachim Müller, W. V. Van Voorhis, 2020, bioRxiv.

A novel calcium-dependent protein kinase inhibitor as a lead compound for treating cryptosporidiosis.

Dustin J Maly, A. White, W. V. Van Voorhis, 2013, The Journal of infectious diseases.

Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii.

Dustin J Maly, C. Verlinde, E. Merritt, 2010, ACS medicinal chemistry letters.

Two Novel Calcium-Dependent Protein Kinase 1 Inhibitors Interfere with Vertical Transmission in Mice Infected with Neospora caninum Tachyzoites

Dustin J Maly, Joachim Müller, W. V. Van Voorhis, 2017, Antimicrobial Agents and Chemotherapy.

Bumped Kinase Inhibitor 1294 Treats Established Toxoplasma gondii Infection

Dustin J Maly, W. V. Van Voorhis, K. Ojo, 2014, Antimicrobial Agents and Chemotherapy.

Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors.

Steven M. Johnson, Dustin J Maly, C. Verlinde, 2012, The Journal of clinical investigation.

Reaktive hochfrequenz-sputterätzung von SiO2 im CF4-Ar-gasgemisch

Dustin J Maly, B. Spangenberg, 1983 .

Parallel Chemoselective Profiling for Mapping Protein Structure.

Dustin J Maly, D. Fowler, M. Guttman, 2020, Cell chemical biology.

Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.

Amanda M. Brock, Dustin J Maly, Inna Goreshnik, 2011, Bioorganic & medicinal chemistry letters.

A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

Dustin J Maly, Shihua Sun, S. Plymate, 2023, bioRxiv.

Chemical genomic and proteomic methods for determining kinase inhibitor selectivity.

Dustin J Maly, R. Krishnamurty, 2007, Combinatorial chemistry & high throughput screening.

A chemically controlled Cas9 switch enables temporal modulation of diverse effectors

Nicholas A. Popp, Cindy T. Wei, Dustin J Maly, 2023, Nature Chemical Biology.

Molecular determinants of Hsp90 dependence of Src kinase revealed by deep mutational scanning

Dustin J Maly, D. Fowler, Jason J. Stephany, 2023, Protein science : a publication of the Protein Society.

A small molecule-regulated guanine nucleotide exchange factor.

Dustin J Maly, Inna Goreshnik, 2010, Journal of the American Chemical Society.

A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer.

Dustin J Maly, S. Plymate, Lucas B. Sullivan, 2024, Molecular cancer therapeutics.

Computationally designed sensors for endogenous Ras activity reveal signaling effectors within oncogenic granules

John C. Rose, Dustin J Maly, D. Baker, 2023, bioRxiv.

Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics.

Dustin J Maly, D. Fowler, Jason J. Stephany, 2023, Cell chemical biology.

A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.

Dustin J Maly, X. Su, K. Comess, 2014, Journal of Infectious Diseases.

Profiling of the drug resistance of thousands of Src tyrosine kinase mutants uncovers a regulatory network that couples autoinhibition to the dynamics of the catalytic domain

Dustin J Maly, D. Fowler, Jason J. Stephany, 2021 .